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20 March 2017, Volume 15 Issue 2 Previous Issue    Next Issue

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Effect of RANKL on chondrocyte differentiation of temporomandibular joint FAN Bao-ting, XU Wei-feng, SHEN Pei, LI Hui-ping, ZHAO Hua-qiang, ZHANG Shan-yong 2017, 15 (2):  97-102.  doi: 10.19438/j.cjoms.2017.02.001 Abstract ( 518 )   PDF (4122KB) ( 530 )   PURPOSE : This study was aimed to identify a novel therapeutic way for joint cartilage degeneration. METHODS : By using ATDC5 chondrogenic cells and bovine cartilages, we studied the role of RANKL in cartilage degeneration in vitro. The protein expression of MMP13, RANK, RANKL and ADAMTS5 was detected using Western blot. The mRNA expression of Col2a1, Col10a, MMP13, RANK and ADAMTS5 was detected using RT-qPCR. Degeneration of cartilage was analyzed by safranin O and alician blue staining and Mankin score. The data were analyzed by paired t test using SPSS17.0 software package. RESULTS : The results of real time PCR confirmed that both RANK and RANKL were dynamically expressed in ATDC5 cells during all differentiation phases (P<0.05). RANK protein expression was significantly enhanced by RANKL treatment for 48 h in comparison to that for 0h. The mRNA and protein level of ADAMTS5 was significantly increased as stimulated by RANKL compared with the control over time (P<0.05). In addition, vacuolation and degeneration were observed in bovine cartilages with RANKL stimulation (P<0.05). CONCLUSION S: RANKL contributes to cartilage degeneration in condylar resorption and inhibition of this pathway may be a useful strategy for condylar resorption treatment. References | Related Articles | Metrics

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Osteogenesis ability of bone marrow-derived mesenchymal stem cells derived from diabetic rabbits ZHOU Yu-ning, MA Wu-di, GUI Zhi-peng, XIA Lun-guo, XU Yuan-jin 2017, 15 (2):  103-108.  doi: 10.19438/j.cjoms.2017.02.002 Abstract ( 446 )   PDF (3925KB) ( 485 )   PURPOSE : To observe the biological characteristics (mainly osteogenesis ability) of bone marrow-derived mesenchymal stem cells (BMSCs) in diabetic rabbits. METHODS : Diabetic rabbit models were established by injecting alloxan intravenously, which were used as the experimental group, rabbits receiving normal saline injection were served as the control group. Rabbit iliac bone marrow was extracted under aseptics and local anesthesia, and BMSCs were isolated and cultured by using whole blood adherent culture method. MTT assay, real-time PCR, and alkaline phosphatase (ALP) staining of the BMSCs in both groups were performed, respectively. Differences between groups were analyzed with SPSS 13.0 software package for ANOVA and SNK post hoc analysis. RESULTS : Compared with the control group, the ability of cell proliferation, osteogenic gene expression, ALP activity and angiogenic gene expression of the diabetic rabbits BMSCs were all decreased, and the difference was statistically significant (P<0.05). CONCLUSION S: The activity of cell proliferation, osteogenesis and angiogenesis of the diabetic rabbit BMSCs is damaged. References | Related Articles | Metrics

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Guided bone regeneration and simultaneous implant placement using membrane in combination with titanium mesh for repair of alveolar defects in Beagle dogs LI Hui-ping, SUN Shou-fu, ZHEN Jin-ze, WANG Ye-xin, XU Wei-feng, ZHENG Ji-si, ZHANG Shan-yong, ZHU Ying-chao, ZHONG Xiao-qi 2017, 15 (2):  109-114.  doi: 10.19438/j.cjoms.2017.02.003 Abstract ( 543 )   PDF (4959KB) ( 496 )   PURPOSE : To evaluate the effect of using guided bone regeneration (GBR) with (titanium) Ti mesh and Bio-Gide membrane in repair of alveolar bone defects in Beagle dogs. METHODS : Three mandibular premolars and one molar on both sides of the jaw in 3 dogs were extracted. Six months after extraction, three implants were inserted into each side, and alveolar bone defects (4 mm×4 mm×4 mm in size) were produced. 24 implants in total 6 sides were assigned to 3 groups and covered with different membranes as follows, group A: implant+Bio-Oss+Ti-mesh; group B: implant+Bio-Oss+Bio-Gide, group C: implant+Bio-Oss+Ti-mesh+Bio-Gide. The claps were sutured over the membranes to complete the wound closure. The animals were sacrificed after 6 months, and non-decalcified histological specimens of the implants and surrounding tissues were prepared. Micro-CT scanning was carried out to test the results. SPSS17.0 software package was used for statistical analysis. RESULTS : Micro-CT with three-dimensional reconstruction revealed that bone regeneration in group C was significantly better than the other two groups (P<0.01), which indicated faster new bone deposition. CONCLUSION S: Combination of Bio-Gide membrane and Ti-mesh may get a better bone regeneration than Ti-mesh or Bio-Gide used alone. References | Related Articles | Metrics

