Top Read Articles

Published in last 1 year |

In last 2 years |

In last 3 years |

All

Please wait a minute...


For Selected: Download Citations EndNote Ris BibTeX Toggle Thumbnails

Select

Expert consensus on surgical treatment of hemangiomas and vascular malformations in the head and neck WANG Yan-an, QIN Zhong-ping, ZHENG Jia-wei, LI Chun-jie, LIU Shao-hua, YANG Yao-wu, CHEN Gang, CHEN Wei-liang, LIU Xue-jian, DU Zhong, ZHANG Lei, WANG Ye-fei, WANG De-ming, SU Li-xin, XIE Feng, DONG Chang-xian, GUO Lei, LI Kai, GU Song, HE Yue, ZHANG Zhi-yuan China Journal of Oral and Maxillofacial Surgery    2024, 22 (2): 105-117.   DOI: 10.19438/j.cjoms.2024.02.001 Abstract （499）      PDF （2515KB）（510）       Knowledge map    Hemangiomas and vascular malformations are common benign vascular diseases in the head and neck region. The evolution and extensive implementation of non-surgical therapeutic modalities have resulted in considerable improvement or even total remission in a significant number of patients in minimally invasive or non-invasive procedures. Nonetheless, under certain circumstances, surgical treatment remains an irreplaceable treatment modality within the comprehensive treatment sequence for hemangiomas and vascular malformations in the head and neck. However, there is no established standard or consensus in the academic community on how to choose and apply surgical treatment. Therefore, to enhance the treatment efficacy of hemangiomas and vascular malformations amongst domestic peers, and to standardize surgical treatment protocols, this consensus brings together the discussion opinions of relevant experts from many medical schools and affiliated hospitals nationwide. Based on the latest domestic and international research results and diagnosis and treatment experience, we formulated this expert consensus from the aspects of preoperative diagnosis and preparation, surgical treatment indications and strategies, postoperative care and observation, common complications and treatment after surgery, follow-up and social psychological support. It is expected to be used in clinical practice and to guide relevant professional doctors carrying out treatment. Reference | Related Articles | Metrics

Select

Recent advances in mouth breathing diagnosis and effects on dento-maxillofacial development in children ZHENG Yang-shan, YUAN Xue-shun, JIANG Jing, QIU Shu-qi, SHI Zhao-hui China Journal of Oral and Maxillofacial Surgery    2024, 22 (1): 92-101.   DOI: 10.19438/j.cjoms.2024.01.016 Abstract （305）      PDF （1261KB）（199）       Knowledge map    Upper airway obstruction can lead to mouth breathing, which is much prevalent in children. Studies have indicated that in early childhood, prolonged mouth breathing leads to muscular and postural alterations which, in turn, result in dentoskeletal changes, or even worse, dentofacial deformities and sleep-related breathing disorders. A multidisciplinary team, involving otolaryngologists, dental providers, and somnologists, should work to provide early diagnosis and appropriate treatment, preventing the consequent disorders of mouth breathing. More and more studies in recent years have focused on mouth breathing diagnosis and its effects on dento-maxillofacial development as well as its possible mechanisms in children. Nevertheless, the etiology, diagnosis, treatment options, postoperative care, mechanism of mouth breathing impact on dento-maxillofacial development, and its relationship with sleep-disordered breathing remain controversial. This review summarized the latest advances in mouth breathing, demonstrating the current status and advances of research on mouth breathing diagnosis, dento-maxillofacial development, and multidisciplinary collaboration. Reference | Related Articles | Metrics

