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Visual analysis of clinical research literatures on temporomandibular joint disorders at both home and abroad from 2013 to 2023 LIU Xing-yu, JIANG Nan China Journal of Oral and Maxillofacial Surgery    2025, 23 (2): 185-195.   DOI: 10.19438/j.cjoms.2025.02.014 Abstract （842）      PDF （2071KB）（853）       Knowledge map    PURPOSE: To analyze the evolution of domestic and international clinical researches on temporomandibular joint disorders(TMD) from 2013 to 2023,to understand the development trends and research hotspots, and to explore future research directions. METHODS: Clinical research literatures on TMD published between 2013 and 2023 were collected through PubMed, China National Knowledge Infrastructure(CNKI), Wanfang Data, and VIP databases. CiteSpace 6.1.R6 software was utilized for visual analysis. Methods included keyword frequency statistics, co-occurrence analysis, clustering analysis, and timeline analysis to construct knowledge maps and identify research hotspots. RESULTS: Domestic research hotspots were primarily focused on pain management, acupuncture therapy, and tissue repair. In contrast, international researches heavily emphasized quality of life and non-invasive treatment approaches. Both domestic and international studies underscored the importance of interdisciplinary integration and the application of new technologies. Keywords such as "acupuncture treatment" have appeared relatively late in domestic researches but showed a clear trend, indicating an interest in the application of traditional medicine and emerging technologies. International researches had earlier focused on psychological factors and quality of life, and leaded in the application of new materials and technologies. CONCLUSIONS: Although there are differences in methods and focal points between domestic and international researches, there is a consistent focus on core issues such as pain management and the application of imaging technologies. Future researches should enhance attention to psychological factors and comprehensive health management, draw on international experience, explore the application of new materials and new technologies, and promote interdisciplinary collaboration to improve the diagnosis and treatment of temporomandibular joint disorders and the quality of life of patients. Reference | Related Articles | Metrics

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Association of preoperative anxiety level and postoperative pain in children undergoing general anesthesia of oral and maxillofacial day surgery SHEN Xiao-min, ZHONG Lin-hong, LI Jing-jie, LIU Jin-xing, QIU Lin China Journal of Oral and Maxillofacial Surgery    2025, 23 (2): 152-158.   DOI: 10.19438/j.cjoms.2025.02.008 Abstract （522）      PDF （1223KB）（531）       Knowledge map    PURPOSE: To explore the association between preoperative anxiety levels and postoperative pain in children undergoing general anesthesia of oral and maxillofacial day surgery. METHOD: A total of 769 children aged 3-12 years undergoing general anesthesia of oral and maxillofacial day surgery were included. According to the postoperative FLACC Pain Assessment Scale score, the children were divided into a postoperative pain group (FLACC≥ 4) and a non-pain group (FLACC< 4). Univariate and multivariate regression analyses were conducted on demographic data, preoperative anxiety levels of the children and their parents, surgical type, perioperative anesthetics and analgesics between the groups to explore the association of preoperative anxiety levels and postoperative pain in these children. R 4.2.3 software package was used for data analysis. RESULTS: The incidence of postoperative pain in children under general anesthesia of oral and maxillofacial day surgery was 25.88%. Univariate regression suggested the preoperative Modified Yale Preoperative Anxiety Inventory(mYPAS) in pediatric patients (OR=3.31, 95%CI: 2.15-5.15, P< 0.001) and preoperative State Anxiety Inventory (SAI) score in parents (OR=2.04, 95%CI: 1.14-3.69, P=0.017) were associated with an increased risk of postoperative pain. After further adjusting for age, gender, BMI, medical history, fentanyl dosage, sufentanil dosage, ketamine dosage, and anesthesia duration, multiple regression analysis showed that higher mYPAS(OR=2.04, 95%CI: 1.27-3.3, P=0.003) in pediatric patients was associated with an increased risk of postoperative pain. There was no significant correlation between parental preoperative Trait Anxiety Inventory (TAI) score and the increased risk of postoperative pain in children. Subgroup analysis results showed that increased mYPAS scores in children without medical or surgery history, as well as increased SAI in parents who underwent plastic surgery or with surgery histories of their children, were associated with the higher risk of postoperative pain. The interaction between preoperative mYPAS and parental SAI-TAI on postoperative pain only showed a trend significance and did not show statistical differences. CONCLUSIONS: Preoperative anxiety levels in children and the parental state anxiety were association with high risk of postoperative pain in children undergoing oral and maxillofacial day surgery. Therefore, effective interventions to reduce preoperative anxiety may improve postoperative pain management in this pediatric population. Reference | Related Articles | Metrics

