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20 May 2017, Volume 15 Issue 3 Previous Issue    Next Issue

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Effect of β-NGF on bone formation and bone remodeling during healing of bone defect LU Meng, ZHUO Li-li, MAO Chuan-qing, WANG Jin, WANG Cheng-yong, CHEN Wei-hui. 2017, 15 (3):  193-197.  doi: 10.19438/j.cjoms.2017.03.001 Abstract ( 338 )   PDF (1247KB) ( 669 )   PURPOSE: Standard rat skull critical bone defects were made and locally continuous infusion of β-NGF animal model was conducted. The effect of β-NGF on bone formation and bone remodeling was evaluated. METHODS: Two 5 mm diameter bone defects were created on the parietal bone of SD rats, the right side was given 10 μg β-NGF PBS solution(experimental group) and the left side was only given PBS solution(control group) via osmotic pump for 7 days. New bone formation was evaluated using H-E staining and Gomori modified trichrome staining. New bone formation in the bone defect of AOI was measured with Image-pro Plus 6.0 software and the data were analyzed using SPSS 19.0 software package. RESULTS: H-E staining showed the new bone formation on the both sides. The results of Gomori modified trichrome staining showed significantly increased new bone formation after application of β-NGF at 21 d and 28 d. The quality of mature bone was significantly higher in the experiment group compared with the control group at 28 d(P<0.05). CONCLUSIONS: Local application of β-NGF during bone healing can promote new bone formation and bone remodeling. References | Related Articles | Metrics

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Influence of temperature on the stability of lauromacrogol foam for sclerotherapy YUE Lin-lin, WANG Yi-fei, DONG Jian-yong, CHEN An-wei, WANG Tao, LIU Shao-hua. 2017, 15 (3):  198-201.  doi: 10.19438/j.cjoms.2017.03.002 Abstract ( 464 )   PDF (435KB) ( 360 )   PURPOSE: To investigate the influence of temperature on the stability of lauromacrogol foam for sclerotherapy. METHODS: Tessari method was used to generate foam. In preconditioning groups: two syringes were connected by a three-way stopcock, and one syringe was filled with lauromacrogol injection and the other with air. They were pre-cooled or pre-heated at different temperatures (5, 15, 25, 35, 45, 55 and 65℃) for 10 minutes. Then the foam was obtained and the foam half-time (FHT) was tested in ambient temperature (T=25℃). In postconditioning groups: the foam was produced in ambient temperature (T=25℃), while FHT was tested at different temperatures (5, 15, 25, 35, 45, 55 and 65℃). The pearson correlation test was used to analyze the effect of temperature on foam stability. Independent-samples t test was used to compare the foam half-time of foam in postconditioning group and preconditioning group using SPSS 19.0 software package. RESULTS: There was a negative relation between the temperature and FHT in both preconditioning group and postconditioning group (preconditioning group: r=-0.984, P＜0.05; postconditioning group: r=-0.969, P＜0.05). There was significant difference of FHT between the two different temperature handling groups, except when the temperature was 25℃ (P>0.05). FHT in preconditioning group was longer than postconditioning group when the temperature was more than 25℃ (P＜0.05). By contrast, FHT in preconditioning group was shorter than in postconditioning group when the temperature was less than 25℃ (P＜0.05). CONCLUSIONS: Temperature was an important factor to affect the stability of sclerosing foam, and the impact was different before or after the foam being produced. References | Related Articles | Metrics

