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20 March 2025, Volume 23 Issue 2 Previous Issue   

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Effects of kaempferol on biological behaviors of Tca-83 cells via TGFBR1 signaling pathway ZHOU Ting-ting, LI Dong-ya, CHEN Wei-fang, WANG Sheng-ming, GE Dian-kui 2025, 23 (2):  105-109.  doi: 10.19438/j.cjoms.2025.02.001 Abstract ( 18 )   PDF (773KB) ( 4 )   PURPOSE: To explore the effect of kaempferol on the malignant biological behavior of Tca-83 cells through TGFBR1 pathway. METHODS: Human tongue squamous cell line Tca-83 cells were treated with different concentrations of kaempferol solution (25, 50, 100 mmol/L) and normal saline, which were set as experimental group and blank control group, respectively. CCK-8 assay was used to assess the growth of Tca-83 cells. The apoptotic status and cycle distribution of these cells were analyzed by flow cytometry, the effect of kaempferol on the invasive and migration ability of Tca-83 cells was detected by Transwell assay. Real-time quantitative PCR was used to detect the changes of mRNA expression of Bcl-2, Bax, Caspase-3 and TGFBR1 signaling pathways associated with apoptosis. SPSS 22.0 software package was used for data analysis. RESULTS: With the increase of kaempferol concentration and the extension of treatment time, the proliferation inhibition effect of cells in the experimental group was gradually enhanced in concentration and time-dependent way. The proportion of cells arrested in G0/G1 and S phase showed significant difference between groups(P< 0.05), and the experimental group had higher apoptosis rate than that of the blank control group (P< 0.05). Compared with the blank control group, the experimental group had smaller number of invaded and migrated cells (P< 0.05), and the number was gradually decreased with the increase of kaempferol concentrations. The mRNA expression of Bax and Caspase-3 in the experimental group was significantly higher than that in the blank control group, and the Bcl-2 mRNA expression was significantly lower than that in the blank control group(P< 0.05). The mRNA expressions of TGFBR1 and Smad 2/3 in the experimental groups were significantly lower than those in the blank control group(P< 0.05), and were decreased with the increase of kaempferol concentration (P< 0.05). CONCLUSIONS: The biological effects of kaempferol on Tca-83 cells include inhibition of their proliferation and migration capacity and promoting apoptosis, which may be related to its inhibition of the activation of the TGFBR1 signaling pathway. References | Related Articles | Metrics

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A Study on early quality of recovery of patients undergoing oral and maxillofacial tumour resection and free flap reconstruction surgery and its relationship with DAH30 ZHANG Yao, GUO Jun, LI Hui, ZHU Wen, LIU Bing, ZHANG Hui 2025, 23 (2):  110-116.  doi: 10.19438/j.cjoms.2025.02.002 Abstract ( 24 )   PDF (930KB) ( 11 )   PURPOSE: To investigate the early quality of recovery (QoR) of patients undergoing oral and maxillofacial tumour resection and free flap reconstruction surgery, and to analyze the relationship between QoR and days at home alive up to 30 days after surgery(DAH30). METHODS: A prospective, single-centre, cohort study was conducted on patients who were admitted to our hospital from September 2022 to October 2023 and scheduled to undergo oral and maxillofacial tumour resection and free flap reconstruction surgery under general anaesthesia. QoR-15 scale was used to evaluate the QoR on the day before surgery, the first day after surgery, and the second day after surgery. The patients were grouped according to the QoR-15 score on the 1st day after surgery, and the main results were the situation of QoR in the early postoperative period and the relationship between QoR of the 1st postoperative day and DAH30. SAS 9.4 software package was used for data analysis. RESULTS: A total of 251 patients were analyzed, the QoR on the 1st day after surgery was 86(34.26%) cases as poor, 165(65.74%) cases as moderate, as well as 25 (9.96%) cases as poor, 213 (84.86%) cases as moderate and 13(5.18%) cases as good on the second day after surgery. On the first day after surgery, the median DAH30 of patients with poor QoR was 18 days, and that of patients with moderate QoR was 20 days, and the difference was statistically significant(P=0.003). CONCLUSIONS: The early QoR of patients undergoing oral and maxillofacial tumour resection and free flap reconstruction surgery is mainly moderate. Enhancing the quality of recovery of such patients on the first day after surgery is beneficial to improve prognosis. References | Related Articles | Metrics

