Most Down Articles

Published in last 1 year | In last 2 years| In last 3 years| All| Most Downloaded in Recent Month | Most Downloaded in Recent Year|

In last 2 years

Please wait a minute...


For Selected: Download Citations EndNote Ris BibTeX Toggle Thumbnails

Select

Expert consensus on diagnosis and clinical management of medication-related osteonecrosis of the jaw HE Yue, CHEN Heng, AN Jin-gang, GUO Yu-xing, PAN Jian, TIAN Lei, LIU Bing, HOU Jin-song, LI Jin-song, JIANG Can-hua, LI Meng-yu, TIAN Zhen, XU Jie, ZHU Ling, SUN Chang-fu, ZHI Ke-qian, QU Qing, ZONG Chun-lin, SUN Jing-jing, ZHANG Zhi-yuan China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 313-325.   DOI: 10.19438/j.cjoms.2023.04.001 Abstract （1169）      PDF （2051KB）（1409）       Knowledge map    Medication-related osteonecrosis of the jaw(MRONJ) is a complication caused by the application of anti-resorptive medications, angiogenesis inhibitors, hormones and other medications for the treatment of some systemic diseases. The clinical symptoms include swelling, pain, masticatory disorders, persistent fistula, bone exposure and even pathological fracture, which seriously affect the patients' quality of life. Domestically, there is a lack of consensus or guidelines on classification, staging and treatment of MRONJ, and different institutions make diagnosis and treatment plans empirically. In order to unify and standardize the diagnosis and treatment of MRONJ and improve the prognosis, an expert panel of MRONJ research from 12 famous domestic medical colleges and affiliated hospitals convened a meeting to discuss the diagnosis and treatment opinions of MRONJ. Meanwhile, consensus recommendations were also revised with a comprehensive literature review of the previous treatment experiences and research findings. Finally, this expert consensus was finished for clinical references. Reference | Related Articles | Metrics

Select

Expert consensus on surgical treatment of hemangiomas and vascular malformations in the head and neck WANG Yan-an, QIN Zhong-ping, ZHENG Jia-wei, LI Chun-jie, LIU Shao-hua, YANG Yao-wu, CHEN Gang, CHEN Wei-liang, LIU Xue-jian, DU Zhong, ZHANG Lei, WANG Ye-fei, WANG De-ming, SU Li-xin, XIE Feng, DONG Chang-xian, GUO Lei, LI Kai, GU Song, HE Yue, ZHANG Zhi-yuan China Journal of Oral and Maxillofacial Surgery    2024, 22 (2): 105-117.   DOI: 10.19438/j.cjoms.2024.02.001 Abstract （500）      PDF （2515KB）（510）       Knowledge map    Hemangiomas and vascular malformations are common benign vascular diseases in the head and neck region. The evolution and extensive implementation of non-surgical therapeutic modalities have resulted in considerable improvement or even total remission in a significant number of patients in minimally invasive or non-invasive procedures. Nonetheless, under certain circumstances, surgical treatment remains an irreplaceable treatment modality within the comprehensive treatment sequence for hemangiomas and vascular malformations in the head and neck. However, there is no established standard or consensus in the academic community on how to choose and apply surgical treatment. Therefore, to enhance the treatment efficacy of hemangiomas and vascular malformations amongst domestic peers, and to standardize surgical treatment protocols, this consensus brings together the discussion opinions of relevant experts from many medical schools and affiliated hospitals nationwide. Based on the latest domestic and international research results and diagnosis and treatment experience, we formulated this expert consensus from the aspects of preoperative diagnosis and preparation, surgical treatment indications and strategies, postoperative care and observation, common complications and treatment after surgery, follow-up and social psychological support. It is expected to be used in clinical practice and to guide relevant professional doctors carrying out treatment. Reference | Related Articles | Metrics

