China Journal of Oral and Maxillofacial Surgery ›› 2020, Vol. 18 ›› Issue (5): 451-456.doi: 10.19438/j.cjoms.2020.05.014

• Clinical Reports • Previous Articles     Next Articles

Clinicopathologic studies of lymphadenoma of the parotid gland in 15 cases

LIU Sheng-wen1, YANG Wen-jun1, WANG Li-zhen2, YUAN Fang3   

  1. 1. Department of Oromaxillofacial Head and Neck Oncology, 2. Department of Oral Pathology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology. Shanghai 200011;
    3. Department of Ultrasound Diagnosis, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200011, China
  • Received:2019-09-11 Revised:2020-04-03 Online:2020-09-20 Published:2020-10-28

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Abstract: PURPOSE: To analysis the clinicaopathological prognostic factors of lymphadenoma in parotid gland. METHODS: The clinicopathological records of 15 patients with diagnosis of parotid gland lymphadenoma treated at Shanghai Ninth People Hospital since 1993/1 to 2017/7 were retrospectively reviewed. Immunohistochemical test was used to detect the expression of S-100, SMA, Vim, Des, Calp, Kp-1, CKp, CK8, CKH, CK19, EMA and P63 in parotid gland lymphadenoma, the relationship with gender, age, size, location and pathological features was analyzed using SAS 9.0 software package. RESULTS: The median age of the patients was 50.5 years old, and the tumor mainly occured in patients over 60 years old. Males were obviously much more prone to it than females. The course of lymphadenoma was different, from 11 days for the shortest to more than twenty years for the longest. All patients had no pain or facial paralysis during the course of disease. Most of the neoplasm were located in the lower lobe of the parotid gland, and all these tumors were smaller than 3 cm in diameter. One of these patients had multiple masses in the parotid gland. Of all 15 patients, there were 11 non-sebaceous lymphadenoma (NSL) and 4 sebaceous lymphadenoma(SL), including 1 low-grade malignancy case. S-100, SMA, Vim, Des, Calp and Kp-1 were negatively expressed in the tumor tissues, while expression of CKp, CK8, CKH, CK19, EMA and p63 was positive. Thirteen patients underwent superficial parotidectomy or regional resection with preservation of facial nerve, while 2 patients underwent total parotidectomy with preservation of facial nerve. Fourteen patients were followed up successfully, including 13 with benign tumor and 1 with low-grade malignancy. Until to 2019/6, the median follow-up period was 111.5 months, with 159 months for the longest and 49 months for the shortest. All patients survived without recurrence or facial paralysis. CONCLUSIONS： Parotid gland lymphadenoma is a kind of benign tumor which mainly occurs in patients over 60 years old; the course of lymphadenoma is different and the tumor is mainly located in the lower lobe of the parotid gland, there may be multiple masses and can be malignancy. For parotid gland lymphadenoma, the radical resection alone is enough and the prognosis is good.

Key words: Lymphadenoma, Parotid gland, Clinicaopathological factor

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