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Construction and validation of predictive model for implant failure in patients with dentition defect TAO Yuan, ZHU Guo-qiang, REN Wei-ping, ZHU Xiu-hong 2025, 23 (2):  117-121.  doi: 10.19438/j.cjoms.2025.02.003 Abstract ( 13 )   PDF (770KB) ( 4 )   PURPOSE: To construct a prediction model for implant failure in patients with dentition defect and verify its efficacy. METHODS: A total of 195 patients who underwent implant repair due to dental defect in the First People's Hospital of Pingdingshan City from March 2020 to March 2023 were selected and followed up for 1 year after discharge. According to the follow-up results, the patients were divided into implant failure group(n=25) and implant success group(n=170). The risk factors of implant failure in patients with denture defect were screened by univariate and multivariate regression analysis. A nomogram model of implant failure in patients with dental defects was constructed based on risk factors, and the predictive efficiency of the nomogram model was evaluated by Hosmer-Lemeshow test and receiver operating characteristic(ROC) curve. SPSS 26.0 software package was used for statistical analysis. RESULTS: Age≥ 60 years old, complicated with diabetes mellitus, smoking history, bad oral habits, maxillary defect, gingival creval bleeding index≥ 2, the proportion of grade Ⅲ to Ⅳ alveolar bone mineral density in the failed implantation group and the successful implantation group had significant difference (P< 0.05). There was no significant difference in sex ratio, hypertension, implantation time, implant diameter and other clinical data(P> 0.05). Logistic multivariate regression analysis results showed age≥ 60 years old (OR=1.857), diabetes mellitus (OR=1.822), history of smoking (OR=1.806), bad oral habits (OR=1.714), maxillary defect (OR=1.885), gingival crevicular bleeding index ≥ 2 (OR=1.874), alveolar bone mineral density (OR=1.869) were independent risk factors for implant failure in patients with denture defects (P< 0.05). Based on age, diabetes, smoking history, bad oral habits, maxillary defect, gingival crevicular bleeding index, and alveolar bone density, a nomogram model of implant failure risk for patients with dental defect was constructed. The results showed that the C-index was 0.905(95%CI: 0.855-0.972), and the measured value was basically consistent with the predicted value. CONCLUSIONS: The factors of implant failure in patients with dentition defect include age, diabetes, smoking history, bad oral habits, maxillary defect, gingival crevicular bleeding index, and alveolar bone mineral density. The nomogram model constructed based on this analysis has a good predictive effect on implant failure. References | Related Articles | Metrics

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Preliminary application of artificial intelligence in the pathological diagnosis of ameloblastoma QIAO Xin-wei, LI Mao, SHEN Ze-liang, ZHANG Lin-han, ZHENG Zhi-jian, TANG Ya-ling 2025, 23 (2):  122-128.  doi: 10.19438/j.cjoms.2025.02.004 Abstract ( 15 )   PDF (3026KB) ( 12 )   PURPOSE: To investigate the effect of artificial intelligence in the pathological diagnosis of ameloblastoma, and to preliminarily explore the value of artificial intelligence in the field of oral pathology. METHODS: The pathological images of 90 cases of ameloblastoma were used as the research objects, and the U-net-like structure neural network was constructed. The 90 H-E images of ameloblastoma were divided into a training set (72 images), a validation set (9 images) and a test set (9 images) for training and testing the model respectively. The mIoU and ROC curve were used to evaluate the ability of the U-net network model in the identification of ameloblastoma epithelium. RESULTS: The mIoU of negative area segmented by U-net model was 0.818 and the positive area was 0.846. The area under the ROC curve was 0.92. CONCLUSIONS: The U-net network model has a good segmentation for the positive and negative regions of ameloblastoma, and can distinguish between negative and positive sections. It can be preliminarily applied to the pathological diagnosis of ameloblastoma, and is expected to be gradually popularized in clinical practice after further validation with large samples. References | Related Articles | Metrics

