Value of multi-voxel 1H-MRS combined with DWI and DCE in diagnosis of squamous cell carcinoma of tongue

doi:10.19438/j.cjoms.2018.06.006

Abstract

Abstract: PURPOSE: To explore the value of multi-voxel ¹H-MRS with DWI and DCE in clinical diagnosis of squamous cell carcinoma (SCC) of the tongue. METHODS: A group of 45 cases that were pathologically determined with SCC and a control group of 25 cases, from June 2016 to October 2017, were selected for retrospective analysis. Both groups underwent routine MR, ¹H-MRS, DWI and DCE examinations. We compared the metabolites of ¹H-MRS (Cho,Cr,Cho/Cr ratio and LL), the variation of ADC value, maximum DCE slope and TIC curve type in focus, relative and distant areas of the SCC, and investigated the relationship of LL peak to ADC value and the maximum DCE slope, as well as its value in diagnosis of SCC. The parameters were analyzed with SPSS 22.0 software package for independent sample t test, paired t test and Chi-square test. RESULTS: The patients group showed significantly higher Cho and LL signals than the control group (P<0.01). The ADC value, maximum DCE slope and TIC curve type were significantly different in focus, relative and distant areas of SCC (P<0.01). The LL signal in the focus SCC area showed inverse linear correlation to ADC value (P<0.01), whereas it was linearly correlated to the maximum DCE slope (P<0.01). Multi-voxel ¹H-MRS combined with DWI and DCE improved the diagnostic accuracy of SCC of the tongue. CONCLUSIONS: Multi-voxel ¹H-MRS is a noninvasive method to acquire metabolic signals of SCC. It offers reliable and valuable approach to diagnose SCC of the tongue when combined with DWI and DCE imaging.

Key words: Multi-voxel, Magnetic resonance spectroscopy, Tongue, Squamous cell carcinoma

CLC Number:

R816.98

WANG Bo-cheng, AI Song-tao, LIANG Hai-sheng, WU Li-zhong, GAO Wei-qing, TAO Xiao-feng, MI Jun. Value of multi-voxel ¹H-MRS combined with DWI and DCE in diagnosis of squamous cell carcinoma of tongue[J]. China Journal of Oral and Maxillofacial Surgery, 2018, 16(6): 511-517.

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Value of multi-voxel ¹H-MRS combined with DWI and DCE in diagnosis of squamous cell carcinoma of tongue

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