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Research progress of application of highly active bone substitute in materialsmaxillofacial bone tissue engineering YUAN Lu-han, CHU Chen, YUAN Rong-tao China Journal of Oral and Maxillofacial Surgery    2024, 22 (4): 394-399.   DOI: 10.19438/j.cjoms.2024.04.013 Abstract （427）      PDF （847KB）（922）       Knowledge map    Jaw defect is one of the most common diseases in oral and maxillofacial surgery. Severe jaw defect will cause different degrees of impact on the life and psychology of patients, and needs timely and effective repair. Due to the unique physiologic appearance and individual differences of jaw bones, the repair of jaw defects can't be completely dependent on standardized bone prosthetics. With the development and maturity of related manufacturing technologies, especially the unique advantages of 3D printing technology in bone defect repair, it has attracted wide attention of scholars both at home and abroad. The repair of bone defects is a complex and precise process. The ideal biomaterials for repairing bone defects should have good histocompatibility, suitable mechanical stress, suitable pore size, and solubility. This article briefly reviewed the existing high-active bone replacement materials for jaw tissue engineering. Reference | Related Articles | Metrics

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Newly revised ISSVA classification for vascular anomalies(2025 version) and interpretation Du Zhong, Zheng Jiawei, Wang Yan'an China Journal of Oral and Maxillofacial Surgery    2025, 23 (4): 313-317.   DOI: 10.19438/j.cjoms.2025.04.001 Abstract （523）      PDF （1054KB）（885）       Knowledge map    Vascular anomalies can be primarily categorized into two major groups: vascular tumors and vascular malformations. In 1982, Mulliken and Glowacki proposed a revolutionary biological classification. Specifically, based on the proliferation characteristics of endothelial cells, these anomalies were differentiated into "hemangiomas" and "vascular malformations". In 1996, this classification system was adopted by the International Society for the Study of Vascular Anomalies (ISSVA) as the standard classification, and has been undergoing continuous refinement up to the present. In May 2025, the latest ISSVA World Congress was convened in Paris. The 2018 classification system, which is currently in wide use, was further optimized. A substantial number of structural and detailed adjustments were made, rendering the new classification system more streamlined. Consequently, its usability has been remarkably enhanced. This evolution of the ISSVA classification mirrors the deepening of the understanding from the morphological level to the molecular mechanism level. Every update holds milestone significance for the standardization of the diagnosis and treatment of vascular diseases globally. This paper aimed to introduce and interpret the newly revised ISSVA classification (2025 version), providing a reference for clinical practice, scientific research, and academic exchanges. Reference | Related Articles | Metrics

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Visual analysis of clinical research literatures on temporomandibular joint disorders at both home and abroad from 2013 to 2023 LIU Xing-yu, JIANG Nan China Journal of Oral and Maxillofacial Surgery    2025, 23 (2): 185-195.   DOI: 10.19438/j.cjoms.2025.02.014 Abstract （849）      PDF （2071KB）（859）       Knowledge map    PURPOSE: To analyze the evolution of domestic and international clinical researches on temporomandibular joint disorders(TMD) from 2013 to 2023,to understand the development trends and research hotspots, and to explore future research directions. METHODS: Clinical research literatures on TMD published between 2013 and 2023 were collected through PubMed, China National Knowledge Infrastructure(CNKI), Wanfang Data, and VIP databases. CiteSpace 6.1.R6 software was utilized for visual analysis. Methods included keyword frequency statistics, co-occurrence analysis, clustering analysis, and timeline analysis to construct knowledge maps and identify research hotspots. RESULTS: Domestic research hotspots were primarily focused on pain management, acupuncture therapy, and tissue repair. In contrast, international researches heavily emphasized quality of life and non-invasive treatment approaches. Both domestic and international studies underscored the importance of interdisciplinary integration and the application of new technologies. Keywords such as "acupuncture treatment" have appeared relatively late in domestic researches but showed a clear trend, indicating an interest in the application of traditional medicine and emerging technologies. International researches had earlier focused on psychological factors and quality of life, and leaded in the application of new materials and technologies. CONCLUSIONS: Although there are differences in methods and focal points between domestic and international researches, there is a consistent focus on core issues such as pain management and the application of imaging technologies. Future researches should enhance attention to psychological factors and comprehensive health management, draw on international experience, explore the application of new materials and new technologies, and promote interdisciplinary collaboration to improve the diagnosis and treatment of temporomandibular joint disorders and the quality of life of patients. Reference | Related Articles | Metrics

