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China Journal of Oral and Maxillofacial Surgery    2012, 10 (5): 417-422.   Abstract （587）      PDF （1339KB）（13103）       Knowledge map    Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2005, 3 (2): 139-141.   Abstract （2052）      PDF （556KB）（813）       Knowledge map    Related Articles | Metrics

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A comparative study of the intraoperative and postoperative response of electric dental handpieces and turbo-pneumatic dental handpieces after mandibular third molar extraction ZHANG Hong-yu, SU Li-wen, SUN Huan, WU Yang China Journal of Oral and Maxillofacial Surgery    2024, 22 (5): 440-445.   DOI: 10.19438/j.cjoms.2024.05.005 Abstract （84）      PDF （1164KB）（62）       Knowledge map    PURPOSE: To compare the differences in intraoperative and postoperative response between electric dental handpieces and pneumatic turbine handpieces in the extraction of impacted mandibular third molars. METHODS: Using a randomized grouped self-crossover control design method, 50 patients who underwent extraction of bilateral mandibular proximal-medial impacted wisdom teeth were selected, and the right and left mandibular impacted wisdom teeth were extracted with dental electric handpieces and pneumatic turbine handpieces, respectively. Intraoperative surgery time, pain degree, and complication rate were collected, and postoperative pain level, swelling level, and mouth opening restriction were recorded on the 1st, 3rd, and 7th days after extraction, and the data of the two groups were compared. SPSS 19.0 software package was used for data analysis. RESULTS: Compared with the turbo-pneumatic dental handpieces group, the electric dental handpieces group had no significant difference in operation time and postoperative complications, but with significant advantages in reducing postoperative pain, postoperative swelling reaction, and accelerating the recovery of patients' mouth opening. CONCLUSIONS: Electric dental handpieces has more advantages than turbo-pneumatic dental handpieces in the extraction of mandibular impacted wisdom teeth, which is worthy of clinical application. Reference | Related Articles | Metrics

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Expert consensus on diagnosis and clinical management of medication-related osteonecrosis of the jaw HE Yue, CHEN Heng, AN Jin-gang, GUO Yu-xing, PAN Jian, TIAN Lei, LIU Bing, HOU Jin-song, LI Jin-song, JIANG Can-hua, LI Meng-yu, TIAN Zhen, XU Jie, ZHU Ling, SUN Chang-fu, ZHI Ke-qian, QU Qing, ZONG Chun-lin, SUN Jing-jing, ZHANG Zhi-yuan China Journal of Oral and Maxillofacial Surgery    2023, 21 (4): 313-325.   DOI: 10.19438/j.cjoms.2023.04.001 Abstract （1169）      PDF （2051KB）（1409）       Knowledge map    Medication-related osteonecrosis of the jaw(MRONJ) is a complication caused by the application of anti-resorptive medications, angiogenesis inhibitors, hormones and other medications for the treatment of some systemic diseases. The clinical symptoms include swelling, pain, masticatory disorders, persistent fistula, bone exposure and even pathological fracture, which seriously affect the patients' quality of life. Domestically, there is a lack of consensus or guidelines on classification, staging and treatment of MRONJ, and different institutions make diagnosis and treatment plans empirically. In order to unify and standardize the diagnosis and treatment of MRONJ and improve the prognosis, an expert panel of MRONJ research from 12 famous domestic medical colleges and affiliated hospitals convened a meeting to discuss the diagnosis and treatment opinions of MRONJ. Meanwhile, consensus recommendations were also revised with a comprehensive literature review of the previous treatment experiences and research findings. Finally, this expert consensus was finished for clinical references. Reference | Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2007, 5 (2): 83-90.   Abstract （2078）      PDF （1354KB）（4384）       Knowledge map    Related Articles | Metrics

