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Application progress of artificial intelligence in diagnosis and treatment of oral genetic diseases Gu Anqi, Zhang Chen, Tao Baoxin, Wu Yiqun, Zhou Wenjie China Journal of Oral and Maxillofacial Surgery    2025, 23 (4): 406-415.   DOI: 10.19438/j.cjoms.2025.04.015 Abstract （310）      PDF （1365KB）（1182）       Knowledge map    Rare condition, scattered cases, complex etiology and clinical features, inadequate diagnostic criteria and methods and other reasons lead to the serious lack of accessibility for early diagnosis and treatment of oral genetic diseases. Artificial intelligence(AI) is expected to make breakthroughs in the prevention, diagnosis, treatment and basic research of oral genetic diseases due to its unique advantages in feature extraction, variant recognition, classification, typing and outcome prediction of large and complex data sets. Many studies have identified and processed patients' medical records, photos, radiographic images, key genes or transcriptome, biomarkers and other data through AI models or software to assist the diagnosis, treatment and research of various oral genetic diseases. Based on the literature evidence, this article reviewed and summarized the application of AI in teeth, periodontal tissues, oral mucosa, orofacial clefts related genetic diseases and other oral genetic diseases that cause craniofacial malformations. The future development of this field was also prospected. Reference | Related Articles | Metrics

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Expert consensus on diagnosis and clinical management of medication-related osteonecrosis of the jaw HE Yue, CHEN Heng, AN Jin-gang, GUO Yu-xing, PAN Jian, TIAN Lei, LIU Bing, HOU Jin-song, LI Jin-song, JIANG Can-hua, LI Meng-yu, TIAN Zhen, XU Jie, ZHU Ling, SUN Chang-fu, ZHI Ke-qian, QU Qing, ZONG Chun-lin, SUN Jing-jing, ZHANG Zhi-yuan China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 313-325.   DOI: 10.19438/j.cjoms.2023.04.001 Abstract （2886）      PDF （2051KB）（2682）       Knowledge map    Medication-related osteonecrosis of the jaw(MRONJ) is a complication caused by the application of anti-resorptive medications, angiogenesis inhibitors, hormones and other medications for the treatment of some systemic diseases. The clinical symptoms include swelling, pain, masticatory disorders, persistent fistula, bone exposure and even pathological fracture, which seriously affect the patients' quality of life. Domestically, there is a lack of consensus or guidelines on classification, staging and treatment of MRONJ, and different institutions make diagnosis and treatment plans empirically. In order to unify and standardize the diagnosis and treatment of MRONJ and improve the prognosis, an expert panel of MRONJ research from 12 famous domestic medical colleges and affiliated hospitals convened a meeting to discuss the diagnosis and treatment opinions of MRONJ. Meanwhile, consensus recommendations were also revised with a comprehensive literature review of the previous treatment experiences and research findings. Finally, this expert consensus was finished for clinical references. Reference | Related Articles | Metrics

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Research and treatment of cleft lip and palate in China: review of 30 years SHI Bing, LI Cheng-hao, LI Jing-tao, YANG Chao, YI Heng, JIA Zhong-lin, LI Yang, HA Pin China Journal of Oral and Maxillofacial Surgery    2016, 14 (5): 385-397.   Abstract （1079）   HTML （17）    PDF （1597KB）（1768）       Knowledge map    Team approach for cleft treatment began in China since first introduced in 1990s. Multidisciplinary teams were established in several cleft centers. Based on the experience from developed countries, the Chinese teams are focusing on the development of indigenized and individualized intervention protocol for Chinese cleft patients; meanwhile, genetic and molecular mechanisms involved in normal and abnormal cleft lip/palate development were intensively investigated. Boosted by modern biological technology and evidence-based medicine, Chinese teams are making progressive exploration on innovative treatment technique. After generations of endeavor, we are able to offer world-class care to cleft patients.This review highlighted current team approach and treatment methods involved in clefts with special respect to recent advances derived from 1990s in China. Reference | Related Articles | Metrics

