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20 September 2026, Volume 24 Issue 5 Previous Issue   

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Expert Consensus

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Expert consensus on rhBMP-2/CPC for alveolar cleft bone grafting Cai Ming, Cui Yingqiu, Li Chenghao, Li Jian, Li Yunpeng, Ren Zhanping, Song Tao, Yang Xuecai, Zhou Lian, Zhu Hongping, Wang Xudong 2026, 24 (5):  437-445.  doi: 10.19438/j.cjoms.2026.05.001 Abstract ( 28 )   PDF (1171KB) ( 46 )   Alveolar bone grafting is an essential component of comprehensive cleft lip and palate management. It restores alveolar continuity, facilitates eruption of permanent teeth, and improves support of the nasal base. Autogenous cancellous bone harvested from the iliac crest remains the most commonly used grafting material; however, donor-site morbidity, including postoperative pain and limited mobility, may affect patients’ acceptance. Recombinant human bone morphogenetic protein-2-loaded self-setting calcium phosphate cement artificial bone (rhBMP-2/CPC) combines osteoinductive and osteoconductive properties and has shown potential for reducing the need for autogenous bone harvesting while promoting bone regeneration. Nevertheless, standardized guidance regarding its indications, safety profile, and postoperative management in alveolar cleft reconstruction remains limited. At present, there is insufficient long-term follow-up data (more than 5 years) for this material. This consensus represents interim recommendations. To promote the appropriate clinical application of rhBMP-2/CPC in alveolar cleft bone grafting, this expert consensus was developed under the leadership of the National Center for Stomatology, Shanghai, with contributions from multidisciplinary experts in relevant fields. Based on the best available evidence, expert clinical experience, and the GRADE framework, recommendations were formulated regarding patient selection, complication risks, effects on tooth eruption and orthodontic tooth movement, strategies for revision or salvage bone grafting, and postoperative radiographic evaluation and follow-up. This consensus is intended to provide practical guidance for oral and maxillofacial surgeons and related specialists involved in the management of alveolar cleft defects. References | Related Articles | Metrics

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Expert consensus on assessment and rehabilitation training for non-neurogenic restricted mouth opening in adults Yang Dongye, Zhou Jianfang, Zhang Qingbin, Li Yun, Zhu Shulian, Fang Xuemei, Yang Yue, Hou Lili, Bi Xiaoqin, Xiao Wei, Li Yan'e, Zhao Fang, Zhao Yiyuan, He Xingfang, Chen Linmin, Wu Shuyi, Chen Yunmei 2026, 24 (5):  446-453.  doi: 10.19438/j.cjoms.2026.05.002 Abstract ( 25 )   PDF (613KB) ( 30 )   Restricted mouth opening is a common complication of oral, maxillofacial, head and neck diseases and their treatments, directly affecting patients' masticatory, swallowing, and speech functions, as well as oral hygiene maintenance. At present, there is still a lack of unified and specific technical standards for assessment and rehabilitation training in China. In order to standardize the clinical assessment and rehabilitation training techniques for restricted mouth opening and promote functional recovery in patients, our team developed the expert consensus on assessment and rehabilitation training for non-neurogenic restricted mouth opening in adults based on the best available evidence-based medicine, integrated with opinions from relevant domestic experts, and through methods such as in-depth interviews, expert correspondence consultations, and expert meetings. This consensus provided standardized recommendations for clinical reference, covering the etiology of non-neurogenic restricted mouth opening in adults, multidisciplinary collaborative management, screening and assessment, rehabilitation training methods, prevention and management of complications, evaluation of rehabilitation training effectiveness, health education, and follow-up. References | Related Articles | Metrics