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Analysis of sagittal jaw movements and pharyngeal airway changes in skeletal Class Ⅱ patients following bimaxillary surgery WU Jia-qing, SHEN Ai-li, QIAN Yi-feng, LIU Jia-qiang 2025, 23 (2):  129-136.  doi: 10.19438/j.cjoms.2025.02.005 Abstract ( 13 )   PDF (1458KB) ( 4 )   PURPOSE: To explore the relationship between jaw movements and changes in pharyngeal airway morphology and volume by studying the preoperative and postoperative jaw movements and pharyngeal airway alterations in skeletal Class Ⅱ patients undergoing bimaxillary surgery. METHODS: A total of 28 skeletal Class Ⅱpatients with maxillary protrusion and mandibular retrusion who received orthognath-orthodontic combined treatment in Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine from January 2021 to June 2024 were selected. All patients underwent maxillary setback via Le Fort I osteotomy combined with mandibular advancement using bilateral sagittal split ramus osteotomy(BSSRO). The difference in sagittal movement of the mandible was defined by subtracting the maxillary retraction from the mandibular forward movement. According to the difference of sagittal movement of the mandible,the patients were divided into two groups: group A(n=14) with a sagittal movement difference > 0 mm, and group B (n=14) with a sagittal movement difference ≤; 0 mm. All patients received CT scans at the end of preoperative orthodontics (T0) and six months after orthognathic surgery(T1). The CT data were imported into Dolphin Imaging 11.9 software to measure pharyngeal airway morphological parameters and jaw movements. Statistical analysis was performed using SPSS 29.0 software package. RESULTS: In group A, the sagittal movement difference was positively and linearly correlated with oropharyngeal airway volume. In group B, the sagittal movement difference had a nonlinear relationship with oropharyngeal airway volume. When the sagittal movement difference was less than -1.24 mm(R2=0.8225, P< 0.05), -1.02 mm(R2=0.6670, P< 0.05), -1.34 mm(R2=0.7717, P< 0.05), and -1.17 mm(R2=0.7332, P< 0.05), the total pharyngeal airway volume, nasopharyngeal airway volume, oropharyngeal airway volume, and hypopharyngeal airway volume decreased, respectively. CONCLUSIONS: In skeletal ClassⅡ patients undergoing maxillary setback combined with mandibular advancement, when the amount of maxillary setback exceeds the amount of mandibular advancement by more than 1 mm, there is significant reduction in pharyngeal airway volume. Therefore, for skeletal Class Ⅱ patients with a predisposition to pharyngeal airway narrowing, the treatment plan should be appropriately adjusted to mitigate airway risks.; References | Related Articles | Metrics