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Relationship between different doses of zoledronic acid and bisphosphonate-related osteonecrosis of jaw: an experiment study in rats SHEN Ya-jun, DU Ming-yan, GUAN Jian, LI Mao, ZHAO Yan-tao, GE Cheng 2017, 15 (2):  115-120.  doi: 10.19438/j.cjoms.2017.02.004 Abstract ( 674 )   PDF (3934KB) ( 443 )   PURPOSE : To investigate the relationship between different doses of zoledronic acid (ZA) and bisphosphonate-related osteonecrosis of jaw (BRONJ) by establishing the model of osteonecrosis of jaw in rats with different doses of ZA. METHODS : Forty SD rats were divided into 4 groups (ten rats in each group), the rats in 4 groups were injected intraperitoneally with 33, 66 and 132 μg/kg ZA or normal saline (control), respectively, three times a week for 12 weeks, and the weight was measured weekly. In the ninth week, all rats was subjected to extraction of the first left mandibular molar. After the last injection, all rats were sacrificed. The jaws were clinically, radiologically and histopathologically examined. Independent samples t test was performed using SPSS19.0 software package. RESULTS : The weight of rats in the experimental groups was significantly lower than that in the control group after extraction (P<0.05). 86.7% rats in the experimental group were observed with unclosed mucosa; however, mucosa on extraction sites in the control group healed completely (P<0.05). Radiological examination revealed radiolucent areas on the extraction sites in the experimental groups were significantly greater than those in the control group (P<0.05). Histopathological examination showed 70% rats in the experimental group developed osteonecrosis,especially in higher dose group,while osteonecrosis was not found in the control group (P<0.05). CONCLUSION : The study showed severe BRONJ was closely associated with high dose of ZA. Low dose of ZA just induces minor BRONJ, or is unable to induce BRONJ. Thus, Patients treated with high dose of ZA are facing great risk of developing BRONJ. References | Related Articles | Metrics

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Effects and mechanism of quercetin on proliferation and apoptosis of human adenoid cystic carcinoma cell line ACC-M MI Jing, ZHANG Ming-bin, WAN Guang-yong 2017, 15 (2):  121-126.  doi: 10.19438/j.cjoms.2017.02.005 Abstract ( 420 )   PDF (3998KB) ( 540 )   PURPOSE : To observe the effect of quercetin on human adenoid cystic carcinoma cells (ACC-M) proliferation and apoptosis. METHODS : CCK-8 staining was used to detect different concentrations of quercetin on ACC-M cell proliferation inhibition, the inhibition rate and IC50 were calculated; flow cytometry was used to detect ACC-M cell apoptosis rate and cell cycle distribution; Survivin mRNA of ACC-M cells was detected by RT-PCR. The difference between each group was analyzed with SPSS20.0 software package. RESULTS : Quercetin inhibited ACC-M cell growth obviously in a concentration dependent manner. The IC50 was 151.12 μmol/L (P<0.05); annexin V/PI double staining assay showed that quercetin can induce apoptosis of ACC-M cells in a dose and time dependent manner (P<0.05); PI staining assay showed that quercetin played an important role in G2/M cells, which were specifically arrested in G2/M phase. RT-PCR showed the quercetin concentration was negatively related with survivin mRNA in ACC-M cells and 200 μmol/L quercetin could inhibit the expression of Survivin mRNA significantly. CONCLUSION S: Quercetin can inhibit the proliferation of ACC-M cells and induce its apoptosis in a time and dose dependent manner by down-regulating the level of Survivin. References | Related Articles | Metrics