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Newly revised ISSVA classification for vascular anomalies(2025 version) and interpretation Du Zhong, Zheng Jiawei, Wang Yan'an China Journal of Oral and Maxillofacial Surgery    2025, 23 (4): 313-317.   DOI: 10.19438/j.cjoms.2025.04.001 Abstract （523）      PDF （1054KB）（886）       Knowledge map    Vascular anomalies can be primarily categorized into two major groups: vascular tumors and vascular malformations. In 1982, Mulliken and Glowacki proposed a revolutionary biological classification. Specifically, based on the proliferation characteristics of endothelial cells, these anomalies were differentiated into "hemangiomas" and "vascular malformations". In 1996, this classification system was adopted by the International Society for the Study of Vascular Anomalies (ISSVA) as the standard classification, and has been undergoing continuous refinement up to the present. In May 2025, the latest ISSVA World Congress was convened in Paris. The 2018 classification system, which is currently in wide use, was further optimized. A substantial number of structural and detailed adjustments were made, rendering the new classification system more streamlined. Consequently, its usability has been remarkably enhanced. This evolution of the ISSVA classification mirrors the deepening of the understanding from the morphological level to the molecular mechanism level. Every update holds milestone significance for the standardization of the diagnosis and treatment of vascular diseases globally. This paper aimed to introduce and interpret the newly revised ISSVA classification (2025 version), providing a reference for clinical practice, scientific research, and academic exchanges. Reference | Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2010, 8 (5): 386-390.   Abstract （832）      PDF （767KB）（1757）       Knowledge map    Related Articles | Metrics

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Visual analysis of clinical research literatures on temporomandibular joint disorders at both home and abroad from 2013 to 2023 LIU Xing-yu, JIANG Nan China Journal of Oral and Maxillofacial Surgery    2025, 23 (2): 185-195.   DOI: 10.19438/j.cjoms.2025.02.014 Abstract （849）      PDF （2071KB）（859）       Knowledge map    PURPOSE: To analyze the evolution of domestic and international clinical researches on temporomandibular joint disorders(TMD) from 2013 to 2023,to understand the development trends and research hotspots, and to explore future research directions. METHODS: Clinical research literatures on TMD published between 2013 and 2023 were collected through PubMed, China National Knowledge Infrastructure(CNKI), Wanfang Data, and VIP databases. CiteSpace 6.1.R6 software was utilized for visual analysis. Methods included keyword frequency statistics, co-occurrence analysis, clustering analysis, and timeline analysis to construct knowledge maps and identify research hotspots. RESULTS: Domestic research hotspots were primarily focused on pain management, acupuncture therapy, and tissue repair. In contrast, international researches heavily emphasized quality of life and non-invasive treatment approaches. Both domestic and international studies underscored the importance of interdisciplinary integration and the application of new technologies. Keywords such as "acupuncture treatment" have appeared relatively late in domestic researches but showed a clear trend, indicating an interest in the application of traditional medicine and emerging technologies. International researches had earlier focused on psychological factors and quality of life, and leaded in the application of new materials and technologies. CONCLUSIONS: Although there are differences in methods and focal points between domestic and international researches, there is a consistent focus on core issues such as pain management and the application of imaging technologies. Future researches should enhance attention to psychological factors and comprehensive health management, draw on international experience, explore the application of new materials and new technologies, and promote interdisciplinary collaboration to improve the diagnosis and treatment of temporomandibular joint disorders and the quality of life of patients. Reference | Related Articles | Metrics

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Progress in anatomy and clinical applications of buccal fat pad Niu Lingxiao, Dang Qingqing, Han Bing China Journal of Oral and Maxillofacial Surgery    2025, 23 (3): 302-306.   DOI: 10.19438/j.cjoms.2025.03.015 Abstract （364）      PDF （765KB）（828）       Knowledge map    Buccal fat padBFP) is an irregular mass of adipose tissue located within the deep facial recesses, with rich blood supply and encapsulated structure, which can isolate mesenchymal stem cells with multidirectional differentiation ability. The pedicled buccal fat pad flap is easy to prepare and has a high survival rate, and has been widely used in the repair of soft and hard tissue defects in the oral and maxillofacial region. The osteogenic ability of buccal fat pad derived mesenchymal stem cells has been demonstrated in vitro and has been used in clinical trials to repair jaw defects in recent years. In plastic surgery, the potential of both pedicled and free buccal fat pad flaps for improving facial contours continues to be explored. However, research on the long-term benefits for patients and the differences between these flaps and other pedicled skin flaps is limited. This review summarized the current advancements in the anatomy and some clinical applications of the buccal fat pad. Reference | Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2011, 9 (5): 420-429.   Abstract （400）      PDF （1422KB）（1349）       Knowledge map    Related Articles | Metrics

