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20 January 2026, Volume 24 Issue 1 Previous Issue   

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Effect of dihydroartemisinin on proliferation, apoptosis and angiogenic capacity of human malignant melanoma A375 cells Li Shuai, Li Xuemin, Hua Chaochao, Li Ting, Zhang Ningning, Zhao Lu 2026, 24 (1):  1-8.  doi: 10.19438/j.cjoms.2026.01.001 Abstract ( 3 )   PDF (1920KB) ( 6 )   PURPOSE: To investigate the effects of dihydroartemisinin(DHA) on the proliferation, apoptosis and angiogenesis of human malignant melanoma A375 cells, and to clarify its potential molecular mechanism. METHODS: Human malignant melanoma A375 cells were used as the research object, and a blank control group and DHA treatment groups with different concentrations (1, 5, 10, 20, 40, 80 μmol/L) were set up. The CCK-8 method was used to detect cell proliferation activity; flow cytometry was used to determine the cell apoptosis rate; Transwell assay was used to evaluate cell invasion ability; tube formation assay was used to detect angiogenesis ability; RT-PCR and Western blot techniques were used to detect the mRNA and protein expression levels of matrix metalloproteinase 9(MMP-9) and chemokine receptor 4 (CXCR4), respectively. RESULTS: Compared with the blank group, cell proliferation in all DHA groups with different concentrations was significantly inhibited in a dose-dependent manner. Flow cytometry analysis showed that the number of apoptotic cells in the DHA-treated groups increased significantly, and it increased with drug concentration. Transwell assay revealed that the number of cells penetrating the matrix membrane in the DHA groups was significantly reduced. The results of tube formation assay indicated that DHA could reduce the angiogenic ability of A375 cells. In addition, DHA down-regulated the mRNA and protein expressions of MMP-9 and CXCR4. CONCLUSIONS: DHA may inhibit the proliferation, invasion and angiogenesis of human malignant melanoma A375 cells and induce cell apoptosis by down-regulating the expressions of MMP-9 and CXCR4. References | Related Articles | Metrics

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Study on the effect of overexpressed ETV2 in co-culturing endothelial cells on promoting angiogenesis of oral squamous cell carcinoma organoid Fang Tianyi, Yang Xi 2026, 24 (1):  9-16.  doi: 10.19438/j.cjoms.2026.01.002 Abstract ( 10 )   PDF (2280KB) ( 4 )   PURPOSE: To establish a vascularized model of patient-derived organoids(PDOs) from oral squamous cell carcinoma(OSCC) patients and optimize the design of preclinical research models. METHODS: Recombinant vascular endothelial cells (R-VECs) overexpressing the ETV2 gene were constructed by lentiviral infection of human umbilical vein endothelial cells(HUVECs). Tumor cells were isolated from OSCC surgical samples and cultured three-dimensionally in Matrigel to self-assemble into PDOs, with the growth dynamics of the model recorded. Hematoxylin-eosin(HE) staining and immunohistochemistry(IHC) were used to detect the expression differences of OSCC markers(CK56, SMA, Ki67) between the PDO model and the patient's primary tumor tissue, so as to evaluate their biological consistency. R-VECs were co-cultured with PDOs. Immunofluorescence (IF) technology was used to detect the proliferative activity of PDOs and the attachment of vascular networks after co-culture, and the structural characteristics of blood vessels inside PDOs were observed by confocal microscopy. RESULTS: A co-cultured vascularized model of R-VECs and OSCC PDOs was successfully established. HE and IHC identification showed that the PDO model was highly consistent with the patient's primary tumor tissue in terms of morphology and marker expression. The vascularized PDO model had significantly enhanced proliferative activity and improved passage stability. HE, IHC, IF and confocal experiments all confirmed that vascular structures could effectively penetrate into the interior of organoids. CONCLUSIONS: The PDO model constructed from OSCC samples can well recapitulate the morphological and biomarker characteristics of the patient's tumor tissue. Vascularization modification can further enhance the proliferative activity of PDOs without changing their inherent tumor biological properties. References | Related Articles | Metrics