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Evaluation of the effect of nitrous oxide combined with local anesthesia in extraction of impacted teeth KANG Cheng, ZHU Ting, HAN Shuang, LOU Yi-yi China Journal of Oral and Maxillofacial Surgery    2024, 22 (2): 165-169.   DOI: 10.19438/j.cjoms.2024.02.009 Abstract （142）      PDF （575KB）（85）       Knowledge map    PURPOSE: To evaluate the effect of nitrous oxide combined with local anesthesia in the extraction of impacted teeth and its effect on patients' anxiety. METHODS: A total of 188 patients undergoing impacted tooth extraction in Shaoxing Stomatological Hospital from December 2021 to December 2022 were selected and randomly divided into experimental group and control group, with 94 patients in each group. The control group was treated under local anesthesia, and the experimental group was treated under local anesthesia combined with nitrous oxide. The heart rate(HR), Ramsay sedation score and pain VAS score during local anesthesia, tooth extraction and 5 min after tooth extraction were compared between the 2 groups. The Modified Dental Anxiety Scale(MDAS) scores and the comfort level of patients after treatment were compared between the two groups. SPSS 22.0 software package was used for data analysis. RESULTS: With the change of treatment time, HR in both groups showed a trend of increasing at first and then decreasing (P<0.05). HR in the experimental group was significantly lower than that in the control group during local anesthesia, tooth extraction and 5 minutes after tooth extraction(P<0.05). The MDAS score of the experimental group was significantly lower than that of the control group(P<0.05). Ramsay sedation scores in both groups decreased at first and then increased with the change of treatment time(P<0.05). The Ramsay sedation score of the experimental group was significantly higher than that of the control group during local anesthesia, tooth extraction and 5 minutes after tooth extraction (P<0.05). With the change of treatment time, the VAS score of the two groups gradually increased (P<0.05). The VAS score of the experimental group was significantly lower than that of the control group during local anesthesia, tooth extraction and 5 min after tooth extraction(P<0.05). The comfort of the experimental group was significantly better than that of the control group(P<0.05). CONCLUSIONS: Nitrous oxide combined with local anesthesia for extraction of impacted teeth can reduce HR, improve patients' anxiety and sedation, reduce pain and improve comfort. Reference | Related Articles | Metrics

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Application of whiskers in bone tissue engineering LI Li-li, LIU Xiao-ming, ZHANG Yuan, WU Feng, GE Xue-jun, TIAN Zhi-qiang China Journal of Oral and Maxillofacial Surgery    2024, 22 (5): 499-504.   DOI: 10.19438/j.cjoms.2024.05.015 Abstract （41）      PDF （1540KB）（34）       Knowledge map    Whiskers are micro-nano sized short fibers grown from high-purity single crystals, and their excellent physicochemical and biological properties show great potential for application in bone tissue engineering BTE. In this paper, the classification, growth mechanism, preparation methods and characteristics of whiskers were reviewed, and their application in BTE was discussed. The research direction and application prospect of whisker in bone tissue engineering were also discussed. Reference | Related Articles | Metrics

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Application of forearm fusiform flap in repairing medium and small defects in oral and maxillofacial region LI Xiao-gao, DENG Hua, HE Qian-ting China Journal of Oral and Maxillofacial Surgery    2024, 22 (5): 473-477.   DOI: 10.19438/j.cjoms.2024.05.011 Abstract （49）      PDF （1574KB）（32）       Knowledge map    PURPOSE: To improve the traditional forearm flap and explore the clinical method of directly closing the donor area of the forearm. METHODS: Twenty-five cases of oral and maxillofacial malignant tumor or maxillofacial defects were collected and reconstructed with forearm fusiform flap. For maxillofacial medium defect, fusiform flap could be folded and sutured in half, and the donor site of the forearm could be closed directly after flap havesting. RESULTS: Among 25 cases of forearm fusiform flaps, only 1 case had flap necrosis after operation, and all the others survived. The donor area of the forearm did not require skin grafting, and the postoperative healing was normal and the scar was small. The average satisfaction score of the subjective questionnaire answered by patients was 8.56. No significant restriction of hand movement was observed after surgery in all cases. Of the 25 patients, 24 patients were satisfied with the surgery and 1 patient was dissatisfied, with a satisfaction rate of 96%. CONCLUSIONS: The application of forearm fusiform flap has good appearance and function recovery, and the preparation of which is simple, safe and reliable. After surgery, the donor area of the forearm can be directly co-sutured and closed, without skin grafting, implying little trauma, normal movement and function of the hand and wrist after surgery, small postoperative scars, high patient satisfaction, and worthy of clinical application. Reference | Related Articles | Metrics