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Three-dimensional changes and related factors of proximal bone segments after BSSRO in patients with bony Class Ⅲ malocclusion and mandibular deviation SONG Xin-li, XU Lei, LI Min, LI Da-lu 2025, 23 (2):  137-144.  doi: 10.19438/j.cjoms.2025.02.006 Abstract ( 11 )   PDF (1662KB) ( 4 )   PURPOSE: To investigate the stability and influencing factors of proximal bone segment in patients with bony Class Ⅲ malocclusion with mandibular deviation after surgery, and to provide reference for the design of preoperative digital orthognathic surgery. METHODS: Seventy patients with bony Class Ⅲ malocclusion were included in this study, which included 35 patients with non-deviated jaws (group A) and 35 patients with deviated jaws(group B), all of them underwent bilateral sagittal split ramus osteotomy(BSSRO). CBCT data were obtained from the patients at 1 week preoperatively(T0), 1 week postoperatively(T1), and 1 year postoperatively (T2). ProPlan CMF 3.0 software was used for reconstruction and separation, and three-dimensional models of the upper and lower jaws were obtained. Relevant items on bilateral paracardial bone segments were measured at different periods. The spatial position movement and rotation of the plane where the connections of the proximal condyle center(CoC), coronoid point(Cor) and mandibular angle point(Go) were located were included. The factors affecting the stability of proximal bone segment after BSSRO in patients with bony Class Ⅲ malocclusion and mandibular deviation were analyzed. SPSS 27.0 software package was used for data analysis. RESULTS: There were statistically significant differences in yaw and roll positions of left and right mandibular ascending branches in group B at stage T0(P< 0.05), but no significant differences in other stages. Compared with stage T0, both proximal cardial segments moved vertically downward, tilted forward, and rotated in patients in stage T1(P< 0.05); meanwhile, in group B, skewed proximal cardial segment rolled(P< 0.05), and the changes of yaw and roll in the skewed and oblique proximal cardial segments were statistically significant(P< 0.05). In group B, the internal rotation and extroversion of the oblique side were correlated with the preoperative mandibular deviation (R-values were -0.590 and 0.573, respectively). Compared with T1, the proximal core segment in T2 group moved vertically upward, tilted backward and abducted (P< 0.05), and the proximal core segment in group B moved horizontally to the medial side as a whole(P< 0.05). ROC curve was used to obtain the preoperative truncation value of the skew of the skew proximal bone segment that caused the horizontal recurrence of the skew proximal bone segment, which was 6.31mm. For patients with skew greater than 6.31mm before surgery, the horizontal change of the skew proximal bone segment had statistical significance(P< 0.05). CONCLUSIONS: The proximal bone segment on the deviated side is more unstable after BSSRO in patients with bony Class Ⅲ malocclusion with mandibular deviation, and may be displaced horizontally and medially. If the preoperative mandibular deviation is large(more than 6.31 mm), when designing the preoperative digital orthognathic surgery plan, it is necessary to be aware of the horizontal movement of the proximal cardiac segment of the postoperative deviation to the medial side, which may aggravate or cause temporomandibular joint disorder, and the risk of postoperative recurrence.; References | Related Articles | Metrics

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The effect of maintenance anesthetics on neurobehavioral development of infants undergoing cleft lip and palate surgery LIU Wen-hui, ZHOU Xun, MA Li, LI Jing-jie, LIU Jin-xing, QIU Lin 2025, 23 (2):  145-151.  doi: 10.19438/j.cjoms.2025.02.007 Abstract ( 14 )   PDF (1111KB) ( 9 )   PURPOSE: To study the effect of different maintenance anesthetics on postoperative short-term neurobehavioral development in children undergoing cleft lip and palate surgery. METHODS: A total of 79 children under 2 years old who underwent cleft lip and palate surgery under general anesthesia were divided into inhalation anesthesia group (group IA) and combined intravenous inhalation anesthesia group (group CIIA) according to different medication methods during anesthesia maintenance. The Gesell Development Diagnosis Scale (GDDS) scores were recorded at preoperative baseline (T0), 6 months after surgery (M6) and 12 months after surgery (M12). The results included 5 functional areas of adaptability, fine motor, gross motor, language and social skills. The difference of GDDS scores between groups at each follow-up point was compared, and corrected regression analysis was performed. R 4.0.5 software was used for data analysis. RESULTS: There was no significant difference in basic characteristics and baseline GDDS scores between the two groups of patients before surgery, the induced medication and the sevoflurane concentration of maintenance during surgery between the two groups also had no significant difference. After adjusting for factors such as gender, maternal education level, BMI, family income, and anesthesia times, the fine motor ability of the combined intravenous inhalation anesthesia group was worse than that of the inhalation anesthesia group at 12 months post surgery (M12) (P< 0.05). CONCLUSIONS: Compared with inhalation anesthesia, combined intravenous and inhalation anesthesia may have a slight effect on the short-term fine motor ability of children after cleft lip and palate surgery under general anesthesia. References | Related Articles | Metrics