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Newly revised ISSVA classification for vascular anomalies(2025 version) and interpretation Du Zhong, Zheng Jiawei, Wang Yan'an China Journal of Oral and Maxillofacial Surgery    2025, 23 (4): 313-317.   DOI: 10.19438/j.cjoms.2025.04.001 Abstract （513）      PDF （1054KB）（876）       Knowledge map    Vascular anomalies can be primarily categorized into two major groups: vascular tumors and vascular malformations. In 1982, Mulliken and Glowacki proposed a revolutionary biological classification. Specifically, based on the proliferation characteristics of endothelial cells, these anomalies were differentiated into "hemangiomas" and "vascular malformations". In 1996, this classification system was adopted by the International Society for the Study of Vascular Anomalies (ISSVA) as the standard classification, and has been undergoing continuous refinement up to the present. In May 2025, the latest ISSVA World Congress was convened in Paris. The 2018 classification system, which is currently in wide use, was further optimized. A substantial number of structural and detailed adjustments were made, rendering the new classification system more streamlined. Consequently, its usability has been remarkably enhanced. This evolution of the ISSVA classification mirrors the deepening of the understanding from the morphological level to the molecular mechanism level. Every update holds milestone significance for the standardization of the diagnosis and treatment of vascular diseases globally. This paper aimed to introduce and interpret the newly revised ISSVA classification (2025 version), providing a reference for clinical practice, scientific research, and academic exchanges. Reference | Related Articles | Metrics

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Research progress on drugs for the prevention and treatment of radiotherapy-induced oral mucositis WANG Jia-min, AN Wei, CHEN Wen-ge China Journal of Oral and Maxillofacial Surgery    2025, 23 (2): 196-201.   DOI: 10.19438/j.cjoms.2025.02.015 Abstract （451）      PDF （674KB）（301）       Knowledge map    Radiation oral mucositis is one of the most common complications of radiotherapy in patients with head and neck cancer. It can lead to mucosal ulceration, severe pain, eating and swallowing difficulties and other functional disorders, resulting in treatment interruption and poor curative effect. Radiation oral mucositis is currently believed to be a complex and dynamic process with multiple targets, and drug therapy targeting these targets can prevent and control the occurrence and development of mucositis. This review discussed the research progress of drugs for prevention and treatment of radiation mucositis, aiming at different targets of mucositis, including DNA damage, oxidative stress pathway, oral microbiota, epithelial proliferation, and analgesic management, which will provide references for the future research and clinical prevention and treatment of radiation oral mucositis. Reference | Related Articles | Metrics

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A Study on early quality of recovery of patients undergoing oral and maxillofacial tumour resection and free flap reconstruction surgery and its relationship with DAH30 ZHANG Yao, GUO Jun, LI Hui, ZHU Wen, LIU Bing, ZHANG Hui China Journal of Oral and Maxillofacial Surgery    2025, 23 (2): 110-116.   DOI: 10.19438/j.cjoms.2025.02.002 Abstract （415）      PDF （930KB）（488）       Knowledge map    PURPOSE: To investigate the early quality of recovery (QoR) of patients undergoing oral and maxillofacial tumour resection and free flap reconstruction surgery, and to analyze the relationship between QoR and days at home alive up to 30 days after surgery(DAH30). METHODS: A prospective, single-centre, cohort study was conducted on patients who were admitted to our hospital from September 2022 to October 2023 and scheduled to undergo oral and maxillofacial tumour resection and free flap reconstruction surgery under general anaesthesia. QoR-15 scale was used to evaluate the QoR on the day before surgery, the first day after surgery, and the second day after surgery. The patients were grouped according to the QoR-15 score on the 1st day after surgery, and the main results were the situation of QoR in the early postoperative period and the relationship between QoR of the 1st postoperative day and DAH30. SAS 9.4 software package was used for data analysis. RESULTS: A total of 251 patients were analyzed, the QoR on the 1st day after surgery was 86(34.26%) cases as poor, 165(65.74%) cases as moderate, as well as 25 (9.96%) cases as poor, 213 (84.86%) cases as moderate and 13(5.18%) cases as good on the second day after surgery. On the first day after surgery, the median DAH30 of patients with poor QoR was 18 days, and that of patients with moderate QoR was 20 days, and the difference was statistically significant(P=0.003). CONCLUSIONS: The early QoR of patients undergoing oral and maxillofacial tumour resection and free flap reconstruction surgery is mainly moderate. Enhancing the quality of recovery of such patients on the first day after surgery is beneficial to improve prognosis. Reference | Related Articles | Metrics