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Repair of critical sized mandibular bone defect with nHAC / PLA scaffold combing with rabbit adipose tissue derived mesenchymal stem cells transfected with BMP-9 / EPO gene ZHANG Guang-de, JIN Xia, LI Rong-liang, YANG Shi-mao, GUO Yan-wei, FANG Dian-ji. 2017, 15 (3):  202-208.  doi: 10.19438/j.cjoms.2017.03.003 Abstract ( 443 )   PDF (2209KB) ( 274 )   PURPOSE: To investigate the effect of recombinant adenovirus-mediated bone morphogenetic protein-9 (BMP-9) and erythropoietin (EPO) genes co-transfection combined with scaffold materials of nHAC/PLA on osteogenesis in vivo. METHODS: ADSCs were isolated with enzyme digestion and adherence method. The recombinant adenovirus-mediated bone morphogenetic protein-9 (BMP-9), erythropoietin (EPO), and BMP-9/EPO genes co-transfection were constructed respectively, and then ADSCs were transfected with recombinant adenovirus. The expression of cell fluorescence was observed under a fluorescence microscope at 14 days, and the transfection efficiency was calculated. Western blot was used to detect the expressions of BMP-9 and EPO proteins at 14 days. 50 New Zealand rabbits were selected, and bone defect was made in bilateral mandibles respectively, and then randomly divided into 5 groups. ADSCs/nHAC/PLA in each group was transplanted into the bilateral bone defects. Rabbits of each group were killed at 4, 8 and 12 weeks after operation respectively, and the healing of the defects was detected by X-ray, histological and scanning electron microscopy (SEM) examination. Statistical analysis was performed using SPSS 17.0 software package. RESULTS: Fluorescence microscope showed that BMP-9 and EPO, BMP-9/EPO recombinant adenovirus could stably transfected ADSCs, with a transfection efficiency of 80%-93%. Gene and protein of BMP-9, EPO as well as BMP-9/EPO in ADSCs could be stably expressed. Osteogenesis in BMP-9/EPO/nHAC/PLA group was significantly better than other groups. SEM indicated that the interface between materials and bone defect was combined closely in BMP-9/EPO/nHAC/PLA group. CONCLUSIONS: Recombinant adenovirus-mediated BMP-9, EPO and BMP-9/EPO genes can transfect ADSCs, which can stably express in ADSCs. ADSCs transfected with recombinant adenovirus-mediated BMP-9/EPO gene combined with nHAC/PLA could improve bone generation in mandibular defect, and provide a possible option for bone tissue engineering. References | Related Articles | Metrics

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Effect and underlying mechanism of miR-21 on proliferation and apoptosis of salivary adenoid cystic carcinoma cells YAN Fei, WANG Chao, LI Ting, CAI Wen-yan, SUN Jin-hu，. 2017, 15 (3):  209-213.  doi: 10.19438/j.cjoms.2017.03.004 Abstract ( 369 )   PDF (913KB) ( 417 )   PURPOSE: To investigate the effect and regulatory mechanisms of miR-21 on proliferation and apoptosis of human salivary adenoid cystic carcinoma (SACC-LM) cells. METHODS: SACC-LM cells were transfected with miR-21 inhibitor by LipofectamineTM 2000. Meanwhile, SACC-LM cells were transfected with NC inhibitor as negative control. Cell survival rate was calculated with CCK-8 assay at 24, 48, 72 and 96 h after transfection. The apoptosis rate was measured by flow cytometry. qRT-PCR analysis and Western blot were used to detect the expression of miR-21, PDCD4 and Bcl-2 in SACC-LM cell lines after transfection. SPSS 16.0 software package was used for statistical analysis. RESULTS: miR-21 expression was remarkably downregulated in miR-21 inhibitor-transfected cells. In the meantime, gene expression of PDCD4 was increased and Bcl-2 was decreased (P<0.05). miR-21 silencing triggered to a decreased cell viability in a time-dependent manner compared with the control groups (P<0.05). The apoptosis rate was dramatically increased compared with the control groups (P<0.01), and PDCD4 protein expression was significantly increased (P<0.05), while Bcl-2 was significantly decreased (P<0.05). CONCLUSIONS: Downregulation of miR-21 can inhibit proliferation of SACC-LM cells and induce apoptosis. The mechanism may be related to the increased expression of PDCD4 and decreased expression of Bcl-2. References | Related Articles | Metrics