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Association of preoperative anxiety level and postoperative pain in children undergoing general anesthesia of oral and maxillofacial day surgery SHEN Xiao-min, ZHONG Lin-hong, LI Jing-jie, LIU Jin-xing, QIU Lin 2025, 23 (2):  152-158.  doi: 10.19438/j.cjoms.2025.02.008 Abstract ( 13 )   PDF (1223KB) ( 6 )   PURPOSE: To explore the association between preoperative anxiety levels and postoperative pain in children undergoing general anesthesia of oral and maxillofacial day surgery. METHOD: A total of 769 children aged 3-12 years undergoing general anesthesia of oral and maxillofacial day surgery were included. According to the postoperative FLACC Pain Assessment Scale score, the children were divided into a postoperative pain group (FLACC≥ 4) and a non-pain group (FLACC< 4). Univariate and multivariate regression analyses were conducted on demographic data, preoperative anxiety levels of the children and their parents, surgical type, perioperative anesthetics and analgesics between the groups to explore the association of preoperative anxiety levels and postoperative pain in these children. R 4.2.3 software package was used for data analysis. RESULTS: The incidence of postoperative pain in children under general anesthesia of oral and maxillofacial day surgery was 25.88%. Univariate regression suggested the preoperative Modified Yale Preoperative Anxiety Inventory(mYPAS) in pediatric patients (OR=3.31, 95%CI: 2.15-5.15, P< 0.001) and preoperative State Anxiety Inventory (SAI) score in parents (OR=2.04, 95%CI: 1.14-3.69, P=0.017) were associated with an increased risk of postoperative pain. After further adjusting for age, gender, BMI, medical history, fentanyl dosage, sufentanil dosage, ketamine dosage, and anesthesia duration, multiple regression analysis showed that higher mYPAS(OR=2.04, 95%CI: 1.27-3.3, P=0.003) in pediatric patients was associated with an increased risk of postoperative pain. There was no significant correlation between parental preoperative Trait Anxiety Inventory (TAI) score and the increased risk of postoperative pain in children. Subgroup analysis results showed that increased mYPAS scores in children without medical or surgery history, as well as increased SAI in parents who underwent plastic surgery or with surgery histories of their children, were associated with the higher risk of postoperative pain. The interaction between preoperative mYPAS and parental SAI-TAI on postoperative pain only showed a trend significance and did not show statistical differences. CONCLUSIONS: Preoperative anxiety levels in children and the parental state anxiety were association with high risk of postoperative pain in children undergoing oral and maxillofacial day surgery. Therefore, effective interventions to reduce preoperative anxiety may improve postoperative pain management in this pediatric population. References | Related Articles | Metrics

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Expression changes and clinical value of miR-155-5p, miR-138, miR-381-3p in oral squamous cell carcinoma WANG Xin, JIN Cheng, CUI Huan-huan 2025, 23 (2):  159-164.  doi: 10.19438/j.cjoms.2025.02.009 Abstract ( 12 )   PDF (650KB) ( 6 )   PURPOSE: To investigate the expression and clinical value of microRNA-155-5p (miR-155-5p), miR-138 and miR-381-3p in oral squamous cell carcinoma(OSCC). METHODS: Cancer tissues and adjacent normal tissues of 72 patients with OSCC were collected. Quantitative real-time PCR(RT-PCR) was used to detect the mRNA expressions of miR-155-5p, miR-138 and miR-381-3p, and to analyze the relationship between the expressions of miR-155-5p, miR-138 and miR-381-3p and clinicopathological characteristics and prognosis in OSCC. SPSS 25.0 software package was used for data analysis. RESULTS: Compared with adjacent normal tissues, the expression of miR-155-5p in cancer tissues was significantly increased, and the expression of miR-138 and miR-381-3p was significantly decreased(P< 0.05). High expression of miR-155-5p mRNA and low expression of miR-138 and miR-381-3p mRNA were found in cancer tissues of patients with tumor maximum diameter ≥ 3 cm, tumor invasion depth ≥ 5 mm, clinical stage Ⅲ-Ⅳ, cervical lymph node metastasis and moderate to high differentiation(P< 0.05). After 2 years of follow-up, the survival rate of 72 patients with OSCC was 40.32%(25/72). Compared with the survival patients, the expression of miR-155-5p mRNA in the dead patients was higher, and the expression of miR-138 and miR-381-3p mRNA was lower. Receiver operating characteristic (ROC) analysis showed that the area under the curve(AUC) of miR-155-5p, miR-138 and miR-381-3p combined to predict poor prognosis in patients with OSCC was 0.957, which was significantly higher than that of single mRNA detection (P< 0.05). CONCLUSIONS: The expression of miR-155-5p in OSCC tissues is high, while miR-138 and miR-381-3p expression are low. The expression of the three factors are related to the invasion depth, clinical stage, cervical lymph node metastasis, differentiation degree and prognosis of the tumor. Clinically, combined detection of the three indicators can be strengthened to evaluate the prognosis of patients. References | Related Articles | Metrics