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Preliminary application of artificial intelligence in the pathological diagnosis of ameloblastoma QIAO Xin-wei, LI Mao, SHEN Ze-liang, ZHANG Lin-han, ZHENG Zhi-jian, TANG Ya-ling China Journal of Oral and Maxillofacial Surgery    2025, 23 (2): 122-128.   DOI: 10.19438/j.cjoms.2025.02.004 Abstract （296）      PDF （3026KB）（786）       Knowledge map    PURPOSE: To investigate the effect of artificial intelligence in the pathological diagnosis of ameloblastoma, and to preliminarily explore the value of artificial intelligence in the field of oral pathology. METHODS: The pathological images of 90 cases of ameloblastoma were used as the research objects, and the U-net-like structure neural network was constructed. The 90 H-E images of ameloblastoma were divided into a training set (72 images), a validation set (9 images) and a test set (9 images) for training and testing the model respectively. The mIoU and ROC curve were used to evaluate the ability of the U-net network model in the identification of ameloblastoma epithelium. RESULTS: The mIoU of negative area segmented by U-net model was 0.818 and the positive area was 0.846. The area under the ROC curve was 0.92. CONCLUSIONS: The U-net network model has a good segmentation for the positive and negative regions of ameloblastoma, and can distinguish between negative and positive sections. It can be preliminarily applied to the pathological diagnosis of ameloblastoma, and is expected to be gradually popularized in clinical practice after further validation with large samples. Reference | Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2006, 4 (1): 24-29.   Abstract （1274）      PDF （1106KB）（1099）       Knowledge map    Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2012, 10 (1): 29-37.   Abstract （319）      PDF （2459KB）（1192）       Knowledge map    Related Articles | Metrics

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Research progress of application of highly active bone substitute in materialsmaxillofacial bone tissue engineering YUAN Lu-han, CHU Chen, YUAN Rong-tao China Journal of Oral and Maxillofacial Surgery    2024, 22 (4): 394-399.   DOI: 10.19438/j.cjoms.2024.04.013 Abstract （427）      PDF （847KB）（922）       Knowledge map    Jaw defect is one of the most common diseases in oral and maxillofacial surgery. Severe jaw defect will cause different degrees of impact on the life and psychology of patients, and needs timely and effective repair. Due to the unique physiologic appearance and individual differences of jaw bones, the repair of jaw defects can't be completely dependent on standardized bone prosthetics. With the development and maturity of related manufacturing technologies, especially the unique advantages of 3D printing technology in bone defect repair, it has attracted wide attention of scholars both at home and abroad. The repair of bone defects is a complex and precise process. The ideal biomaterials for repairing bone defects should have good histocompatibility, suitable mechanical stress, suitable pore size, and solubility. This article briefly reviewed the existing high-active bone replacement materials for jaw tissue engineering. Reference | Related Articles | Metrics

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Advances of using sirolimus to treat venous malformations ZHENG Jia-wei China Journal of Oral and Maxillofacial Surgery    2020, 18 (6): 553-558.   DOI: 10.19438/j.cjoms.2020.06.001 Abstract （793）      PDF （1192KB）（1274）       Knowledge map    Venous malformations are the most common vascular malformations seen in the clinic, most of them are caused by gain-of-function somatic mutations in the genes encoding TIE2 or PI3K. Management of complicated or refractory lesions is still a great challenge for clinicians. mTOR inhibitor sirolimus is the first targeting agent for venous malformation treatment, its efficacy and safety have attracted much attention in recent years. This article reviewed the related problems and advances of using sirolimus to treat venous malformationsl. Reference | Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2017, 15 (2): 180-184.   DOI: 10.19438/j.cjoms.2017.02.017 Abstract （525）      PDF （2772KB）（1284）       Knowledge map    Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2010, 8 (3): 265-268.   Abstract （412）      PDF （762KB）（1326）       Knowledge map    Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2009, 7 (4): 290-297.   Abstract （561）      PDF （1203KB）（1427）       Knowledge map    Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2010, 8 (5): 406-410.   Abstract （411）      PDF （968KB）（1045）       Knowledge map    Related Articles | Metrics