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Progress in anatomy and clinical applications of buccal fat pad Niu Lingxiao, Dang Qingqing, Han Bing China Journal of Oral and Maxillofacial Surgery    2025, 23 (3): 302-306.   DOI: 10.19438/j.cjoms.2025.03.015 Abstract （361）      PDF （765KB）（816）       Knowledge map    Buccal fat padBFP) is an irregular mass of adipose tissue located within the deep facial recesses, with rich blood supply and encapsulated structure, which can isolate mesenchymal stem cells with multidirectional differentiation ability. The pedicled buccal fat pad flap is easy to prepare and has a high survival rate, and has been widely used in the repair of soft and hard tissue defects in the oral and maxillofacial region. The osteogenic ability of buccal fat pad derived mesenchymal stem cells has been demonstrated in vitro and has been used in clinical trials to repair jaw defects in recent years. In plastic surgery, the potential of both pedicled and free buccal fat pad flaps for improving facial contours continues to be explored. However, research on the long-term benefits for patients and the differences between these flaps and other pedicled skin flaps is limited. This review summarized the current advancements in the anatomy and some clinical applications of the buccal fat pad. Reference | Related Articles | Metrics

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In vitro and in vivo study on the structural regulation of porous hydrogels and promoting angiogenic regeneration Duan Shuhan, Wang Jiajia, Wang Shaoyi China Journal of Oral and Maxillofacial Surgery    2025, 23 (4): 318-324.   DOI: 10.19438/j.cjoms.2025.04.002 Abstract （301）      PDF （2356KB）（114）       Knowledge map    PURPOSE: To develop a highly porous hydrogel microsphere scaffold based on aqueous biphasic separation technology, aimed at enhancing its angiogenic potential in both in vitro and in vivo environments. METHODS: Porous hydrogels were prepared through phase separation. The porous structure was observed using confocal microscopy, and the microscopic pore structure of the material was examined using scanning electron microscopy(SEM). The mechanical strength of the material and the thermal stability of the hydrogel were measured. Porous hydrogel microspheres were fabricated using microfluidic technology. In vitro tests were performed to assess the biocompatibility and angiogenesis-promoting ability of the material. The porous hydrogel microspheres were implanted subcutaneously in mice, and histological staining was conducted to observe biocompatibility and vascular formation. RESULTS: A porous hydrogel system was successfully constructed. Confocal and SEM confirmed that after crosslinking of gelatin methacryloyl (GelMA), the selective removal of sodium alginate(SA) phase formed a network of interconnected pores, exhibiting the ability to bear stress and stability. CCK-8 assay and live/dead staining results demonstrated that the material exhibited excellent biocompatibility. The GelMA/SA material extract significantly promoted the formation of tubular structures in human umbilical vein endothelial cells(HUVECs). Subcutaneous implantation in mice showed that the porous hydrogel facilitated tissue ingrowth and localized angiogenesis. CONCLUSIONS: The phase separation-engineered porous hydrogel microsphere system, combining continuous pore structure and angiogenesis-promoting effects, provides a novel scaffold material for tissue engineering and regenerative repair. Reference | Related Articles | Metrics

