Research advances in the mechanism of malignant progression of oral submucous fibrosis

doi:10.19438/j.cjoms.2020.01.015

Abstract

Abstract: Oral submucosal fibrosis is one of the precancerous lesions of oral squamous cell carcinoma. The process of its malignant transformation is complex and its malignant mechanism is still unclear. In this paper, the latest research progress on the mechanism of OSF malignant transformation was reviewed, including chewing areca nut and OSF malignant progression, hypoxia and angiogenesis, epithelial mesenchymal transformation and epigenetic regulation.

Key words: Oral submucous fibrosis, Oral mucosal squamous cell carcinoma, Malignant transformation

CLC Number:

R739.8

ZHANG Da-he, ZHOU Shang-hui. Research advances in the mechanism of malignant progression of oral submucous fibrosis[J]. China Journal of Oral and Maxillofacial Surgery, 2020, 18(1): 71-76.

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