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Combined mandibular distraction osteogenesis and surgical-assisted maxillary rapid expansion to treat patients with severe skeletal Class Ⅱ malocclusion and narrow maxillary dental arch secondary to bilateral idiopathic condylar resorption XUE Xiao-chen, LI Biao, SUN Hao, LIU Zhi-xu, ZHU Min, WANG Xu-dong China Journal of Oral and Maxillofacial Surgery    2017, 15 (2): 165-170.   DOI: 10.19438/j.cjoms.2017.02.014 Abstract （409）      PDF （4262KB）（461）       Knowledge map    PURPOSE : To introduce a treatment approach for severe skeletal Class Ⅱ malocclusion and narrow maxillary dental arch secondary to bilateral idiopathic condylar resorption. METHODS : Six cases with severe skeletal Class Ⅱ malocclusion and narrow maxillary dental arch secondary to bilateral ICR were included in this study, and they were treated with mandibular distraction osteogenesis and surgery-assisted rapid maxillary expansion. The path and magnitude of distraction were simulated using computer-aided surgical simulation technique. The outcome of distraction, the necessity of secondary surgery and stability were evaluated through 4 aspects: profile, occlusion, temporomandibular joint (TMJ) condition and sleep respiratory function at T0, T1, T2 and T3. CT, TMJ questionnaire, MRI of TMJ and PSG were acquired at this 4 time points. RESULTS : Three cases finished all treatments. The distraction magnitudes were 13.0mm, 6.7mm and 8.1mm, respectively. Chin advanced in genioplasity for 7.2 mm, 0 and 11 mm, respectively. Maxillary dental arch widened 5.3mm, 7.3 mm and 4.9 mm, respectively. Polysomnography data revealed that severe obstructive sleep apnea hypopnea syndrome was cured. Skeletal malocclusion was effectively corrected in all 3 cases and there was no obvious relapse during remodeling phase. TMJ condition remained stable. CONCLUSION S: Mandibular DO and SARME approach can effectively correct severe skeletal Class II malocclusion and narrow maxillary dental arch secondary to bilateral ICR. Using CASS technology to simulate the magnitude and path of distraction, the outcomes are more stable and predictable. Reference | Related Articles | Metrics

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Chinese experts consensus on the use of oral propranolol for treatment of infantile hemangiomas(version 2022) ZHENG Jia-wei, WANG Xu-kai, QIN Zhong-ping, FAN Xin-dong, LI Kai, YANG Yao-wu, HUO Ran, LIU Shao-hua, ZHAO Ji-hong, WANG Xiao-yong, ZHOU De-kai, LIU Xue-jian China Journal of Oral and Maxillofacial Surgery    2022, 20 (4): 313-319.   DOI: 10.19438/j.cjoms.2022.04.001 Abstract （1305）      PDF （1061KB）（1201）       Knowledge map    Since 2008, propranolol has become the first-line treatment for infantile hemangiomas. Many researches have been reported on its treatment mechanism both at home and abroad, and several expert consensus or clinical practice guidelines have been formulated and published. In recent years, with the continuous accumulation of clinical experience, increasing number of basic research works, and deepening understanding of the pathogenesis of hemangioma and the mechanism of action of propranolol, it is necessary to update the expert consensus to be more consistent with clinical practice, in order to guide medication and management, provide scientific norms for the clinical use of propranolol in the treatment of infantile hemangiomas. This updated version mainly simplified the process of clinical examination, medication, and monitoring, making it more convenient and operable. Reference | Related Articles | Metrics