Select

Application and advancement of minimally invasive instruments and micro-power devices in tooth extraction LI Yan-xiang, YAN Li-jun, LING Xiao-wan, ZHOU Wen-jie, WANG Yue-ping China Journal of Oral and Maxillofacial Surgery    2023, 21 (2): 191-196.   DOI: 10.19438/j.cjoms.2023.02.016 Abstract （673）      PDF （914KB）（417）       Knowledge map    Tooth extraction is to remove the affected teeth that can no longer provide oral function, and it is also one of the most basic and common procedures in alveolar surgery. Conventional tooth extraction applies elevators, forceps, chisels and other instruments, which may cause severe physical and psychological trauma to the patient. In recent years, the concepts of minimally invasive tooth extraction has been accepted in the clinic, and the development of materials has led to more refined extraction instruments. Meanwhile the use of micro-power devices has greatly improved the efficiency of tooth extraction. Advancements in tooth extraction techniques and equipments are aimed to maximumly preserve the integrity of the alveolar bone, reduce the complications, and relieve the pain. This paper described the development of minimally invasive tooth extraction techniques through the evolution of instruments and the application of micro-power devices, so as to provide reference for more dentists to understand and apply minimally invasive equipments in daily practice. Reference | Related Articles | Metrics

Select

Evaluation of the application of double wire anchor nails in temporomandibular joint disc anchorage WUERGULI Alifu, REYILAI Abudukeremu, LIU Jiang-long, MAIMAITITUXUN Tuerdi China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 397-402.   DOI: 10.19438/j.cjoms.2023.04.013 Abstract （347）      PDF （1789KB）（403）       Knowledge map    PURPOSE: To evaluate the clinical efficacy of double wire anchorage in the treatment of temporomandibular joint disc anterior displacement. METHODS: Thirty patients with anterior disc displacement without reduction(ADDWoR) diagnosed in First Affiliated Hospital of Xinjiang Medical University from June 2021 to February 2022 were included to fix the discs with double wire anchors. The maximal open mouth, visual analogue scale (VAS) scores of the patients before and at different time periods were analyzed, the patients' self-satisfaction was recorded, and the length of MRI discs and condylar height before and after operation were measured. SPSS 25.0 software was used to analyze the data and evaluate the surgical results. RESULTS: The mean age was 24.43±8.87 years old, the mean mouth opening before operation was (29.17±5.38) mm (19-42 mm), the mean maximum mouth opening after operation was (39.17±2.57) mm (35-45 mm), and 93.3% of the patients after operation had the maximum mouth opening >35 mm; the mean VAS before operation was 58.33±21.19 (10-90), the mean VAS 6 months after operation was 11.67±6.99(0-20), the mouth opening and the value of VAS 6 months after operation had significant difference compared with prior to operation(P<0.05). The disc length was (9.77±0.63), (11.96±0.68) and (12.72±0.55) mm preoperatively, immediately postoperatively and 6 months after surgery. The condyle height increased by (1.08±0.61) mm 6 months after surgery compared with immediately postoperatively (P<0.05). CONCLUSIONS: Double wire anchorage in the reduction and anchorage of TMJ disc can improve the mouth opening, relieve pain, increase the length of TMJ disc and increase the height of condyle. Reference | Related Articles | Metrics

Select

Research progress of the effect of osteoporosis on dental implant restoration JIN Xia-yue, GU Yin-xin China Journal of Oral and Maxillofacial Surgery    2023, 21 (1): 81-86.   DOI: 10.19438/j.cjoms.2023.01.014 Abstract （329）      PDF （700KB）（388）       Knowledge map    Osteoporosis is a systemic bone metabolism disease that occurs in middle-aged and elderly people. The incidence of osteoporosis is increasing year by year with the increase of the elderly population. Meanwhile, with the progress of dental implant technology, more and more elderly people undergo implant restoration. Osteoporosis was once considered to be one of the risk factors for dental implant restoration, which may influence the initial stability and survival rate of implants, and drugs for osteoporosis treatment also inevitably affect the osseointegration of implants. This article reviewed relevant studies to summarize the impact of osteoporosis on dental implant restoration. Reference | Related Articles | Metrics

Select

Research progress of ferritinophagy and related genes FTH1 and NCOA4 in oral squamous cell carcinoma LIU Heng, DUAN Xiao-feng China Journal of Oral and Maxillofacial Surgery    2023, 21 (1): 87-91.   DOI: 10.19438/j.cjoms.2023.01.015 Abstract （458）      PDF （508KB）（288）       Knowledge map    Ferritinophagy is a type of autophagy closely related to ferroptosis. The special cargo receptor NCOA4 mediates the degradation of ferritin in autophagolysosomal lysosomes, and then makes the iron drop bound by ferritin explain the release of free iron, which is an important means of iron metabolism. In recent years, more and more studies have shown that ferritinophagy and ferroptosis play an important role in the occurrence and development of tumors. However, the mechanism of iron autophagy in oral squamous cell carcinoma has not been fully elucidated at present. The in-depth study of the mechanism of ferritinophagy in oral squamous cell carcinoma is expected to become a new target for the treatment of such diseases. This paper summarized the latest progress in the study of the role of ferritinophagy in oral squamous cell carcinoma. Reference | Related Articles | Metrics

