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25 December 2021, Volume 19 Issue 6 Previous Issue    Next Issue

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Expert Consensus

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Expert consensus on clinical diagnosis and treatment for Chinese oral mucosal melanoma GUO Wei, REN Guo-xin, SUN Mo-yi, KONG Yun-yi, WANG Li-zhen, BU Rong-fa, RAN Wei, TANG Zhan-gui, LI Long-jiang, MENG Jian, SUN Zhi-jun, SHANG Wei, LV Jiong, WU He-ming, ZHANG Chen-ping, HE Yue, MA Xu-hui, SONG Hao, JU Hou-yu, ZHENG Jia-wei, GONG Zhong-cheng, YANG Kai, ZHANG Jie, WU Yun-teng 2021, 19 (6):  481-488.  doi: 10.19438/j.cjoms.2021.06.001 Abstract ( 753 )   PDF (1408KB) ( 726 )   [Summary] Head and neck mucosal melanoma (HNMM) is a kind of highly malignant solid tumor. The 5-year survival rate of HNMM is about 20% for a long time. Its pathogenic factors, driving genes, clinical manifestations and treatment methods are quite different from skin melanoma. In 2015, the first Chinese expert consensus on the diagnosis and treatment of head and neck mucosal malignant melanoma was established. After more than six years of application, the clinical diagnosis and treatment of HNMM has been greatly improved. With the deepening of clinical and basic research on mucosal melanoma, the diagnosis, treatment and prognosis of HNMM have changed greatly in recent years, especially with the vigorous development of various branches of head and neck. Oral, nasal, sinus, eye and other mucosal melanoma have developed their own unique diagnosis and treatment model. This consensus can’t meet the actual needs of the current clinical practice. In this regard, the expert group believes that head and neck mucosa contains a wide range of anatomy, involving more clinical departments, and the diagnosis and treatment mode of melanoma varies significantly between different disciplines. It is urgent to meet the clinical consensus of more specialized diagnosis and treatment of individualized treatment and precise treatment. In order to further improve the long-term survival rate and quality of life of oral mucosal melanoma (OMM) and make the consensus to better guide clinical work, this expert group will focus on OMM and conduct in-depth discussion, and establish expert consensus based on evidence-based medicine and empirical medicine. Considering the individual differences of patients, this consensus can be used as a reference for clinical practice of OMM. References | Related Articles | Metrics

Clinlcal Guideline

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Clinical application and operational practice of simultaneous repair of soft and bone tissues of oroantral fistula based on bag-like absorbable biofilm XIA Liang, ZHAO Zheng-yi, ZOU Duo-hong, YANG Chi, ZHANG Zhi-yuan 2021, 19 (6):  489-493.  doi: 10.19438/j.cjoms.2021.06.002 Abstract ( 495 )   PDF (888KB) ( 194 )   [Summary] Oroantral fistula, defined by abnormal oral-maxillary sinus communication resulted from many factors, is a common disease in oral and maxillofacial surgery. The traditional repair method of oroantral fistula was based on various soft tissue flap grafting. Although it can repair the oroantral fistula, there is a lack of simultaneous repair of bone tissue. With the rapid development of dental implantology, patients with oroantral fistula also require implant restoration of the missing teeth when repairing soft tissue. This poses a new challenge to the treatment of oroantral fistula, which means that both soft and hard tissue need to be repaired. Based on the bag-shaped absorbable membrane invented by the authors, using biomaterials alone, simultaneous repair and regeneration of soft and hard tissues in the area of oroantral fistula can be achieved without autologous bone. This new treatment has the advantages of less invasion, moderate difficulty of operation, reliable clinical effect and easy to be promoted and popularized. Therefore, it is currently favored by more and more doctors and patients. However, due to the uneven clinical skills of dentists, in order to standardize clinical operating standards, ensure medical treatment effects, and reduce postoperative complications, the clinical application and operating specifications of simultaneous repair of soft and hard tissues of oroantral fistula have been proposed in this paper. It was aimed to provide a certain reference and basis for the majority of dentists in the application of this technology and promote its clinical application. References | Related Articles | Metrics