Select

Chinese expert consensus on prevention and management of perioperative venous thromboembolism in head and neck cancer patients REN Zhen-hu, CHEN Ming-tao, WU Han-jiang, ZHANG Sheng, FANG Kun, XIE Shang4, LIU Yu, HU Chuan-yu6, LIU Bing, LI Chun-Jie, ZHU Gui-quan, WANG Cheng, GAO Yang, ZHANG Xiao-chen, SHI Jian-bo, ZHANG Yong-hong, CUI Ming-zhe, JI Tong, REN Guo-xin, WANG Yan-an, CHEN Wei-liang, ZHANG Chen-ping, HE Yue, ZHANG Zhi-yuan China Journal of Oral and Maxillofacial Surgery    2024, 22 (1): 1-9.   DOI: 10.19438/j.cjoms.2024.01.001 Abstract （257）      PDF （1276KB）（229）       Knowledge map    Venous thromboembolism (VTE) is a common complication after surgical procedures, and an important risk factor for unexpected death in hospitals, and the second leading cause of death for tumor patients. Patients with advanced head and neck cancer usually require extensive radical surgery and simultaneous repair and reconstruction surgery, and have many risk factors such as elderly, long surgical time, long postoperative bed rest, and hypercoagulable state caused by tumor and chemotherapy drugs, which suggest that patients with head and neck cancer should be an extremely high risk group for VTE. However, little attention has been paid to the occurrence of VTE in patients with cancer in the head and neck, and the data on the incidence of VTE after head and neck cancer surgery are also limited. So far, there is a lack of relevant treatment consensus or guidelines for perioperative VTE of head and neck cancer in China. The level of prevention and management of perioperative VTE of head and neck cancer varies among different institutions, and there is a lack of unified and scientific diagnosis and treatment standards and objective evaluation system for prevention and management. In order to unify and standardize the diagnosis and treatment of perioperative VTE in head and neck cancer, reduce the waste of medical resources and improve the treatment effectiveness, domestic experts in this field have repeatedly discussed the diagnosis and treatment opinions from 14 famous medical institutions in China. This article refers to the research results and diagnosis and treatment experience of perioperative VTE in head and neck cancer world wide in recent years, and formulates this expert consensus for reference by relevant clinicians. Reference | Related Articles | Metrics

Select

Imaging and clinical analysis of 25 cases of osteosarcoma of the jaw ZHANG Qiang, LI Qing, ZHANG Jia China Journal of Oral and Maxillofacial Surgery    2024, 22 (2): 186-191.   DOI: 10.19438/j.cjoms.2024.02.013 Abstract （210）      PDF （1657KB）（62）       Knowledge map    PURPOSE: To investigate the clinical, imaging and prognosis of osteosarcoma of the jaw. METHODS: A total of 25 patients with osteosarcoma of the jaw confirmed by pathology and relevant preoperative examinations were collected from Xuzhou Central Hospital from January 2015 to December 2021. The clinical and imaging findings of the patients were summarized, and the factors influencing the prognosis of the patients were analyzed. SPSS 25.0 software package was used for data analysis. RESULTS: The male and female ratio of osteosarcoma of jaw was 9∶16, but there was no significant difference in gender and age distribution of osteosarcoma of jaw. The incidence of osteosarcoma in maxilla and mandible was 11∶14, involving zygomatic bone in 2 cases. The main clinical symptoms were maxillofacial mass/swelling, followed by numbness or pain. A total of 19 patients were followed up, including 11 negative surgical margins and 8 positive ones. Six cases(32%) had no recurrence and no metastasis, 11 cases(57%) had local recurrence with/without distant metastasis, and 2 cases(11%) had only distant metastasis. The most common site of metastasis was the lung, followed by the thoracolumbar spine. Plain CT showed bone destruction, continuous/discontinuous cortical bone (6∶19), with or without periosteum reaction (18∶7), with/without soft tissue mass formation (20∶5), with/without tumor bone formation (17∶8). Enhanced CT showed annular enhancement at the edge of the soft tissue mass but no enhancement at the center. MRI showed slightly low signal intensity in the bone destruction area and soft tissue mass on T1WI, equal or high signal intensity on T2WI, unclear signal of bone cortex, fluid accumulation along the edge of jaw bone, unclear boundary with adjacent muscle space. Prognostic analysis showed that there was significant difference in surgical margin status between maxillary osteosarcoma and mandibular osteosarcoma (P=0.024), and there was significant difference in the influence of surgical margin status on postoperative recurrence/metastasis of patients (P=0.018). CONCLUSIONS: The main clinical manifestations of osteosarcoma of jaw bone were maxillofacial mass/swelling, followed by numbness or pain. The diagnosis of osteosarcoma of the jaw can be indicated when the bone destruction of the jaw is accompanied by soft tissue mass and tumor bone formation, and the mass has obvious circular enhancement at the edge and no central enhancement. The location of osteosarcoma of jaw bone affected the status of surgical margin, and the status of surgical margin had significant influence on postoperative recurrence/metastasis. Reference | Related Articles | Metrics