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Radiographic evaluation of using concentrate growth factor for alveolar ridge preservation in Beagle dog CHIU Han-hsuan, ZHENG Ji-si, ZHANG Shan-yong. 2017, 15 (3):  214-219.  doi: 10.19438/j.cjoms.2017.03.005 Abstract ( 421 )   PDF (913KB) ( 307 )   PURPOSE: To compare bone dimensional changes following extraction alone, extraction plus ridge preservation (using deproteinized boving bone mineral Bio-Oss, concentrate growth factors CGF and bioresorbable collagen membrane Bio-Gide) on radiographs. METHODS: In 4 Beagle dogs, the distal roots of the first and the second mandibular premolars were removed. The sockets in the right or the left jaw quadrant were grafted randomly with either deproteinized boving bone mineral(Bio-Oss with Bio-gide) as experimental group 2 or with concentrate growth factors (CGF with Bio-gide) as experimental group 1 or both of them(Bio-Oss plus CGF wit Bio-gide) as experimental group 3 and control group (no treament , natural healing). Raidographic examination was taken every month for 3 months. Simplant software was used for image reconstruction, SPSS13.0 software package was used for analysis. RESULTS: CT scanning showed that there was significant difference in alveolar ridge width between experimental group 2 (2.497±0.1823)mm, experimental group 3 (2.790±0.2230)mm and control group(1.800±0.2400 )mm(P<0.05). In buccal height, there was significant difference between experimental group 2 (4.927±0.4260mm), experimental group 3 (5.320±1.165)mm,experimental group 1 (4.770±0.2178)mm, and control group(3.850±0.3000)mm (P<0.05). However, there was no significant difference between 4 groups in lingual height and in buccal thickness. Lingual bone thickness in experimental group 2 was （1.573±0.08102） mm and （1.320±0.3842）mm in experimental group 3, which had significant difference from control group (1.355±0.05500)mm and experimental group 1 (1.010 ± 0.1607)mm(P<0.05). CONCLUSIONS: The results suggest that alveolar preservation with Bio-Oss plus CGF is better than CGF alone. References | Related Articles | Metrics

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Expression of Smad7 protein in oral squamous cell carcinoma and the impact on cell proliferation and migration of oral squamous cell carcinoma ZHENG Chen, SHI Chao-ji, ZHENG Bo, JIN Xiao-ming, JIANG Yin-hua. 2017, 15 (3):  220-226.  doi: 10.19438/j.cjoms.2017.03.006 Abstract ( 389 )   PDF (1113KB) ( 408 )   PURPOSE: To investigate the expression of Smad7 in oral squamous cell carcinoma (OSCC) and determine if Smad7 was associated with tumor cell proliferation and migration. METHODS: Thirty-one primary OSCC patients were enrolled in this study. Smad7 expression in tissue specimens were investigated by using immunohistochemistry staining, CCK-8, cell scratch assay, western blotting and qRT- PCR were performed after Smad7 siRNA interference in HN4 cells. Paired t test was used for analysis with SPSS18.0 software package. RESULTS: Nuclear and cytoplasmic expression of Smad7 was increased in primary OSCC tissue samples. Expression of Smad7 was associated with cervical lymph node metastasis. Smad7 knockdown significantly suppressed cell proliferation but promoted tumor cell migration in HN4 cells. Smad7 knockdown promoted N-cadherin and Vimentin expression. CONCLUSIONS: Smad7 expression in OSCC was associated with cervical lymph nodal metastasis and Smad7 might play an essential role in the proliferation and migration of OSCC cells. References | Related Articles | Metrics