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Progress in anatomy and clinical applications of buccal fat pad Niu Lingxiao, Dang Qingqing, Han Bing China Journal of Oral and Maxillofacial Surgery    2025, 23 (3): 302-306.   DOI: 10.19438/j.cjoms.2025.03.015 Abstract （364）      PDF （765KB）（827）       Knowledge map    Buccal fat padBFP) is an irregular mass of adipose tissue located within the deep facial recesses, with rich blood supply and encapsulated structure, which can isolate mesenchymal stem cells with multidirectional differentiation ability. The pedicled buccal fat pad flap is easy to prepare and has a high survival rate, and has been widely used in the repair of soft and hard tissue defects in the oral and maxillofacial region. The osteogenic ability of buccal fat pad derived mesenchymal stem cells has been demonstrated in vitro and has been used in clinical trials to repair jaw defects in recent years. In plastic surgery, the potential of both pedicled and free buccal fat pad flaps for improving facial contours continues to be explored. However, research on the long-term benefits for patients and the differences between these flaps and other pedicled skin flaps is limited. This review summarized the current advancements in the anatomy and some clinical applications of the buccal fat pad. Reference | Related Articles | Metrics

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Preliminary application of artificial intelligence in the pathological diagnosis of ameloblastoma QIAO Xin-wei, LI Mao, SHEN Ze-liang, ZHANG Lin-han, ZHENG Zhi-jian, TANG Ya-ling China Journal of Oral and Maxillofacial Surgery    2025, 23 (2): 122-128.   DOI: 10.19438/j.cjoms.2025.02.004 Abstract （293）      PDF （3026KB）（784）       Knowledge map    PURPOSE: To investigate the effect of artificial intelligence in the pathological diagnosis of ameloblastoma, and to preliminarily explore the value of artificial intelligence in the field of oral pathology. METHODS: The pathological images of 90 cases of ameloblastoma were used as the research objects, and the U-net-like structure neural network was constructed. The 90 H-E images of ameloblastoma were divided into a training set (72 images), a validation set (9 images) and a test set (9 images) for training and testing the model respectively. The mIoU and ROC curve were used to evaluate the ability of the U-net network model in the identification of ameloblastoma epithelium. RESULTS: The mIoU of negative area segmented by U-net model was 0.818 and the positive area was 0.846. The area under the ROC curve was 0.92. CONCLUSIONS: The U-net network model has a good segmentation for the positive and negative regions of ameloblastoma, and can distinguish between negative and positive sections. It can be preliminarily applied to the pathological diagnosis of ameloblastoma, and is expected to be gradually popularized in clinical practice after further validation with large samples. Reference | Related Articles | Metrics

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Evaluation of the therapeutic effect of polidocanol foam sclerotherapy in the treatment of head and neck venous malformations under medical and nursing collaboration ZHANG Fang, SHOU Wei-dong, LI Yan China Journal of Oral and Maxillofacial Surgery    2024, 22 (3): 274-278.   DOI: 10.19438/j.cjoms.2024.03.012 Abstract （291）      PDF （662KB）（692）       Knowledge map    PURPOSE: To explore the difference in therapeutic effect and injection frequency between polidocanol liquid injection and foam injection in the treatment of head and neck venous malformations under medical and nursing collaboration. METHODS: A total of 120 patients with head and neck venous malformations were treated with polidocanol sclerotherapy, of which 60 were treated with liquid injection and 60 with foam injection. All patients were classified into 4 groups respectively according to the types of venous malformations, namely, group A for typeⅠvenous malformation, group B for type Ⅱ venous malformation, group C for type Ⅲ venous malformation, and group D for type Ⅳ venous malformation. There were a total of 8 groups with 15 cases in each group. The therapeutic effect and the number of polidocanol injection were compared between each group. SPSS 23.0 software package was used for statistical analysis of the data. RESULTS: There was no significant difference in therapeutic effect between two injection methods in group A and group B, and the average number of injections was reduced by 0.5 with foam compared to liquid in group A and 1.2 in group B. The therapeutic effect of foam injection was better than that of liquid injection in group C and group D, but the difference was not statistically significant(P>0.05), and the average number of injections was reduced by 2.7 with foam compared to liquid method in group C and 3.9 in group D. CONCLUSIONS: In the treatment of head and neck venous malformations, the therapeutic effect of foam injection is better than liquid injection for venous malformations with fast drainage. The faster the drainage of venous malformations, the greater is the reduction in average number of treatments with foam injection in relation to that with liquid injection. The reduction in the number of treatments is conducive to reducing patients’ economic burden, time consumption and incidence of adverse reactions, and thus foam injection is worth promoting and applying in clinical practice. Reference | Related Articles | Metrics