Select

Risk factors for obstructive sleep apnea in snoring adults ZHENG Tong, YAO Kan, QIAN Yi-feng, SUN Hong-xia, LU Xiao-feng, YU Wen-wen China Journal of Oral and Maxillofacial Surgery    2024, 22 (2): 137-142.   DOI: 10.19438/j.cjoms.2024.02.004 Abstract （192）      PDF （757KB）（115）       Knowledge map    PURPOSE: To explore the risk factors for obstructive sleep apnea in snoring adults. METHODS: A cross-sectional study was conducted in 1 155 adult snoring patients who were overnight polysomnography(PSG) monitored for obstructive sleep apnea(OSA) from January 2012 to October 2021 in Sleep Medicine Center of Shanghai Ninth People's Hospital. The patients were divided into two groups based on apnea hypopnea index (AHI): non-OSA and OSA groups. The prevalence and risk factors of OSA were analyzed. RESULTS: The prevalence of OSA was 88.23%, and the male to female ratio was 4.12∶1. The risk factors for OSA in snoring adults were age, neck circumference/height ratio, gender and waist circumference, of which the thresholds were 30.5 years old, 22.93, male, 86.25 cm. WRAG-N was proposed to predict OSA, with an AUC of 0.789, a sensitivity of 87.2%, and a specificity of 29.4%. CONCLUSIONS: For adult snoring population, the risk factors for OSA were over 30 years old, male and waist circumference greater than 86.25 cm. Meanwhile, neck circumference/height ratio is one of the key risk factors for OSA. WRAG-N, innovatively proposed as the predictive tool for OSA, may help communities screen OSA in high-risk snoring adults to provide efficient and high-quality diagnosis and treatment. Reference | Related Articles | Metrics

Select

The effect of preemptive analgesia on postoperative pain relief and MDAS score after minimally invasive extraction of impacted teeth ZHU Cheng-zhang, WAN Hong-kun China Journal of Oral and Maxillofacial Surgery    2024, 22 (1): 49-52.   DOI: 10.19438/j.cjoms.2024.01.008 Abstract （188）      PDF （490KB）（99）       Knowledge map    PURPOSE: To investigate the effect of preemptive analgesia on postoperative pain relief after minimally invasive extraction of impacted teeth and the modified Dental Anxiety Scale (MDAS) score. METHODS: A total of 100 patients with impacted teeth admitted to Rudong Hospital of Traditional Chinese Medicine in Nantong City from July 2021 to May 2022 were selected and randomly divided into the experimental group(minimally invasive tooth extraction combined with preemptive pain relief treatment, n=50) and control group (minimally invasive tooth extraction, n=50) using a random number table method. The operation time, intraoperative blood pressure and heart rate, analgesic efficacy, postoperative visual analogue scale (VAS score) of pain, postoperative MDAS score and adverse reactions were compared between the two groups, and the data were statistically analyzed by SPSS 22.0 software package. RESULTS: The operation time of the experimental group was significantly less than that of the control group(P<0.05). VAS scores at 5 h, 10 h and 24 h in the experimental group were significantly lower than those in the control group(P<0.05). The MDAS score after treatment was lower than before treatment, and the experimental group was significantly lower than the control group(P<0.05). The incidence of adverse reactions after treatment was lower in both groups, and there was no significant difference between the two groups (P>0.05). CONCLUSIONS: Preemptive analgesia has a good analgesic effect on minimally invasive extraction of impacted teeth, which can improve the anxiety of patients, and has fewer adverse reactions. It can be widely used in clinical practice. Reference | Related Articles | Metrics

Select

Research progress on indications and applications of autogenous teeth transplantation AILIMAIERDAN Ainiwaer, WANG Ling China Journal of Oral and Maxillofacial Surgery    2024, 22 (3): 300-308.   DOI: 10.19438/j.cjoms.2024.03.016 Abstract （182）      PDF （941KB）（112）       Knowledge map    Autogenous teeth transplantation (ATT) is a surgical method for repairing missing teeth. Although the selection of indications for ATT is strict,with continuous development of technique in oral surgery,more and more researches have expanded the indications of ATT. This article discussed research progress in application and clinical indications of ATT reported in recent years, including ATT as an alternative to dental implants, immediate ATT into recipient sites with inflammation, application of artificial materials in cases with insufficient bone mass, the application of autogenous tooth transplantation in various oral diseases and the transplantation of different types of autogenous teeth, aiming at providing reference for clinical practice. Reference | Related Articles | Metrics