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Surgical treatment of recurrent pleomorphic adenoma of parotid gland and prevention of complications DENG Gang, LI Xiao-guang, HE Yue, YU De-dong. 2017, 15 (3):  227-229.  doi: 10.19438/j.cjoms.2017.03.007 Abstract ( 1618 )   PDF (779KB) ( 708 )   PURPOSE: To investigate the prognostic factors after surgical treatment of recurrent pleomorphic adenoma. METHODS: We retrospectively analyzed 39 patients diagnosed with recurrent pleomorphic adenoma who received surgical treatment in our hospital from January 2010 to January 2015. Clinical variables, imaging features and surgical outcomes were analyzed using SAS 9.0 software package. RESULTS: Among 39 patients, 14 (35.89%) were female while 25 (64.10%) were male. Their age ranged from 31 to 72 years old (median: 45). 66.66% (n=26) of the patients underwent total parotidectomy, while 11 patients (28.21%) underwent superficial parotidectomy and 2 (5.31%) with partial parotidectomy. Facial nerves were sacrificed in 6 patients due to nerve invasion by tumors. Postoperative complications were reported as temporary palsy (n=29, 74.36%) and Frey's syndrome (n=9, 23.08%). Median follow-up time was 2.1 years, during which 3 patients re-recurred. CONCLUSIONS: Recurrent pleomorphic adenoma is challenging from a surgical standpoint. Facial nerves are closely involved with these neoplasms. Close follow-up is necessary after operation. References | Related Articles | Metrics

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Removal of metal foreign bodies retained in the cranio-maxillofacial region under ultrasonic navigation combined with CT: report of 32 cases FENG Hang, XING Le-jun, WANG Li, CHEN You-bai, ZHAO Rui, BU Rong-fa, ZHANG Hai-zhong 2017, 15 (3):  230-234.  doi: 10.19438/j.cjoms.2017.03.008 Abstract ( 504 )   PURPOSE: To investigate the clinical efficiency of using ultrasonic navigation combined with CT to remove metal foreign bodies in the skull base and maxillofacial region. METHODS: The clinical data of 32 patients were reviewed. The metal foreign bodies were removed under ultrasonic navigation combined with CT. RESULTS: All 32 patients had good results and minor side effects. The foreign bodies were located accurately and removed with short operation time and less bleeding. Among 194 foreign bodies, 36 were removed under navigation ultrasound, 153 were removed under CT navigation; the total removal rate was 97.4%. CONCLUSIONS: Ultrasonic navigation and CT could fix accurately on the position of foreign body, avoiding important blood vessel and nerve injury during operation. References | Related Articles | Metrics

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Influence of preoperative comorbidities and nutrition status on elderly patients with oral squamous cell carcinoma LIU Zhe-qi, CAO Wei, REN Zhen-hu, PENG Can-bang, JI Tong, WANG Yue-ping. 2017, 15 (3):  235-239.  doi: 10.19438/j.cjoms.2017.03.009 Abstract ( 403 )   PDF (442KB) ( 367 )   PURPOSE: To evaluate the influence of pre-operative comorbidities and nutrition status on elderly patients with oral squamous cell carcinoma (OSCC). METHODS: The data of elderly patients with OSCC treated between January 2010 to December 2012 in the Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine was analyzed. Patients who were histologically diagnosed as squamous cell carcinoma, aged over 60 years and surgically managed were included. The comorbidity index including Charlson, HNCA and ACT index and nutrition index (NI) were analyzed. RESULTS: Among 465 patients, preoperative Charlson, HNCA and ACT index didn't show significant impact on outcome of disease (P=0.747, 0.530, 0.869). Preoperative nutrition status and nutrition index were independent factors for prediction of prognosis (P<0.001). CONCLUSIONS: For elderly patients with OSCC, preoperative systemic disease is not a predictive factor for prognosis; however, the worse the preoperative nutritional status, the lower the survival rate. References | Related Articles | Metrics