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Effects of platelet-derived growth factor D on migration and odontogenic differentiation of human dental pulp stem cells LIAO Yin-xiu, ZHANG Mao-lin, ZOU Duo-hong China Journal of Oral and Maxillofacial Surgery    2024, 22 (5): 417-423.   DOI: 10.19438/j.cjoms.2024.05.001 Abstract （79）      PDF （2254KB）（33）       Knowledge map    PURPOSE: To investigate the effect of human recombinant platelet-derived growth factor D(PDGFD) on migration and odontogenic differentiation of human dental pulp stem cells(hDPSCs). METHODS: Primary hDPSCs were isolated by enzymolysis and cultured. The expression of molecular markers on the surface of cultured mesenchymal stem cells was identified by flow cytometry. Three lines of hDPSCs were induced and identified by corresponding staining to characterize their potential for multidirectional differentiation. The effect of PDGFD on the migration ability of hDPSCs was investigated by cell scratching test. RT-PCR and Western blotting were used to detect the effects of PDGFD on the expression of odontoblast-related mRNA and proteins in hDPSCs. Alkaline phosphatase(ALP) and alizarin red staining(ARS) were used to detect the effect of PDGFD on the mineralization of hDPSCs. SPSS 26.0 software package was used for data analysis. RESULTS: Morphological analysis, flow cytometry identification and three-line differentiation showed that the isolated cells were consistent with the characteristics of hDPSCs and had multidirectional differentiation potentials. The results of cell scratching test showed that only 50 ng/mL PDGFD at 12 h had an effect on the migration ability of hDPSCs, but both 10 and 50 ng/mL PDGFD at 24 h had an effect on the migration ability of hDPSCs. PCR results showed that PDGFD of 10 and 50 ng/mL could promote the odontogenic differentiation of hDPSCs, and PDGFD of 50 ng/mL had a more significant effect on the odontogenic differentiation of hDPSCs. The results of Western blotting, ALP and ARS were the same as those of PCR. CONCLUSIONS: hDPSCs with typical mesenchymal stem cell phenotype and multidirectional differentiation potential were successfully isolated and cultured. PDGFD at the concentration of 10 ng/mL and 50 ng/mL can promote the migration and odontogenic differentiation of human dental pulp stem cells, and the promotion effect of PDGFD at the concentration of 50 ng/mL is more significant. Reference | Related Articles | Metrics

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Reconstruction of large head and neck defects with extended vertical lower trapezius island myocutaneous flap CHEN Wei-liang China Journal of Oral and Maxillofacial Surgery    2023, 21 (1): 1-10.   DOI: 10.19438/j.cjoms.2023.01.001 Abstract （257）      PDF （3397KB）（145）       Knowledge map    The extended vertical lower trapezius island myocutaneous flap (eVLTIMF) supplied by the transverse cervical artery is safe and reliable for reconstruction of large head and neck defects. The flap is easy to harvest, and the survival rate is high. The donor area is hidden, which can be closed and sutured directly, with fewer complications and less impact on shoulder movement. It can also be made into folded flaps, combined with other pedicled flaps or combined scapular osteomyocutaneous flap was used to repair huge through-and-through defect or defects of the mandible. It is believed that eVLTIMF can play an important role in the repair of large head and neck defects, especially in the repair and reconstruction of huge defects flowing salvage surgery for advanced recurrent head and neck tumors. The clinical applied anatomy of the trapezius muscle, harvesting eVLTIMF flap and application in the reconstruction of craniomaxillofacial, oral maxillofacial and maxillocervical defects were described in this paper. Reference | Related Articles | Metrics

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Clinical analysis of 7 cases of 125I radioactive seed implant for recurrent palatal minor salivary gland malignancy WANG Shou-peng, LI Sheng-nan, CHEN Lin, GE Liang-yu, LI Meng, MENG Jian China Journal of Oral and Maxillofacial Surgery    2023, 21 (5): 497-501.   DOI: 10.19438/j.cjoms.2023.05.012 Abstract （200）      PDF （969KB）（76）       Knowledge map    PURPOSE: To explore the effect of 125I radioactive seed implant for recurrent palatal minor salivary gland malignancy. METHODS: Seven patients with palatal minor salivary gland malignancy who relapsed after surgery and radiotherapy and refused secondary surgery were treated with iodine 125 radioactive seed implant. According to the treatment planning system, iodine 125 radioactive seeds were implanted into the target area during surgery. Prosthesis-like applicators with radioactive seeds were wore according to the patients' conditions after surgery. The patients were followed up at regular intervals after operation and the treatment efficacy and side effects were evaluated. RESULTS: Tumor recurrence was not found in any patient treated after 17 to 62 months of follow-up. All patients did not show obvious radiation-related complications of grade 3 or more. During the follow-up, 1 elderly patient died of systemic disease and temporary mild adverse effects were noted in 3 patients. CONCLUSIONS: For patients with recurrent palatal minor salivary gland malignancy, iodine 125 radioactive seed implant has achieved good short-term efficacy and is a safe, minimally invasive, and effective treatment. Reference | Related Articles | Metrics