Select

Effect of columnar collagen sponge on the extraction of impacted teeth and the risk of complications WANG Chen-xin, PENG Jing, HUANG Xin, SHI Le, DAI Xiao-feng China Journal of Oral and Maxillofacial Surgery    2023, 21 (2): 146-151.   DOI: 10.19438/j.cjoms.2023.02.008 Abstract （544）      PDF （963KB）（258）       Knowledge map    PURPOSE: To investigate the effect of collagen sponge in the extraction of impacted teeth and the risk of complications. METHODS: A total of 160 patients with impacted teeth extraction were selected from June 2021 to December 2021 in Shanghai Jing'an Dental Clinic. The patients were randomly divided into experimental group and control group, 80 cases in each group. Both groups underwent conventional extraction of impacted teeth, and the control group was rinsed with 20 mL sodium chloride solution after extraction. In the experimental group, on the basis of the control group, columnar collagen sponge was inserted into the extraction wound. Bleeding, postoperative pain score, postoperative swelling degree 7 days after surgery, levels of inflammatory factors[prostaglandin E2(PGE2), myeloperoxidase(MPO), calcitonin gene-related peptide(CGRP)] in gingival crevicular fluid before and after treatment and postoperative complications (restricted opening, inflammatory induration or bruising of maxillofacial region, infection, dry socket) were compared between the two groups. SPSS 22.0 software package was used for data analysis. RESULTS: The postoperative bleeding time of the experimental group was significantly lower than that of the control group(P<0.05). The VAS scores of spontaneous pain and dysphagia in the experimental group were significantly lower than those of the control group(P<0.05). The swelling degree of experimental group was significantly lower than that of control group 7 days after tooth extraction(P<0.05). There was no difference in PGE2, MPO and CGRP between the two groups before treatment(P>0.05). After treatment, PGE2, MPO and CGRP in the two groups were significantly increased(P<0.05), PGE2, MPO and CGRP of the experimental group after treatment were significantly lower than those of the control group after treatment(P<0.05). The incidence of postoperative complications in the experimental group was significantly lower than that in the control group (P<0.05). CONCLUSIONS: Columnar collagen sponge has a good effect in extraction of impacted teeth, and can effectively avoid postoperative complications, and has little influence on inflammatory factors in gingival crevicular fluid, which is worthy of wide application. Reference | Related Articles | Metrics

Select

Single-cell transcription atlas for mandibular condyle cartilage and subchondral bone marrow in rat temporomandibular joint osteoarthritis YU Ye-ke, DING Ruo-yi, SUN Jia-li, ZHANG Zhi-yuan, HE Dong-mei China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 332-339.   DOI: 10.19438/j.cjoms.2023.04.003 Abstract （351）      PDF （2829KB）（256）       Knowledge map    PURPOSE: To establish the single-cell transcriptome atlas for rat condyle osteochondral tissue and bone marrow both in normal and temporomandibular joint osteoarthritis (TMJOA) condition. METHODS: Rat unilateral anterior crossbite(UAC) model was built to induce TMJOA. Osteochondral cells and bone marrow immune cells were extracted for single-cell RNA sequencing. Quality control, dimension reducing, clustering and marker gene detection were used to depict cell subclusters. Differential gene expression analysis and functional enrichment were utilized to demonstrate cell cluster functions and their changes under UAC. Pseudo-time analysis was applied for cell development trajectory, while cell communication prediction was used to show alternations in the interaction among cell clusters. RESULTS: There were 9 cell clusters in rat condyle, containing osteochondral cells and bone marrow immune cells. Under UAC, the number of osteochondrocytes decreased whereas immune cells accumulated. Condyle cartilage and bone tissue contained 6 functional groups of cells. Among them, D and F group maintained progenitor characteristics and possessed the ability to develop into other groups. In UAC condition, osteochondrocytes witnessed impaired extracellular matrix organization, activated senescent or inflammatory pathways, and diminished cell-cell interaction. Meanwhile, in the bone marrow, neutrophils showed enhanced chemotaxis and degranulation, mononuclear-phagocytes displayed increased phagosomes, activated B cells were also recruited. CONCLUSIONS: There are progenitor cells in condyle cartilage and bone tissue, whose function impaired under UAC. At the same time, immune cells in the bone marrow are activated. Targeted modulation of osteochondral progenitors and immune cells could contribute in alleviation the condyle tissue damage in TMJOA. Reference | Related Articles | Metrics