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Expression and significance of IFNAR1 in oral squamous cell carcinoma ZHU Li-lin, YANG Wen-yi, MA Hai-long, HU Jing-zhou. 2017, 15 (3):  240-244.  doi: 10.19438/j.cjoms.2017.03.010 Abstract ( 460 )   PDF (1022KB) ( 371 )   PURPOSE: To investigate the expression of type I interferon receptor 1(IFNAR1) in oral squamous cell carcinoma (OSCC) and normal mucosa, and to explore its relationship with clinical pathological characteristics and prognosis. METHODS: The expression of IFNAR1 in 108 cases with OSCC and 16 cases with normal oral mucosa was detected by immunohistochemistry. The relationship between the expression of IFNAR1 in OSCC tissues and clinical pathological characteristics were analyzed. The data were analyzed with SPSS17.0 software package. RESULTS: The expression of IFNAR1 in OSCC was significantly higher than that in normal oral mucosa. The expression of IFNAR1 was closely correlated with T stage, cervical lymph node metastasis, TNM stage and pathological differentiation (P<0.05); while gender, age, location, smoking and drinking had no correlation with IFNAR1 (P>0.05). IFNAR1 expression was an important factor to predict prognosis of OSCC patients with HR=1.879(95% CI=0.967-3.651, P=0.063). Patients with higher expression of IFNAR1 had poorer prognosis shown by Log-rank test (P=0.057). CONCLUSIONS: The expression of IFNAR1 in OSCC was significantly higher than that in normal oral mucosa, and it is a potential risk factor for OSCC. It has a tendency to be related to the prognosis of OSCC patients. IFNAR1 expression in tumor tissues can be a surrogate to select patients who can benefit from interferon alpha treatment in OSCC. References | Related Articles | Metrics

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Computer-assisted surgical simulation for temporomandibular joint reconstruction with costochondral graft ZHEN Jin-ze, ZHONG Xiao-qi, ZHANG Shan-yong, ZHENG Ji-si, SUN Shou-fu, LI Hui-ping. 2017, 15 (3):  245-248.  doi: 10.19438/j.cjoms.2017.03.011 Abstract ( 401 )   PDF (985KB) ( 260 )   PURPOSE: This study was to introduce the application of computer-assisted surgical simulation (CASS) for temporomandibular joint (TMJ) reconstruction with costochondral graft (CCG). METHODS: Patients who underwent TMJ reconstruction with CCG from November 2013 to March 2015 were included in this study. Cranio-maxillofacial and chest CT scans were performed and imported into the Mimics software for virtual positioning and osteotomy planning to guide the selection and placement of the rib and bone trimming of the condyle and ramus before surgery. The implanted deviation of the rib was measured or calculated in Mimics software. RESULTS: Seven patients (9 joints) who underwent CCG utilizing CASS were included. There were 5 females and 2 males with a mean age of 30.2 years (range, 21 to 45 years). There were 5 patients with unilateral joints reconstruction and 2 patients with bilateral joints reconstruction. In 7 joint reconstructions, the 6th rib was selected, while the 7th rib was selected in 2 joints. All the grafted ribs were not trimmed or contoured intraoperatively. Postoperative CT scans indicated that all patients had successful reconstruction of the mandibular condyle with CCG using CASS. 46 titanium screws in total were implanted and located behind the inferior alveolar neurovascular bundle. There were 16 titanium screws protruding from the medial surface of the ramus, and the mean exposed length was 0.7 mm (range, 0.2 to 1.3 mm). The merged CT scans indicated that the distal end of the CCG was implanted obliquely and anteriorly compared with the predesigned positions, and the mean deviated degree was 5.4°(range, 1.7 to 7.3°). CONCLUSIONS: CASS is an accurate method to select a suitable rib (usually the 6th and 7th) matching with the TMJ anatomy and avoid the blindness of CCG. References | Related Articles | Metrics

