Effect of TPF induced chemotherapy combined with postoperative radiotherapy on oral squamous cell carcinoma and its impact on expression of ING4 and Annexin A1

doi:10.19438/j.cjoms.2018.05.010

Abstract

Abstract: PURPOSE: To observe the clinical effect of TPF induced chemotherapy combined with postoperative radiotherapy on oral squamous cell carcinoma (OSCC) and its impact on expression of ING4 and Annexin A1. METHODS: A total of 146 patients with oral squamous cell carcinoma (OSCC) treated from June 2013 to June 2015 in our hospital were selected. According to random digital table, the patients were divided into observation group and control group with 73 cases in each group. Patients in observation group were treated with TPF induced chemotherapy and postoperative radiotherapy; while patients in the control group were treated with surgical resection plus postoperative radiotherapy. The clinical efficacy of the two groups was observed and compared. The expression of ING4 and Annexin A1 in the two groups before and after treatment was detected. The incidence of adverse reactions, 1- and 2-year survival rates were recorded and compared between the two groups. SPSS19.0 software package was used for statistical analysis. RESULTS: The total remission rates of the observation group and the control group were 88.41% and 58.57%, respectively. The total remission rate of the observation group was significantly higher than that of the control group (χ²=23.690, P=0.000). Before treatment, the positive expression rate of ING4 and the relative expression level of Annexin A1 were similar between the two groups (P>0.05). After treatment, the positive expression rate of ING4 in the observation group was significantly higher than that of the control group (P<0.05), and the relative expression level of Annexin A1 in the observation group was significantly lower than that of the control group (P<0.05). The 1- and 2-year survival rates in the observation group were significantly higher than those in the control group (P<0.05). The incidence of nausea, vomiting, oral mucosa damage, leucopenia and radionuclide rash in the observation group were significantly higher than those in the control group (P<0.05). CONCLUSIONS: TPF induced chemotherapy combined with postoperative radiotherapy can effectively improve the clinical efficacy and short-term survival rate of patients with oral squamous cell carcinoma. The possible mechanisms involved increasing the expression of ING4, reducing the expression of Annexin A1 and promoting apoptosis.

Key words: Oral squamous cell carcinoma, TPF induced chemotherapy, Postoperative radiotherapy, ING4, Annexin A1

CLC Number:

R739.8

LI Huai-qi, WU He-ming, DING Xu, YE Jin-hai, WU Yu-nong. Effect of TPF induced chemotherapy combined with postoperative radiotherapy on oral squamous cell carcinoma and its impact on expression of ING4 and Annexin A1[J]. China Journal of Oral and Maxillofacial Surgery, 2018, 16(5): 436-440.

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