Select

Risk factors for complications and ICU care of 144 cases with oral and maxillofacial space infection ZHANG Yin-yin, ZHU Yan-yan, DING Jia-hui, SUN Yu-hua China Journal of Oral and Maxillofacial Surgery    2024, 22 (2): 148-152.   DOI: 10.19438/j.cjoms.2024.02.006 Abstract （176）      PDF （544KB）（85）       Knowledge map    PURPOSE: To analyze the related risk factors of complications and intensive care unit(ICU) monitoring in patients hospitalized for oral and maxillofacial space infection(OMSI). METHODS: A total of 144 patients with OMSI admitted to the Affiliated Hospital of Xuzhou Medical University from January 2021 to March 2022 were selected. The patient's age, gender, length of hospital stay, systemic diseases, body mass index(BMI), source of infection and number of involved sites, complications, and laboratory indicators including white blood cell count(WBC), neutrophil percentage (NEU%), C-reactive protein (CRP) were collected. SPSS 25.0 software package was used for data analysis. RESULTS: Among 144 patients with OMSI, 52 cases (36.1%) had complications, of which 34.6% had symptoms of airway obstruction; 54 cases (37.5%) were transferred to ICU. Multivariate logistic regression analysis showed that high CRP value (OR=1.005, 95%CI: 1.000-1.011, P=0.048) were risk factors for patients with possible complications. Complications(OR=5.249, 95% CI: 1.644-16.754, P=0.005), hospital stay longer than 10 days (OR=1.166, 95%CI: 1.049-1.295, P=0.004), more space involvement(OR=2.719, 95%CI: 1.658-4.460, P<0.001), and high BMI (OR=1.262, 95%CI: 1.050-1.515, P=0.013) were independent risk factors affecting ICU monitoring. CONCLUSIONS: High CRP and BMI values and the number of infected spaces are closely related to the complications of patients and ICU monitoring. Therefore, it is necessary to strengthen the management of such patients and take comprehensive consideration in the treatment process to avoid the occurrence of adverse prognosis. Reference | Related Articles | Metrics

Select

Screening and validation of miRNAs differentially expressed by exosomes of tumor-associated macrophages in microenvironment of salivary gland adenoid cystic carcinoma XI Qi, GAO Wan-peng, LI Huan, ZHAO Qi, WANG Jun, WEI Jian-hua, YANG Xin-jie, YANG Zi-hui China Journal of Oral and Maxillofacial Surgery    2024, 22 (3): 209-215.   DOI: 10.19438/j.cjoms.2024.03.001 Abstract （176）      PDF （1444KB）（49）       Knowledge map    PURPOSE: To investigate the expression patterns of exosomal miRNAs in tumor-associated macrophages (TAMs) and analyze the potential function in progression of salivary adenoid cystic carcinoma (SACC). METHODS: SACC cells and macrophages were co-cultured to obtain TAMs. Exosomes of both macrophages and TAMs were isolated according to the ultracentrifugation protocol, and then the exosomes were identified using transmission electron microscope, Western blot, and nanoparticle tracking analysis(NTA). RNA-seq analysis was performed to compare the differential expression of miRNAs in TAMs-derived exosomes and the control macrophages-derived exosomes. The target genes of the differential miRNAs were predicted by miRanda and RNAhybrid database. Then GO and KEGG enrichment analysis were performed on the set of target genes. Assays of qRT-PCR, CCK-8, Wound healing, and Transwell were performed to validate the expression patterns and functions of TAMs-derived exosomes. SPSS 22.0 software package was used for data analysis. RESULTS: A total of 1 595 differentially expressed miRNAs were screened out, among which 15 were significantly expressed(P<0.05). Enrichment analysis showed that the target genes of TAMs-derived exosomes were mainly involved in the regulation of cancer-related signaling pathways. Results of qRT-PCR showed that TAMs-derived exosomes carried higher levels of hsa-miR-21-5p than control macrophages derived exosomes. Results of CCK-8, Wound healing, and Transwell assay showed that TAMs-derived exosomal hsa-miR-21-5p promoted proliferation, motility, migration, and invasion of SACC cells. CONCLUSIONS: TAMs-derived exosomal hsa-miR-21-5p promoted malignant progression of SACC cells. TAMs-derived exosomal miRNAs may play important roles in the progression of SACC, and may provide a potential strategy for the diagnosis and treatment of SACC. Reference | Related Articles | Metrics