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Effect of early swallowing treatment on dysphagia and quality of life in tongue cancer patients after surgery HUANG Zhuo-shan, ZHANG Da-min, WANG You-yuan, XIAO Ling-jun, CHEN Wei-liang. 2017, 15 (3):  249-253.  doi: 10.19438/j.cjoms.2017.03.012 Abstract ( 645 )   PDF (563KB) ( 531 )   PURPOSE: The aim of the present study was to evaluate the effect of early swallowing treatment on dysphagia and quality of life (QOL) in tongue cancer patients after surgery. METHODS: A sample of 134 tongue cancer patients aging 36 to 74 years was divided into treatment group (67 patients) and control group (67 patients). All patients were scheduled to undergo partial tongue resection and flap reconstruction. Changes in dysphagia and QOL before and after swallowing training (10 days and 20 days after operation) were measured. The 10-item Eating Assessment Tool (EAT-10) and the Functional Assessment of Cancer Therapy-Head and Neck (FACT-H&N) were used to evaluate the severity of dysphagia and QOL, respectively. The data were analyzed by using SPSS 13.0 software package. RESULTS: The EAT-10 scores were significantly higher and the FACT-H&N scores were significantly lower than those measured in the treatment group after swallowing treatment. No significant difference was observed in either score between the two time points in the control group. The EAT-10 scores and FACT-H&N scores of the treatment group after swallowing training were significantly lower and higher, respectively, than those measured 20 days after operation in the control group（P＜0.05）. Lower EAT-10 scores were associated with higher FACT-H&N scores（P＜0.01）. CONCLUSIONS: Early identification and management of postoperative dysphagia in tongue cancer patients can improve swallowing outcomes and QOL. References | Related Articles | Metrics

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The relationship between fibroblast growth factor receptor type 2 and clinical characteristics of primary/recurrent ameloblastoma TANG Yu, JI Tong. 2017, 15 (3):  254-258.  doi: 10.19438/j.cjoms.2017.03.013 Abstract ( 362 )   PDF (1261KB) ( 414 )   PURPOSE: To detect the immunohistochemical expression of fibroblast growth factor receptor type 2 (FGFR2) in primary ameloblastoma and recurrent ameloblastoma, and to determine its role in development of ameloblastoma, especially in invasion and recurrence of ameloblastoma. METHODS: Ninety-six formalin-fixed, paraffin-embedded tissue blocks of ameloblastoma specimens from 32 patients who had two surgeries due to recurrence and 32 patients who had only one surgery were compared at protein expression level using immunohistochemistry for FGFR2 staining. Statistical analysis was performed by use of SAS 9.3 software package, to determine the relationship between the expression of FGFR2 and clinical parameters. RESULTS: FGFR2 immunostaining was evident in all specimens, the staining in recurrent ameloblastoma was significantly stronger than in primary ameloblastoma. Statistical analysis showed that FGFR2 expression was significantly higher in recurrent ameloblastoma than in primary ameloblastoma; FGFR2 expression was significantly higher in maxillary recurrent ameloblastoma than in mandibular recurrent ameloblastoma; patient with tumor size over 3.9 cm had a higher rate of recurrence. CONCLUSION: High expression of FGFR2 plays an important role in invasion and recurrence of ameloblastoma. References | Related Articles | Metrics

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Analysis of related factors of postoperative complications in patients with benign tumors of parotid gland WANG Xu-cheng, GONG Zhong-cheng, LIN Zhao-quan, LING Bin, YIN Xiao-peng, SHAO Bo. 2017, 15 (3):  259-263.  doi: 10.19438/j.cjoms.2017.03.014 Abstract ( 705 )   PDF (868KB) ( 404 )   PURPOSE: To explore the related factors of postoperative complications of parotid benign tumor. METHODS: The medical records of 215 cases with surgical treatment of parotid benign tumor were collected, the general data and different factors in surgical treatment and occurrence of postoperative complications were reviewed. SPSS 17.0 software package was used for data analysis. RESULTS: There was significant correlation (P＜0.05) between parotid gland fistula, facial nerve paralysis, Frey's syndrome and different factors (surgical incision， transfixion of residual parotid gland, method of facial nerve dissection, extent of resection, and employment of sternocleidomastoid flap). CONCLUSIONS: "N" shaped incision is not beneficial to routine drainage after operation, suction drainage was effective to decrease parotid gland fistula; the transfixion of residual parotid gland can avoid fistula after surgery; anterograde method for dissection of facial nerve and partial superficial parotidectomy can accelerate the speed of surgery and decrease the time of exposure of the facial nerve, which reduce the facial nerve paralysis; sternocleidomastoid flap is beneficial to avoid Frey's syndrome after surgery. References | Related Articles | Metrics