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Effect of sub-brow incision and coronal incision on rehabilitation and aesthetic satisfaction after zygomatic fracture HU Chao, HUANG Qing, XU Wei 2025, 23 (2):  165-169.  doi: 10.19438/j.cjoms.2025.02.010 Abstract ( 9 )   PDF (804KB) ( 3 )   PURPOSE: To investigate the effect of sub-brow combined intraoral incision and coronal incision on postoperative recovery and aesthetic satisfaction in patients with zygomatic arch fractures. METHODS: A total of 60 patients with zygomatic arch fractures admitted to Hefei Second People's Hospital from January 2021 to December 2023 were selected and divided into two groups with 30 cases in each group, based on the surgical method. The control group received a coronal incision, while the experimental group received a sub-brow combined intraoral incision. The two groups were compared in terms of postoperative 3-month excellent rate and treatment satisfaction, complications, preoperative and postoperative 3-month scores on the Self-rating Anxiety Scale(SAS), Self-rating Depression Scale(SDS), comfort level, dietary disorder score, pink esthetic score(PES), soft tissue swelling subsidence time, fracture healing time, hospital stay, and scar incidence. SPSS 23.0 software package was used for statistical analysis. RESULTS: The experimental group showed higher postoperative 3-month excellent rate and treatment satisfaction compared to the control group(P< 0.05). At 3 months post-surgery, the experimental group had lower SAS, SDS, comfort level, and dietary disorder scores compared to the control group(P< 0.05), and higher PES scores(P< 0.05). The experimental group also had shorter soft tissue swelling subsidence time, fracture healing time, and hospital stay, with lower scar incidence compared to the control group(P< 0.05). There was no significant difference in complication rates between the two groups(P> 0.05). CONCLUSIONS: Sub-brow combined intraoral incision demonstrates significant advantages in the treatment of zygomatic arch fractures. This technique can reduce scar incidence, alleviate early postoperative stress responses, and accelerate postoperative recovery and improve the satisfaction of treatment, aesthetic satisfaction and psychological state of patients (anxiety, depression). References | Related Articles | Metrics

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Development and clinical application of a new type of oral and maxillofacial local compression band ZOU Can, GONG Cheng-xia, JIANG Jue 2025, 23 (2):  170-173.  doi: 10.19438/j.cjoms.2025.02.011 Abstract ( 8 )   PDF (570KB) ( 12 )   PURPOSE: To develop a new type of oral and maxillofacial local compression band and evaluate its effectiveness in oral and maxillofacial surgery. METHODS: A total of 72 patients undergoing alveolar surgery in Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine were randomly divided into control group and experimental group, with 36 patients in each group. The control group was subjected to postoperative local compression with conventional bandage, while the experimental group was subjected to a new type of oral and maxillofacial local compression band. Both groups were operated by the same physician. The compression band was removed on the second day after surgery, and the swelling, bleeding and healing of the wound were observed, and the comfort of the patients and the satisfaction of the attending physicians were scored. SPSS 20.0 software package was used for data analysis. RESULTS: There was no significant difference in general data such as gender, age and surgery between the two groups of patients. The incidence of facial swelling in the experimental group was 5.6%(2/36), significantly lower than 33.3%(12/36) in the control group (P< 0.05); the incidence of bleeding in the experimental group was 2.8% (1/36), significantly lower than 16.7% (6/36) in the control group (P< 0.05). The postoperative mouth opening degree and skin compression comfort of the patients in the experimental group were significantly better than those in the control group(P< 0.05); the satisfaction of the attending physicians in the experimental group in terms of operation convenience, time-saving and labor-saving, and treatment effect was significantly better than that in the control group (P< 0.05). CONCLUSIONS: The new type of oral and maxillofacial local compression band is simple and easy to use. It can reduce the incidence of maxillofacial swelling and bleeding, and is beneficial for wound healing, thus is worthy of promoting. References | Related Articles | Metrics