Tutorial

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The current treatment status and clinical research progress of vascular malformations Cheng Wei, Wang Xipeng, Zhang Jinrui, Liu Le, Zou Linfeng, Wei Shanpo, Ni Xin 2026, 24 (5):  454-460.  doi: 10.19438/j.cjoms.2026.05.003 Abstract ( 17 )   PDF (1025KB) ( 10 )   Vascular malformations (VMs) refer to a cluster of vascular structural anomalies arising from defects during embryonic vascular development. These abnormalities are typically present at birth or shortly postnatally, while some may remain latent and manifest in later life. As VMs involve multiple systemic organs and present considerable therapeutic challenges, they severely compromise patients' quality of life. Conventional therapeutic modalities include surgical resection, sclerotherapy, laser therapy, interventional embolization, and pharmacotherapy. In recent years, with the advancement of molecular biology research, targeted therapy for the pathogenesis of vascular malformations has become a research hotspot. In particular, targeted drugs against the PI3K/AKT/mTOR pathway and the RAS/RAF/MEK/ERK pathway have demonstrated promising therapeutic prospects in clinical studies. The implementation of combined treatment strategies, multidisciplinary team (MDT) collaboration models, and individualized therapeutic regimens has further offered novel perspectives and approaches for VM management. Additionally, the evolution of emerging technologies such as nanotechnology, radiofrequency ablation, and gene therapy has ushered in new hope for the treatment of VMs. References | Related Articles | Metrics

Original Articles

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Experimental study on the use of VEGF@SFNP-loaded microneedles to accelerate oral mucosal wound healing Pang Xuefei, Jiang Shengjie, Wang Huilin, Cai Ming 2026, 24 (5):  461-469.  doi: 10.19438/j.cjoms.2026.05.004 Abstract ( 20 )   PDF (2121KB) ( 16 )   PURPOSE: To investigate the therapeutic effect of microneedles loaded with silk fibroin nanoparticles (SFNP) encapsulating vascular endothelial growth factor (VEGF) for oral mucosal wound healing. METHODS: Microneedles were fabricated using methacrylated hyaluronic acid (HAMA) and loaded with VEGF encapsulated in silk fibroin nanoparticles (VEGF@SFNP). The pro-angiogenic capacity was evaluated in vitro through CCK-8 assays, wound healing and tube formation experiments. After that, a rat oral mucosal wound model was established to assess the wound healing efficacy in vivo. RESULTS: CCK-8 assay demonstrated that the proliferation of cells treated with VEGF@SFNP was significantly higher than that in the control group. Wound healing assays indicated enhanced cell migration ability following VEGF@SFNP treatment. Tube formation experiments showed that the VEGF@SFNP group exhibited improved angiogenic capacity. In vivo animal experiments revealed that the microneedle patch treatment accelerated the healing rate of oral mucosal wounds in rats. CONCLUSIONS: The microneedle patch can significantly promote angiogenesis, markedly enhance vascular regeneration, and accelerate the healing process of oral mucosal wounds. References | Related Articles | Metrics

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Randomized controlled trial of head and neck lymphatic surgery for Alzheimer's disease Ren Zhenhu, Wang Shiyu, Li Keyan, Zhang Xiaochen, Zhang Zhiyuan, He Yue, Li Xia 2026, 24 (5):  470-476.  doi: 10.19438/j.cjoms.2026.05.005 Abstract ( 22 )   PDF (1207KB) ( 19 )   PURPOSE: To investigate the safety and efficacy of cervical shunting to unclog cerebral lymphatic systems surgery (CSULs) in patients with Alzheimer's disease (AD), so as to provide a new reference and alternative for clinical intervention of AD. METHODS: A total of 10 patients diagnosed with AD hospitalized from January to June 2024 at Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine and Shanghai Mental Health Center were enrolled as research subjects. The patients were divided into an experimental group and a control group via the random number table method, with 5 cases in each group. Patients in the experimental group received CSULs combined with routine anti-AD medications, whereas those in the control group continued conventional anti-AD pharmacotherapy and non-surgical conservative management only. Preliminary safety/efficacy were evaluated by comparing intra- and inter-group changes in neuropsychological scale scores from baseline to 3, 6, 12 and 18 months. RESULTS: Statistical analysis of scale scores demonstrated that disease progression was arrested in 3 patients of the experimental group without progressive deterioration relative to baseline, while cognitive impairment continued to deteriorate in the remaining 2 cases. In the control group, only 1 patient maintained stable baseline status, and progressive dementia was observed in the other 4 patients. No perioperative or long-term postoperative adverse events such as surgical site hemorrhage or surgical infection were recorded among all patients in the experimental group during regular follow-up. CONCLUSIONS: Compared with conventional medication-only conservative therapy, CSULs present favorable safety and preliminary efficacy in slowing AD progression, indicating promising potential as an innovative breakthrough for surgical intervention of AD. Given the limited sample size of the present trial, further large-sample clinical investigations are required to verify the therapeutic effect of this surgical technique. References | Related Articles | Metrics