Select

Synthesis of carbon dots with dual roles of osteogenic and antibacterial effects for infected bone defects treatment LIU Yi-ge, WANG Zi-lin, GUO Zhi-yong, WU Hao, WANG Wen-ying, HAN Jing, LIU Jian-nan, ZHANG Chen-ping China Journal of Oral and Maxillofacial Surgery    2023, 21 (1): 11-18.   DOI: 10.19438/j.cjoms.2023.01.002 Abstract （335）      PDF （2337KB）（232）       Knowledge map    PURPOSE: To investigate the effects of a new kind of carbon dots (CDots) made from gentamicin and folic acid on osteogenic differentiation and autophagy of rat bone marrow stromal cells (BMSCs), as well as the inhibition of common oral pathogenic bacteria. METHODS: CDots were prepared by hydrothermal method using gentamicin and folic acid as raw materials, and characterized by transmission electron microscopy and UV spectrophotometer. Biocompatibility was evaluated by CCK-8 assay and apoptosis assay, and uptake by cells was observed by laser confocal microscopy. Alkaline phosphatase staining and alizarin red staining were used to detect the effect on osteogenic differentiation of BMSCs. Real-time quantitative PCR was performed to detect the mRNA expression levels of osteogenic and autophagy-related genes. Scanning electron microscopy and plate colony assay were performed to observe the ability of CDots to inhibit Porphyromonas gingivalis and Fusobacterium nucleatum. Graph Pad Prism 9 software was used for statistical analysis. RESULTS: The CDots solution emitted blue fluorescence under UV light irradiation with a UV absorption peak at 330 nm; the PL emission peak of CDots was concentrated at 440 nm under the excitation of 405 nm laser. Transmission electron microscopy showed that the average diameter of CDots was about 12 nm. CCK-8 assay and apoptosis assay showed that CDots were biocompatible. Laser confocal microscopy results showed that CDots could be taken up by BMSCs. The results of alkaline phosphatase staining and alizarin red staining showed that CDots increased staining. mRNA expression of the osteogenic genes OPN, OCN, BMP-2, and autophagy-related genes LC3, Beclin1, ATG-12 was increased by CDots compared to the control group(P<0.05). In vitro antibacterial assays indicated that CDots could inhibit the growth of Porphyromonas gingivalis and Fusobacterium nucleatum. CONCLUSIONS: CDots prepared with gentamicin and folic acid are biocompatible, have dual osteogenic and antibacterial effects, promote osteogenic differentiation of BMSCs, promote elevated autophagy levels, and have inhibitory effects on the growth of Porphyromonas gingivalis and Fusobacterium nucleatum. Reference | Related Articles | Metrics

Select

Chinese expert consensus on prevention and management of perioperative venous thromboembolism in head and neck cancer patients REN Zhen-hu, CHEN Ming-tao, WU Han-jiang, ZHANG Sheng, FANG Kun, XIE Shang4, LIU Yu, HU Chuan-yu6, LIU Bing, LI Chun-Jie, ZHU Gui-quan, WANG Cheng, GAO Yang, ZHANG Xiao-chen, SHI Jian-bo, ZHANG Yong-hong, CUI Ming-zhe, JI Tong, REN Guo-xin, WANG Yan-an, CHEN Wei-liang, ZHANG Chen-ping, HE Yue, ZHANG Zhi-yuan China Journal of Oral and Maxillofacial Surgery    2024, 22 (1): 1-9.   DOI: 10.19438/j.cjoms.2024.01.001 Abstract （257）      PDF （1276KB）（231）       Knowledge map    Venous thromboembolism (VTE) is a common complication after surgical procedures, and an important risk factor for unexpected death in hospitals, and the second leading cause of death for tumor patients. Patients with advanced head and neck cancer usually require extensive radical surgery and simultaneous repair and reconstruction surgery, and have many risk factors such as elderly, long surgical time, long postoperative bed rest, and hypercoagulable state caused by tumor and chemotherapy drugs, which suggest that patients with head and neck cancer should be an extremely high risk group for VTE. However, little attention has been paid to the occurrence of VTE in patients with cancer in the head and neck, and the data on the incidence of VTE after head and neck cancer surgery are also limited. So far, there is a lack of relevant treatment consensus or guidelines for perioperative VTE of head and neck cancer in China. The level of prevention and management of perioperative VTE of head and neck cancer varies among different institutions, and there is a lack of unified and scientific diagnosis and treatment standards and objective evaluation system for prevention and management. In order to unify and standardize the diagnosis and treatment of perioperative VTE in head and neck cancer, reduce the waste of medical resources and improve the treatment effectiveness, domestic experts in this field have repeatedly discussed the diagnosis and treatment opinions from 14 famous medical institutions in China. This article refers to the research results and diagnosis and treatment experience of perioperative VTE in head and neck cancer world wide in recent years, and formulates this expert consensus for reference by relevant clinicians. Reference | Related Articles | Metrics