Clinical Reports

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Application of autologous tooth transplantation in the repair of oroantral communication in 12 cases BUMAIREMU Yiminjiang, PAN Yue-ying, AILIMAIERDAN Ainiwaer, GU Li, WANG Ling 2025, 23 (2):  174-179.  doi: 10.19438/j.cjoms.2025.02.012 Abstract ( 11 )   PDF (1401KB) ( 12 )   PURPOSE: To investigate the effect of autogenous tooth transplantation in the repair of oroantral communication. METHODS: A total of 12 patients who underwent autologous tooth transplantation to repair oroantral communication in the Outpatient Department of Oral Surgery of the First Affiliated Hospital of Xinjiang Medical University from September 2022 to September 2023 were selected. All patients had oroantral communication due to extraction of the first or second maxillary molar because of severe dental caries, periapical disease, periodontal disease, residual root, residual crown, or trauma. The patient met the indications of autologous tooth transplantation and were willing to receive autologous tooth transplantation. The clinical and imaging data of the patients were retrospectively analyzed, and the success rate of oroantral communication repair and autologous tooth transplantation was statistically analyzed. RESULTS: At 12 months after operation, all the transplanted teeth had good occlusion and normal function, without clinical or imaging pathological signs. Imaging examinations showed that there was continuous periosteal formation in the maxillary sinus floor after transplanting teeth. CONCLUSIONS: When oroantral communication occurs during extraction of the maxillary first or second molar, autologous tooth transplantation is a suitable treatment option if the patient has a suitable third molar. References | Related Articles | Metrics

Dental Education

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Application and challenges of virtual simulation technology in oral implant nursing teaching FENG Yi, HUANG Jian-fang, ZHAO Yao-yu, YAN Qi, WANG Li 2025, 23 (2):  180-184.  doi: 10.19438/j.cjoms.2025.02.013 Abstract ( 8 )   PDF (607KB) ( 10 )   Virtual simulation technology combines computer technology, 3D graphics, multimedia, and more to provide a multi-sensory immersive experience, and it is widely applied in various fields. This paper analyzed the application of virtual simulation technology in basic nursing and oral implantology care education, summarizing its effectiveness and the challenges it faces. Traditional teaching methods have limitations in fostering students' self-directed learning and practical skills. In contrast, virtual simulation technology, with its immersive and interactive nature, enhances students' interest in learning and operational skills, effectively addressing some shortcomings of traditional education. The paper discussed technical, cost and design challenges encountered in the application of virtual simulation technology in nursing education and proposes corresponding solutions. References | Related Articles | Metrics