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Analysis of the efficacy and influencing factors of anterior repositioning splint in the treatment of temporomandibular joint anterior disc displacement with reduction Li Minhan, Zhang Chuhan, Zhu Yan, He Jiaying, Yang Chi, Ma Zhigui 2026, 24 (1):  17-22.  doi: 10.19438/j.cjoms.2026.01.003 Abstract ( 4 )   PDF (945KB) ( 3 )   PURPOSE: To explore the efficacy of anterior repositioning splint(ARS) in the treatment of anterior disc displacement with reduction(ADDWR) and its influencing factors, so as to provide reference for clinical treatment selection. METHODS: A total of 58 ADDWR patients who received ARS treatment in Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine from January 2009 to June 2018 were included. According to the effect of articular disc reduction 6 months after the end of treatment, they were divided into the success group(n=40) and the failure group(n=18). The initial clinical characteristics and cephalometric indexes of the two groups were compared, and the independent influencing factors of treatment effect were screened by multivariate logistic regression. RESULTS: In the initial stage of treatment, the degree of chin deviation in the failure group was significantly greater than that in the success group (P<0.001), while the Sn-G Vert distance (P<0.05) and S Vert-Co distance (P<0.001) were significantly smaller than those in the success group. Multivariate logistic regression showed that chin deviation(OR=0.12, 95%CI=0.03-0.58), S Vert-Co distance(OR=2.53, 95%CI=1.128-5.67) and Sn-G Vert distance(OR=4.67, 95%CI=1.14-19.09) were independent influencing factors for the efficacy of ARS(P<0.05). CONCLUSIONS: The degree of chin deviation, S Vert-Co distance and Sn-G Vert distance in the initial stage of treatment are key indicators for the efficacy of ARS in the treatment of ADDWR. In clinical practice, these indicators can be combined to evaluate the prognosis and optimize the treatment plan. References | Related Articles | Metrics

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Predictive value of preoperative neutrophil to platelet ratio in the diagnosis of parotid malignant tumors Xue Xingyue, Cao Kun, Lu Fang, Bao Qiang, Sun Yuhua, Li Jiafeng 2026, 24 (1):  23-27.  doi: 10.19438/j.cjoms.2026.01.004 Abstract ( 4 )   PDF (700KB) ( 6 )   PURPOSE: To explore the diagnostic value of preoperative neutrophil-to-platelet ratio(NPR) in malignant parotid tumors, and to analyze its correlation with tumor stage and lymph node metastasis. METHODS: A total of 248 patients with parotid tumors admitted to Affiliated Hospital of Xuzhou Medical University from October 2022 to October 2024 were selected, including 124 cases in the malignant tumor group (experimental group) and 124 cases in the benign tumor group (control group). Inflammatory indicators such as preoperative peripheral blood NPR, neutrophil-to-lymphocyte ratio (NLR), and systemic inflammatory response index (SIRI) were compared between the two groups. Logistic regression analysis was used to screen independent risk factors for malignant parotid tumors, and receiver operating characteristic (ROC) curve was employed to evaluate the diagnostic efficacy of NPR. RESULTS: The level of NPR in the experimental group was significantly higher than that in the control group(P<0.001). Multivariate logistic regression showed that NPR was an independent risk factor for malignant parotid tumors(OR=1.055, 95%CI: 1.007-1.104, P=0.022). In the experimental group, NPR in the lymph node metastasis group was significantly higher than that in the non-metastasis group(P<0.001), and NPR in the advanced stage group(stage Ⅲ + Ⅳ) was significantly higher than that in the early stage group (stage Ⅰ+Ⅱ)(P<0.05). The ROC curve showed that the area under the curve(AUC) of NPR for diagnosing malignant parotid tumors was 0.663(95%CI: 0.587-0.739). At the optimal cut-off value of 0.014, the sensitivity was 68.8% and the specificity was 58.3%. CONCLUSIONS: The level of preoperative peripheral venous blood NPR can be used as an auxiliary diagnostic indicator for malignant parotid tumors. A high NPR indicates a high risk of malignant tumors, advanced stage, and a high possibility of lymph node metastasis. However, its diagnostic efficacy is limited and needs to be comprehensively judged in combination with clinical examination. References | Related Articles | Metrics