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Chinese expert consensus on diagnosis and treatment of localized intravascular coagulopathy TAI Mao-zhong, QIN Zhong-ping, ZHENG Jia-wei, LI Ke-lei, LIU Xue-jian, LI Kai, YUAN Si-ming, FAN Xin-dong, ZHOU De-kai, DONG Chang-xian, JI Yi, GU Song, HUO Ran, YANG Yao-wu, WANG Xu-kai China Journal of Oral and Maxillofacial Surgery    2024, 22 (4): 313-321.   DOI: 10.19438/j.cjoms.2024.04.001 Abstract （557）      PDF （1160KB）（682）       Knowledge map    Localized intravascular coagulopathy(LIC) refers to coagulation disorders such as thrombosis and bleeding that occurred in venous malformations(VMs). It is characterized by abnormally elevated D-dimer(DD) levels, with or without decreased fibrinogen(FIB), and generally without thrombocytopenia. LIC can be complicated with acute pain, excessive bleeding, arthrogryposis, etc. Controversies in its diagnosis and treatment still existed. In order to improve the diagnosis and standardize treatment of LIC in China, we invited relevant experts to discuss and formulate Chinese expert consensus. The consensus provides standardized suggestions on the pathogenesis, clinical manifestations, diagnostic methods and treatment process of LIC, which can provide reference for clinical practice. Reference | Related Articles | Metrics

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Progress in the application of artificial intelligence in the early diagnosis of oral cancer ZHAO An-yuzhuo, SHI Xing-lian, LIU Huan, JIANG Jian-hong, LI Zhe-zhen, LIU Mei China Journal of Oral and Maxillofacial Surgery    2024, 22 (5): 493-498.   DOI: 10.19438/j.cjoms.2024.05.014 Abstract （921）      PDF （831KB）（659）       Knowledge map    The early diagnosis of cancer is conducive to the subsequent clinical management of patients. Artificial intelligenceAI has been widely used in the medical field, improving the accuracy and efficiency of disease diagnosis. This paper summarized the relevant studies on AI in the diagnosis and screening of oral cancer from three aspects: overview of AI in the early diagnosis of oral cancer, application status of commonly used AI types, and personal outlook, aiming to provide a new perspective for the application of early diagnosis of oral cancer, further help medical workers improve medical decision-making rate, and provide references for the early diagnosis and treatment of oral cancer. Reference | Related Articles | Metrics

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Research progress of autogenous bone graft in repairing alveolar bone defect LIU Zi-hua, XU Guang-zhou China Journal of Oral and Maxillofacial Surgery    2025, 23 (1): 84-93.   DOI: 10.19438/j.cjoms.2025.01.015 Abstract （601）      PDF （848KB）（654）       Knowledge map    Bone grafts are widely used in bone augmentation before implantation. The commonly used bone grafts are autogenous bone, allogeneic bone, xenogeneic bone and synthetic materials. Autologous bone graft is regarded as the gold standard of bone transplantation since it has three properties: bone conduction, bone induction and bone formation. This article reviewed the autologous bone transplantation technique before implantation, summarized the structure, morphology, harvesting sites and methods and previewed the application of autologous bone transplantation. Reference | Related Articles | Metrics