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Guided bone regeneration and simultaneous implant placement using membrane in combination with titanium mesh for repair of alveolar defects in Beagle dogs LI Hui-ping, SUN Shou-fu, ZHEN Jin-ze, WANG Ye-xin, XU Wei-feng, ZHENG Ji-si, ZHANG Shan-yong, ZHU Ying-chao, ZHONG Xiao-qi 2017, 15 (2):  127-130.  doi: 10.19438/j.cjoms.2017.02.006 Abstract ( 442 )   PDF (3006KB) ( 592 )   PURPOSE : To evaluate the effect of using guided bone regeneration (GBR) with (titanium) Ti mesh and Bio-Gide membrane in repair of alveolar bone defects in Beagle dogs. METHODS : Three mandibular premolars and one molar on both sides of the jaw in 3 dogs were extracted. Six months after extraction, three implants were inserted into each side, and alveolar bone defects (4 mm×4 mm×4 mm in size) were produced. 24 implants in total 6 sides were assigned to 3 groups and covered with different membranes as follows, group A: implant+Bio-Oss+Ti-mesh; group B: implant+Bio-Oss+Bio-Gide, group C: implant+Bio-Oss+Ti-mesh+Bio-Gide. The claps were sutured over the membranes to complete the wound closure. The animals were sacrificed after 6 months, and non-decalcified histological specimens of the implants and surrounding tissues were prepared. Micro-CT scanning was carried out to test the results. SPSS17.0 software package was used for statistical analysis. RESULTS : Micro-CT with three-dimensional reconstruction revealed that bone regeneration in group C was significantly better than the other two groups (P<0.01), which indicated faster new bone deposition. CONCLUSION S: Combination of Bio-Gide membrane and Ti-mesh may get a better bone regeneration than Ti-mesh or Bio-Gide used alone. References | Related Articles | Metrics

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Relationship between different doses of zoledronic acid and bisphosphonate-related osteonecrosis of jaw: an experiment study in rats SHEN Ya-jun, DU Ming-yan, GUAN Jian, LI Mao, ZHAO Yan-tao, GE Cheng 2017, 15 (2):  131-135.  doi: 10.19438/j.cjoms.2017.02.007 Abstract ( 530 )   PDF (3608KB) ( 459 )   PURPOSE : To investigate the relationship between different doses of zoledronic acid (ZA) and bisphosphonate-related osteonecrosis of jaw (BRONJ) by establishing the model of osteonecrosis of jaw in rats with different doses of ZA. METHODS : Forty SD rats were divided into 4 groups (ten rats in each group), the rats in 4 groups were injected intraperitoneally with 33, 66 and 132 μg/kg ZA or normal saline (control), respectively, three times a week for 12 weeks, and the weight was measured weekly. In the ninth week, all rats was subjected to extraction of the first left mandibular molar. After the last injection, all rats were sacrificed. The jaws were clinically, radiologically and histopathologically examined. Independent samples t test was performed using SPSS19.0 software package. RESULTS : The weight of rats in the experimental groups was significantly lower than that in the control group after extraction (P<0.05). 86.7% rats in the experimental group were observed with unclosed mucosa; however, mucosa on extraction sites in the control group healed completely (P<0.05). Radiological examination revealed radiolucent areas on the extraction sites in the experimental groups were significantly greater than those in the control group (P<0.05). Histopathological examination showed 70% rats in the experimental group developed osteonecrosis,especially in higher dose group,while osteonecrosis was not found in the control group (P<0.05). CONCLUSION : The study showed severe BRONJ was closely associated with high dose of ZA. Low dose of ZA just induces minor BRONJ, or is unable to induce BRONJ. Thus, Patients treated with high dose of ZA are facing great risk of developing BRONJ. References | Related Articles | Metrics

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Hypoxia induces epithelial-to-mesenchymal transition in human tongue squamous cell carcinoma via hypoxia inducible factor-1α WU Ze-jian, ZHOU Bin, CHEN Wei-sheng, WU Xiao-ping, HUANG Zhi-quan 2017, 15 (2):  136-141.  doi: 10.19438/j.cjoms.2017.02.008 Abstract ( 405 )   PDF (4515KB) ( 328 )   PURPOSE : To investigate the effect of hypoxia on epithelial-to-mesenchymal transition in human tongue squamous cell carcinoma (TSCC) and the role of HIF-1α in this process. METHODS : TSCC cell lines SCC9 and CAL27 were cultured under hypoxia (1% O2) or normoxia (20% O2) for 48 h. Western blot and qRT-PCR were used to detect expression of vimentin, fibronectin, E-cadherin and HIF-1α at protein and mRNA level, respectively. Transwell assay was used to detect cell invasion. After transfected HIF-1α with siRNA, HIF-1α, vimentin, fibronectin and E-cadherin expression, as well as invasion, were furthered detected in SCC9 and CAL27 cells. SPSS 13.0 software package was used for statistical analysis. RESULTS : Both SCC9 and CAL27 cells under hypoxia for 48 h showed upregulated vimentin and fibronectin, downregulated E-cadherin and upregulated HIF-1α expression, as well as increased invasion. After knocking down of HIF-1α with siRNA, HIF-1α, vimentin and fibronectin were significantly downregulated but E-cadherin was upregulated in SCC9 and CAL27 cells under hypoxia, with decreased invasion. CONCLUSION : Hypoxia induces epithelial-to-mesenchymal transition and metastasis of TSCC via upregulating HIF-1α. References | Related Articles | Metrics