Literature Analysis

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Visual analysis of clinical research literatures on temporomandibular joint disorders at both home and abroad from 2013 to 2023 LIU Xing-yu, JIANG Nan 2025, 23 (2):  185-195.  doi: 10.19438/j.cjoms.2025.02.014 Abstract ( 19 )   PDF (2071KB) ( 18 )   PURPOSE: To analyze the evolution of domestic and international clinical researches on temporomandibular joint disorders(TMD) from 2013 to 2023,to understand the development trends and research hotspots, and to explore future research directions. METHODS: Clinical research literatures on TMD published between 2013 and 2023 were collected through PubMed, China National Knowledge Infrastructure(CNKI), Wanfang Data, and VIP databases. CiteSpace 6.1.R6 software was utilized for visual analysis. Methods included keyword frequency statistics, co-occurrence analysis, clustering analysis, and timeline analysis to construct knowledge maps and identify research hotspots. RESULTS: Domestic research hotspots were primarily focused on pain management, acupuncture therapy, and tissue repair. In contrast, international researches heavily emphasized quality of life and non-invasive treatment approaches. Both domestic and international studies underscored the importance of interdisciplinary integration and the application of new technologies. Keywords such as "acupuncture treatment" have appeared relatively late in domestic researches but showed a clear trend, indicating an interest in the application of traditional medicine and emerging technologies. International researches had earlier focused on psychological factors and quality of life, and leaded in the application of new materials and technologies. CONCLUSIONS: Although there are differences in methods and focal points between domestic and international researches, there is a consistent focus on core issues such as pain management and the application of imaging technologies. Future researches should enhance attention to psychological factors and comprehensive health management, draw on international experience, explore the application of new materials and new technologies, and promote interdisciplinary collaboration to improve the diagnosis and treatment of temporomandibular joint disorders and the quality of life of patients. References | Related Articles | Metrics

Review Articles

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Research progress on drugs for the prevention and treatment of radiotherapy-induced oral mucositis WANG Jia-min, AN Wei, CHEN Wen-ge 2025, 23 (2):  196-201.  doi: 10.19438/j.cjoms.2025.02.015 Abstract ( 14 )   PDF (674KB) ( 11 )   Radiation oral mucositis is one of the most common complications of radiotherapy in patients with head and neck cancer. It can lead to mucosal ulceration, severe pain, eating and swallowing difficulties and other functional disorders, resulting in treatment interruption and poor curative effect. Radiation oral mucositis is currently believed to be a complex and dynamic process with multiple targets, and drug therapy targeting these targets can prevent and control the occurrence and development of mucositis. This review discussed the research progress of drugs for prevention and treatment of radiation mucositis, aiming at different targets of mucositis, including DNA damage, oxidative stress pathway, oral microbiota, epithelial proliferation, and analgesic management, which will provide references for the future research and clinical prevention and treatment of radiation oral mucositis. References | Related Articles | Metrics

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Current research on the loss of contact between implant prostheses and adjacent natural teeth LAI Zi-ya, ZHAO Tian, GAO Yi-ming 2025, 23 (2):  202-205.  doi: 10.19438/j.cjoms.2025.02.016 Abstract ( 13 )   PDF (438KB) ( 8 )   As one of the current treatment options for defect of dentition, implant restoration has been widely used in clinical practice. However, some complications have also seriously affected patient' quality of life after implant restoration, such as loss of proximal contact between implant prostheses and natural teeth, which can easily lead to implant peri-endodontitis, increase the probability of food impaction, and periodontitis. The current treatment methods for this postoperative phenomenon are relatively limited, and research on the etiology of the disease is also lacking. Therefore, this paper analyzed and discussed the problem of loss of adjacent contact between implant prostheses and natural teeth, comprehensively analyzed the causes of this disease, and summarized the current research status of clinical treatment methods. It also provided feasible suggestions for prevention and treatment in the later stage. References | Related Articles | Metrics

Case Reports

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A case of chronic pain caused by residual small foreign body during wisdom tooth extraction was misdiagnosed as somatoform disorder LI Shi-yong, WU Yong, ZHANG Xin, WANG Si-hang, FU Shuai 2025, 23 (2):  206-208.  doi: 10.19438/j.cjoms.2025.02.017 Abstract ( 9 )   PDF (874KB) ( 3 )   Foreign bodies in oral and maxillofacial region are not rare in clinical practice. This paper reported a patient with long-term chronic pain caused by small metal foreign body remaining in the soft tissue during wisdom tooth extraction, and was later misdiagnosed as somatoform disorder. After the foreign body was removed, the patient's symptoms disappeared. The residual foreign bodies, causes of misdiagnosis, prevention and treatment were discussed based on relevant literature review, in order to strengthen the understanding of the disease and reduce misdiagnosis. References | Related Articles | Metrics