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Study on the correlation between modified frailty index and postoperative adverse outcomes in elderly patients with maxillofacial space infection Fan Jingxian, Wu Jiajun, Ge Kui, Wang Fanlin 2026, 24 (1):  28-33.  doi: 10.19438/j.cjoms.2026.01.005 Abstract ( 6 )   PDF (838KB) ( 4 )   PURPOSE: To explore the relationship between the modified frailty index(mFI) and adverse outcomes after general anesthesia in elderly patients with maxillofacial space infection, so as to provide a reference for clinical risk assessment. METHODS: The clinical data of 83 elderly patients with maxillofacial space infection who required general anesthesia surgery in Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine from June 2016 to January 2025 were retrospectively analyzed. The 11-item mFI was used to assess the patients' frailty status, and they were divided into the frail group(mFI≥0.27, 43 cases) and the non-frail group(mFI<0.27, 40 cases). Univariate and multivariate logistic regression analyses were used to analyze the correlation between mFI and postoperative complications as well as length of stay(LOS). The receiver operator characteristic(ROC) curve was drawn to evaluate the predictive efficacy of mFI for prolonged LOS. RESULTS: The incidences of new-onset pneumonia (41.86% vs 20.00%), respiratory failure (19.05% vs 2.56%) and cardiovascular events (48.84% vs 23.08%) in the frail group were significantly higher than those in the non-frail group (P<0.05), and the LOS was longer(P<0.05). Multivariate logistic regression analysis showed that mFI ≥0.27 was an independent risk factor for prolonged LOS(OR=2.53, 95%CI: 1.02-6.31). ROC curve analysis showed that the predictive efficacy of mFI combined with APACHE-II score for prolonged LOS reached above the moderate level(AUC=0.772, 95%CI: 0.664-0.859). CONCLUSIONS: The modified frailty index can effectively assess the risk of adverse outcomes after general anesthesia in elderly patients with maxillofacial space infection. Its combination with APACHE-II score has high predictive value for prolonged hospital stay, which can provide a basis for perioperative diagnosis and treatment decisions. References | Related Articles | Metrics

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Construction and validation of a risk prediction model for medical device-related pressure injury in ICU patients with indwelling artificial airway Chen Xinyu, Wang Zhiwei, Yang Gong, Yu Zhaoxia 2026, 24 (1):  34-39.  doi: 10.19438/j.cjoms.2026.01.006 Abstract ( 6 )   PDF (833KB) ( 5 )   PURPOSE: To explore the influencing factors of medical device related pressure injury (MDRPI) in ICU patients with indwelling artificial airways and construct a risk nomogram prediction model. METHODS: A total of 537 ICU patients with indwelling artificial airways in the First Affiliated Hospital of Xinjiang Medical University from January to October 2023 were selected as the research objects. The relevant clinical data of the patients were collected, and logistic regression was used to screen the independent risk factors for MDRPI. A nomogram prediction model was established and internally validated. RESULTS: Among the 537 patients, 169(31.47%) developed MDRPI. Logistic regression analysis showed that age, ICU type (cardiac surgery), IL-6, history of diabetes, and use of vasoactive drugs were independent risk factors (OR> 1, P<0.05), while higher scores of friction/shear force were protective factors (OR<1, P< 0.05). The nomogram model constructed based on the above influencing factors showed good calibration(P=0.774) and discrimination(AUC=0.886, 95%CI: 0.857-0.915). The calibration curve and decision curve indicated good consistency and benefit of the model. CONCLUSIONS: The risk prediction model for MDRPI in ICU patients with indwelling artificial airways constructed in this study has high predictive value, which can provide a reference for clinical early identification of high-risk patients and formulation of intervention measures. References | Related Articles | Metrics