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Therapeutic effect of individualized template-guided 125I seed implants for unresectable malignant salivary gland tumors ZHENG Hao, YANG Xu-dong, Meng Jian 2017, 15 (2):  142-146.  doi: 10.19438/j.cjoms.2017.02.009 Abstract ( 477 )   PDF (3630KB) ( 461 )   PURPOSE : To evaluate the short-term effect of individualized template guided 125I seed implants for advanced unresectable malignant salivary gland tumors, and explore its superiority. METHODS : Fourteen patients with histologically documented advanced unresectable malignant salivary gland tumors were treated by radioactive 125I seeds interstitial implantation under the aid of individualized template guide. The treatment response, distribution of seeds, local control rate and survival rate were evaluated and the adverse events observed. RUSULTS: The actuarial median number of 125I seeds treated was 43, and actuarial median D90,V100,V150 was 186.2 Gy, 98.2%, 43.4%, respectively; The average radiation dose received by the eyes and brain was 3.2 Gy, 32.5 Gy, respectively; The overall response rate was 78.3%. The patients were followed up for 15 to 28 months (median 23 months). The local control rate was 78.6%, and overall survival rate was 78.6%. No serious side radiotherapeutic effect was observed. CONCLUSION S: The method of individualized template-guided 125I seed implants for advanced unresectable malignant salivary gland tumors is feasible, minimally invasive, safe and easy to operate, which can be widely used in clinical practice. References | Related Articles | Metrics

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Efficacy and safety of oral propranolol for the treatment of infantile hemangiomas in the noses ZHAO Zhi-guo, PAN Yao, YANG Dong-sheng, ZHANG Li-ping 2017, 15 (2):  147-152.  doi: 10.19438/j.cjoms.2017.02.010 Abstract ( 442 )   PDF (3738KB) ( 506 )   PURPOSE : To estimate the efficacy and safety of oral propranolol for the treatment of infantile hemangiomas in the noses. METHODS : From March, 2013 to March, 2015, 29 infantile hemangiomas in the noses were treated with oral propranolol at a dose of 2.0 mg/(kg·d), divided into 2 times. The changes of the tumor size, texture and color were monitored and recorded at a regular interval. The adverse reactions after medication were observed and managed accordingly. The efficacy was evaluated using Achauer's system. RESULTS : The average mediation duration was 6 months. The overall response was gradeⅡ in 2 patients, grade Ⅲ in 9 patients, grade Ⅳ in 18 patients. Adverse reactions were observed in 2 patients, including mild diarrhea and sleep disturbance. CONCLUSION S: Oral propranolol is effective and safe for the treatment of infantile hemangiomas in the noses, and the adverse reaction is minimal. References | Related Articles | Metrics

