Meta analysis of risk factors for surgical site infection after oral and maxillofacial malignancies surgery

doi:10.19438/j.cjoms.2023.06.012

Abstract

Abstract: PURPOSE: To systematically evaluate the risk factors of surgical site infection in patients with oral and maxillofacial malignant tumors. METHODS: Case control studies, cohort studies, on the incidence of surgical site infections in patients with oral and maxillofacial malignancies were searched and collected by searching the CNKI, Wanfang database, VIP, CBM, PubMed, EmBase, The Cochrane Library, and Web of Science databases. The search period was from the establishment to Jan, 2023. RevMan5.3 were used for meta analysis. RESULTS: A total of 13 articles including 4318 patients with oral and maxillofacial malignant tumors were included. According to meta analysis, the risk factors for surgical site infection of oral and maxillofacial malignancies were diabetes (OR=3.82, 95%CI: 2.21-6.62, P<0.0001), ASA score [OR=1.39, 95%CI: 1.22-1.59, P<0.0001), BMI<20 kg/m²(OR=2.43, 95%CI: 1.85-3.18, P<0.0001), surgical procedure(OR=4.39, 95%CI: 1.86-10.31, P=0.0007), defect repair method(OR=5.29, 95%CI: 2.08-13.42, P=0.0005), mandibulectomy(OR=1.94, 95%CI: 1.04-3.61, P=0.04), duration of surgery(OR=3.38, 95%CI: 1.22-9.38, P=0.02), length of hospital stay(≥18 days) (OR=26.33,95%CI：7.53~92.05,P<0.0001), preoperative periodontal calculus level 3 (OR=7.29, 95%CI: 2.91-18.28, P<0.0001) ,and the protective factor was prealbumin>35 g/L(OR=0.11, 95%CI: 0.04-0.29, P<0.0001). CONCLUSIONS: The risk intensity of surgical site infection for malignant tumors in oral and maxillofacial region from high to low was: hospitalization days ≥18, periodontal calculus level 3, defect repair method, surgical method, operation duration, diabetes mellitus, BMI<20 kg/m², mandibular resection, high ASA score. Preoperative albumin>35 g/L was the protective factor.

Key words: Oral and maxillofacial malignancies, Surgical site infection, Risk factors, Meta analysis

CLC Number:

R739.8

WANG Yu, WANG Ming-yi, HOU Li-li, XIANG Fu-ping, LIANG Jia-qing, ZHAO Xiao-mei. Meta analysis of risk factors for surgical site infection after oral and maxillofacial malignancies surgery[J]. China Journal of Oral and Maxillofacial Surgery, 2023, 21(6): 603-609.

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