Select

Imaging evaluation and analysis of jaw invasion in mandibular gingival carcinoma based on micro-CT WANG Jian, ZHANG Ye, HOU Cheng-su China Journal of Oral and Maxillofacial Surgery    2023, 21 (1): 36-40.   DOI: 10.19438/j.cjoms.2023.01.006 Abstract （331）      PDF （937KB）（218）       Knowledge map    PURPOSE: To evaluate and analyze the imaging features of mandibular invasion, in order to provide imaging evidences for optimizing the operation plan and guiding postoperative treatment for gingival squamous cell carcinoma (GSCC). METHODS: Sixty patients underwent surgery for mandibular GSCC were included. Preoperative panoramic radiograph, ordinary CT and enhanced CT scanning were analyzed. Micro-CT three-dimensional reconstruction was performed on 30 eligible surgical specimens in order to measure bone mineral density, trabecular thickness, trabecular separation and other related parameters. SPSS 22.0 software package was used for data analysis. RESULTS: Conventional imaging examination with panoramic radiograph, CT and enhanced CT scaning were insufficient. Micro-CT three-dimensional reconstruction could accurately distinguish between cancellous bone and bone cortex, assess the scope and degree of mandibular invasion. The corresponding data parameter analysis indicated that bone mineral density (BMD) of the GSCC central and marginal area was significantly reduced comparing with the BMD at the normal mandibular bone area(P<0.05). In addition, the thickness of trabecular bone was also significantly reduced（P<0.05). The BMD of cancellous bone was significantly decreased(P<0.05). The separation degree of trabecular bone in cancer center was obviously increased comparing with the normal mandibular tissue(P<0.05). CONCLUSIONS: Currently, there are still controversies about the surgical plan for mandibular gingival cancer, and further improving the accuracy of CT examination may provide more accurate guidance for making surgical plan for mandibular gingival cancer. Reference | Related Articles | Metrics

Select

Application and efficacy evaluation of functional fixator in the fenestration treatment of jaw cyst ZHOU Yun, WANG Zhen, ZHAO Xiao-mei China Journal of Oral and Maxillofacial Surgery    2023, 21 (3): 263-266.   DOI: 10.19438/j.cjoms.2023.03.010 Abstract （356）      PDF （794KB）（212）       Knowledge map    PURPOSE: To evaluate the effect of functional occlusal device in the fenestration of jaw cyst. METHODS: Fifty patients with jaw cyst who underwent fenestration surgery for the first time were selected. According to the treatment methods, they were divided into the conventional treatment group and functional treatment group, with 25 cases in each group. Obturator functioning scale (OFS) was used to evaluate the comfort, masticatory efficiency and aesthetics of patients wearing two kinds of different endodontics during fenestration treatment. The patients' satisfaction with the final restoration was investigated by questionnaire. SPSS 20.0 software package was used for data analysis. RESULTS: Compared to conventional obturators, the functional obturator group showed a statistically significant reduction in mandibular and maxillary tooth extension after healing of the lesion (P<0.01). However, there was no significant difference in chewing efficiency during the wearing of the obturator(P>0.05). The esthetic satisfaction of the functional obturator was significantly higher in patients with anterior tooth loss(P<0.01). CONCLUSIONS: The functional obturator, which combines the functions of denture restoration, not only has good esthetics and wearing comfort, but also better maintains stability in missing interdental spaces and is more favorable for the restoration of missing teeth. Reference | Related Articles | Metrics