Select

Integration of WGNCA and PPI networks to identify key genes for oral squamous cell carcinoma LI Jin-cun, ZHAI Kun, HU Chen, LIU Xu-ying, MA Xing-ping, MA Jian China Journal of Oral and Maxillofacial Surgery    2024, 22 (2): 128-136.   DOI: 10.19438/j.cjoms.2024.02.003 Abstract （171）      PDF （4935KB）（65）       Knowledge map    PURPOSE: To screen important biomarkers associated with oral squamous cell carcinoma (OSCC) by using bioinformation technology. METHODS: The gene expression profiles of OSCC were obtained from GEO database and differentially expressed genes (DEGs) extracted. WGCNA was used to obtain the core genes in the module with the most significant relationship with OSCC and intersected with DEGs. At the same time, pathway analysis as well as protein network analysis(PPI) were performed. The CytoHubba was used to extract candidate key genes. Secondly, survival analysis was used to identify key genes, and verify expression in OSCC. Furthermore, the association between key genes and immune infiltrating cells and immune checkpoints was explored in OSCC. GraphPad Prism 8 software was used for data analysis. RESULTS: A total of 53 co-expressed DEGs were identified. Enrichment analysis revealed that these genes mainly involved in extracellular matrix, extracellular region, PI3K-Akt and other pathways. Twenty candidate core genes were identified from PPI networks, among which 5 key genes(SERPINE1, SERPINH1, LAMC2, ITGA5 and ITGA3) were identified using survival analysis. GEPIA and GSE30784 showed that these five genes had differential expression in OSCC tissues (P< 0.05). SERPINE1 was not expressed at the protein level of OSCC through HPA database, but SERPINH1, LAMC2, ITGA5 and ITGA3 were highly expressed. They significantly correlated with immune infiltration cells such as CD8+ T cells and dendritic cells and immune checkpoints such as CD276, VEGFA, and PDCD1(P< 0.05). CONCLUSIONS: SERPINE1, SERPINH1, LAMC2, ITGA5 and ITGA3 can be used as biomarkers of OSCC, providing new clues for the diagnosis, prognosis and treatment of OSCC. Reference | Related Articles | Metrics

Select

The bur broken into soft palate during tooth extraction: a case report and literature review GUO Lei, LEI Rong-chang, QU Bin-bin, GUO Ge, CHAI An, LUO Ying China Journal of Oral and Maxillofacial Surgery    2024, 22 (2): 202-205.   DOI: 10.19438/j.cjoms.2024.02.016 Abstract （168）      PDF （986KB）（120）       Knowledge map    When high-speed dental handpiece combined with surgical cutting bur are used to remove impacted teeth, instrument separation is rare, and bur breaking into the soft palate is even rarer. This paper reported a rare case in which the bur broke into the soft palate during tooth extraction and was successfully removed under local anesthesia with the help of imaging and 3D visualization techniques. Combined with literature review, this paper discussed the causes of this complication and corresponding treatment methods, and explored how to reduce the occurrence of this complication. Reference | Related Articles | Metrics

Select

Comparison of the application effects of three occlusal papers in artificial dental implantation PAN Xu-zhen, WANG Yu-jun China Journal of Oral and Maxillofacial Surgery    2024, 22 (1): 63-67.   DOI: 10.19438/j.cjoms.2024.01.011 Abstract （161）      PDF （578KB）（80）       Knowledge map    PURPOSE: To compare the application effects of 3 kinds of occlusal paper in artificial dental implantation. METHODS: From February 2020 to February 2022, a total of 117 patients in Zhoushan Stomatological Hospital were selected and divided into 3 groups according to the degree of occlusal tightness, with 39 patients in each group, all of which were single implantation. The occlusal paper with a diameter of 12 μm was used in group A, while 20 μm in group B, and 30 μm in group C. The periodontal indexes(peri-implant bone resorption, probing depth around the implant, gingival index, and tooth mobility) were compared among the three groups at 3 months after restoration. The absolute value of occlusal balance index before restoration, on the day of restoration, and at 3 months after restoration were compared, and the satisfaction of patients and physicians was evaluated. SPSS 22.0 software package was used for data analysis. RESULTS: There was no significant difference in periodontal indexes among the three groups (P>0.05). The absolute value comparison of occlusal balance index among the 3 groups showed that 6 months after repair < 3 months after repair < day of repair < before repair (P<0.05). The absolute value of occlusal balance index in group A was significantly lower than that in group B and group C 3 months after repair(P<0.05). The satisfaction of patients and doctors in group A was significantly higher than that in group B and C (P<0.05). CONCLUSIONS: Compared with 20 μm and 30 μm occlusal paper, the application of 12 μm occlusal paper in artificial dental implant restoration can adjust the occlusal balance and improve the satisfaction of patients and doctors. Reference | Related Articles | Metrics