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Combined mandibular distraction osteogenesis and surgical-assisted maxillary rapid expansion to treat patients with severe skeletal Class Ⅱ malocclusion and narrow maxillary dental arch secondary to bilateral idiopathic condylar resorption XUE Xiao-chen, LI Biao, SUN Hao, LIU Zhi-xu, ZHU Min, WANG Xu-dong 2017, 15 (2):  153-156.  doi: 10.19438/j.cjoms.2017.02.011 Abstract ( 452 )   PDF (3007KB) ( 460 )   PURPOSE : To introduce a treatment approach for severe skeletal Class Ⅱ malocclusion and narrow maxillary dental arch secondary to bilateral idiopathic condylar resorption. METHODS : Six cases with severe skeletal Class Ⅱ malocclusion and narrow maxillary dental arch secondary to bilateral ICR were included in this study, and they were treated with mandibular distraction osteogenesis and surgery-assisted rapid maxillary expansion. The path and magnitude of distraction were simulated using computer-aided surgical simulation technique. The outcome of distraction, the necessity of secondary surgery and stability were evaluated through 4 aspects: profile, occlusion, temporomandibular joint (TMJ) condition and sleep respiratory function at T0, T1, T2 and T3. CT, TMJ questionnaire, MRI of TMJ and PSG were acquired at this 4 time points. RESULTS : Three cases finished all treatments. The distraction magnitudes were 13.0mm, 6.7mm and 8.1mm, respectively. Chin advanced in genioplasity for 7.2 mm, 0 and 11 mm, respectively. Maxillary dental arch widened 5.3mm, 7.3 mm and 4.9 mm, respectively. Polysomnography data revealed that severe obstructive sleep apnea hypopnea syndrome was cured. Skeletal malocclusion was effectively corrected in all 3 cases and there was no obvious relapse during remodeling phase. TMJ condition remained stable. CONCLUSION S: Mandibular DO and SARME approach can effectively correct severe skeletal Class II malocclusion and narrow maxillary dental arch secondary to bilateral ICR. Using CASS technology to simulate the magnitude and path of distraction, the outcomes are more stable and predictable. References | Related Articles | Metrics

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Effect of radiofrequency ablation combined with DSA-guided percutaneous ethanol sclerotherapy for refractory arteriovenous malformations in oral and maxillofacial region GU Jian-min, MENG Jian, GU Qian-ping, ZHANG Jie, LI Zhi-ping, WANG Xing 2017, 15 (2):  157-160.  doi: 10.19438/j.cjoms.2017.02.012 Abstract ( 515 )   PDF (2635KB) ( 823 )   PURPOSE : To evaluate the clinical effect and safety of radiofrequency ablation (RF) combined with digital subtraction angiography (DSA) -guided percutaneous ethanol sclerotherapy for refractory arteriovenous malformations(AVMs) in oral and maxillofacial region and to investigate its feasibility. METHODS : A retrospective review of patients, medical and imaging records was performed. Seven patients (4 males,3 females) with craniofacial arteriovenous malformations underwent staged RF combined with DSA-guided percutaneous ethanol sclerotherapy between March 2014 and April 2016. RESULTS : Six of 7 patients were cured,1 had no response. The therapeutic outcome was considered effective in 6 patients (85.7%). No major complications occurred. CONCLUSION S: RF with percutaneous ethanol sclerotherapy under DSA has the potential for curing refractory AVMs in oral and maxillofacial region, which may become an effective and safe tool for AVM management. References | Related Articles | Metrics

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Efficacy and safety of oral propranolol for the treatment of infantile hemangiomas in the noses ZHAO Zhi-guo, PAN Yao, YANG Dong-sheng, ZHANG Li-ping 2017, 15 (2):  161-164.  doi: 10.19438/j.cjoms.2017.02.013 Abstract ( 421 )   PURPOSE : To estimate the efficacy and safety of oral propranolol for the treatment of infantile hemangiomas in the noses. METHODS : From March, 2013 to March, 2015, 29 infantile hemangiomas in the noses were treated with oral propranolol at a dose of 2.0 mg/(kg·d), divided into 2 times. The changes of the tumor size, texture and color were monitored and recorded at a regular interval. The adverse reactions after medication were observed and managed accordingly. The efficacy was evaluated using Achauer's system. RESULTS : The average mediation duration was 6 months. The overall response was gradeⅡ in 2 patients, grade Ⅲ in 9 patients, grade Ⅳ in 18 patients. Adverse reactions were observed in 2 patients, including mild diarrhea and sleep disturbance. CONCLUSION S: Oral propranolol is effective and safe for the treatment of infantile hemangiomas in the noses, and the adverse reaction is minimal. References | Related Articles | Metrics