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Comparative study on donor site recovery and cutaneous sensory function after two types of forearm flap procedures for defect repair in oral and maxillofacial tumors Lin Tianzhen, Wang Wenfeng, Ren Changqun, Li Yong, Zhou Jianhong 2026, 24 (1):  40-46.  doi: 10.19438/j.cjoms.2026.01.007 Abstract ( 4 )   PDF (1082KB) ( 3 )   PURPOSE: To compare the effects of two forearm flap techniques on donor site recovery and skin sensory function after repair of oral and maxillofacial tumor defects. METHODS: A total of 206 patients with oral and maxillofacial tumors admitted to the 910th Hospital of the Joint Logistic Support Force of the PLA from January 2022 to January 2025 were selected. All patients underwent tumor resection and defect repair, and were divided into an experimental group and a control group according to the different flap repair methods, with 103 cases in each group. The control group was treated with the traditional forearm flap repair technique, while the experimental group was treated with the modified forearm flap repair technique. The clinical indicators, repair effect, oral function, donor site recovery, hematological indicators, and flap survival rate and postoperative complications were compared between the two groups. RESULTS: There was no significant difference in operation time, postoperative hospital stay, oral feeding time, and vascular anastomosis time between the two groups(P>0.05); the flap area in the experimental group was significantly smaller than that in the control group(P<0.05). The effective repair rate in the experimental group(91.26%) was significantly higher than that in the control group(80.58%, P<0.05). The scores of speech function, appearance status, mouth opening, oral closure, eating status, occlusal function, masticatory function, and swallowing function in the experimental group were significantly higher than those in the control group(P<0.05). The proportions of patients with no persistent numbness in the forearm surgical area and the superficial branch of the radial nerve in the experimental group were significantly higher than those in the control group(P<0.05). After surgery, the levels of SA, sIL-2R, and CRP in the experimental group were significantly lower than those in the control group (P<0.05). There were no significant differences in flap survival rate, flap crisis rate, or total complication rate between the two groups(P>0.05). CONCLUSIONS: The modified forearm flap repair technique is superior to the traditional technique in terms of flap area control, repair effect, oral function recovery, donor site nerve protection, and immune-inflammatory regulation, and has comparable safety. It is worthy of clinical promotion. References | Related Articles | Metrics

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Application of internet outpatient preoperative anesthesia evaluation model in day surgery patients undergoing oral and maxillofacial surgery Cui Xuewei, Zhang Minmin, Cao Shuang, Kang Hua 2026, 24 (1):  47-53.  doi: 10.19438/j.cjoms.2026.01.008 Abstract ( 9 )   PDF (1043KB) ( 8 )   PURPOSE: To explore the application effect of internet outpatient services in preanesthesia evaluation (PAE) for patients undergoing oral and maxillofacial day surgery. METHODS: A retrospective analysis was conducted on the outpatient data of patients scheduled for oral and maxillofacial day surgery in Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine from June 2024 to December 2024. The patients were divided into two groups based on the method of anesthesia assessment: the in-office PAE group (in-office group) and the internet outpatient PAE group (internet group). After balancing the baseline data of the two groups using propensity score matching(PSM), the surgical cancellation rate, difficult airway assessment, transportation costs, lost work costs, and patient satisfaction were compared between the two groups. RESULTS: A total of 1 828 patients were included in the study, and 457 pairs of patients were successfully matched by PSM. The surgical cancellation rate in the internet group(2.2%) showed no significant difference from that in the in-office group(1.3%). The number of anticipated difficult airway cases in the internet group (n=20) was not significantly different from the in-office group(n=24). Patients in the internet group saved an average of 551.8 RMB in transportation costs and 135.9 RMB in lost work costs. Patients' satisfaction in the internet group(99.2%) was significantly higher than that in the in-office group (90.9%) (P<0.001). CONCLUSIONS: Compared with traditional outpatient PAE, internet outpatient PAE significantly reduces medical costs, improves the patient experience, and enhances patient satisfaction, without increasing the surgical cancellation rate or affecting difficult airway assessment. It is worthy of promotion and application. References | Related Articles | Metrics