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Effectiveness of non-pharmacological interventions in preventing postoperative delirium in patients with oral cancer: a systematic review WANG Shuai, HE Xing-fang, WANG Yun-jie, WU Wei-qin, HUANG Qiu-yu China Journal of Oral and Maxillofacial Surgery    2024, 22 (3): 279-286.   DOI: 10.19438/j.cjoms.2024.03.013 Abstract （113）      PDF （1357KB）（59）       Knowledge map    PURPOSE: To evaluate the effect of non-pharmacological interventions in preventing postoperative delirium in patients with oral cancer, summarize the main components of non-pharmacological interventions in patients with oral cancer, and aid clinical decision-making. METHODS: The literatures on the prevention of postoperative delirium by non-pharmacological interventions in patients with oral cancer were searched in 8 Chinese and English electronic databases(Embase, PubMed, Web of Science, The Cochrane Library, CNKI, Wanfang database, VIP, China Biomedical Literature Service System). The search was conducted from inception to October 2023. The primary outcomes were the incidence and duration of postoperative delirium. Cochrane risk of bias assessment tool was used to evaluate the randomized controlled trials. Review manager 5.3 was used for meta-analysis. Heterogeneity was examined by sensitivity analysis, and subgroup analysis was performed. RESULTS: Five randomized controlled trials with 849 participants were included. The main components of multicomponent non-pharmacological interventions included enhancement of relevant training for healthcare professionals, intensive preoperative education and familiarity with ICU environment, postoperative sleep management, pain management, music therapy, cognitive stimulation, and full participation of family members. Meta-analysis showed that non-pharmacologic intervention reduced the overall incidence of postoperative delirium in oral cancer patients[RR=0.41, 95%CI:(0.31,0.54), I2=0%], decreased the duration of postoperative delirium [MD=-38.51, 95%CI:(-46.25,-30.77),I2=88%]. Subgroup analysis showed that non-pharmacologic intervention reduced the incidence of delirium on the first postoperative day[RR=0.37, 95%CI:(0.20,0.70), I2=0%], but had non-significant improvement in the incidence of delirium on the second and third postoperative day. Non-pharmacological interventions improved assessment of postoperative agitated sedation and quality of recovery. CONCLUSIONS: The current evidence shows that non-pharmacological interventions can reduce the overall incidence and duration of postoperative delirium, and improve agitated sedation and quality of recovery in oral cancer patients. Reference | Related Articles | Metrics

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China Journal of Oral and Maxillofacial Surgery    2011, 9 (6): 442-449.   Abstract （193）      PDF （2132KB）（259）       Knowledge map    Related Articles | Metrics

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Outcomes of maxillary reconstruction after total maxillectomy using 3-D computer-assisted fabricated individual titanium mesh technique in 6 cases LIU Bing-yao, CAO Gang, DONG Zhen, CHEN Wei, Xu Jin-ke, ZHANG Sen-lin China Journal of Oral and Maxillofacial Surgery    2016, 14 (6): 562-566.   Abstract （400）   HTML （1）    PDF （2040KB）（291）       Knowledge map    PURPOSE: To evaluate the usefulness and clinical outcomes of reconstruction of maxillary class Ⅲ defect using 3-D computer-assisted fabricated individual titanium mesh technique. METHODS: This retrospective study included 6 patients with maxillary class Ⅲ defect after total maxillectomy performed from May 2014 to August 2015. A 3-dimensional individualized stereo maxillary model based on mirror images of the unaffected maxilla was obtained to fabricate an anatomically adapted titanium mesh using computer-assisted design and manufacturing. The individual titanium mesh was inserted into the maxillary class Ⅲ defect after total maxillectomy. The incidence of postoperative complications was evaluated and the postoperative globe projection and orbital volume were measured. SPSS 17.0 software package was used for statistical analysis. RESULTS: All patients were satisfied with their postoperative facial symmetry and did not develop diplopia or endophthalmos. The postoperative orbital volume was 26.53±0.73 mL on the affected side and 26.63±0.66 mL on the unaffected side (P=0.65), and the globe projection was 16.15±0.37 mm and 16.67±0.65 mm, respectively (P=0.07). Titanium mesh exposure was observed in 1 patient and mild limitation of mouth opening was observed in 2 patients who underwent postoperative radiotherapy. CONCLUSIONS: Reconstruction of maxillary class Ⅲ defect with individual titanium mesh fabricated using computer-assisted techniques can achieve successful clinical outcomes, preserving orbital volume and globe projection. Reference | Related Articles | Metrics

