Advances in research of long non-coding RNAs in head and neck squamous cell carcinoma

Abstract

Abstract: LncRNA is a novel class of the non-coding RNA with length ranging from 200 bp to 100 kbp. LncRNAs participates in the epigenetic modification such as transcriptional and posttranscriptional processes. LncRNAs play an important role in progression of head and neck squamous cell carcinoma (HNSCC) and may serve as a marker for cancer prognosis and early diagnosis. This article reviewed the characteristics of lncRNAs related with HNSCC as well as their functions and underlying molecular mechanism to provide new insights into genetic diagnosis and treatment of HNSCC.

Key words: LncRNA, Tumor marker, Head and neck region, Squamous cell carcinoma

CLC Number:

R739.8

FENG Yu-huan, LI Jin-song. Advances in research of long non-coding RNAs in head and neck squamous cell carcinoma[J]. China Journal of Oral and Maxillofacial Surgery, 2015, 13(2): 182-186.

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