Original Articles

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Expression and clinical significance of cystatin A in oral squamous cell carcinoma YANG Yun-bo, WANG Yu-pu, LI Hang, HAN Nan-nan, YAN Ming, RUAN Min 2021, 19 (6):  494-499.  doi: 10.19438/j.cjoms.2021.06.003 Abstract ( 279 )   PDF (1931KB) ( 284 )   PURPOSE: To evaluate the expression of cystatin A (CSTA) in oral squamous cell carcinoma (OSCC), and its association with clinicopathological factors. METHODS: The expression of CSTA was examined using quantitative real-time PCR, immunohistochemistry, and Western blotting. Statistical analysis was performed to determine the association between CSTA expression and clinicopathological characteristics of patients with OSCC. The effect of CSTA on migration and invasion was evaluated using in vitro assays. The results were analyzed using SPSS 25.0 and GraphPad Prism 8.4.3 software. RESULTS: CSTA expression was significantly downregulated in primary OSCC tissues, and lower CSTA expression was significantly correlated with high tumor grade (P=0.001), cervical lymph node metastasis(P=0.028), and poor overall survival(P<0.001). CTSA overexpression inhibited OSCC cell migration and invasion in vitro. CONCLUSIONS: This study revealed that CSTA is a promising biomarker and therapeutic target with prognostic implications in patients with OSCC. CSTA may play an essential role in cervical lymph node metastasis and tumor differentiation. References | Related Articles | Metrics

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Correlation between oral microbial homeostasis and cisplatin sensitivity in patients with oral squamous cell carcinoma HUANG Jin-yun, ZHANG Xin-yi, JU Hou-yu, JI Hong-hai, REN Guo-xin 2021, 19 (6):  500-505.  doi: 10.19438/j.cjoms.2021.06.004 Abstract ( 323 )   PDF (2152KB) ( 258 )   PURPOSE: To explore the correlation between oral microbial homeostasis and cisplatin sensitivity in patients with oral squamous cell carcinoma(OSCC). METHODS: Saliva samples were collected from 29 OSCC patients before chemotherapy, according to RECIST 1.1 evaluation criteria, the recruited patients were sorted into two groups: cisplatin resistant group (ineffective) and cisplatin sensitive group (effective). 16S rRNA gene sequencing was used to analyze the species composition, community diversity, abundance of oral microorganisms and comparison between samples. The data were analyzed with SPSS 19.0 software package, and LEfSe was used to analyze the species difference between the two groups. RESULTS: Compared with cisplatin chemotherapy-sensitive group, the microbial diversity in saliva samples of the cisplatin resistant group increased significantly. At genus level, Atopobium, Coriobacteriaceae, Parvimonas, Eubacterium yurii and Fusobacteriumin in the chemotherapy-resistant group were significantly increased compared with the sensitive group. CONCLUSIONS: There is significant difference in the structure and composition of oral microorganisms between cisplatin resistant group and cisplatin sensitive group, suggesting that microbes may become biomarkers before chemotherapy for patients with OSCC. References | Related Articles | Metrics