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Exploration on construction of remote medical model for the diagnosis and treatment of dento-maxillofacial deformities Hu Lingling, Sun Yingjia, Jiang Peiling, Xie Zhijian China Journal of Oral and Maxillofacial Surgery    2025, 23 (3): 209-214.   DOI: 10.19438/j.cjoms.2025.03.001 Abstract （251）      PDF （871KB）（616）       Knowledge map    The orthodontic-orthognathic treatment is presently the predominant approach to rectifying dentomaxillofacial deformities. Nevertheless, the extended duration of the treatment cycle and the intricacy of the surgical procedures pose significant challenges for patients situated in various locations and restrict the accessibility of superior medical resources. To mitigate these limitations, this study introduced a remote medicine model for dentomaxillofacial deformities, predicated on the "internet + medicine" paradigm, and delineated its standardized procedures and quality control framework. This model adhered to the "1+1+N" paradigm, where a remote medical center served as the nucleus, and a dentomaxillofacial deformity consultation e-cloud platform functioned as the interconnecting nexus. This arrangement facilitated the effective amalgamation of superior medical resources, thereby augmenting treatment efficacy and enhancing patient experience. Additionally, this study focused on the detailed construction of a multifunctional dentomaxillofacial deformity consultation e-cloud platform and comprehensive quality control framework. This approach provided a scientific and effective solution for strengthening remote medical quality supervision, promoting the rational allocation of medical resources, and improving the service level of primary hospitals. Reference | Related Articles | Metrics

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Carotid artery variation and its influence on clinical practice of oromaxillofacial head and neck oncology XIAO Meng, DU Zhong, TIAN Zhuo-wei, YOU Yuan-he, WANG Yan-an China Journal of Oral and Maxillofacial Surgery    2025, 23 (1): 1-5.   DOI: 10.19438/j.cjoms.2025.01.001 Abstract （272）      PDF （1401KB）（611）       Knowledge map    As the incidence and treatment of oral and maxillofacial-head and neck tumors trend towards an aging and complex patient population, carotid artery variations are increasingly observed in clinical practice. However, there is a notable lack of systematic summaries regarding the impact of these variations on the clinical management of such tumors. Therefore, this paper aimed to systematically summarize the etiology, clinical characteristics, examination methods, classification, treatment strategies for carotid artery variations. Furthermore, it sought to explore their potential influence on the clinical practice of oral and maxillofacial-head and neck oncology from eight perspectives: differential diagnosis of oropharyngeal masses, intubation under general anesthesia or endoscopic procedure, neck dissection, radical surgery of tumor, selection of recipient vessels during tissue reconstruction, tracheostomy, application of interventional diagnosis and treatment, and radiation therapy, in order to provide guidance for clinicians to avoid or minimize accidental injuries or potential complications resulting from these variations while enhancing the accuracy and safety in treating such tumors. Reference | Related Articles | Metrics

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Research progress of etiology, prevention and treatment of limited mouth opening HOU Ming-jiao, ZHU Yue, WU Shu-yi, YANG Dong-ye China Journal of Oral and Maxillofacial Surgery    2024, 22 (6): 597-604.   DOI: 10.19438/j.cjoms.2024.06.013 Abstract （450）      PDF （1049KB）（610）       Knowledge map    Limited mouth opening refers to a clinical manifestation that the distance between the upper and lower dentition is significantly reduced when opening mouth. It is mostly caused by limited movement of the temporomandibular joint, which can affect the patient's chewing, swallowing, speech, oral hygiene and other oral and jaw functions. Long-term inability of mouth opening to eat normally may lead to malnutrition, and even severe physical and mental disabilities, affecting the quality of life. Nowadays, clinical medical workers have not yet payed enough attention to the causes and therapies of limited mouth opening. Therefore, this paper reviewed the measurement, classification, etiology, prevention and treatment methods, risk and prognosis of patients with limited mouth opening, aiming to strengthen the attention of medical staff to patients with restricted mouth opening, so as to achieve early diagnosis, prevention and treatment. Reference | Related Articles | Metrics

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The accuracy of robot-assisted dental implant surgery and factors affecting precision MIREALIMU·Miadili, LI Xiao-man, GAO Yi-ming China Journal of Oral and Maxillofacial Surgery    2024, 22 (6): 611-614.   DOI: 10.19438/j.cjoms.2024.06.015 Abstract （363）      PDF （519KB）（610）       Knowledge map    With the evolution of the fourth industrial revolution, the development of more complex intelligent systems has greatly improved the availability and reliability of digital technology. Digital technology has blurred the boundaries between the physical world and the virtual reality through the means of virtual reality and augmented reality. The field of oral implantation has benefited from technological advancements, gradually evolving from digital static guide technology to the use of new dynamic navigation equipment and real-time tracking technology with novel autonomous robots. This article reviewed the principles of various dental robotics and common surgical deviations, aiming to provide relevant references for oral clinical practice and basic research. Reference | Related Articles | Metrics