Select

A primary study on application of neuralized fibula flap for mandibular reconstruction and sensory restoration of the lower lip ZHANG Bing-qing, SHI Jing-cun, WU Zi-qian, ZHANG Yu-han, WANG Jie-yu, XIAO Meng, WANG Lei China Journal of Oral and Maxillofacial Surgery    2024, 22 (2): 143-147.   DOI: 10.19438/j.cjoms.2024.02.005 Abstract （160）      PDF （1359KB）（102）       Knowledge map    PURPOSE: To explore a new method of simultaneous jaw reconstruction and sensory recovery after resection of the mandible and inferior alveolar nerve due to tumor, so as to provide reference for clinical practice. METHODS: Segmental resection of mandibular bone was performed in a patient with mandibular ameloblastoma. The inferior alveolar nerve closely associated with the lesion was removed during the operation, neurovascularized fibula free flap was transplanted at the same time. The graft resorption was observed by postoperative imaging, and sensory preservation was evaluated by applying two-point discriminative sensation and touch test using sensory test wire. RESULTS: At the 9-month postoperative follow-up, the patient exhibited a naturally symmetrical facial appearance, with the flap displaying excellent survival and blood supply. The grafted bone remained stable without noticeable resorption, and the lower lip regained good sensory function while sensory function was partially restored to the chin. There were no issues such as lip-biting or salivation. Furthermore, neither recipient nor donor areas exhibited adverse complications. CONCLUSIONS: This innovative approach of simultaneous nerve reconstruction demonstrates promising efficacy in restoring lower lip sensation and preventing postoperative grafted bone resorption in fibula flap transplantation for mandibular reconstruction. Reference | Related Articles | Metrics

Select

A perspective of evidence-based medicine on exploring the treatment strategy of head and neck cancer in pregnancy LI Chen-xi, DING Yi, LIU Hui, GONG Zhong-cheng, ZHANG Wei-na, ZHAO Hua-rong China Journal of Oral and Maxillofacial Surgery    2024, 22 (2): 118-127.   DOI: 10.19438/j.cjoms.2024.02.002 Abstract （158）      PDF （1573KB）（67）       Knowledge map    The occurrence of malignant tumor during pregnancy is relatively rare, but with the increased age of pregnant women and the decreased age of patients suffering from head and neck cancer(HNC), the incidence of HNC complicated with pregnancy is slightly increasing. However, at present, there has been a lack of standardized diagnosis and treatment standards for pregnant woman with HNC. This paper evaluated the frequency, tumor type, associated factors, and specific biomarkers in HNCs occurring in pregnant women (including peripartum), based on systematic literature retrieval that performed on PubMed databank. From an evidence-based medicine view, this review presents a comprehensive description of the studies of pregnancy complicated with HNC, and intends to provide guidance in clinical practice. Reference | Related Articles | Metrics

Select

Research progress on the effect of cancer-associated fibroblasts on biological behavior of oral squamous cell carcinoma HAN Lin-zi, ZHOU Jian-hua, DONG lei, ZHAO Lu, YUAN Rong-tao China Journal of Oral and Maxillofacial Surgery    2024, 22 (1): 84-91.   DOI: 10.19438/j.cjoms.2024.01.015 Abstract （156）      PDF （719KB）（91）       Knowledge map    Oral squamous cell carcinoma(OSCC) is the sixth most common malignant tumor in the world. The occurrence and development of oral cancer are closely related to tumor microenvironment (TME). Cancer-associated fibroblast (CAF) participated in epithelial-mesenchymal transition, remodel extracellular matrix, and activate various biological pathways by secreting various growth factors, cytokines, inflammatory factors, and exosomes, which are of great significance to the occurrence, development, and treatment of OSCC. This article reviews the origin, characteristics, heterogeneity of CAF, and the impact of CAF on the biological behavior of OSCC. Reference | Related Articles | Metrics

