China Journal of Oral and Maxillofacial Surgery ›› 2022, Vol. 20 ›› Issue (4): 378-383.doi: 10.19438/j.cjoms.2022.04.011

• Original Articles • Previous Articles     Next Articles

Survival analysis of 336 patients with HPV-mediated and non-mediated oropharyngeal squamous cell carcinoma

LI Heng-yong1,2, YANG Song1,2, ZHOU Kai1,2, KONG Yu3, LI Jie-ying1,2, LI Gui-zhong1,2, GE Sheng-you1,2, YANG Xiao-chen1,2, FENG Yuan-yong1,2, SONG Kai1,2, SHANG Wei1,2   

  1. 1. Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Qingdao University. Qingdao 266003;
    2. College of Stomatology, Qingdao University. Qingdao 266003;
    3. Department of Stomatology, Qingdao Third People's Hospital. Qingdao 266041, Shandong Province, China
  • Received:2022-01-09 Revised:2022-04-23 Online:2022-07-20 Published:2022-07-20

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Abstract: PURPOSE: To analyze and compare the difference in survival and prognosis of patients with HPV-mediated and non-mediated oropharyngeal squamous cell carcinoma(OPSCC) in different stages of new and old TNM, so as to provide clinical basis for the treatment strategy and prognosis evaluation of OPSCC. METHODS: Clinical data of primary OPSCC patients treated at Affiliated Hospital of Qingdao University between January 2010 and December 2016 were collected. Immunohistochemical staining of the pathological specimens was used to detect p16 expression level. Patients' survival information was evaluated using version 7, 8 edition of TNM staging system for tumor staging. The effects of different stages of HPV-mediated and non-mediated OPSCC on survival and prognosis were analyzed and compared. SPSS 25.0 software package was used for data analysis. RESULTS: Among 336 OPSCC patients, one hundred and one patients (30.1%) were HPV-mediated OPSCC. The 5-year survival rate of HPV-mediated OPSCC patients was 47.5% (48/101), and the median survival time was 58 months. The 5-year survival rate of patients with non-mediated OPSCC was 34.0% (80/235), with a median survival time of 37 months. In HPV-mediated OPSCC patients with version 8 TNM stage and version 7 TNM stage, the overall rate of degradation was 77.2% (78/101), 100% (69/69) in patients with advanced stage, and 69.6%(48/69) in patients with advanced stage degraded to early stage. CONCLUSIONS: The survival rate and median survival time of HPV-mediated OPSCC patients are significantly better than those of non-mediated OPSCC patients. The OPSCC stage in the 8th edition of TNM staging manual is more consistent with clinical reality than that in the 7th edition, and the prognosis stratification is more clear, which can better guide clinical decision-making.

Key words: Oropharyngeal squamous cell carcinoma, HPV, AJCC 8, TNM staging, Survival rate

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