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The effect of maintenance anesthetics on neurobehavioral development of infants undergoing cleft lip and palate surgery LIU Wen-hui, ZHOU Xun, MA Li, LI Jing-jie, LIU Jin-xing, QIU Lin China Journal of Oral and Maxillofacial Surgery    2025, 23 (2): 145-151.   DOI: 10.19438/j.cjoms.2025.02.007 Abstract （191）      PDF （1111KB）（607）       Knowledge map    PURPOSE: To study the effect of different maintenance anesthetics on postoperative short-term neurobehavioral development in children undergoing cleft lip and palate surgery. METHODS: A total of 79 children under 2 years old who underwent cleft lip and palate surgery under general anesthesia were divided into inhalation anesthesia group (group IA) and combined intravenous inhalation anesthesia group (group CIIA) according to different medication methods during anesthesia maintenance. The Gesell Development Diagnosis Scale (GDDS) scores were recorded at preoperative baseline (T0), 6 months after surgery (M6) and 12 months after surgery (M12). The results included 5 functional areas of adaptability, fine motor, gross motor, language and social skills. The difference of GDDS scores between groups at each follow-up point was compared, and corrected regression analysis was performed. R 4.0.5 software was used for data analysis. RESULTS: There was no significant difference in basic characteristics and baseline GDDS scores between the two groups of patients before surgery, the induced medication and the sevoflurane concentration of maintenance during surgery between the two groups also had no significant difference. After adjusting for factors such as gender, maternal education level, BMI, family income, and anesthesia times, the fine motor ability of the combined intravenous inhalation anesthesia group was worse than that of the inhalation anesthesia group at 12 months post surgery (M12) (P< 0.05). CONCLUSIONS: Compared with inhalation anesthesia, combined intravenous and inhalation anesthesia may have a slight effect on the short-term fine motor ability of children after cleft lip and palate surgery under general anesthesia. Reference | Related Articles | Metrics

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Study on the correlation between tertiary lymphoid structure and clinical pathological characteristics and prognosis of head and neck squamous cell carcinoma XUE Jun-qing, ZHANG Ying, HU Yu-hua, LI Jiang, XIA Rong-hui China Journal of Oral and Maxillofacial Surgery    2024, 22 (6): 541-546.   DOI: 10.19438/j.cjoms.2024.06.004 Abstract （398）      PDF （2821KB）（590）       Knowledge map    PURPOSE: To explore the relationship between tertiary lymphoid structure(TLS) and clinicopathological characteristics, programmed death ligand 1(PD-L1), CD8 positive infiltrating cells, and prognosis in head and neck squamous cell carcinoma(HNSCC). METHODS: A total of 72 patients diagnosed with HNSCC in the Department of Oral Pathology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine from May 2017 to September 2022 were enrolled in this study. The expressions of CD20, CD3, CD21, PNAd, PD-L1 and CD8 in tumor tissues were detected by immunohistochemistry, and combined positive score(CPS) was used to evaluated the PD-L1 expression level. The Caseviewer software was used to calculate the infiltration degree and proportion of CD8 positively staining cells. Statistical analysis of the correlation between TLS status and clinicopathological characteristics, PD-L1 expression, tumor immune microenvironment, and prognosis was performed using SPSS 25.0 software package. RESULTS: Of the 72 patients with HNSCC, TLS positive rate was 41.7% (30/72). The TLS positive rate in patients <58 years old was significantly higher than that in patients ≥58 years old (P=0.004). There was no significant correlation between TLS status and other clinicopathological characteristics. The positive rate of TLS in the PD-L1 high expression group was significantly higher than that in the PD-L1 low expression group (60.7% vs. 29.5%, P=0.014). The infiltration degree and proportion of CD8 positive cells in TLS positive HNSCC cases are significantly higher than those in TLS negative HNSCC cases. The PD-L1 high expression group and TLS positive patients have a higher overall survival rate. CONCLUSIONS: TLS structure is significantly positively correlated with PD-L1 expression, CD8 positive cell infiltration degree, and infiltration proportion in HNSCC. Patients in the TLS positive group had a significantly better prognosis than those in the TLS negative group, indicating a close relationship between TLS and the tumor immune microenvironment, tumor immunotherapy response, and prognosis in HNSCC. Reference | Related Articles | Metrics