Select

Pain control effect and safety analysis of hydromorphone patient-controlled intravenous analgesia and subcutaneous injection for postoperative analgesia in patients with oral tumors WANG Yuan, ZHI Yan-kang China Journal of Oral and Maxillofacial Surgery    2024, 22 (1): 53-57.   DOI: 10.19438/j.cjoms.2024.01.009 Abstract （154）      PDF （629KB）（30）       Knowledge map    PURPOSE: To compare pain control effect and safety of hydromorphone patient-controlled intravenous analgesia (PCIA) and subcutaneous injection for patients after oral tumor surgery. METHODS: A total of 200 patients after oral tumor surgery from January 2022 to March 2023 in Shanghai Ninth People's hospital were selected and divided into two groups according to the random number table method (control group, n=100, who received subcutaneous injection of hydromorphone; experimental group, n=100, who received hydromorphone PCIA). Chinese version of the brief pain inventory(BPI-C), serum markers [prostaglandin E2 (PGE2), 5-hydroxytryptamine (5-HT), nitric oxide (NO), and growth hormone (GH) ], expression levels of inflammatory factors [serum tumor necrosis factor-α, (TNF-α), interleukin 6 (IL-6), interleukin 1β (IL-1β)], sleep quality [insomnia severity index (ISI)], and the incidence of adverse reactions were compared between the two groups. SPSS 23.0 software package was used for data analysis. RESULTS: Forty-eight hours after surgery, BPI-C score of the experimental group including current pain degree, average pain degree, most painful pain degree in the past 24 hours, least painful pain degree in the past 24 hours, pain relief degree after pain treatment in the past 24 hours, and the levels of PGE2, 5-HT, NO, GH, Cor, PRL, TNF-α, IL-6 and IL-1β were significantly lower than those of the control group(P<0.05). One week after surgery, ISI scores in the experimental group were significantly lower than those in the control group(P<0.05). The incidence of adverse reactions was 10.00% in experimental group and 13.00% in control group, with no significant difference (P>0.05). CONCLUSIONS: Application of hydromorphone PCIA in postoperative patients with oral tumors can not only effectively relieve the pain perception of patients, but also reduce the expression of pain mediators and inflammatory factors in serum, thus alleviating the stress response. It can also help improving the sleep quality of patients, while not increase the occurrence of adverse reactions. So it is worthy of clinical application. Reference | Related Articles | Metrics

Select

Research progress of the machanism of ossification in maxillary sinus after maxillary sinus floor elevation GUAN Xiang-yu, GAO Yi-ming China Journal of Oral and Maxillofacial Surgery    2024, 22 (2): 198-201.   DOI: 10.19438/j.cjoms.2024.02.015 Abstract （145）      PDF （448KB）（99）       Knowledge map    In posterior maxillary area, due to progressive bone resorption and the limitation of anatomic location of maxillary sinus after tooth loss, routine implant surgery was restricted. Maxillary sinus floor elevation is the main mean to solve the problems. In this paper,the mechanism of ossification in the maxillary sinus and its influential factory, and problems which need to be further studied were summarized. Reference | Related Articles | Metrics

Select

Research progress of adoptive T cell therapy in head and neck squamous cell carcinoma CHEN Yin-yu, CHEN Lin, XU Feng, ZOU Zi-chuan, GE Liang-yu, MENG Jian China Journal of Oral and Maxillofacial Surgery    2024, 22 (2): 192-197.   DOI: 10.19438/j.cjoms.2024.02.014 Abstract （144）      PDF （585KB）（94）       Knowledge map    Adoptive T cell therapy(ACT) is a new adoptive cell immunotherapy, which is developing rapidly in clinical research. Several studies have shown that ACT could enhance the specificity and reactivity of tumor tissue by increasing the number of T cells, thereby overcoming the suppression of tumor immune deficiency. There are three main modes of ACT: tumor infiltrating lymphocytes(TILs), chimeric antigen receptor T cells(CAR-T), and T cell receptor engineered T cells(TCR-T). In this review, we discussed the classification and research progress of various ACT therapies, including TILs, TCR-T, CAR-T and adoptive T cell therapy based on organoid co-culture, and explored the application prospects of ACT as a treatment method for head and neck squamous cell carcinoma. Reference | Related Articles | Metrics