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Effect of implant restoration on the condylar position of bilateral temporomandibular joints in patients with unilateral free-end multiple tooth loss Guo Ziwei, Liu Yi, Shen Xinran, Zheng Yaqing, Pan Yingdan, Bi Wei 2026, 24 (5):  477-482.  doi: 10.19438/j.cjoms.2026.05.006 Abstract ( 17 )   PDF (836KB) ( 7 )   PURPOSE: To investigate the positional changes of the condyles in bilateral temporomandibular joints (TMJ) in patients with unilateral free-end edentulism before and after implant-supported fixed denture restoration. METHODS: A retrospective analysis was performed on 40 patients who received implant restoration for unilateral distal-extension tooth loss in Zhongshan Hospital, Fudan University from January 2024 to January 2025. Clinical data and CBCT images were collected and analyzed. Six joint space parameters of bilateral TMJ were measured on CBCT: anterior joint space (AJS), superior joint space (SJS), posterior joint space (PJS), lateral joint space (LJS), intermediate joint space (IJS), and medial joint space (MJS). Condylar cortical bone density, trabecular bone density, mediolateral length (MLL), anteroposterior length (APL) were also measured, and condylar morphological destruction and bone resorption were evaluated. RESULTS: Following implant-fixed restoration, a significant reduction was observed only in the SJS on the affected side (mean change: -0.29 mm, P=0.001), indicating a vertical repositioning of the affected condyle. On the healthy side, only the MJS demonstrated a significant decrease (mean change: -0.91 mm, P=0.001), suggesting a superomedial adaptive relocation. No significant differences were found in the other joint space parameters on either side(P>0.05). Furthermore, no significant changes were detected in bilateral condylar cortical and trabecular bone density, MLL, or APL(P>0.05), and no cases of new-onset condylar morphological destruction or bone resorption were identified. CONCLUSIONS: Implant-fixed prostheses can facilitate adaptive displacement of bilateral TMJ condyles, thereby restoring balanced joint relationships without causing pathological damage to condylar hard tissues. Precisely restoring the occlusal vertical dimension and establishing a stable three-dimensional occlusal balance are of significant importance for temporomandibular joint health. References | Related Articles | Metrics

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Clinical study on the "reading man" flap for repairing tumorous skin defects in the buccal region Xu Xiyao, Zhang Xin, Zhang Wenxia, Zhong Junbo 2026, 24 (5):  483-487.  doi: 10.19438/j.cjoms.2026.05.007 Abstract ( 17 )   PDF (1377KB) ( 14 )   PURPOSE: To explore the application value and clinical effect of the "reading man" flap in repairing wounds after resection of relatively large buccal tumors. METHODS: A retrospective analysis was performed on 56 patients with buccal defects repaired by the "reading man" flap in Zigong Fourth People's Hospital from June 2011 to June 2021. Flaps were designed perpendicular to the relaxed skin tension lines according to the defect location and area, and wounds were repaired by rotation and transposition. The defect area ranged from 2.3 cm×2.5 cm to 4.5 cm×5.0 cm, with an average of 10.7 cm2. RESULTS: Among the 56 patients, 2 cases with defects adjacent to the lower eyelid developed obvious immediate ectropion after repair with the standard "reading man" flap and were converted to skin grafting. Of the remaining 54 cases, 49 achieved primary wound healing without infection, and 5 had minor necrosis at the flap tip that healed after dressing changes. During 7-24 months of follow-up, no obvious facial deformity or dysfunction occurred in the 54 flap-repaired patients. Local tumor recurrence was noted in 3 patients with cutaneous squamous cell carcinoma, who underwent reoperation successfully. CONCLUSIONS: The "reading man" flap can make full use of the surrounding tissues of the wound and is suitable for repairing large buccal skin defects with advantages of simple operation, low incidence of facial deformity and hidden scar. Reasonable flap design and precise surgical manipulation are the key to successful application. References | Related Articles | Metrics