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Correlation between oral microbial homeostasis and cisplatin sensitivity in patients with oral squamous cell carcinoma HUANG Jin-yun, ZHANG Xin-yi, JU Hou-yu, JI Hong-hai, REN Guo-xin 2021, 19 (6):  506-510.  doi: 10.19438/j.cjoms.2021.06.005 Abstract ( 228 )   PDF (2344KB) ( 95 )   PURPOSE: To explore the correlation between oral microbial homeostasis and cisplatin sensitivity in patients with oral squamous cell carcinoma(OSCC). METHODS: Saliva samples were collected from 29 OSCC patients before chemotherapy, according to RECIST 1. 1 evaluation criteria, the recruited patients were sorted into two groups: cisplatin resistant group (ineffective) and cisplatin sensitive group (effective). 16S rRNA gene sequencing was used to analyze the species composition, community diversity, abundance of oral microorganisms and comparison between samples. The data were analyzed with SPSS 19. 0 software package, and LEfSe was used to analyze the species difference between the two groups. RESULTS: Compared with cisplatin chemotherapy-sensitive group, the microbial diversity in saliva samples of the cisplatin resistant group increased significantly. At genus level, Atopobium, Coriobacteriaceae, Parvimonas, Eubacterium yurii and Fusobacteriumin in the chemotherapy-resistant group were significantly increased compared with the sensitive group. CONCLUSIONS: There is significant difference in the structure and composition of oral microorganisms between cisplatin resistant group and cisplatin sensitive group, suggesting that microbes may become biomarkers before chemotherapy for patients with OSCC. References | Related Articles | Metrics

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Comparison of socket-shield technique and routine immediate implantation in anterior maxillary region YAO Chen-yang, MEI Dong-mei, TENG Min-hua, Xu Hao, WANG Wen-xue, LI Jing, ZHOU Chen, ZHAO Bao-dong 2021, 19 (6):  511-516.  doi: 10.19438/j.cjoms.2021.06.006 Abstract ( 400 )   PDF (1122KB) ( 235 )   PURPOSE: To compare the changes in the thickness of labial bone mass and clinical effects between socket-shield technique and routine immediate implant placement in the aesthetic area of anterior maxillary region, and discuss operation details of the socket-shield technique. METHODS: Forty-eight patients were included for immediate implantation between September 2017 to March 2019 in the Affiliated Hospital of Qingdao University. Of them, twenty-six patients underwent routine immediate implantation(RI group), while 22 patients received socket-shield technique(SS group). The follow-up periods were 18-36 months, and the following parameters were employed for comparison: implant success rate, the changes of labial bone plate at 0 mm (I0), 3 mm (I3) and 6 mm (I6) below the shoulder of the implant, the pink aesthetics index(PES) at the last follow-up, gingival sulcus bleeding index and clinical satisfaction. SPSS 25. 0 software package was used for data analysis. RESULTS: The success rate in both groups was 100%. At 6 months and 18 months after operation , the changes of labial bone plate in SS group were lower than those in RI group, with significant difference at I0 and I3. PES score in SS group was higher than that in RI group, but with no significant difference. There was no significant difference in the modified sulcus bleeding index between these two techniques, and both groups obtained high patient satisfaction. CONCLUSIONS: Compared with routine immediate implantation, socket-shield technique maintains bone mass in the labial side of the neck of the implant and soft tissue profile in a short period of time, but has no obvious effect on the success rate. However, these two methods still need long-term clinical observation. It is recommended to prepare root film to the level of the bone surface, with a thickness of about 1 mm,keep a gap of about 1-2 mm on the labial side of the implant and then fill the bone graft material into the defect site. Pitifully, this technique needs highly difficult requirement of clinical procedure. References | Related Articles | Metrics

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Study of 2 different deformation registration softwares in head and neck sketch FAN Wen-hui, SHI Hui-feng, TU Wen-yong 2021, 19 (6):  517-524.  doi: 10.19438/j.cjoms.2021.06.007 Abstract ( 376 )   PDF (1692KB) ( 325 )   PURPOSE: To compare the results of two deformation registration softwares of CT deformation registration in image registration and select a reasonable deformation registration software. METHODS: Fifteen reposition patients with head and neck cancer were collected, the normal tissues of the two groups of CT images were contoured by the same senior doctors, then the deformation and registration proceeded in MIM software and AccuContour software respectively. The normal tissues of the first group were deformed into the second group, and the tissues directly delineated by the second group were calculated to obtain the similarity coefficient (Dice coefficient) and spatial evaluation index (Hausdorff distance). SPSS 23. 0 software package was used for data analysis. RESULTS: Both of the two softwares had good deformation and registration function. Different imaging results of normal tissues had a certain impact on the registration results. The registration results of tissues with good imaging such as eyeball and mandible were better, while the registration results of tissues with small volume such as crystal, optic nerve and optic chiasm were relatively poor. Among the comparison results of the two groups of softwares, MIM software had more advantages. In the evaluation of Dice coefficient, the ratio of MIM software with better data was 67%, 55% of which was statistically significant(P< 0. 05). Hausdorff distance showed that the ratio of MIM software data was better was 74%, of which 48% indicators had statistical significance(P< 0. 05). CONCLUSIONS: In the aspect of deformation registration, both kinds of deformation registration softwares had good deformation registration ability. In comparison, MIM software has more advantages, and it is better to choose MIM software when the requirement of deformation registration accuracy is high. References | Related Articles | Metrics