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Study on the role of PRF combined with preformed titanium mesh in implant restoration of severe horizontal defects in maxillary anterior alveolar ridge Zhang Wentao, Xin Dan, Pang Lifeng 2026, 24 (1):  54-58.  doi: 10.19438/j.cjoms.2026.01.009 Abstract ( 4 )   PDF (593KB) ( 5 )   PURPOSE: To explore the application effect of platelet-rich fibrin(PRF) combined with preformed titanium mesh in the implant restoration of severe horizontal defects of the maxillary anterior alveolar ridge. METHODS: A total of 64 patients who underwent implant restoration for severe horizontal defects of the maxillary anterior alveolar ridge in Xi'an Labor Union Hospital from January 2021 to January 2024 were selected and randomly divided into a control group and an experimental group, with 32 cases in each group. In the control group, preformed titanium mesh was placed over the bone defect area after implantation; in the experimental group, PRF was applied in combination with the treatment used in the control group. The implant success rate, changes in alveolar bone morphology (alveolar bone volume increment, height increment, width increment), periodontal health status, red aesthetic score, occlusal and masticatory functions were compared between the two groups after 12 months, and complications were recorded. RESULTS: The implant success rate was 100% in both groups. The postoperative alveolar bone volume increment, height increment, and width increment in the experimental group were significantly higher than those in the control group(P<0.05). The periodontal status and anterior tooth aesthetics in the experimental group were significantly better than those in the control group(P<0.05), and the occlusal and masticatory abilities were significantly higher than those in the control group (P<0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05). CONCLUSIONS: PRF combined with preformed titanium mesh can significantly improve bone increment effect in severe horizontal defects of the maxillary anterior alveolar ridge, enhance periodontal health and aesthetic appearance, and strengthen occlusal and masticatory functions, with good safety. References | Related Articles | Metrics

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Application of computer-aided design based on CBCT in open reduction and internal fixation of sagittal fractures of the mandibular condyle Cheng Lijun, Zhao Lili, Wei Zequan, Jiang Yuxin, Zhao Minchao 2026, 24 (1):  59-64.  doi: 10.19438/j.cjoms.2026.01.010 Abstract ( 6 )   PDF (1953KB) ( 3 )   PURPOSE: To explore the value of CBCT in the diagnosis and treatment of sagittal condylar fractures, and to evaluate the application of computer-aided design in open reduction and internal fixation of condylar sagittal fractures. METHODS: A total of 21 patients with condylar sagittal fracture who were treated in the Third Hospital of Hebei Medical University from March 2022 to October 2023 were selected as the study objects. All patients were examined by CBCT before surgery and underwent 3D reconstruction and computer-aided design using Mimics software. Through the analysis of preoperative imaging data, the fracture type, displacement and fixation plan were determined. The reduction outcomes and prognosis were evaluated by imaging and clinical examinations. RESULTS: Intraoperative diagnosis of all patients was consistent with preoperative CBCT imaging diagnosis. Postoperative imaging results showed that the actual length, implant position and angle of the internal fixation were basically consistent with the preoperative design, and 19 patients achieved or approached anatomical reduction. At 3 months after surgery, the maximum opening of the patients was significantly improved compared with that before surgery, and imaging evaluation showed that 12 patients achieved grade 1 healing and 7 patients achieved grade 2 healing. CONCLUSIONS: CBCT provides an effective reference for clinical diagnosis and treatment of sagittal fracture of condyle. The combination of preoperative CBCT and computer-aided design is helpful to guide the surgical treatment of sagittal fracture of condyle and has high clinical value. References | Related Articles | Metrics