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Evaluation of the application effect of intraoperative CT in the treatment of orbital wall fractures Li Ailong, Qiu Qingyuan, Pang Chaoyuan 2026, 24 (5):  488-493.  doi: 10.19438/j.cjoms.2026.05.008 Abstract ( 18 )   PDF (1156KB) ( 21 )   PURPOSE: To investigate the application value of intraoperative computed tomography (iCT) in the surgical repair of orbital wall fractures. METHODS: Twenty-eight patients with unilateral orbital wall fractures admitted at the 940th Hospital of Joint Logistics Support Force of PLA from July 2023 to July 2025 were enrolled and randomly divided into the iCT group (n=14) and the conventional group (n=14). In the iCT group, iCT scanning (slice thickness: 0.625 mm) was performed before wound closure to evaluate fracture reduction and implant position; immediate adjustment was carried out in case of malreduction. The conventional group underwent surgery solely based on the surgeons' experience. Postoperative comparisons between the two groups included operation time, complication rate, improvement in enophthalmos, and orbital volume difference. RESULTS: The cohort was predominantly male (75.0%), with a mean age of 32.7 years. Road traffic accidents were the leading etiology (35.7%). Left-sided fractures were more common (60.7%), and zygomaticomaxillary complex fractures with periorbital involvement constituted 82.1% of the cases. Intraoperative adjustments based on iCT findings were required in 50% of the iCT group patients. At 6 months postoperatively, the improvement in enophthalmos [(2.7±1.4) mm] and the orbital volume difference [(997.9±445.6) mm3] in the iCT group were both superior to those in the traditional group, with no exacerbation of diplopia observed. CONCLUSIONS: Intraoperative CT enables real-time and accurate evaluation of orbital wall fracture reduction. It significantly improves postoperative orbital volume symmetry and enophthalmos correction, reduces the risk of aggravated diplopia, and has important clinical significance for enhancing the precision of complex orbital wall fracture repair. References | Related Articles | Metrics

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Retrospective analysis of treatment strategies for advanced medication-related osteonecrosis of the maxilla Wu Zhuhao, Sun Yawei, He Jinyuan, Li Fuyan, Xu Huixia, Cao Ting, Jiang Chenxi, Zhao Xulong, Sun Guowen 2026, 24 (5):  494-500.  doi: 10.19438/j.cjoms.2026.05.009 Abstract ( 17 )   PDF (1998KB) ( 20 )   PURPOSE: To explore effective therapeutic strategies and prognosis for advanced medication-related osteonecrosis of the jaw (MRONJ) in the maxilla, and to provide evidence for standardized clinical management. METHODS: A retrospective analysis was performed on 74 patients with stage Ⅱ and Ⅲ maxillary MRONJ treated in Affiliated Hospital of Medical School, Nanjing University from January 2022 to December 2025. All patients received preoperative preparation including alternating mouth rinses with chlorhexidine gluconate and 1% hydrogen peroxide, systemic hyperthermia, and antibiotic prophylaxis. Surgical methods were selected according to the staging: 43 patients with stage Ⅱ underwent maxillary alveolectomy; 31 patients with stage Ⅲ underwent partial maxillectomy, subtotal maxillectomy, or local anesthesia-guided sequestrectomy combined with maxillary sinus fenestration. Among them, 23 cases were repaired with pedicled buccal fat pad flap combined with double-layer soft tissue closure technique. Postoperative regular follow-up was performed to observe wound healing and complications. RESULTS: The 74 patients were followed up for 3 to 48 months, with an average of 25.8 months. Among 68 patients undergoing surgery under general anesthesia, 65 cases (95.6%) achieved complete mucosal healing with resolution of clinical symptoms and absence of new sequestrum formation. Postoperatively, adverse outcomes were observed in only 3 cases: 1 case involved a simple recurrence of MRONJ, and 2 cases involved simple concurrent oral-maxillary sinus fistulas. No instances of postoperative recurrence combined with maxillary sinus fistula were reported. The 6 patients who underwent local anesthesia surgery experienced pain relief and improved osteomyelitis symptoms; all 23 cases repaired with buccal fat pad flap successfully closed the oroantral communication. CONCLUSIONS: For patients with stage Ⅱ and Ⅲ maxillary MRONJ, stage tailored surgical procedures (alveolectomy, partial or subtotal maxillectomy, etc.) combined with pedicled buccal fat pad flap transfer and double-layer closure can effectively promote wound healing, reduce recurrence, and lower the incidence of complications. References | Related Articles | Metrics