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Radiographic analysis of osteogenesis of two bone implant materials after augmented corticotomy-assisted surgical orthodontics ZHU Lei, LIU Qing-cheng, YU Hong-bo 2021, 19 (6):  525-530.  doi: 10.19438/j.cjoms.2021.06.008 Abstract ( 312 )   PDF (962KB) ( 302 )   PURPOSE: To evaluate the osteogenesis for patients with malocclusion after augmented corticotomy-assisted surgical orthodontics. METHODS: Forty-two patients with malocclusion augmented corticotomy-assisted surgical orthodontics were selected in this study. The patients were divided into 2 groups, twenty-two were treated with Rebone (group 1), twenty were treated with Bio-oss (group 2). Cone-beam CT was used to measure the alveolar bone indexes of the two groups at different time(T0: preoperative, T1: after 2 week, T2: after 3 month, T3: after 6 month). SPSS 21.0 software package was used for statistical analysis. RESULTS: Among the 42 patients, the labial bone height (HL) in group 2 increased from T0 to T2 (P<0.001); the apical labial bone thickness (TL1) and middle root labial bone thickness (TL2) increased from T0 to T1 and decreased from T1 to T2 (P<0.001). CT value of the area without bone graft(CTn) decreased from T0 to T1 and increased from T1 to T3(P<0.001). CT value of the bone graft area(CTg) decreased from T1 to T3(P<0.001). The differences of TL1, TL2, CTn, and CTg between the two groups were significant(P<0.001). CONCLUSIONS: Patients with malocclusion can achieve sufficient bone increment in the operation area through augmented corticotomy-assisted surgical orthodontics, without periodontal injury and root resorption. The osteogenic effect of the two materials was ideal, and the osteogenesis was stable after half a year follow-up. References | Related Articles | Metrics

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Effect of 2 mm short healing abutment in early implant bone increment in anterior teeth aesthetic area LI Jing, MEI Dong-mei, JIANG Ya-ping, XU Hao, WANG Wen-xue, YAO Chen-yang, LI Ya-nan, ZHAO Bao-dong 2021, 19 (6):  531-535.  doi: 10.19438/j.cjoms.2021.06.009 Abstract ( 401 )   PDF (1109KB) ( 146 )   PURPOSE: To evaluate the effect of 2 mm short healing abutment on incremental preservation of labial bone during early implantation in the aesthetic area of anterior teeth. METHODS: From August, 2018 to May, 2019, fifty patients were treated in the Department of Dental Implantation, Affiliated Hospital of Qingdao University. All patients in the experimental group were treated with 2 mm short healing abutment, while patients in the control group were treated with closed screws. The patients were followed up for 18 months. The changes of bone mass at the level of 0, 3 and 6 mm from the labial side of the anterior teeth area to the shoulder of the implant were compared between the two groups 6 and 18 months after operation, and implant retention rate, pink aesthetic score(PES) and improved gingival sulcus bleeding index (mSBI) were compared between the two groups 18 months after operation. SPSS 26.0 software package was used for statistical analysis of the data. RESULTS: After 6 months and 18 months, the changes of bone mass in the labial shoulder of the experimental group were significantly lower than those in the control group(P<0.05). There was no significant difference in other loci. Eighteen months after operation, the retention rate of implants in both groups was 100%. PES in the experimental group was significantly higher than that in the control group(P>0.05). There was no significant difference in mSBI between the two groups. CONCLUSIONS: Low healing abutment has obvious effect on preserving the labial bone mass and maintaining soft tissue morphology in the aesthetic area of anterior teeth, which is worthy of clinical promotion. References | Related Articles | Metrics