Select

Recent advances in mouth breathing diagnosis and effects on dento-maxillofacial development in children ZHENG Yang-shan, YUAN Xue-shun, JIANG Jing, QIU Shu-qi, SHI Zhao-hui China Journal of Oral and Maxillofacial Surgery    2024, 22 (1): 92-101.   DOI: 10.19438/j.cjoms.2024.01.016 Abstract （305）      PDF （1261KB）（200）       Knowledge map    Upper airway obstruction can lead to mouth breathing, which is much prevalent in children. Studies have indicated that in early childhood, prolonged mouth breathing leads to muscular and postural alterations which, in turn, result in dentoskeletal changes, or even worse, dentofacial deformities and sleep-related breathing disorders. A multidisciplinary team, involving otolaryngologists, dental providers, and somnologists, should work to provide early diagnosis and appropriate treatment, preventing the consequent disorders of mouth breathing. More and more studies in recent years have focused on mouth breathing diagnosis and its effects on dento-maxillofacial development as well as its possible mechanisms in children. Nevertheless, the etiology, diagnosis, treatment options, postoperative care, mechanism of mouth breathing impact on dento-maxillofacial development, and its relationship with sleep-disordered breathing remain controversial. This review summarized the latest advances in mouth breathing, demonstrating the current status and advances of research on mouth breathing diagnosis, dento-maxillofacial development, and multidisciplinary collaboration. Reference | Related Articles | Metrics

Select

Effect of extranodal extension on TNM staging and survival in patients with oral squamous cell carcinoma LI Gui-zhong, LI Jie-ying, ZHOU Kai, MENG Yu-xiang, WANG Ke-xin, GE Sheng-you, SONG Kai, FENG Yuan-yong, TAO Yue-qin, ZHAN Xiao-hong, SHANG Wei China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 377-383.   DOI: 10.19438/j.cjoms.2023.04.010 Abstract （315）      PDF （1371KB）（200）       Knowledge map    PURPOSE: By analyzing the influence of extranodal extension (ENE) on TNM staging manual and survival after included into the staging, to learn about the significance of ENE on clinical decision-making and prognosis of oral cancer. METHODS: A retrospective cohort study of 485 patients with primary oral squamous cell carcinoma(OSCC) from January 2014 to June 2017 was performed in the Affiliated Hospital of Qingdao University. The AJCC 7th and 8th edition staging systems was applied to the patients. Overall survival and disease-specific survival were analyzed by Kaplan-Meier analysis and Log-rank test with SPSS 26.0 software package. Concordance index and Akaike information criterion(AIC) was used to evaluate the system’s prognostic capacity. RESULTS: A total of 485 patients with OSCC were followed up. The pathological N stage of 69 (14.43%) patients (including 16 pN2a and 53 pN3b) was changed by extranodal extension. The pathological TNM stage of 67(13.81%) patients (including 14 ⅣA and 53 ⅣB) was also changed because of ENE. Overall survival and disease-specific survival model analysis of N stage, TNM stage and ENE showed that patients with positive ENE (OS:27.1%, DSS:31.2%) had a lower survival rate than those with negative ENE(OS:72.2%, DSS:78.0%). AIC of AJCC 8th edition staging systems was lower than 7th edition and there was little difference between them in terms of concordance index. CONCLUSIONS: Extranodal extension changed TNM staging of OSCC patients. The number of advanced patients increased significantly and the survival prognosis became worse. ENE can objectively refect the status of the patients. It has more guiding significance for decision-making and prognosis evaluation of oral cancer patients. Reference | Related Articles | Metrics

Select

Research progress in the role and mechanism of Porphyromonas gingivalis in promoting oral squamous cell carcinoma REZIWANGULI·Yasen, MAIREPATI·Maiming, LI Chen-xi, GONG Zhong-cheng China Journal of Oral and Maxillofacial Surgery    2023, 21 (2): 186-190.   DOI: 10.19438/j.cjoms.2023.02.015 Abstract （333）      PDF （550KB）（185）       Knowledge map    A large number of studies have shown that P.gingivalis is one of the bacterial species, as an important risk factor, of oral squamous cell carcinoma (OSCC). P.gingivalis is closely associated with the pathogenicity, development, invasion, metastasis and prognosis of OSCC. For its potential mechanisms, it may accelerate OSCC occurrence and progress probably through multiple ways as follows: resisting and destroying the innate immune system of the host, promoting epithelial-mesenchymal transition, promoting cancerous invasion and metastasis, inhibiting cell apoptosis, activating cell proliferation. This review summarized the research progress in the role and mechanism of P.gingivalis in promoting OSCC. Reference | Related Articles | Metrics