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Application of whiskers in bone tissue engineering LI Li-li, LIU Xiao-ming, ZHANG Yuan, WU Feng, GE Xue-jun, TIAN Zhi-qiang China Journal of Oral and Maxillofacial Surgery    2024, 22 (5): 499-504.   DOI: 10.19438/j.cjoms.2024.05.015 Abstract （262）      PDF （1540KB）（564）       Knowledge map    Whiskers are micro-nano sized short fibers grown from high-purity single crystals, and their excellent physicochemical and biological properties show great potential for application in bone tissue engineering BTE. In this paper, the classification, growth mechanism, preparation methods and characteristics of whiskers were reviewed, and their application in BTE was discussed. The research direction and application prospect of whisker in bone tissue engineering were also discussed. Reference | Related Articles | Metrics

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Association of preoperative anxiety level and postoperative pain in children undergoing general anesthesia of oral and maxillofacial day surgery SHEN Xiao-min, ZHONG Lin-hong, LI Jing-jie, LIU Jin-xing, QIU Lin China Journal of Oral and Maxillofacial Surgery    2025, 23 (2): 152-158.   DOI: 10.19438/j.cjoms.2025.02.008 Abstract （525）      PDF （1223KB）（536）       Knowledge map    PURPOSE: To explore the association between preoperative anxiety levels and postoperative pain in children undergoing general anesthesia of oral and maxillofacial day surgery. METHOD: A total of 769 children aged 3-12 years undergoing general anesthesia of oral and maxillofacial day surgery were included. According to the postoperative FLACC Pain Assessment Scale score, the children were divided into a postoperative pain group (FLACC≥ 4) and a non-pain group (FLACC< 4). Univariate and multivariate regression analyses were conducted on demographic data, preoperative anxiety levels of the children and their parents, surgical type, perioperative anesthetics and analgesics between the groups to explore the association of preoperative anxiety levels and postoperative pain in these children. R 4.2.3 software package was used for data analysis. RESULTS: The incidence of postoperative pain in children under general anesthesia of oral and maxillofacial day surgery was 25.88%. Univariate regression suggested the preoperative Modified Yale Preoperative Anxiety Inventory(mYPAS) in pediatric patients (OR=3.31, 95%CI: 2.15-5.15, P< 0.001) and preoperative State Anxiety Inventory (SAI) score in parents (OR=2.04, 95%CI: 1.14-3.69, P=0.017) were associated with an increased risk of postoperative pain. After further adjusting for age, gender, BMI, medical history, fentanyl dosage, sufentanil dosage, ketamine dosage, and anesthesia duration, multiple regression analysis showed that higher mYPAS(OR=2.04, 95%CI: 1.27-3.3, P=0.003) in pediatric patients was associated with an increased risk of postoperative pain. There was no significant correlation between parental preoperative Trait Anxiety Inventory (TAI) score and the increased risk of postoperative pain in children. Subgroup analysis results showed that increased mYPAS scores in children without medical or surgery history, as well as increased SAI in parents who underwent plastic surgery or with surgery histories of their children, were associated with the higher risk of postoperative pain. The interaction between preoperative mYPAS and parental SAI-TAI on postoperative pain only showed a trend significance and did not show statistical differences. CONCLUSIONS: Preoperative anxiety levels in children and the parental state anxiety were association with high risk of postoperative pain in children undergoing oral and maxillofacial day surgery. Therefore, effective interventions to reduce preoperative anxiety may improve postoperative pain management in this pediatric population. Reference | Related Articles | Metrics

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The analgesic effects of a lidocaine-loaded transdermal delivery system in orofacial pain WANG Ting, LUO Tao, ZHI Yan-kang, SUN Yu China Journal of Oral and Maxillofacial Surgery    2024, 22 (3): 222-227.   DOI: 10.19438/j.cjoms.2024.03.003 Abstract （349）      PDF （1248KB）（523）       Knowledge map    PURPOSE: To study the analgesic effect of transdermal drug delivery system loaded lidocaine in orofacial pain model. METHODS: The soluble microneedle patch loaded with lidocaine hydrochloride (Lido/MN) was prepared by microfabrication technology, and its insertion performance and transdermal release ability in vitro were measured. The analgesic effect of Lido/MN was observed in the orofacial formalin-induced pain model and capsaicin induced pain model in rats, and its biological safety was evaluated. SPSS 21.0 software package was used for data analysis. RESULTS: The study demonstrated that Lido/MN exhibited a complete and smooth external morphology, excellent mechanical properties, and skin penetration capability. It could rapidly dissolve and release lidocaine intradermally, exerting a rapid onset of action and providing good local anesthesia. CONCLUSIONS: The use of Lido/MN addresses the issue of slow onset of action in current lidocaine topical formulations, showing promising prospects for further research and clinical significance. Reference | Related Articles | Metrics

