Evaluation of the therapeutic effect of polidocanol foam sclerotherapy in the treatment of head and neck venous malformations under medical and nursing collaboration

doi:10.19438/j.cjoms.2024.03.012

Abstract

Abstract: PURPOSE: To explore the difference in therapeutic effect and injection frequency between polidocanol liquid injection and foam injection in the treatment of head and neck venous malformations under medical and nursing collaboration. METHODS: A total of 120 patients with head and neck venous malformations were treated with polidocanol sclerotherapy, of which 60 were treated with liquid injection and 60 with foam injection. All patients were classified into 4 groups respectively according to the types of venous malformations, namely, group A for typeⅠvenous malformation, group B for type Ⅱ venous malformation, group C for type Ⅲ venous malformation, and group D for type Ⅳ venous malformation. There were a total of 8 groups with 15 cases in each group. The therapeutic effect and the number of polidocanol injection were compared between each group. SPSS 23.0 software package was used for statistical analysis of the data. RESULTS: There was no significant difference in therapeutic effect between two injection methods in group A and group B, and the average number of injections was reduced by 0.5 with foam compared to liquid in group A and 1.2 in group B. The therapeutic effect of foam injection was better than that of liquid injection in group C and group D, but the difference was not statistically significant(P>0.05), and the average number of injections was reduced by 2.7 with foam compared to liquid method in group C and 3.9 in group D. CONCLUSIONS: In the treatment of head and neck venous malformations, the therapeutic effect of foam injection is better than liquid injection for venous malformations with fast drainage. The faster the drainage of venous malformations, the greater is the reduction in average number of treatments with foam injection in relation to that with liquid injection. The reduction in the number of treatments is conducive to reducing patients’ economic burden, time consumption and incidence of adverse reactions, and thus foam injection is worth promoting and applying in clinical practice.

Key words: Polidocanol, Venous malformation, Sclerotherapy, Head and neck region

CLC Number:

R782.2

ZHANG Fang, SHOU Wei-dong, LI Yan. Evaluation of the therapeutic effect of polidocanol foam sclerotherapy in the treatment of head and neck venous malformations under medical and nursing collaboration[J]. China Journal of Oral and Maxillofacial Surgery, 2024, 22(3): 274-278.

References

[1] Markovic JN, Nag U, Shortell CK.Safety and efficacy of foam sclerotherapy for treatment of low-flow vascular malformations in children[J]. J Vasc Surg Venous Lymphat Disord, 2020, 8(6): 1074-1082.
[2] Carqueja IM, Sousa J, Mansilha A.Vascular malformations: classicatian, diagnosis and treatment[J].Int Angiol, 2018, 37(2): 127-142.
[3] Dompmartin A, Vikkula M, Boon LM.Venous malformation: update on aetiopathogenesis, diagnosis and management[J]. Phlebol, 2010, 25(5): 224-235.
[4] Li L, Feng J, Zeng XQ, et al.Fluoroscopy-guided foam sclerotherapy with sodium morrhuate for peripheral venous malformations: preliminary experience[J].J Vasc Surg,2009,49(4): 961-967.
[5] 庄乾伟, 李芳芳, 孟箭, 等. 射频消融联合经皮造影DSA引导下聚多卡醇泡沫硬化剂灌注治疗口腔颌面部静脉畸形38例疗效评价[J].中国口腔颌面外科杂志, 2022, 20(2): 135-140.
Zhuang QW, Li FF, Meng J, et al.Radiofrequency ablation combined with DSA-guided sclerotherapy of polidocanol foam for 38 patients with oral and maxillofacial venous malformation[J]. China Journal of Oral and Maxillofactal Surgery, 2022, 20(2): 135-140.
[6] 王亮, 吴长华, 宋丹, 等. 聚多卡醇泡沫硬化剂联合平阳霉素在学龄前儿童舌静脉畸形治疗中的应用[J]. 组织工程与重建外科杂志, 2020, 16(3): 182-185.
Wang L,Wu CH, Song D,et al.Sclerotherapy using polidocanol injectable foam combined with pinyangmycin in the treatment of venous malformation in tongue of preschoolers[J]. Journal of Tissue Engineering and Reconstruetive Surgery, 2020, 16(3): 182-185.
[7] Tessari L, Cavezzi A, Frullini A.Preliminary experience with a new sclerosing foam in the treatment of varicose veins[J]. Dermatol Surg, 2001, 27(1): 58-60.
[8] Mukul SK, Singh A, Kumar A, et al.Foam polidocanol sclerotherapy for low-flow vascular malformations of tongue[J].Ann Maxillofac Surg, 2019, 9(2): 257-260.
[9] 杨耀武, 郑家伟, 孙沫逸, 等. 聚桂醇硬化剂治疗口腔颌面部血管瘤和脉管畸形专家共识[J].中国口腔颌面外科杂志, 2018, 16(3): 275-278.
Yang YW, Zhang JW, Sun MY,et al.Expert consensus on the treatment of oral and maxillofacial hemangiomas and vascular malformations by lauromacrogol sclerotherapy[J]. China journal of Oral and Maxillofactal Surgery, 2018, 16(3): 275-278.
[10] Achauer BM, Chang CJ, Vander Kam VM.Management of hemangioma of infancy: review of 245 patients[J]. Plast Reconstr Surg, 1997, 99(5): 1301-1308.
[11] 李鹏, 李东繁, 郭正团, 等.平阳霉素治疗婴幼儿血管瘤作用机制的实验研究[J].中华口腔医学杂志, 2013, 48(1): 18-22.
Li P, Li DF, Gou ZT, et al.Therapeutic mechanism of bieomycin A5 on infancy hemangioma: an experimental study[J].Chin J Stomatol, 2013, 48(1): 18-22.
[12] 刘珍银, 李海波, 周少毅, 等. 无水乙醇联合聚多卡醇泡沫硬化治疗儿童颌面部静脉畸形的临床研究[J]. 中华介入放射学电子杂志, 2017, 5(4): 235-240.
Liu ZY, Li HB, Zhou SY, et al.Clinical study on sclerotherapy using absolute ethanol combined with polidocanol injectable foam in treatment of venous malformation in maxillofacial region of children[J]. Chinese Journal of Interventional Radiology: Electronic Edition, 2017, 5(4): 235-240.
[13] 程鹏, 程乐达, 朱保玉. 聚多卡醇与平阳霉素治疗颌面部静脉畸形的效果比较[J]. 河南医学研究, 2019, 28(7): 1175-1177.
Cheng P, Cheng LD, Zhu BY.Comparison of the effect of polidocanol and pingyangmycin in the treatment of maxillofacial venous malformation[J].Henan Medical Research, 2019, 28(7): 1175-1177.
[14] 牛传强, 姜华, 周少毅, 等. 泡沫硬化疗法治疗口咽部静脉畸形的效果分析[J].中华耳鼻咽喉头颈外科杂志, 2018, 53(3): 209-213.
Niu CQ, Jiang H, Zhou SY, et al.Effect of foam sclerotherapy for the treatment of oropharyngeal venous malformation[J]. Chinese Journal of Otorhinolaryngology Head and Neck Surgery, 2018, 53(3): 209-213.
[15] 宋佩健, 张华. 头颈部静脉畸形研究进展[J].国际耳鼻喉头颈外科杂志,2022,46(1):49-53.
Song PJ, Zhang H.Research progress of head and neck venous malformations[J]. International Journal of Otolaryngology-Head and Neck Surgery, 2022, 46(1): 49-53.