Propranolol treatment for deep infantile hemangiomas on the parotid area: a report of 23 cases

Abstract

Abstract: PURPOSE : To evaluate the efficacy and safety of propranolol for the treatment of deep infantile hemangiomas(IH) on the parotid area. METHODS : Oral propranolol at a dose of 1.0-1.5 mg/kg three times per day was administered to 23 deep parotid IHs.The duration of treatment ranged from 6 to 10 months. The changes of the tumor colour and texture were monitored and recorded at a regular interval. At the same time, size was documented by ultrasound echo color doppler. The adverse effects after medication were observed and managed accordingly. To assess the efficacy, a 4 scales system was adopted. RESULTS : The average propranolol treatment duration for the 23 patients was 7.8 months, the overall response was slight in 0 patient，moderate in 1 patients, good in 4 patients，and excellent in 18 patients. No serious adverse events were encountered.A second course of propranolol readily controlled the rebound growth of deep IH in 3 patients(13%). CONCLUSIONS : Propranolol yielded excellent results with very good clinical tolerance and also seems to be effective for IH rebound growth. The optimal duration of the treatment remains to be defined by long-term observation.

Key words: Deep infantile hemangiomas, Parotid gland, Propranolol

CLC Number:

R739.8

SI Ya-meng, MENG Jian, ZHANG Xing, ZHANG Ai-xia, ZHENG Hao, WEI Jing-jian.. Propranolol treatment for deep infantile hemangiomas on the parotid area: a report of 23 cases[J]. China Journal of Oral and Maxillofacial Surgery, 2015, 13(6): 530-533.

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