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Evaluation of the therapeutic effect of polidocanol foam sclerotherapy in the treatment of head and neck venous malformations under medical and nursing collaboration ZHANG Fang, SHOU Wei-dong, LI Yan China Journal of Oral and Maxillofacial Surgery    2024, 22 (3): 274-278.   DOI: 10.19438/j.cjoms.2024.03.012 Abstract （291）      PDF （662KB）（692）       Knowledge map    PURPOSE: To explore the difference in therapeutic effect and injection frequency between polidocanol liquid injection and foam injection in the treatment of head and neck venous malformations under medical and nursing collaboration. METHODS: A total of 120 patients with head and neck venous malformations were treated with polidocanol sclerotherapy, of which 60 were treated with liquid injection and 60 with foam injection. All patients were classified into 4 groups respectively according to the types of venous malformations, namely, group A for typeⅠvenous malformation, group B for type Ⅱ venous malformation, group C for type Ⅲ venous malformation, and group D for type Ⅳ venous malformation. There were a total of 8 groups with 15 cases in each group. The therapeutic effect and the number of polidocanol injection were compared between each group. SPSS 23.0 software package was used for statistical analysis of the data. RESULTS: There was no significant difference in therapeutic effect between two injection methods in group A and group B, and the average number of injections was reduced by 0.5 with foam compared to liquid in group A and 1.2 in group B. The therapeutic effect of foam injection was better than that of liquid injection in group C and group D, but the difference was not statistically significant(P>0.05), and the average number of injections was reduced by 2.7 with foam compared to liquid method in group C and 3.9 in group D. CONCLUSIONS: In the treatment of head and neck venous malformations, the therapeutic effect of foam injection is better than liquid injection for venous malformations with fast drainage. The faster the drainage of venous malformations, the greater is the reduction in average number of treatments with foam injection in relation to that with liquid injection. The reduction in the number of treatments is conducive to reducing patients’ economic burden, time consumption and incidence of adverse reactions, and thus foam injection is worth promoting and applying in clinical practice. Reference | Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2006, 4 (6): 467-470.   Abstract （2029）      PDF （747KB）（1949）       Knowledge map    Related Articles | Metrics

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Exploration on construction of remote medical model for the diagnosis and treatment of dento-maxillofacial deformities Hu Lingling, Sun Yingjia, Jiang Peiling, Xie Zhijian China Journal of Oral and Maxillofacial Surgery    2025, 23 (3): 209-214.   DOI: 10.19438/j.cjoms.2025.03.001 Abstract （251）      PDF （871KB）（617）       Knowledge map    The orthodontic-orthognathic treatment is presently the predominant approach to rectifying dentomaxillofacial deformities. Nevertheless, the extended duration of the treatment cycle and the intricacy of the surgical procedures pose significant challenges for patients situated in various locations and restrict the accessibility of superior medical resources. To mitigate these limitations, this study introduced a remote medicine model for dentomaxillofacial deformities, predicated on the "internet + medicine" paradigm, and delineated its standardized procedures and quality control framework. This model adhered to the "1+1+N" paradigm, where a remote medical center served as the nucleus, and a dentomaxillofacial deformity consultation e-cloud platform functioned as the interconnecting nexus. This arrangement facilitated the effective amalgamation of superior medical resources, thereby augmenting treatment efficacy and enhancing patient experience. Additionally, this study focused on the detailed construction of a multifunctional dentomaxillofacial deformity consultation e-cloud platform and comprehensive quality control framework. This approach provided a scientific and effective solution for strengthening remote medical quality supervision, promoting the rational allocation of medical resources, and improving the service level of primary hospitals. Reference | Related Articles | Metrics