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Comparison of socket-shield technique and routine immediate implantation in anterior maxillary region YAO Chen-yang, MEI Dong-mei, TENG Min-hua, Xu Hao, WANG Wen-xue, LI Jing, ZHOU Chen, ZHAO Bao-dong 2021, 19 (6):  536-541.  doi: 10.19438/j.cjoms.2021.06.010 Abstract ( 606 )   PDF (1672KB) ( 250 )   PURPOSE: To compare the changes in the thickness of labial bone mass and clinical effects between socket-shield technique and routine immediate implant placement in the aesthetic area of anterior maxillary region, and discuss operation details of the socket-shield technique. METHODS: Forty-eight patients were included for immediate implantation between September 2017 to March 2019 in the Affiliated Hospital of Qingdao University. Of them, twenty-six patients underwent routine immediate implantation(RI group), while 22 patients received socket-shield technique(SS group). The follow-up periods were 18-36 months, and the following parameters were employed for comparison: implant success rate, the changes of labial bone plate at 0 mm (I0), 3 mm (I3) and 6 mm (I6) below the shoulder of the implant, the pink aesthetics index(PES) at the last follow-up, gingival sulcus bleeding index and clinical satisfaction. SPSS 25. 0 software package was used for data analysis. RESULTS: The success rate in both groups was 100%. At 6 months and 18 months after operation , the changes of labial bone plate in SS group were lower than those in RI group, with significant difference at I0 and I3. PES score in SS group was higher than that in RI group, but with no significant difference. There was no significant difference in the modified sulcus bleeding index between these two techniques, and both groups obtained high patient satisfaction. CONCLUSIONS: Compared with routine immediate implantation, socket-shield technique maintains bone mass in the labial side of the neck of the implant and soft tissue profile in a short period of time, but has no obvious effect on the success rate. However, these two methods still need long-term clinical observation. It is recommended to prepare root film to the level of the bone surface, with a thickness of about 1 mm,keep a gap of about 1-2 mm on the labial side of the implant and then fill the bone graft material into the defect site. Pitifully, this technique needs highly difficult requirement of clinical procedure. References | Related Articles | Metrics

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Effect of different timing of dexmedetomidine administration in children's dental caries treatment under general anesthesia JIANG Chao, QIU Lin, LIN Yu 2021, 19 (6):  546-548.  doi: 10.19438/j.cjoms.2021.06.011 Abstract ( 241 )   PDF (407KB) ( 156 )   PURPOSE: To investigate the effect of different timing of dexmedetomidine administration in children's dental caries treatment under general anesthesia. METHODS: One hundred and twenty children scheduled for caries treatment were randomly divided into group D1, group D2 and group D3 with 40 cases in each group. Sevoflurane 1.5 Mac was used to maintain anesthesia in all children. Group D1 was not given dexmedetomidine. Group D2 was given 0.5 μg/(kg·h)dexmedetomidine for 10 min after intubation. Group D3 was given 0.5 μg/(kg·h) dexmedetomidine for 10 min before the end of operation. HR and MAP at the time of entering the operation room (T0), beginning of operation(T1), HR and MAP 1 hour after beginning of operation(T2) and ending of operation(T3) were measured; extubation time and recovery time were recorded; the anesthesia recovery agitation score (PAED) and pain score (FLACC) were calculated after entering the anesthesia treatment unit (PACU). SPSS 21.0 software package was used to analyze the data. RESULTS: HR and MAP at T1, T2 and T3 were significantly lower than those at T0(P<0.05). Compared with group D1, HR and MAP at T1, T2 and T3 were significantly decreased in group D2(P<0.05). Compared with group D1, HR and MAP at T3 in group D3 decreased significantly(P<0.05). The extubation time and recovery time of group D1 and D2 were significantly shorter than those of group D3(P<0.05). Compared with group D1, PAED and FLACC in group D2 and D3 were significantly lower than those in group D1(P<0.05). CONCLUSIONS: Dexmedetomidine 0.5 μg/(kg·h) pumped for 10 min after anesthesia induction intubation can stabilize the hemodynamics during operation, reduce agitation of anesthesia recovery, and do not affect the time of anesthesia recovery and extubation, which is a more reasonable time for clinical medication. References | Related Articles | Metrics