Select

Effect of EGFR-targeted therapy in combination with chemotherapy versus chemotherapy alone on oral cancer pain WANG Zi-heng, ZHOU Ren, YAN Jia, ZHANG Lei, YANG Ya-qiong, JIANG Hong China Journal of Oral and Maxillofacial Surgery    2023, 21 (3): 225-230.   DOI: 10.19438/j.cjoms.2023.03.003 Abstract （151）      PDF （789KB）（183）       Knowledge map    PURPOSE: To compare the effect of epidermal growth factor receptor-targeted (EGFR-targeted) therapy in combination with chemotherapy versus chemotherapy alone on oral cancer pain. METHODS: Ninety oral cancer patients with chronic cancer pain were divided into chemotherapy alone group (group G0) and EGFR-targeted therapy combined with chemotherapy group (group G1) according to the type of treatment they received. Pain intensity was assessed at baseline (T0), day 1 (T1), day 7 (T2) and at the end of month 3 (T3) using visual analogue scale (VAS) and numerical rating scale for pain(NRS). The patients were assessed for neuropathic pain using self-administrative Leeds neuropathic pain signs and symptoms scale (S-LANSS), and adjunctive analgesic use, sleep duration were recorded at T0 and T3. Treatment side effects and satisfaction were recorded at T3. SPSS 26.0 software package was used to analyze the data. RESULTS: Of the 90 patients, 31 cases were included in G0 group and 59 cases were included in G1 group. The average age of patients was 60.64 years and 70% were male. There was no significant difference in VAS and NRS at T0 between G0 group and G1 group(P>0.05). VAS and NRS at T1, T2 and T3 were significantly lower in G1 group compared to G0 group(P<0.05). Patients in G1 group used significantly less analgesic medication (P<0.05), slept longer(P<0.05) and were more satisfied (P<0.05) than those in G0 group at T3. CONCLUSIONS: EGFR-targeted therapy in combination with chemotherapy are more effective than chemotherapy alone in the alleviation of oral cancer pain and reduce the use of adjuvant analgesics. Reference | Related Articles | Metrics

Select

A case report of AL amyloidosis complicated with multiple myeloma with dysphagia as the first symptom CHEN Lin, CHEN Yin-yu, DING Zi-xue, MENG Jian China Journal of Oral and Maxillofacial Surgery    2023, 21 (1): 97-101.   DOI: 10.19438/j.cjoms.2023.01.017 Abstract （232）      PDF （1025KB）（177）       Knowledge map    Systemic light-chain-type amyloidosis combined with multiple myeloma(MM) is a clinically rare plasma cell-associated malignant disease. Most of the patients with this disease are complained for heart/renal impairment or substantial myeloma, and very few cases presented dysphagia or other oral related diseases as the first symptom, so it is easy to miss diagnosis or make misdiagnosis during first visit. Therefore, the diagnosis and treatment of amyloidosis with dysphagia was reported in the article. Based on the relevant literature review, the characteristics, diagnostic criteria and treatment of the disease were discussed. Reference | Related Articles | Metrics

Select

Study on risk model for postextraction bleeding of mandibular third molars WANG Jian-rong, SUN Jing, ZHAO Shu-hong, SHANG Jiang China Journal of Oral and Maxillofacial Surgery    2023, 21 (5): 479-485.   DOI: 10.19438/j.cjoms.2023.05.009 Abstract （243）      PDF （987KB）（174）       Knowledge map    PURPOSE: To explore the risk factors of bleeding after mandibular third molar extraction and establish a prediction model to provide reference for clinical decision-making. METHODS: Clinical data of 610 cases of mandibular third molar extraction were collected for the study. Association of postextraction bleeding with the patient demographic variables (gender), tooth variables(position, impacted angle) and other variables (periodontitis, intraoperative anesthetic drugs, flap, postoperative treatment, hemostatic materials, patient compliance). SAS 9.4 software package was used to analyze the data. RESULTS: The incidence of postextraction bleeding was 10.33% in 610 patients after mandibular third molars extraction, and 63 patients had postextraction bleeding. Multivariate logistic regression analysis showed that the position, impacted angle, flap, postoperative treatment, patient compliance were independent risk factors for postextraction bleeding of mandibular third molars. The results showed that the prediction model had good differential validity(AUC=0.916), high calibration degree (P=0.605), and certain clinical application value. CONCLUSIONS: The position, impacted angle, flap, postoperative treatment and patient compliance are not only risk factors for postextraction bleeding, but also predictive factors for predictive models. Reference | Related Articles | Metrics