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Necrotizing fasciitis of the head and neck: an update on diagnosis and management Chen Shujun China Journal of Oral and Maxillofacial Surgery    2025, 23 (3): 215-220.   DOI: 10.19438/j.cjoms.2025.03.002 Abstract （295）      PDF （912KB）（182）       Knowledge map    Necrotizing fasciitis of the head and neck is a rare and severe infectious disease characterized by necrosis of subcutaneous tissue and fascia, leaving the muscles initially unaffected. This infection progresses rapidly, if no intervention, and has a high mortality rate with no or inappropriate intervention. The purpose of this article was to systematically review the etiology, clinical manifestations, diagnosis, treatment and prognosis of necrotizing fasciitis of the head and neck, and to discuss its diagnosis and treatment based on clinical experience, so as to enhance the understanding of the disease, reduce the mortality rate, and improve the diagnosis and treatment level of the disease. Reference | Related Articles | Metrics

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Preliminary application of artificial intelligence in the pathological diagnosis of ameloblastoma QIAO Xin-wei, LI Mao, SHEN Ze-liang, ZHANG Lin-han, ZHENG Zhi-jian, TANG Ya-ling China Journal of Oral and Maxillofacial Surgery    2025, 23 (2): 122-128.   DOI: 10.19438/j.cjoms.2025.02.004 Abstract （291）      PDF （3026KB）（780）       Knowledge map    PURPOSE: To investigate the effect of artificial intelligence in the pathological diagnosis of ameloblastoma, and to preliminarily explore the value of artificial intelligence in the field of oral pathology. METHODS: The pathological images of 90 cases of ameloblastoma were used as the research objects, and the U-net-like structure neural network was constructed. The 90 H-E images of ameloblastoma were divided into a training set (72 images), a validation set (9 images) and a test set (9 images) for training and testing the model respectively. The mIoU and ROC curve were used to evaluate the ability of the U-net network model in the identification of ameloblastoma epithelium. RESULTS: The mIoU of negative area segmented by U-net model was 0.818 and the positive area was 0.846. The area under the ROC curve was 0.92. CONCLUSIONS: The U-net network model has a good segmentation for the positive and negative regions of ameloblastoma, and can distinguish between negative and positive sections. It can be preliminarily applied to the pathological diagnosis of ameloblastoma, and is expected to be gradually popularized in clinical practice after further validation with large samples. Reference | Related Articles | Metrics

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Application and challenges of virtual simulation technology in oral implant nursing teaching FENG Yi, HUANG Jian-fang, ZHAO Yao-yu, YAN Qi, WANG Li China Journal of Oral and Maxillofacial Surgery    2025, 23 (2): 180-184.   DOI: 10.19438/j.cjoms.2025.02.013 Abstract （281）      PDF （607KB）（188）       Knowledge map    Virtual simulation technology combines computer technology, 3D graphics, multimedia, and more to provide a multi-sensory immersive experience, and it is widely applied in various fields. This paper analyzed the application of virtual simulation technology in basic nursing and oral implantology care education, summarizing its effectiveness and the challenges it faces. Traditional teaching methods have limitations in fostering students' self-directed learning and practical skills. In contrast, virtual simulation technology, with its immersive and interactive nature, enhances students' interest in learning and operational skills, effectively addressing some shortcomings of traditional education. The paper discussed technical, cost and design challenges encountered in the application of virtual simulation technology in nursing education and proposes corresponding solutions. Reference | Related Articles | Metrics

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Current research on the loss of contact between implant prostheses and adjacent natural teeth LAI Zi-ya, ZHAO Tian, GAO Yi-ming China Journal of Oral and Maxillofacial Surgery    2025, 23 (2): 202-205.   DOI: 10.19438/j.cjoms.2025.02.016 Abstract （270）      PDF （438KB）（387）       Knowledge map    As one of the current treatment options for defect of dentition, implant restoration has been widely used in clinical practice. However, some complications have also seriously affected patient' quality of life after implant restoration, such as loss of proximal contact between implant prostheses and natural teeth, which can easily lead to implant peri-endodontitis, increase the probability of food impaction, and periodontitis. The current treatment methods for this postoperative phenomenon are relatively limited, and research on the etiology of the disease is also lacking. Therefore, this paper analyzed and discussed the problem of loss of adjacent contact between implant prostheses and natural teeth, comprehensively analyzed the causes of this disease, and summarized the current research status of clinical treatment methods. It also provided feasible suggestions for prevention and treatment in the later stage. Reference | Related Articles | Metrics

