Clinicopathologic analysis of 15 lymphoepithelial carcinoma

doi:10.19438/j.cjoms.2017.03.017

Abstract

Abstract: PURPOSE: To investigate the clinicopathologic features of lymphoepithelial carcinoma (LEC) of the salivary gland for improving the diagnostic and therapeutic strategies. METHODS: Fifteen cases with pathologically confirmed LEC from Jan 2006 to Sep 2016 were reviewed including clinicopathologic feature, etiology, diagnosis, treatment and prognosis. RESULTS: Among 15 cases, 8 cases were located in the parotid gland and 7 in the submandibular gland, including 9 men and 7 women, aged from 24 to 61 year old. All patients came from south of China except 1 from Heilongjiang province. Immunohistochemical examination showed positive results of EB virus in 8 cases. One patient died of local recurrence or metastasis during 13 months to 10 years of follow-up, and 3 cases were lost to follow up. CONCLUSIONS: LEC is an extremely rare tumor in salivary gland, with extensive invasion and metastasis potential. Differential diagnosis of this disease is depended on histology. Radical resection was considered as the primary treatment. Radiotherapy should be given to cases with residual tumor or metastasis.

Key words: Lymphoepithelial carcinoma；Salivary gland, Clinical pathological analysis

CLC Number:

R739.8

JIN Lei, YANG Hong-yu, WANG Yu-fan, YANG Hui-jun, SHEN Shi-yue, WANG Feng.. Clinicopathologic analysis of 15 lymphoepithelial carcinoma[J]. China Journal of Oral and Maxillofacial Surgery, 2017, 15(3): 273-276.

References

[1] Barnes L, Eveson JW, Reichart P, et al. World health organization classification of tumours: pathology and genetics of head and neck tumours [M]. Lyon: IARC Press, 2005: 251-252.
[2] Nagao T, Ishida Y, Sugano I, et al. Epstein-Barr virus-associated undifferentiated carcinoma with lymphoid stroma of the salivary gland in Japanese patients. comparison with benign lymphoepithelial lesion [J]. Cancer, 1996, 78(4): 695-703.
[3] Ambrosio MR, Mastrogiulio MG, Barone A, et al. Lymphoepithelial-like carcinoma of the parotid gland: a case report and a brief review of the western literature[J]. Diagn Pathol, 2013, 8: 115.
[4] Leiser Y, Peled M, Wolff A, et al. Lymphoepithelial carcinoma--review of the treatment modalities and report of a rare case in the sublingual gland[J]. J Oral Maxillofac Surg, 2014, 72(4): 823-828.
[5] 李旭东, 翦新春. 大涎腺淋巴上皮病的临床分析 [J]. 口腔颌面外科杂志, 2009, 19(2): 121-124.
[6] Rosai J. Rosai and Ackerman's surgical pathology [M]. 9th Ed. London: Elsevier Inc., 2004: 876- 878, 1945- 1946.
[7] 殷学民, 徐国翔, 张磊涛, 等. 17例涎腺淋巴上皮癌临床病理分析[J]. 临床耳鼻咽喉头颈外科杂志, 2013, 27(21): 1171-1174.
[8] Lo YM, Chan AT, Chan LY, et al. Molecular prognostication of nasopharyngeal carcinoma by quantitative analysis of circulating Epstein-Barr virus DNA [J]. Cancer Res, 2000, 60(24): 6878-6881..
[9] Ellis GL, Auclair PL. Atlas of tumor pathology, tumor of the salivary glands [M]. Washington DC: Armed Forces Institute of Pathology, 1999: 311-318.
[10] Zhan KY, Nicolli EA, Khaja SF, et al. Lymphoepithelial carcinoma of the major salivary glands: Predictors of survival in a non-endemic region [J]. Oral Oncol, 2016, 52(1): 24-29.
[11] Manganaris A, Patakiouta F, Xirou P, et al. Lymphoepithelial carcinoma of the parotid gland: is an association with Epstein-Barr virus possible in non-endemic areas? [J]. Int J Oral Maxillofac Surg, 2007, 36(6): 556-559.
[12] 李江. 良性淋巴上皮病、淋巴上皮癌、MALT淋巴瘤的关系 [J]. 中国口腔颌面外科杂志, 2007, 5(5): 379-380.
[13] Wenig BM. Lymphoepithelial-like carcinomas of the head and neck [J]. Semin Diagn Pathol, 2015, 32(1): 74-86.
[14] 叶为民, 竺涵光, 张志愿, 等. 36例良、恶性淋巴上皮病临床病理分析 [J]. 中国口腔颌面外科杂志, 2007, 5(3): 188-194.
[15] Anantharajan N, Ravindranathan N, Rajadurai P. Lymphoepithelial carcinoma of the parotid gland, a very unusual tumor: case report and review [J]. Ear Nose Throat J, 2013, 92(9): E7-E9
[16] Schneider M, Rizzardi C. Lymphoepithelial carcinoma of the parotid glands and its relationship with benign lymphoepithelial lesions [J]. Arch Pathol Lab Med, 2008, 132(2): 278-282.
[17] 蔡以理, 王中和, 陆顺娟. 手术联合放射治疗伴有淋巴样间质的未分化癌的疗效分析 [J]. 上海口腔医学, 2002, 11(4): 310-314.
[18] Hatta C, Terada T, Okita J, et al. Clinicopathological study of undifferentiated carcinoma of the parotid gland [J]. Auris Nasus Larynx, 2003, 30(3): 273-277.
[19] Hsu YC, Lu HF, Huang CC, et al. Malignant lymphoepithelial lesions of the salivary gland [J]. Otolaryngol Head Neck Surg, 2006, 134(4): 661-666.
[20] Teo PM, Chan AT, Lee WY, et al. Failure patterns and factors affecting prognosis of salivary gland carcinoma: retrospective study [J]. Hong Kong Med J, 2000, 6(1): 29-36
[21] 利伟军, 傅向军, 刘华盛, 等. 25例大涎腺淋巴上皮癌临床分析[J]. 中国耳鼻咽喉颅底外科杂志, 2015, 21(3): 220-224.