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Application of 3D-CT reconstruction in comparison of upper airway between obese patients with obstructive sleep apnea-hypopnea syndrome and normal persons WANG Jia-yi, SHI Wei, HU Rong, LI Jing-jie, JIANG Hong 2021, 19 (6):  549-552.  doi: 10.19438/j.cjoms.2021.06.012 Abstract ( 353 )   PDF (607KB) ( 155 )   PURPOSE: To evaluate the upper airway condition more precisely by using three-dimensional CT reconstruction (3D-CT) in patients with difficult airway during preoperative assessment. METHODS: A total of 62 obese patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and normal adults were recruited. ASA grade Ⅱ of obese OSAHS patients was 34. 33± 10. 07 (17-55) years old, with a BMI of (39. 05± 5. 17)kg/m2. In the control group, ASA grade Ⅰ to Ⅱ was 28. 34±6. 41 (18-35) years old, and the BMI was (23. 23± 4. 51)kg/m2. Mimics 11. 04 was used to analyze the upper airway of OSAHS patients and normal people by reviewing the upper airway 3D-CT data which included the minimum area and the volume of the upper airway. Difference of the upper airway between OSAHS patients and normal ones in 3D-CT reconstruction was analyzed with SPSS 21. 0 software package. RESULTS: OSAHS patients' volume of total airway, retropalatal region and epiglottal region were significantly smaller than the controls (P< 0. 05). There was no significant difference in retroglossal region between OSAHS patients and the controls(P> 0. 05). CONCLUSIONS: 3D-CT reconstruction can display upper airway stenosis and is a good preoperative assessment of difficult airway. References | Related Articles | Metrics

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Clinical value of Orem self-care model in 90 patients with oral squamous cell carcinoma after free flap surgery LI Man-rong, LOU Ya-jing 2021, 19 (6):  553-556.  doi: 10.19438/j.cjoms.2021.06.013 Abstract ( 248 )   PDF (551KB) ( 110 )   [Summary] To achieve alveolar bone tissue regeneration is a hot research direction in the field of stomatology. Many studies have shown that growth factors play an important role in alveolar bone regeneration, and they have broad application prospects in many fields, such as oral implant, periodontal treatment, tooth extraction and so on. This article reviewed the application and research progress of growth factors in promoting alveolar bone regeneration in different dental fields. References | Related Articles | Metrics