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A case of chronic pain caused by residual small foreign body during wisdom tooth extraction was misdiagnosed as somatoform disorder LI Shi-yong, WU Yong, ZHANG Xin, WANG Si-hang, FU Shuai China Journal of Oral and Maxillofacial Surgery    2025, 23 (2): 206-208.   DOI: 10.19438/j.cjoms.2025.02.017 Abstract （262）      PDF （874KB）（387）       Knowledge map    Foreign bodies in oral and maxillofacial region are not rare in clinical practice. This paper reported a patient with long-term chronic pain caused by small metal foreign body remaining in the soft tissue during wisdom tooth extraction, and was later misdiagnosed as somatoform disorder. After the foreign body was removed, the patient's symptoms disappeared. The residual foreign bodies, causes of misdiagnosis, prevention and treatment were discussed based on relevant literature review, in order to strengthen the understanding of the disease and reduce misdiagnosis. Reference | Related Articles | Metrics

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Correlation between p53 staining and TP53 mutation status in 60 patients with oral squamous cell carcinoma Liu Yu, Miao Keyan, Hu Yuhua, Wu Yue, Feng Guanying, Xia Ronghui, Yang Xi China Journal of Oral and Maxillofacial Surgery    2025, 23 (3): 244-252.   DOI: 10.19438/j.cjoms.2025.03.006 Abstract （257）      PDF （1196KB）（239）       Knowledge map    PURPOSE: This study aimed to investigate the correlation between p53 staining patterns and TP53 mutation status in oral squamous cell carcinoma(OSCC), as well as their associations with clinicopathologic features. METHODS: Tissue samples from 60 OSCC patients were analyzed using whole-exome sequencing and immunohistochemical staining with p53 antibodies (MX008 and YN01766m). TP53 mutation status and p53 staining patterns (Null, overexpression [OE], and wild type[WT]) were compared with clinicopathologic features. Correlations between p53 staining patterns and TP53 mutation status were evaluated. GraphPad Prism 8 software package was used for data analysis. RESULTS: TP53 was the most frequently mutated gene in OSCC, with mutations significantly associated with higher pTNM stage, DOI, and PNI, and correlated with poor prognosis in public datasets. The Null pattern exhibited the highest sensitivity in detecting loss-of-function (LOF) mutations, while OE pattern predicted gain-of-function (GOF) mutations and showed clinical value for patient stratification. Both antibodies had similar performance in detecting and matching TP53 mutation status. CONCLUSION: TP53 is the most common mutation in OSCC,and its mutation is associated with adverse clinicopathological features and poor prognosis. p53 staining is sensitive to LOF mutations and is expected to be a biomarker of GOF mutations, providing a cost-effective method for patient stratification and targeted therapy. Reference | Related Articles | Metrics