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Propranolol in the treatment of ulcerated infantile hemangiomas: a clinical analysis of 18 cases CHENG Mo-sha, ZHANG Kai-chi, WANG Xu-kai. 2017, 15 (3):  264-267.  doi: 10.19438/j.cjoms.2017.03.015 Abstract ( 477 )   PDF (813KB) ( 457 )   PURPOSE: To evaluate the clinical efficacy and safety of oral propranolol in the management of ulcerated infantile hemangiomas (IHs). METHODS: Oral propranolol was administered to 18 infants with hemangioma complicated by ulceration at a dose of 1-1.5 mg/kg of body weight per day. The treatment was continued for 3-12 months. Weekly visits were required until the ulcerations were healed, then changed to monthly visits. The therapeutic outcomes and safety were assessed by the changes of colors, size of tumor, healing of the ulcers and adverse effects throughout the course of treatment. RESULTS: Among 18 patients, ulcerations were healed within 2-7 weeks. The mean therapeutic duration was 8 months ranging from 3 to 12 months. Two of them left scars in the end of treatment. The main adverse effects were bradycardia, diarrhea, milk regurgitation, sleep disturbance, which resolved without special management. No major adverse effects were observed. CONCLUSIONS: Oral propranolol for ulcerated IHs can make the ulcer heal in a short time, and can significantly reduce hemangioma size; the adverse reactions were minimal. References | Related Articles | Metrics

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Literature metrology research of navigation technology applied in head and neck neoplasm WANG Shao-jie, SUI Ming-shuang, XU Dan, LIU Chun-li, TAN Xue-xin, SUN Chang-fu. 2017, 15 (3):  268-272.  doi: 10.19438/j.cjoms.2017.03.016 Abstract ( 319 )   PDF (636KB) ( 326 )   PURPOSE: To analyze the research status and development tendency of navigation technology applied in head and neck neoplasm, and provide theoretical foundation and information guide for further studies of this subject. METHODS: Literatures about navigation technology applied in head and neck neoplasm were retrieved from PubMed, Web of Science(WOS), China Biology Medical Disc(CBM) and China National Knowledge Infrastructure (CNKI), and then analyzed using BICOMB 2.0 and NetDraw software. RESULTS: We screened out 6 foreign and 3 Chinese periodicals, confirmed 6 foreign and 4 domestic major research institutions as well as 13 foreign and 3 domestic important researchers through assessing the number and citation frequency of published papers. CONCLUSIONS: Navigation technology has a promising future in head and neck neoplasm, which is worthy of wide application. References | Related Articles | Metrics

Clinical Reports

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Clinicopathologic analysis of 15 lymphoepithelial carcinoma JIN Lei, YANG Hong-yu, WANG Yu-fan, YANG Hui-jun, SHEN Shi-yue, WANG Feng. 2017, 15 (3):  273-276.  doi: 10.19438/j.cjoms.2017.03.017 Abstract ( 1342 )   PDF (627KB) ( 511 )   PURPOSE: To investigate the clinicopathologic features of lymphoepithelial carcinoma (LEC) of the salivary gland for improving the diagnostic and therapeutic strategies. METHODS: Fifteen cases with pathologically confirmed LEC from Jan 2006 to Sep 2016 were reviewed including clinicopathologic feature, etiology, diagnosis, treatment and prognosis. RESULTS: Among 15 cases, 8 cases were located in the parotid gland and 7 in the submandibular gland, including 9 men and 7 women, aged from 24 to 61 year old. All patients came from south of China except 1 from Heilongjiang province. Immunohistochemical examination showed positive results of EB virus in 8 cases. One patient died of local recurrence or metastasis during 13 months to 10 years of follow-up, and 3 cases were lost to follow up. CONCLUSIONS: LEC is an extremely rare tumor in salivary gland, with extensive invasion and metastasis potential. Differential diagnosis of this disease is depended on histology. Radical resection was considered as the primary treatment. Radiotherapy should be given to cases with residual tumor or metastasis. References | Related Articles | Metrics