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Relationship between serum TFF1, CCL22, and TGF-β1 levels and the clinical characteristics, prognosis, and efficacy of neoadjuvant chemotherapy in patients with oral cancer Wang Yuesen, Li Hong, Wu Baofeng 2026, 24 (5):  501-506.  doi: 10.19438/j.cjoms.2026.05.010 Abstract ( 18 )   PDF (673KB) ( 10 )   PURPOSE: To investigate the relationship between serum trefoil factor 1 (TFF1), CC chemokine ligand 22 (CCL22), and transforming growth factor-β1 (TGF-β1) levels and the clinical characteristics, prognosis, and efficacy of neoadjuvant chemotherapy in patients with oral cancer. METHODS: A total of 192 oral cancer patients admitted to the First Affiliated Hospital of Henan University of Science and Technology from January 2022 to December 2023 were enrolled and classified into a poor-prognosis group (n=76) and a good-prognosis group (n=116) based on follow-up outcomes. Among them, 65 patients received neoadjuvant chemotherapy and were further divided into a complete response group (n=34) and an incomplete response group (n=31). Serum levels of TFF1, CCL22, and TGF-β1 were compared across patients with different clinical characteristics, prognoses, and neoadjuvant chemotherapy responses. Binary logistic regression analysis was performed to examine the relationship between these biomarker levels and patients’ prognosis, and receiver operating characteristic (ROC) curves were plotted to evaluate the predictive value of each marker alone or in combination for poor prognosis, using the area under the curve (AUC). RESULTS: The serum TFF1, CCL22, and TGF-β1 levels in patients with poorly differentiated, clinical stage Ⅲ-Ⅳ, and cervical lymph node metastasis were significantly higher than those in patients with well-differentiated, clinical stage Ⅰ-Ⅱ, and non-cervical lymph node metastasis (P<0.01). The levels of serum TFF1, CCL22, and TGF-β1 in the poor prognosis group of oral cancer patients were significantly higher than those in the good prognosis group, and the differences were statistically significant (P<0.01). Binary logistic regression analysis results showed that TFF1, CCL22 and TGF-β1 were independent influencing factors for poor prognosis in oral cancer patients (P<0.05). ROC curve showed that the AUC of combined detection of TFF1, CCL22 and TGF-β1 for predicting the prognosis of oral cancer patients was 0.921 (95%CI: 0.879-0.964), which was higher than that of the three tests alone. The levels of serum TFF1, CCL22 and TGF-β1 in the incomplete response group of oral cancer patients were significantly higher than those in the complete response group, and the differences were statistically significant (P<0.01). CONCLUSIONS: Serum levels of TFF1, CCL22, and TGF-β1 are closely correlated with the differentiation degree, clinical stage, and cervical lymph node metastasis in patients with oral cancer, and they are important factors affecting patients' prognosis and the efficacy of neoadjuvant chemotherapy. Combined detection of these biomarkers exhibits high prognostic predictive value. References | Related Articles | Metrics

Literature Analysis

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Visualization analysis of literature on epigenetic regulatory mechanisms of Dnmt3B in osteoarthritis Luo Jiacheng, Chen Jiayu, Zhou Xiaoxuan, Zhang Ruiyan, Qi Yuyue, Xu Yuzhen, Huang Shuoting, Cui Chenqi, Sun Ziyi, Liu Xiaohan, Xiong Yingying, Wang Yexin, Zhang Shanyong 2026, 24 (5):  507-516.  doi: 10.19438/j.cjoms.2026.05.011 Abstract ( 19 )   PDF (1886KB) ( 8 )   PURPOSE: To analyze the literature on epigenetic regulatory mechanisms of DNA methyltransferase 3B (Dnmt3B) in osteoarthritis (OA), delineate the research landscape, key trends, and limitations in this field, and provide insights for future studies. METHODS: Original publications published between 2010 and 2025 were retrieved from PubMed, Web of Science, Scopus, and CNKI databases. CiteSpace 6.3.R1 was employed for keyword co-occurrence analysis, clustering, prominence analysis, and bibliometric visualization. RESULTS: A total of 21 valid articles were identified. Research focuses primarily revolve around DNA methylation, chondrocytes, and inflammation, with an increasing emphasis shifting from fundamental mechanism elucidation to the analysis of Dnmt3B-specific signaling pathways. Dnmt3B is involved in maintaining cartilage homeostasis, inflammatory responses, and metabolic reprogramming through regulation of pathways such as miR-34a, ABAT, and Wnt/β-catenin. Interdisciplinary approaches incorporating natural compounds, animal models, and metabolic epigenetics represent emerging research directions; however, existing studies predominantly concentrate on single pathways and basic experiments, lacking sufficient clinical translational evidence. CONCLUSIONS: Dnmt3B serves as a pivotal molecular player in OA epigenetic regulation, with its aberrant expression driving cartilage degeneration, bone remodeling, and synovial inflammation. Future investigations should integrate multi-omics data, conduct large-scale clinical cohort studies, and develop precision intervention strategies, ultimately establishing diagnostic biomarker systems based on Dnmt3B genetic polymorphisms and methylation profiles. References | Related Articles | Metrics