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Study of Piezo1 expression in venous malformation tissues and HUVECs Maidina Imam, Zhou Yuchuan, Muzafar Muhetar, Gong Zhongcheng China Journal of Oral and Maxillofacial Surgery    2025, 23 (3): 221-227.   DOI: 10.19438/j.cjoms.2025.03.003 Abstract （255）      PDF （1173KB）（168）       Knowledge map    PURPOSE: To investigate the expression of Piezo1 in venous malformation(VM) tissues and human umbilical vein endothelial cells (HUVECs). METHODS: The wax samples of patients diagnosed with venous malformations were obtained, and the expression levels of antibodies Piezo1, TRPV4, P2X7, CD31 and α-SMA were detected by immunohistochemistry in the samples of venous malformations and normal veins. Overexpression of TIE2-L914F and TIE2-WT genes in HUVECs led to construction of venous malformation cell models and wild-type cell models, with HUVECs as the control group. The expression of mRNA and protein levels of Piezo1, TRPV4 and P2X7 in each group were detected by RT-qPCR, Western blot and enzyme-linked immunosorbent assay(ELISA). SPSS 27.0 software package was used for data analysis. RESULTS: Immunohistochemical results showed that Piezo1 expression was positive in both normal vein tissue and VM tissue, while TRPV4 and P2X7 expression were negative. Western blot results showed that there were significant differences in Piezo1 protein expression levels among the three groups, and the Piezo1 protein levels of the TIE2-L914F group were significantly down-regulated(P<0.01). There were no significant differences in the expression levels of TRPV4 and P2X7 proteins among the three groups(P>0.05). ELISA results showed that the expression of Piezo1 in the VM group was significantly lower than that in the normal cell group(P<0.0001), and the expression of TRPV4 in the three groups had no significant difference (P>0.05), and the expression of P2X7 in the three groups had no significant difference (P>0.05). RT-qPCR results showed that Piezo1 mRNA levels in TIE2-L914F group were significantly down-regulated compared with TIE2-WT and HUVEC group (P<0.001). CONCLUSIONS: The expression of Piezo1 in venous malformation tissues is lower than that in normal tissues, suggesting that Piezo1 is involved in the development and remodeling of blood vessels. Reference | Related Articles | Metrics

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Effects of comprehensive nursing combined with intraoperative correction via computer navigation on mouth opening and satisfaction in patients with temporomandibular joint ankylosis Tao Lili, Zhao Baojian, Liu Qianzi, Sun Guowen, Liu Xiaoyun China Journal of Oral and Maxillofacial Surgery    2025, 23 (3): 284-289.   DOI: 10.19438/j.cjoms.2025.03.012 Abstract （254）      PDF （765KB）（389）       Knowledge map    PURPOSE: To investigate the effects of comprehensive nursing combined with intraoperative correction via computer navigation on mouth opening and satisfaction in patients with temporomandibular joint(TMJ) ankylosis. METHODS: A total of 104 patients with TMJ ankylosis who underwent treatment in Nanjing Stomatological Hospital from February 2016 to February 2023 were included and randomly divided into the control group (n=52, treated with intraoperative correction via computer navigation) and the experimental group(n=52, treated with comprehensive nursing on the basis of the control group). TMJ function, masticatory efficiency, Connor-Davidson Resilience Scale(CD-RISC) scores, Oral Health Impact Profile-14 (OHIP-14) scores, and patients' satisfaction were compared between the two groups before and after treatment. SPSS 27.0 software package was used for data analysis. RESULTS: After treatment, the maximum mouth opening and masticatory efficiency in the experimental group were significantly higher than those in the control group, while DI, PI and CMI were significantly lower than those of the control group(P<0.05). The CD-RISC subscale scores in the experimental group were significantly higher than those in the control group, and the OHIP-14 subscale scores were significantly lower (P<0.05). Patients' satisfaction was significantly higher in the experimental group than in the control group(P<0.05). CONCLUSIONS: Comprehensive nursing combined with intraoperative correction via computer navigation demonstrates significant therapeutic effects in patients with TMJ ankylosis, which can effectively improve mouth opening, patients' satisfaction and joint function, and is suitable for clinical application. Reference | Related Articles | Metrics

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Exploration on construction of remote medical model for the diagnosis and treatment of dento-maxillofacial deformities Hu Lingling, Sun Yingjia, Jiang Peiling, Xie Zhijian China Journal of Oral and Maxillofacial Surgery    2025, 23 (3): 209-214.   DOI: 10.19438/j.cjoms.2025.03.001 Abstract （250）      PDF （871KB）（608）       Knowledge map    The orthodontic-orthognathic treatment is presently the predominant approach to rectifying dentomaxillofacial deformities. Nevertheless, the extended duration of the treatment cycle and the intricacy of the surgical procedures pose significant challenges for patients situated in various locations and restrict the accessibility of superior medical resources. To mitigate these limitations, this study introduced a remote medicine model for dentomaxillofacial deformities, predicated on the "internet + medicine" paradigm, and delineated its standardized procedures and quality control framework. This model adhered to the "1+1+N" paradigm, where a remote medical center served as the nucleus, and a dentomaxillofacial deformity consultation e-cloud platform functioned as the interconnecting nexus. This arrangement facilitated the effective amalgamation of superior medical resources, thereby augmenting treatment efficacy and enhancing patient experience. Additionally, this study focused on the detailed construction of a multifunctional dentomaxillofacial deformity consultation e-cloud platform and comprehensive quality control framework. This approach provided a scientific and effective solution for strengthening remote medical quality supervision, promoting the rational allocation of medical resources, and improving the service level of primary hospitals. Reference | Related Articles | Metrics