Evidence-Based Medicin

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Comparison of the efficacy and quality of repair of soft tissue defects after oral squamous cell carcinoma with anterolateral thigh flap and forearm flap: a meta-analysis Zhan Fang, Wang Kexin, He Zongxuan, Wang Lin, Song Kai, Shang Wei 2026, 24 (1):  65-77.  doi: 10.19438/j.cjoms.2026.06.011 Abstract ( 6 )   PDF (3936KB) ( 6 )   PURPOSE: To systematically evaluate the effectiveness and quality of anterolateral thigh flaps(ALTF) and forearm flaps (FF) for repairing soft tissue defects after oral squamous cell carcinoma surgery. METHODS: The literatures on the repair of soft tissue defects in patients with oral squamous cell carcinoma after surgery by ALTF and FF were systematically retrieved from databases such as PubMed, Embase, Medline, Cochrane Library, CNKI, Wanfang, and VIP. The retrieval time was from the establishment of the databases to October 1, 2024. The researchers conducted literature collection, quality evaluation, data extraction strictly in accordance with the inclusion and exclusion criteria, and cross-checked. Then, meta-analysis was performed using RevMan 5.4 software. RESULTS: A total of 36 studies were finally included,involving 2 570 patients. The results of meta-analysis showed that in terms of flap preparation time, the time for FF was significantly less than that for ALTF [MD=3.73, 95%CI(0.20, 7.26), P=0.04], but there was no significant difference in the total duration of operation [MD=17.20, 95%CI(-9.33, 43.73), P=0.20]. In terms of postoperative complications in the surgical area, ALTF had a lower incidence of postoperative pigmentation, hypertrophic scarring, and abnormal sensation in the surgical area [OR=0.07, 95%CI(0.03, 0.16), P<0.00001; OR=0.18, 95%CI(0.11, 0.29), P<0.00001; OR=0.24, 95%CI(0.10, 0.59), P=0.002]. In terms of postoperative oral function, ALTF had a lower incidence of temporal/permanent functional impairment [OR=0.10, 95%CI (0.06, 0.15), P<0.00001; OR=0.12, 95%CI(0.05, 0.25), P<0.00001], and ALTF also significantly outperformed FF in terms of postoperative chewing function scores [MD=0.72, 95%CI (0.62, 0.82), P<0.00001]. CONCLUSIONS: FF can reduce the technical difficulty of flap harvesting and shorten operative time, making it more suitable for surgeons or institutions newly adopting free flap techniques. In contrast, ALTF demonstrates a lower incidence of postoperative complications and provides superior oral functional recovery compared to FF. Therefore, if the goal is to minimize postoperative complication risks or achieve better oral functional rehabilitation, ALTF is the preferred choice. References | Related Articles | Metrics

Dental Education

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Evaluation of the application of CBL teaching method combined with "Internet + medical popular science" model in the teaching of oral and maxillofacial surgery Zhou Xing'an, Wang Lihua, Ma Hongyu, Xia Fengjun, Shen Tiebing, De Leheibateer 2026, 24 (1):  78-82.  doi: 10.19438/j.cjoms.2026.01.012 Abstract ( 8 )   PDF (660KB) ( 4 )   PURPOSE: To explore the application of CBL teaching method combined with "Internet+medical popular science" teaching mode on the undergraduate teaching of oral and maxillofacial surgery. METHOD: Sixty students from grade 2020 undergraduate class of Inner Mongolia Medical University were randomly divided into three groups, A, B and C, with 20 students in each group. Some courses of "oral and maxillofacial surgery" were selected for different teaching models. Among them, group A adopted traditional teaching model, group B adopted the CBL teaching method combined with traditional teaching model, and group C adopted CBL teaching method combined with traditional teaching model. At the same time, they participated in the writing of popular science articles and the production of popular science videos. After the teaching course was completed, the teaching effects of the three groups of students were compared: theoretical assessment score, practical assessment score and questionnaire survey evaluation. RESULTS: The theoretical and practical assessment scores of both group B and group C were superior to those of group A. Meanwhile, group C had further improvement on the basis of group B(P<0.05). The questionnaire survey indicated that group B had significant improvements in teaching quality, basic clinical skills and personal assessment, while group C had significant improvements in the clarity, independence and workload of professional goals. CONCLUSIONS: CBL teaching method combined with "Internet+medical popular science" teaching model is conducive to enhancing the basic knowledge mastery ability and clinical practice operation ability of undergraduate students majoring in stomatology. At the same time, it can increase students' learning interest, clinical thinking ability and social responsibility, and lay a solid foundation for their future clinical diagnosis and treatment work. References | Related Articles | Metrics