Review Articles

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Advances in multidimensional metabolic evolution and regulatory mechanisms of infantile hemangioma Jin Song, Wu Haiwei, Zhang Dongsheng 2026, 24 (5):  517-526.  doi: 10.19438/j.cjoms.2026.05.012 Abstract ( 18 )   PDF (1340KB) ( 17 )   Infantile hemangioma (IH) evolution is fundamentally driven by integrated metabolic reprogramming. Hemangioma endothelial cells (HemECs) sustain rapid proliferation via 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) dependent glycolysis, glutamine metabolism, and the SRY-box transcription factor 18 (SOX18)-mevalonate pathway. This metabolic shift is transcriptionally regulated by the hypoxia-inducible factor-1α (HIF-1α)/ mammalian target of rapamycin (mTOR) axis and supported by a complex microenvironment where stem cells and pericytes enable energy sharing through exosomal and substrate shuttling. Decoding this multicellular metabolic network is crucial for understanding the biochemical mechanisms of IH involution and establishing new therapeutic strategies centered on metabolic vulnerability. References | Related Articles | Metrics

Case Reports

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Chondrosarcoma in the temporomandibular joint with skull base invasion: a case report Gong Yuze, Xue Jiao, Wang Qimin, Jiang Yuanzheng, Qiu Jianzhong, Yuan Rongtao 2026, 24 (5):  527-531.  doi: 10.19438/j.cjoms.2026.05.013 Abstract ( 19 )   PDF (1999KB) ( 22 )   Temporomandibular joint chondrosarcoma is clinically rare, and its diagnosis and surgical management become significantly more challenging when the tumor invades the skull base. This article reported a case of highly differentiated temporomandibular joint chondrosarcoma involving and destroying the middle cranial fossa. The complete resection of the skull base tumor in the temporal fossa was performed under computer-assisted surgical navigation, combined with mandibular condylectomy. Key diagnostic and therapeutic principles are summarized based on imaging findings, intraoperative observations, and pathological immunohistochemical results, with a review of relevant domestic and international literature, providing reference for the clinical management of this rare lesion. References | Related Articles | Metrics

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Digital tooth-supported guide plate for extraction of bilateral mandibular low-impacted second molars: a case report Wang Wanting, Gong Shuqing, Huang Xinmin, Yan Guangqi, Dong Lijia 2026, 24 (5):  532-536.  doi: 10.19438/j.cjoms.2026.05.014 Abstract ( 15 )   PDF (1247KB) ( 11 )   Impacted mandibular second molars (MM2) are extremely rare cases, and the extraction of low-impacted MM2 is one of the challenging procedures in oral and maxillofacial surgery. Digital tooth-supported guide plates enable precise and minimally invasive operations for the extraction. This article reported a case of minimally invasive extraction of bilaterally low-impacted MM2 with a digital tooth-supported guide plate. Additionally, it summarized the design of common digital guide plate currently used as adjuvants in tooth extraction and the surgeon's clinical application strategies in combination with literature review. References | Related Articles | Metrics

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Giant lymphoma at the base of the tongue: a case report Zhang Aolin, Zhang Yonghong 2026, 24 (5):  537-540.  doi: 10.19438/j.cjoms.2026.05.015 Abstract ( 15 )   PDF (1449KB) ( 13 )   Lymphoma is a heterogeneous group of malignant tumors of lymphoid cells that can affect lymphoid tissue, bone marrow, or lymph nodes. Giant lymphomas occurring in the base of the tongue are often misdiagnosed as benign tumors or infectious diseases due to their rarity and diverse clinical manifestations. This article reported a case of a giant mass at the base of the tongue in a 27-year-old male, which was pathologically confirmed as diffuse large B-cell lymphoma. By reviewing relevant literature, we analyzed its clinical-pathological characteristics, diagnostic and therapeutic considerations, aiming to provide reference for clinical practice. References | Related Articles | Metrics