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Combined mandibular distraction osteogenesis and surgical-assisted maxillary rapid expansion to treat patients with severe skeletal Class Ⅱ malocclusion and narrow maxillary dental arch secondary to bilateral idiopathic condylar resorption XUE Xiao-chen, LI Biao, SUN Hao, LIU Zhi-xu, ZHU Min, WANG Xu-dong 2017, 15 (2):  165-170.  doi: 10.19438/j.cjoms.2017.02.014 Abstract ( 409 )   PDF (4262KB) ( 461 )   PURPOSE : To introduce a treatment approach for severe skeletal Class Ⅱ malocclusion and narrow maxillary dental arch secondary to bilateral idiopathic condylar resorption. METHODS : Six cases with severe skeletal Class Ⅱ malocclusion and narrow maxillary dental arch secondary to bilateral ICR were included in this study, and they were treated with mandibular distraction osteogenesis and surgery-assisted rapid maxillary expansion. The path and magnitude of distraction were simulated using computer-aided surgical simulation technique. The outcome of distraction, the necessity of secondary surgery and stability were evaluated through 4 aspects: profile, occlusion, temporomandibular joint (TMJ) condition and sleep respiratory function at T0, T1, T2 and T3. CT, TMJ questionnaire, MRI of TMJ and PSG were acquired at this 4 time points. RESULTS : Three cases finished all treatments. The distraction magnitudes were 13.0mm, 6.7mm and 8.1mm, respectively. Chin advanced in genioplasity for 7.2 mm, 0 and 11 mm, respectively. Maxillary dental arch widened 5.3mm, 7.3 mm and 4.9 mm, respectively. Polysomnography data revealed that severe obstructive sleep apnea hypopnea syndrome was cured. Skeletal malocclusion was effectively corrected in all 3 cases and there was no obvious relapse during remodeling phase. TMJ condition remained stable. CONCLUSION S: Mandibular DO and SARME approach can effectively correct severe skeletal Class II malocclusion and narrow maxillary dental arch secondary to bilateral ICR. Using CASS technology to simulate the magnitude and path of distraction, the outcomes are more stable and predictable. References | Related Articles | Metrics

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Analysis of incidence and time trend of oral malignancies in Shanghai from 2003 to 2012 FU Jin-ye, WU Chun-xiao, ZHANG Chen-ping, SUN Jian, ZHENG Jia-wei, ZHANG Zhi-yuan, ZHENG Ying 2017, 15 (2):  171-175.  doi: 10.19438/j.cjoms.2017.02.015 Abstract ( 319 )   PDF (3281KB) ( 369 )   PURPOSE : To analyze the incidence of oral malignancies in Shanghai from 2003 to 2012 and to study its time trend, for the purpose of searching for the clues of etiology. METHODS : Based on the incidence data of oral malignancies registered in Shanghai Municipal Center for Disease Control & Prevention, the incidence rate, sex ratio and age distribution were calculated by Excel and SPSS 17.0 software package. The time trend of the incidence of oral malignancies were studied by APC (annual percent change) model, Z-test and Cochran test. RESULTS : A total of 4935 oral malignancy cases were newly diagnosed from 2003 to 2012 in Shanghai. The crude incidence was 35.8 per 1 000 000 and the age-adjusted incidence was 18.8 per 1 000 000. The male/female ratio was 1.36:1 with the median age of 63. The average age of women was greater than man. The risk of oral malignancy increased with aging. During the 10 years' time, the crude incidence of oral malignancies in Shanghai showed an increasing trend. CONCLUSION S: With the progress of city aging trend in Shanghai, the incidence of oral malignancies was increasing. More attentions should be paid to the senile population for oral malignancies. References | Related Articles | Metrics

Clinical Reports

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Observation of long-term effect of autologous artery to repair parotid duct defect WANG Wei, CHI Yu-feng, TAN Xi-tao, WANG Pei, FEI Xiao-dong, WANG Xiao-xia. WANG Wei, CHI Yu-feng, TAN Xi-tao, WANG Pei, FEI Xiao-dong, WANG Xiao-xia 2017, 15 (2):  176-179.  doi: 10.19438/j.cjoms.2017.02.016 Abstract ( 457 )   PDF (2855KB) ( 843 )   PURPOSE : To evaluate the effect of autologous artery in repair of parotid duct defect. METHODS : From August 2003 to December 2012, six patients with parotid duct defect were reconstructed with autologous artery. The clinical data were retrospective analyzed to evaluate the effect based on clinical observation and parotid sialography. All patients were followed up for 1 month to 9 years. RESULTS : During the follow-up period of 1 month to 2 years, no swelling was present in the parotid gland of 6 patients, the parotid duct were patent, the secretory function of parotid were normal. During the follow-up period of 2-9 years, bilateral parotid gland seemed symmetric. The parotid duct in 2 patients exerted a small amount of saliva, the parotid duct reconstructed with autologous artery showed stenosis through parotid sialography. Three patients had no salivary secretion. One patient was lost follow-up. CONCLUSION S: Using autologous artery to reconstruct parotid duct can achieve a good short-term effect, but the long-term results were not ideal, therefore, parotid duct isn't suitable to be reconstructed with autologous artery. References | Related Articles | Metrics