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Clinical evaluation of partial odontectomy for the removal of impacted third molar invading the inferior alveolar nerve canal Yan Weifeng, Chen Zhifang, Lu Luyun China Journal of Oral and Maxillofacial Surgery    2025, 23 (4): 355-360.   DOI: 10.19438/j.cjoms.2025.04.007 Abstract （247）      PDF （1182KB）（277）       Knowledge map    PURPOSE: To explore the clinical efficacy of performing a second surgical extraction of impacted third molars with roots invading the inferior alveolar nerve canal after partial crown resection. METHODS: A total of 64 cases of mesially or horizontally impacted third molars with roots invading the inferior alveolar nerve canal, which were diagnosed by CBCT and treated in the Department of Oral Surgery at Hefei Stomatological Hospital West Branch from January 2023 to December 2024 were selected. The patients were randomly divided into two groups, with 32 cases in each group. The experimental group underwent partial crown resection first, and then complete tooth extraction was performed 3 or 6 months later. The control group underwent routine one-time tooth extraction. The adverse reactions of the experimental group were observed during the follow-up interval after partial crown resection, and the incidence of lower alveolar nerve injury, infection and dry socket after complete tooth extraction, pain and swelling at 1, 3 and 7 days after surgery were compared between the two groups. RESULTS: After partial crown resection, only 2 patients in the experimental group experienced mild pain, 1 patient had slight swelling, and one impacted tooth developed pericoronitis after eruption. There were no pulp symptoms, and no other abnormalities were observed. After the complete extraction of tooth in both groups, the incidence of inferior alveolar nerve injury in the experimental group was significantly lower than that in the control group(P<0.05), and the degree of postoperative pain and swelling was also significantly milder than that in the control group(P<0.05). CONCLUSIONS: Partial odontectomy can significantly reduce the risk of inferior alveolar nerve injury, minimize surgical trauma, and result in milder postoperative reactions. It is a safer and more effective method for impacted tooth extraction. Reference | Related Articles | Metrics

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Differences in cellular composition and molecular phenotype between HPV-related and non-HPV-related head and neck cancers Xue Pengxin, Sun Lulu, Sun Shuyang China Journal of Oral and Maxillofacial Surgery    2025, 23 (3): 236-243.   DOI: 10.19438/j.cjoms.2025.03.005 Abstract （245）      PDF （1301KB）（221）       Knowledge map    PURPOSE: To investigate the differences in tumor microenvironment and molecular phenotype between human papillomavirus (HPV)-related (HPV+) and non-HPV-related (HPV-) head and neck cancers (HNC). METHODS: Genomic, transcriptomic, and proteomic sequencing data for HNC were obtained from the TCGA public database via open-access platforms such as cbioportal. The patients were categorized into HPV+ and HPV- group based on HPV infection status. First, the CIBERSORTx cell-type deconvolution algorithm was applied to transcriptomic data to estimate differences in cellular composition between HPV+ and HPV- HNC. Subsequently, genomic, transcriptomic, and proteomic data were analyzed to identify genes with significantly increased mutation frequencies, enriched pathways, and upregulated proteins in HPV+ HNC compared to HPV- HNC. RESULTS: Significant differences were observed between HPV+ and HPV- HNC. ①Cellular composition: HPV+ tumors exhibited significantly higher infiltration of B cells, CD4+ T cells, and dendritic cells. ②Multi-omics alterations: genes such as CCM2L, CBFA2T2, and NECAB3 showed higher mutation frequencies in HPV+ tumors. The neuroactive ligand-receptor interaction pathway was significantly enriched in HPV+ tumors, proteins such as CLDN7 and SYK displayed higher expression levels in HPV+ tumors. ③FADS1 and ELF3 potentially participated in or regulated the phenotypic evolution of HPV+ HNC. FADS1 was a potential interacting protein of HPV16 E2, while ELF3 was a transcription factor specifically expressed in HPV+ epithelial tissues. Both genes exhibited a significant positive correlation with the gene set associated with the neuroactive ligand-receptor interaction pathway. CONCLUSIONS: Compared to HPV- HNC, the distribution of microenvironmental cell subtypes and potential regulatory elements in HPV+ HNC is significantly different, characterized by a higher proportion of immune cells and enrichment in pathways related to neural signaling and immune response. Reference | Related Articles | Metrics