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Salvage surgery for 18 patients with recurrent oral and oropharyngeal squamous cell carcinoma involving carotid artery: short-term follow-up results CHEN Rui, YANG Zhao-hui, CHEN Wei-liang, WANG You-yuan, FAN Song, ZHANG Da-ming. 2017, 15 (3):  277-281.  doi: 10.19438/j.cjoms.2017.03.018 Abstract ( 474 )   PDF (1696KB) ( 544 )   PURPOSE: Outcomes of salvage surgery and carotid artery (CA) management were evaluated in patients with oral and oropharyngeal cancer. METHODS: Eighteen patients with recurrent oral and oropharyngeal squamous cell carcinoma involving CA underwent salvage surgery consisting of extended resection of the tumor, CA resection with and without reconstruction, and CA subadventitial dissection with and without encapsulation. Major tissue defects were reconstructed using composite flaps. RESULTS: One patient showed postoperative transient hemiplegia, and wound dehiscence occurred at the recipient site in 2 patients. Two patients developed carotid blowout. One patient who underwent CA resection and reconstruction suffered from carotid embolism. After 5-42 months of follow-up, 12 patients were disease-free, 2 alive with tumor, and 4 died of local recurrence or distant metastases. CONCLUSIONS: Salvage surgery remains an effective treatment modality. The affected carotid artery should be managed according to preoperative evaluation. Major defects can be reconstructed with a trapezius flap. References | Related Articles | Metrics

Dental Education

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Combining visualization teaching with traditional teaching in temporomandibular joint course learning WANG Ye-xin, SHEN Pei, ZHENG Ji-si, XIE Qian-yang, ZHONG Xiao-qi, ZHANG Shan-yong, YANG Chi, ZHENG Jia-wei, XIE Chun-yu, ZHU Ying-chao. 2017, 15 (3):  282-285.  doi: 10.19438/j.cjoms.2017.03.019 Abstract ( 444 )   PDF (736KB) ( 277 )   PURPOSE: To evaluate the teaching effect of combining visualization teaching with traditional teaching in temporomandibular joint (TMJ) course learning. METHODS: Twenty-eight seven-year dental students in Shanghai Jiao Tong University College of Stomatology were randomly allocated into 2 groups. In the experimental group, visualization teaching combined with traditional teaching were used while only traditional teaching in the control group. SPSS 14.0 software package was used to evaluate the teaching effect between the 2 groups. RESULTS: Theory test indicated that students in the experimental group had higher score than in the control group(P＜0.05).Comprehensive abilities test indicated that students in the experimental group had higher score than in the control group(P＜0.05). Questionnaire results indicated that students in the experimental group had higher enthusiasm for study and better thinking mode. CONCLUTIONS: Visualization teaching combined with traditional teaching significantly enhance teaching effect in dental students for TMJ course learning. References | Related Articles | Metrics

Case Reports

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Autotransplantation of mandibular second molar impacted in mandibular ramus to its normal position XU Guang-jie, HOU Rui, TIAN Lei, ZHU Qing-lin, GUO Yu-xuan, LIU Yan-pu, WANG Xiao-nan, YANG Xia. 2017, 15 (3):  286-288.  doi: 10.19438/j.cjoms.2017.03.020 Abstract ( 578 )   PDF (1026KB) ( 868 )   This paper reported a case with autotransplantation of a mandibular second molar impacted in mandibular ramus to its normal position. By using digital surgery and minimally invasive tooth extraction, an impacted mandibular second molar was immediately autotransplanted from mandibular ramus to its normal position. After the buccal and distal bone defect was filled by autologous bone, the transplanted tooth was elastically fixed. Postoperative occlusal relationship was good, the immediate mobility was I degree, and the bone defect was repaired. Root canal therapy was completed 6 months later. Clinical and radiographic examination showed the transplanted tooth healed well 1 year later. Transplantation of impacted molar from mandibular ramus to its normal position can be an option for autogenous teeth transplantation. References | Related Articles | Metrics