Select

Evaluation of the effect of nitrous oxide combined with local anesthesia in extraction of impacted teeth KANG Cheng, ZHU Ting, HAN Shuang, LOU Yi-yi China Journal of Oral and Maxillofacial Surgery    2024, 22 (2): 165-169.   DOI: 10.19438/j.cjoms.2024.02.009 Abstract （142）      PDF （575KB）（85）       Knowledge map    PURPOSE: To evaluate the effect of nitrous oxide combined with local anesthesia in the extraction of impacted teeth and its effect on patients' anxiety. METHODS: A total of 188 patients undergoing impacted tooth extraction in Shaoxing Stomatological Hospital from December 2021 to December 2022 were selected and randomly divided into experimental group and control group, with 94 patients in each group. The control group was treated under local anesthesia, and the experimental group was treated under local anesthesia combined with nitrous oxide. The heart rate(HR), Ramsay sedation score and pain VAS score during local anesthesia, tooth extraction and 5 min after tooth extraction were compared between the 2 groups. The Modified Dental Anxiety Scale(MDAS) scores and the comfort level of patients after treatment were compared between the two groups. SPSS 22.0 software package was used for data analysis. RESULTS: With the change of treatment time, HR in both groups showed a trend of increasing at first and then decreasing (P<0.05). HR in the experimental group was significantly lower than that in the control group during local anesthesia, tooth extraction and 5 minutes after tooth extraction(P<0.05). The MDAS score of the experimental group was significantly lower than that of the control group(P<0.05). Ramsay sedation scores in both groups decreased at first and then increased with the change of treatment time(P<0.05). The Ramsay sedation score of the experimental group was significantly higher than that of the control group during local anesthesia, tooth extraction and 5 minutes after tooth extraction (P<0.05). With the change of treatment time, the VAS score of the two groups gradually increased (P<0.05). The VAS score of the experimental group was significantly lower than that of the control group during local anesthesia, tooth extraction and 5 min after tooth extraction(P<0.05). The comfort of the experimental group was significantly better than that of the control group(P<0.05). CONCLUSIONS: Nitrous oxide combined with local anesthesia for extraction of impacted teeth can reduce HR, improve patients' anxiety and sedation, reduce pain and improve comfort. Reference | Related Articles | Metrics

Select

Long term efficacy analysis of interventional embolization treatment for intraosseous arteriovenous malformations of the jaw LI Xiao, WANG Hao-wei, YANG Xi-tao, WANG De-ming, FAN Xin-dong, SU Li-xin China Journal of Oral and Maxillofacial Surgery    2024, 22 (1): 78-83.   DOI: 10.19438/j.cjoms.2024.01.014 Abstract （140）      PDF （721KB）（52）       Knowledge map    PURPOSE: To explore the effectiveness and safety of interventional embolization for the treatment of intraosseous arteriovenous malformations (AVMs) in the jaw. METHODS: A retrospective study was conducted to analyze a total of 9 patients with intraosseous AVMs in the jaw bone who were treated at Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. Under the guidance of DSA, interventional embolization was performed to observe the lesion and predict the injection dose of sclerosing agents. The efficacy, adverse reactions and complications of patients were observed in a long-term follow-up. RESULTS: This study included 9 patients with intraosseous AVMs in the jaw, including 6 male patients (66.7%) and 3 female patients(33.3%), aged 7-51 years, with an average age of 21.3 years. Bleeding was the main reported symptom of patients, accounting for 66.7% of all cases. The blood supply arteries involved in this study included the branches of the inferior alveolar artery, facial artery, and maxillary artery. Nine cases of jaw bone AVMs were treated with interventional embolization under general anesthesia for a total of 20 times (each patient received 1-5 times, with an average of 2.2 times per person). The average single application dose of absolute ethanol was 21.95 mL. Among the 20 interventional embolization treatments, 9 were treated with coil assisted ethanol embolization, with a total of 158 coils used, with an average of 17.6 coils per treatment(80 coils per 9 treatments). Another 2 used bleomycin and 5 used a small amount of 150 μm PVA particles as auxiliary embolization therapy. Among the 9 cases of jaw bone AVMs included in this study, 4 were cured, 3 were basically cured, and 2 had improvement. The effective rate of treatment was 100%. CONCLUSIONS: In the treatment of intraosseous AVMs of the jaw, correct diagnosis based on clinical and imaging manifestations, and the use of ethanol embolization based on DSA imaging results can reduce trauma, improve symptoms, control lesions, and achieve relatively satisfactory treatment results. This treatment plan is safe and effective. Reference | Related Articles | Metrics