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Comparison of 2 treatment methods for distal alveolar bone resorption of mandibular second molars QI Qing-long, YU Hong-mei, PAN Yang China Journal of Oral and Maxillofacial Surgery    2024, 22 (5): 463-467.   DOI: 10.19438/j.cjoms.2024.05.009 Abstract （51）      PDF （761KB）（29）       Knowledge map    PURPOSE: To investigate the effect of photodynamic therapy(PDT) combined with scaling and root planing and only scaling and root planing in the management of distal alveolar bone resorption of mandibular second molars. METHODS: A total of 82 mandibular second molars in 57 patients whose mandibular third molars were mesially impacted and distal alveolar bone were resorbed were randomly divided into experimental group and control group. In the experimental group, the distal surface of the distal root of the mandibular second molar received scaling and root planing combined with PDT after mandibular third molar was extracted, while the control group only received scaling and root planing. The observation lasted for 1 year, the tooth mobility, probing depth (PD), clinical attachment level (CAL) and the osseous defect depth(ODD) were examined and recorded. The data were compared and analyzed using SPSS 25.0 software package. RESULTS: There was no significant difference in tooth mobility of mandibular second molar between the two groups at 1 week, 3 months, 6 months and 12 months after surgery (P>0.05). PD and CAL in the experimental group were significantly improved at 3 months, 6 months(P<0.05), while the clinical outcome changes at 1 week and 12 months after surgery between the 2 groups were not significant(P>0.05). There was no significant difference in ODD between the two groups 12 months after surgery(P>0.05). CONCLUSIONS: In the short term (< 6 months), PDT combined with scaling and root planing on the distal surface of the mandibular second molar distal root is more effective than scaling and root planing alone, when the mandibular third molar is mesially impacted and the distal alveolar bone of mandibular second molar is resorbed. Reference | Related Articles | Metrics

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Surgical excision of sialoblastoma in the parotid gland in newborn WANG You-yuan, ZHANG Da-ming, FAN Song, WANG Lei, HUANG Zhi-quan, YANG Zhao-hui, LI Jin-song, CHEN Wei-liang China Journal of Oral and Maxillofacial Surgery    2015, 13 (2): 167-170.   Abstract （399）   HTML （0）    PDF （898KB）（299）       Knowledge map    PURPOSE: To evaluate the outcome of surgical excision of sialoblastoma in the parotid gland in newborn. METHODS: This was a retrospective review of 3 pediatric patients with sialoblastoma in the parotid gland undergoing surgical resection. All patients were newborn boys. The lesions ranged from 5 cm×5 cm to 8 cm×5 cm in size. The tumor was resected en bloc, and the facial nerve was preserved. RESULTS: No complications occurred. The mean follow-up period was 34 months; no patients had recurrent lesions. CONCLUSIONS: Surgical resection of sialoblastoma in the parotid gland in newborn is efficient and safe. Reference | Related Articles | Metrics

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CT and MRI features of 29 patients with inflammatory myofibroblastic tumor in the head and neck WANG Can, ZHANG Chun-ye, TAO Xiao-feng, WANG Bo-cheng, ZHU Ling China Journal of Oral and Maxillofacial Surgery    2022, 20 (5): 494-499.   DOI: 10.19438/j.cjoms.2022.05.014 Abstract （319）      PDF （1266KB）（254）       Knowledge map    PURPOSE: To analyze the imaging features of inflammatory myofibroblastic tumor (IMT) in the head and neck through CT and MRI, and improve the correct diagnosis of the tumor before operation. METHODS: From January 2012 to December 2018, a total of 29 patients with IMT in the head and neck who were initially diagnosed and confirmed by postoperative pathology were retrospectively collected in Shanghai Ninth People′s Hospital, Shanghai Jiao Tong University School of Medicine. Their preoperative CT and MRI findings were analyzed. RESULTS: Of the 29 patients with IMT in the head and neck, 67.0%(20/29) were misdiagnosed as malignant tumors before operation. The imaging findings of IMT in the head and neck were varied, 7 cases were identified as localized soft tissue mass, 12 cases with soft tissue mass and adjacent bone destruction (5 in the infratemporal fossa, 6 in the maxillary sinus, 1 in the wide maxillofacial region), and 10 cases with intraosseous mass (5 in the maxilla, 4 in the mandible, 1 in the temporal bone). 89.7%（26/29）were presented as uneven margins. 75.9%（22/29）showed bone destruction, 34.5%（10/29）with hyperostosis and remodeling. Eight cases had a peri-neural infiltration(6 cases occurred in the infratemporal fossa, with 4 cases suffered from invasion through foramen rotundum and foramen ovale, 2 cases invaded the optic canal, 2 cases occurred in the mandible and invaded the mandibular nerve canal). The IMT in the head and neck showed isodense or slightly hypodense, with no calcification on CT plain scan, and moderate/marked enhancement after contrast-enhanced scanning. MRI showed 9 cases with isointense or hypointense on T1 weighted images, 7 cases with hypointense on T2 weighted images, 9 cases with hyperintense on DWI. The range of ADC value of IMT (9 cases) was about (0.6-1.0)×10-3mm2/s. The TIC type of 7 cases was typeⅠ, and 2 cases with typeⅡ. There were no cervical lymph node metastasis and distant metastasis. CONCLUSIONS: IMT in the head and neck has certain imaging characteristics that are commonly found in malignant tumors. However, IMT in the head and neck can erode and remodel bone, with striped hypointense on T2 weighted image, mostly type I, few cervical lymph node metastasis and distant metastasis. CT, MRI and functional examination can reflect the tissue composition of the lesion to a certain extent, and provide an important basis for the correct preoperative diagnosis. Reference | Related Articles | Metrics