Select

The regulation and mechanism of cancer-associated fibroblasts on tumor-infiltrating immune cells in head and neck squamous cell carcinoma HAN Lin-zi, ZHOU Jian-hua, ZHAO Qian, DONG Lei, CHEN Zheng-gang, QIU Jian-zhong, YUAN Rong-tao China Journal of Oral and Maxillofacial Surgery    2023, 21 (2): 119-124.   DOI: 10.19438/j.cjoms.2023.02.003 Abstract （269）      PDF （1002KB）（173）       Knowledge map    PURPOSE: To explore the mechanism of cancer-associated fibroblasts (CAFs) regulating the expression of tumor-infiltrating immune cells in head and neck squamous cell carcinoma (HNSCC). METHODS: The expression profile and clinical data analysis of lncRNA MIR99AHG related to HNSCC were obtained through the TCGA database, and clinical tumor samples. Primary cell culture and identification of CAFs and normal fibroblasts(NFs) were taken. The expression of lncRNA MIR99AHG in tongue cancer cells co-cultured with CAFs or NFs were detected by qRT-PCR. Correlation of lncRNA MIR99AHG in HNSCC and tumor-infiltrating immune cells was analyzed with Graph Pad 8.0.2 software. RESULTS: LncRNA MIR99AHG was a low expression gene in HNSCC and high expression of lncRNA MIR99AHG was positively correlated with prognosis. Western blot analysis showed that α-SMA was highly expressed in CAFs. qRT-PCR showed that the expression of lncRNA MIR99AHG in tongue cancer cells co-cultured with CAFs was significantly downregulated compared with the negative control group. LncRNA MIR99AHG was positively correlated with T cells, CD8+ T cells, B cells, NK cells, but negatively correlated with Th1, Th2, neutrophils, Tgd. CONCLUSIONS: CAFs may inhibit the expression of lncRNA MIR99AHG to regulate the expression of tumor-infiltrating immune cells in HNSCC. Reference | Related Articles | Metrics

Select

A new clinical classification of severe oromaxillofacial head and neck multi-space infections QIU Yin-xiu, DAI Tian-guo, XU Bo, CHENG Jin-qiang, LIU Zhong-long China Journal of Oral and Maxillofacial Surgery    2023, 21 (2): 125-130.   DOI: 10.19438/j.cjoms.2023.02.004 Abstract （284）      PDF （1483KB）（168）       Knowledge map    PURPOSE: To explore a new clinical classification method for oromaxillofacial head and neck multi-space infections. METHODS: The clinical and radiographic data of patients with severe oromaxillofacial head and neck multiple-space infections treated under general anesthesia in Panzhihua Central Hospital from July 2015 to March 2022 were retrospectively analyzed, and a new classification method was proposed. SPSS 17.0 software package was used for data analysis. RESULTS: Severe oromaxillofacial head and neck multi-space infections can be divided into five types. Type Ⅰ(n=82, 68.33%), the infection was concentrated between the hyoid plane and the zygomatic arch plane, and the infection in each space could be fully drained through the submaxillary incision. Type Ⅱ(n=13, 10.83%), the infection spread upward to the deep temporal space, and two submandibular and temporal incisions were needed for full drainage. Type Ⅲ(n=14, 11.67%), the infection spread down to the lower cervical space above the clavicle, and full drainage through submaxillary and supraclavicular incision was needed. Type Ⅳ(n=5, 4.17%), the infection spread from the temporal to the supraclavicle area, and multiple submaxillary, temporal and supraclavicle incisions were needed for drainage. In 6 cases (5%) of type Ⅴ, the infection broke through the clavicular plane and spread to the mediastinum and thorax. Mediastinum and thorax drainage must be combined with cardiothoracic surgery at the same time. From typeⅠto typeⅤ, the general condition gradually worsened, the treatment difficulty and risk gradually increased, and the consumption of medical resources such as average ICU monitoring time, hospitalization time, hospitalization cost and antibacterial drug cost also gradually increased (P<0.0001). CONCLUSIONS: Severe oromaxillofacial head and neck multi-space infections are life-threatening, and multidisciplinary therapy is the premise of treatment. Reasonable classification of the disease is the basis of accurate and standardized treatment. Extensive incision and drainage combined with effective auxiliary irrigation technology is the key to treatment. Reference | Related Articles | Metrics