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Natural course following extraction of impacted mandibular third molars and their effect on mandibular second molars YANG Qing-ran, XU Guang-zhou China Journal of Oral and Maxillofacial Surgery    2024, 22 (4): 365-372.   DOI: 10.19438/j.cjoms.2024.04.008 Abstract （459）      PDF （833KB）（517）       Knowledge map    PURPOSE: To observe the natural course after extraction of impacted mandibular third molars(IM3Ms) and their influence on adjacent mandibular second molars (M2Ms). METHODS: Thirty-four patients (51 IM3Ms) with bone impaction of mandibular third molars were selected. The affected teeth were extracted by piezosurgery and pneumatic turbine handpiece. The postoperative reaction and distal bone defect of M2Ms were observed before operation, 1 week and 6 months after operation. The depth of distal bone defect at M2Ms before and after operation was compared, and the influencing factors were analyzed. SPSS 29.0 software package was used for data analysis. RESULTS: Before surgery, no apparent bone defects were observed in the distal mesial bone of M2Ms, but bone defects occurred during IM3Ms extraction due to bone removal and tooth extraction procedures. After 6 months, although some recovery in bone height was observed and the rate of bone defects decreased, it did not reach the preoperative level. The depth of IM3Ms impaction was the main influencing factor for the recovery rate. Probing depth significantly increased compared to preoperative levels. Patients experienced more pain within 24 hours postoperatively, which eased after 1 week, although mild limitation of mouth opening and facial swelling persisted. The extraction of IM3Ms had minimal impact on patients' daily life, emotions, work, and sleep. CONCLUSIONS: After the mandibular third molar extraction, the distal bone height adjacent to the second molar will partially recover, but it doesn't reach the preoperative level. In order to reduce the impact on adjacent teeth and bone tissue, surgeons need to adopt more refined surgical techniques during tooth extraction. At the same time, analgesic drugs should be given after removal of IM3Ms, and health education should be strengthened to improve the comfort of patients. Reference | Related Articles | Metrics

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Research on the preventive effect of lutein on traumatic temporomandibular joint ankylosis of rabbits MI Na, AN Wei, JIN Xue-mei, XIE Shuai, YAO Zhi-tao China Journal of Oral and Maxillofacial Surgery    2024, 22 (3): 216-221.   DOI: 10.19438/j.cjoms.2024.03.002 Abstract （341）      PDF （1435KB）（503）       Knowledge map    PURPOSE: To explore the effect of lutein on traumatic temporomandibular joint ankylosis. METHODS: Sixteen New Zealand white rabbits were randomly divided into blank control group and lutein intervention group (experimental group). The traumatic temporomandibular joint ankylosis model was established in all experimental animals under the premise of protecting the joint capsule. Postoperatively, the experimental group was given oral lutein 10 mg·kg-1·d-1 for 4 consecutive weeks. The maximum mouth opening, body weight, histology, imaging and bone metabolism indexes were compared between the two groups. GraphPad Prism 9.4.0 software package was used for data analysis. RESULTS: The body weight, mouth opening, serum osteocalcin concentration, condylar surface area and volume measured by CT in the experimental group were significantly higher than those in the control group after operation(P<0.05). Histomorphological observation showed that braid bone and new bone could be seen at the condylar stump of the two groups of experimental animals, sometimes chondrometaplasia could be seen in the fibers, occasionally granulation tissue and long-standing bleeding could be seen. The experimental group had thickening fibrous layer of the condyle, active cell proliferation, and a more pronounced cellular hierarchy. CONCLUSIONS: Lutein has certain preventive effect on traumatic temporomandibular joint ankylosis, and its mechanism of action may be related to its ability to promote bone formation and increase serum osteocalcin concentration. Reference | Related Articles | Metrics