Dental Education

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Development and application of a novel microsurgery training tool based on 3D printed hydrogel YANG Yong, DING Ming-chao, YANG Tao, LIU Yi-wen, LU Jin-biao, TIAN Lei 2021, 19 (6):  557-561.  doi: 10.19438/j.cjoms.2021.06.014 Abstract ( 259 )   PDF (1055KB) ( 215 )   PURPOSE: To develop a novel microsurgical training tool based on 3D printed hydrogel and evaluate its practicality and teaching effectiveness. METHODS: A series of micro-vessels were designed and produced with hydrogel by 3D printing technology and were loaded into a piping connection system with pump and other components to compose a set of microsurgical training tool; then 10 senior microsurgeons who had rich clinical teaching experience in microsurgery were selected to evaluate the differences between this new teaching aid and the traditional teaching instruments by questionnaire. Another 24 interns who were in the 5th year program of stomatology were randomly divided into the control group and the experimental group. The interns in the control group were trained for anastomosis skill twice a day by traditional instrument for 10 days, while the interns in experimental group were trained by the novel teaching tool. Then the two groups of students were given a test of microsurgery skill by doing anastomosis with rat carotid artery. Each intern's capacity of microsurgery was scored to compare the effectiveness of this novel teaching tool with the traditional one. The data were analyzed with SPSS 19.0 software package. RESULTS: A set of novel microsurgery training aid with 3D printed hydrogel blood vessels as the core was developed. The questionnaire results of 10 senior microsurgeons showed that this new teaching aid was more practical, scientific and effective than the traditional one. The score of the interns in the experimental group was significantly higher than that of the control group (P< 0.05). CONCLUSIONS: This set of teaching aid for microsurgery based on 3D printing hydrogel vascular technology is highly practical, scientific in design, convenient in use and economic in cost. Its effect in actual clinical teaching practice of microsurgery is obviously better than the traditional teaching model, indicating that this novel teaching aid is convenient for standardized training and worthy of wide application. References | Related Articles | Metrics

Review Articles

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Application of lineage tracing technique based on Cre/Loxp recombinase system in the study of osteogenic remodeling XU Ning-wei, WANG Jing, GONG Jia-jing, ZHANG Jin, JIN An-ting, JIANG Ling-yong 2021, 19 (6):  562-567.  doi: 10.19438/j.cjoms.2021.06.015 Abstract ( 306 )   PDF (735KB) ( 410 )   [Summary] Cell lineage tracing technology is an important tool to study the characteristics of stem cells, among which, the one based on Cre/Loxp recombinase system is a great breakthrough. General recombinase system realizes the tissue specificity of reporter gene, based on which, inducible recombinase system makes controlling the expression time of reporter gene possible. The study of the mechanism of osteogenic remodeling is related to the fate of osteoblast lines, which is of great significance to the study of bone remodeling and the application of tissue engineering. This paper reviewed the application of lineage tracing technique based on Cre/Loxp recombinase system in the study of the origin, differentiation, lineage and hierarchy of osteoblast lines and their function in development and repair, and discussed its scope of application, advantages and disadvantages. References | Related Articles | Metrics

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Application and study of growth factor in alveolar bone regeneration FEI Chen-yan, JIANG Yin-hua 2021, 19 (6):  568-572.  doi: 10.19438/j.cjoms.2021.06.016 Abstract ( 434 )   PDF (626KB) ( 309 )   [Summary] To achieve alveolar bone tissue regeneration is a hot research direction in the field of stomatology. Many studies have shown that growth factors play an important role in alveolar bone regeneration, and they have broad application prospects in many fields, such as oral implant, periodontal treatment, tooth extraction and so on. This article reviewed the application and research progress of growth factors in promoting alveolar bone regeneration in different dental fields. References | Related Articles | Metrics

Case Reports

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A case report of malignant transformation of parotid recurrent pleomorphic adenoma invading the zygoma XU Fei-hu, XU Wan-lin, LIU Sheng-wen, DING Xiu-ming, ZHANG Xiang, YANG Wen-jun 2021, 19 (6):  573-576.  doi: 10.19438/j.cjoms.2021.06.017 Abstract ( 346 )   PDF (1842KB) ( 171 )   [Summary] Recurrent pleomorphic adenoma in the parotid region has certain probability of malignant transformation, but until now there is no report of zygomatic invasion in the literatures. This article reported a case of recurrent pleomorphic adenoma in parotid region with malignant transformation and invasion of the zygoma, and analyzed its clinical, imaging and pathological characteristics based on literature review, so as to improve our understanding of this disease and avoid misdiagnosis and mistreatment. References | Related Articles | Metrics