Review Articles

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Progress in the regulation and mechanisms of osteoinduction by the surface microstructure of calcium phosphate ceramics Wang Yue, Bao Chongyun 2026, 24 (1):  83-88.  doi: 10.19438/j.cjoms.2026.01.013 Abstract ( 7 )   PDF (653KB) ( 3 )   Critical bone defects caused by trauma, tumors, congenital malformations, infections, and other factors present significant challenges in clinical treatment. Calcium phosphate ceramics(CaPs) not only promote bone formation at the defect site but also induce ectopic bone formation in sites such as muscle and subcutaneous tissue, addressing challenges in repairing critical bone defects. The surface microstructure of CaPs is a key factor influencing their osteoinductive properties. This paper reviewed the impact of microstructural features on the osteoinductive potential of CaPs, explored the mechanisms by which surface microstructure induces ectopic bone formation, and provided theoretical insights for future design and clinical application of CaPs materials. References | Related Articles | Metrics

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Advances in the study of venous malformations complicated with localized intravascular coagulation Wang Zilu, Wang deming, Su lixin, Fan Xindong 2026, 24 (1):  89-95.  doi: 10.19438/j.cjoms.2026.01.014 Abstract ( 7 )   PDF (829KB) ( 6 )   Venous malformations(VMs) are congenital low-flow vascular anomalies associated with consumptive coagulopathy, characterized by elevated D-dimer and decreased fibrinogen levels, termed localized intravascular coagulation (LIC). Patients with LIC may present with localized swelling and pain. In rare cases, LIC can progress to severe coagulopathic complications, such as disseminated intravascular coagulation(DIC). This article provided a comprehensive review of the pathophysiology, clinical manifestations, laboratory findings, diagnosis, and treatment of VMs complicated by LIC, aiming to support clinical decision-making in this patient population. References | Related Articles | Metrics

Case Reports

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Mandibular coronoid process hyperplasia leading to restricted mouth opening: a case report Jin Wenzhao, Xu Kai 2026, 24 (1):  96-99.  doi: 10.19438/j.cjoms.2026.01.015 Abstract ( 9 )   PDF (1001KB) ( 5 )   Coronoid process hyperplasia(CPH) is a rare disorder of mandibular development, mainly characterized by painless progressive limitation of mouth opening, which is easily confused with temporomandibular joint disorder(TMD). This article reported a case of severe mouth opening limitation caused by bony hyperplasia of the coronoid process. After coronoidotomy via an intraoral approach, the mouth opening degree was significantly improved. For patients with clinical manifestations of painless mouth opening limitation, the possibility of CPH should be considered, and CBCT examination should be performed as early as possible to avoid misdiagnosis. References | Related Articles | Metrics

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Tooth movement of a displaced maxillary tooth via the sinus pathway assisted by autogenous tooth bone graft Liu Wei, Huang Tianhao, Xu Qiyu 2026, 24 (1):  100-104.  doi: 10.19438/j.cjoms.2026.01.016 Abstract ( 8 )   PDF (1775KB) ( 7 )   This case report described a 28-year-old female who presented with a retained maxillary deciduous tooth and palatally displaced permanent tooth 25. Cone-beam CT revealed extensive pneumatization of both maxillary sinuses, with the residual bone height at the left sinus floor measuring only 1.45 mm. To augment the deficient alveolar bone, autogenous tooth bone graft (ATBG) was prepared chairside and used to perform a lateral sinus floor elevation at the site of tooth 25. At 2.5 months postoperatively, CBCT demonstrated a significant increase in vertical bone height to approximately 15.99 mm. Subsequently, staged invisible orthodontic treatment was adopted: in the first stage, tooth 25 was tractioned to rotate and be upright into the dental arch; in the second stage, fine adjustment was conducted. CBCT examination at 2 years postoperatively demonstrated that the bone height in the bone-grafted area was maintained at approximately 14.39 mm, the bone width exceeded 9 mm, the newly formed bone showed good integration, and it could support normal masticatory function. References | Related Articles | Metrics