Research progress on the effect of cancer-associated fibroblasts on biological behavior of oral squamous cell carcinoma

doi:10.19438/j.cjoms.2024.01.015

Abstract

Abstract: Oral squamous cell carcinoma(OSCC) is the sixth most common malignant tumor in the world. The occurrence and development of oral cancer are closely related to tumor microenvironment (TME). Cancer-associated fibroblast (CAF) participated in epithelial-mesenchymal transition, remodel extracellular matrix, and activate various biological pathways by secreting various growth factors, cytokines, inflammatory factors, and exosomes, which are of great significance to the occurrence, development, and treatment of OSCC. This article reviews the origin, characteristics, heterogeneity of CAF, and the impact of CAF on the biological behavior of OSCC.

Key words: Cancer-associated fibroblast, Tumor microenvironment, Oral squamous cell carcinoma

CLC Number:

R739.8

HAN Lin-zi, ZHOU Jian-hua, DONG lei, ZHAO Lu, YUAN Rong-tao. Research progress on the effect of cancer-associated fibroblasts on biological behavior of oral squamous cell carcinoma[J]. China Journal of Oral and Maxillofacial Surgery, 2024, 22(1): 84-91.

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