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Construction and validation of predictive model for implant failure in patients with dentition defect TAO Yuan, ZHU Guo-qiang, REN Wei-ping, ZHU Xiu-hong China Journal of Oral and Maxillofacial Surgery    2025, 23 (2): 117-121.   DOI: 10.19438/j.cjoms.2025.02.003 Abstract （244）      PDF （770KB）（138）       Knowledge map    PURPOSE: To construct a prediction model for implant failure in patients with dentition defect and verify its efficacy. METHODS: A total of 195 patients who underwent implant repair due to dental defect in the First People's Hospital of Pingdingshan City from March 2020 to March 2023 were selected and followed up for 1 year after discharge. According to the follow-up results, the patients were divided into implant failure group(n=25) and implant success group(n=170). The risk factors of implant failure in patients with denture defect were screened by univariate and multivariate regression analysis. A nomogram model of implant failure in patients with dental defects was constructed based on risk factors, and the predictive efficiency of the nomogram model was evaluated by Hosmer-Lemeshow test and receiver operating characteristic(ROC) curve. SPSS 26.0 software package was used for statistical analysis. RESULTS: Age≥ 60 years old, complicated with diabetes mellitus, smoking history, bad oral habits, maxillary defect, gingival creval bleeding index≥ 2, the proportion of grade Ⅲ to Ⅳ alveolar bone mineral density in the failed implantation group and the successful implantation group had significant difference (P< 0.05). There was no significant difference in sex ratio, hypertension, implantation time, implant diameter and other clinical data(P> 0.05). Logistic multivariate regression analysis results showed age≥ 60 years old (OR=1.857), diabetes mellitus (OR=1.822), history of smoking (OR=1.806), bad oral habits (OR=1.714), maxillary defect (OR=1.885), gingival crevicular bleeding index ≥ 2 (OR=1.874), alveolar bone mineral density (OR=1.869) were independent risk factors for implant failure in patients with denture defects (P< 0.05). Based on age, diabetes, smoking history, bad oral habits, maxillary defect, gingival crevicular bleeding index, and alveolar bone density, a nomogram model of implant failure risk for patients with dental defect was constructed. The results showed that the C-index was 0.905(95%CI: 0.855-0.972), and the measured value was basically consistent with the predicted value. CONCLUSIONS: The factors of implant failure in patients with dentition defect include age, diabetes, smoking history, bad oral habits, maxillary defect, gingival crevicular bleeding index, and alveolar bone mineral density. The nomogram model constructed based on this analysis has a good predictive effect on implant failure. Reference | Related Articles | Metrics

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Stafne bone cavity: report of 2 cases and literature review Ge Yaping, Luo Yalan, Liu Xiangzhen, Chen Jieyu, Zhang Min, She Yangyang China Journal of Oral and Maxillofacial Surgery    2025, 23 (4): 421-424.   DOI: 10.19438/j.cjoms.2025.04.017 Abstract （240）      PDF （1370KB）（83）       Knowledge map    Stafne bone cavity(SBC), also known as the static bone cavity, is a rare and non-progressive defect in the lingual side of the mandible. Clinically, patients with SBC are usually asymptomatic. This paper reported two cases of SBCs in the posterior part of the unilateral mandible and discussed its etiology, clinical manifestations, diagnosis and differential diagnosis in combination with relevant literature. Reference | Related Articles | Metrics