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Expression of ferritin heavy chain 1 in head and neck squamous cell carcinoma and its effect on proliferation, migration and invasion of oral squamous cell carcinoma LIU Heng, LI Yong-di, YIN Xin-hai, DUAN Xiao-feng China Journal of Oral and Maxillofacial Surgery    2023, 21 (6): 529-537.   DOI: 10.19438/j.cjoms.2023.06.001 Abstract （185）      PDF （1297KB）（114）       Knowledge map    PURPOSE: To clarify the expression of ferritin heavy chain 1(FTH1) in head and neck squamous cell carcinoma(HNSCC), oral squamous cell carcinoma(OSCC) and adjacent tissues, and to analyze the relationship between FTH1 expression and prognosis and clinicopathological features of patients with HNSCC and OSCC. To explore its effect on OSCC in CLA-27 cell line, and to provide a new strategy for molecular detection and treatment of OSCC. METHODS: The transcriptome data samples and clinical sample information of HNSCC were downloaded from The Cancer Genome Atlas ( TCGA). R software was used to study the expression of FTH1 in HNSCC tissues and normal tissues. The relationship between the expression of FTH1 and the clinicopathological features of patients with HNSCC was analyzed. The cancer and adjacent tissue samples of 40 patients with OSCC were collected, and the expression of FTH1 in the samples was detected by RT-qPCR to clarify the differential expression of FTH1 in OSCC tissues, and the correlation analysis was performed in combination with the clinicopathological features of the patients. Human normal oral mucosal epithelial cell (OMECs) and OSCC CAL-27 cells were cultured to further detect and clarify the expression of FTH1 in oral squamous cell carcinoma cells. The effects of FTH1 on the proliferation, invasion and migration of CAL-27 were studied in vitro. The effect of FTH1 on the proliferation of CAL-27 was observed by CCK-8 assay. The effect of FTH1 on the migration and invasion of CAL-27 was detected by scratch healing assay and Transwell chamber assay. Matrigel Transwell assay was used to detect the effect of FTH1 on the invasion of CAL-27. RESULTS: The results of TCGA database showed that the expression of FTH1 in HNSCC tissues was significantly higher than that in adjacent tissues (P<0.001),its expression was associated with poor pathological features and poor prognosis (P<0.05). FTH1 was significantly higher in OSCC tissues than in adjacent tissues (P<0.001). The expression of FTH1 was correlated with cervical lymph node metastasis, pathological grade and clinical stage (P<0.05). The expression of FTH1 in CAL-27 was significantly higher than that in OMECs (P<0.001). CCK-8 results showed that knockdown of FTH1 inhibited the proliferation of CAL-27(P<0.05). The results of scratch healing experiment and Transwell chamber experiment showed that knockdown of FTH1 could inhibit the migration and invasion of CAL-27(P<0.05). CONCLUSIONS: FTH1 gene expression is up-regulated in HNSCC and OSCC, and its expression is related to poor pathological features and poor prognosis. At the same time, knockdown of FTH1 gene will inhibit the proliferation, migration and invasion of CAL-27, which may play a role in promoting cancer in OSCC. Reference | Related Articles | Metrics