A case-control study on the risk factors of patients with non-syndromic cleft lip and palate in Kashgar area of Xinjiang Uygur Autonomous Region

doi:10.19438/j.cjoms.2019.05.009

Abstract

Abstract: PURPOSE: To investigate the risk factors of non-syndromic cleft lip with or without cleft palate (NSCL/P) in Kashgar area of Xinjiang Uygur Autonomous Region. METHODS: This case-control study involved 102 NSCL/P patients and 204 normal children from Kashgar area. A questionnaire focusing on various possible risk factors, and responses were analyzed through univariate and multivariate Logistic regression with SPSS 17.0 software package. RESULTS: Logistic regression analysis revealed that family history, consanguineous marriage, drugs, sickness and malnutrition in early pregnancy, contact with pesticides, chemicals, poor mental state increased the risk of NSCL/P(P<0.05). Folic acid supplementation decreased the risk of NSCL/P(P<0.05). CONCLUSIONS: Taking sufficient folic acid, avoiding consanguineous marriage, avoiding contact with pesticides and chemicals, improving health and nutritional status during early pregnancy may decrease the birth rate of NSCL/P in Kashgar area of Xinjiang Uygur Autonomous Region.

Key words: Kashgar area, NSCL/P, Risk factors

CLC Number:

R783.5

ALIMUJIANG Sufuer, BILIKEZI Yusufu, RENAGUZI Abudumijiti. A case-control study on the risk factors of patients with non-syndromic cleft lip and palate in Kashgar area of Xinjiang Uygur Autonomous Region[J]. China Journal of Oral and Maxillofacial Surgery, 2019, 17(5): 436-439.

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