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20 May 2021, Volume 19 Issue 3 Previous Issue    Next Issue

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Hard and soft tissue alterations around bone-level implants with different depths in fresh extraction sockets: a histomorphometric study ZHANG Chu-nan, ZHAO Xu, QIAO Shi-chong, ZHANG Xiao-meng, GU Ying-xin 2021, 19 (3):  193-196.  doi: 10.19438/j.cjoms.2021.03.001 Abstract ( 357 )   PDF (919KB) ( 308 )   PURPOSE: To investigate the alterations of soft and hard tissue around implants with different insertion depth. METHODS: Bilateral premolars of 6 adult Labrador dogs were extracted and 24 implants were immediately placed into the extraction sockets with various insertion depths. Straumann® Bone Level (BL) implants were positioned at 4 levels: 2 mm below, 1 mm below, flush with, and 1 mm above the alveolar crest. Six months after implant placement, all animals were sacrificed to obtain undecalcified block sections for histological analysis. Vertical bone loss and biologic width were recorded. SPSS 19.0 software package was used for data analysis. RESULTS: All implants osseointegrated uneventfully. The most significant bone resorption was observed when implants were inserted 2 mm below the buccal wall of the sockets(P<0.05). No significant difference in biologic widths was found. CONCLUSIONS: The insertion depths appeared to have influence on bone remodeling around implants in fresh extraction sockets. More pronounced vertical bone resorption was observed when implants were inserted 2 mm below the buccal alveolar ridge. References | Related Articles | Metrics

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Effect of soybean isoflavoneon on osteoclastic differentiation of mandible bone marrow-derived macrophages CHEN Fu-min, DAI Qing-gang, WU Chun-lan, WANG Yue-ping 2021, 19 (3):  197-200.  doi: 10.19438/j.cjoms.2021.03.002 Abstract ( 220 )   PDF (948KB) ( 216 )   PURPOSE: To study the effects of soybean isoflavoneon on osteoclastic differentiation of mandible bone marrow-derived macrophages (mBMMs). METHODS: Four-week-old female S-D rats were used to obtain mBMMs. CCK-8 assay was used to analyze the changes of cell viability of mBMMs due to different concentration of soybean isoflavoneon. The effect of soybean isoflavoneon on osteoclastic formation and osteoclastic gene expression was determined by tartrate resistant acid phosphatase staining (TRAP) and q-PCR. SPSS16.0 software package was used for data analysis. RESULTS: Cell viability of mBMMs treated with 1 μmol/L, 100 nmol/L, 10 nmol/L and 1 nmol/L soybean isoflavoneon was comparable with the control group, while100 μmol/L and10 μmol/L soybean isoflavoneon inhibited cell viability of mBMMs (P<0.05). With TRAP staining, both 1 μmol/L and 100 nmol/L soybean isoflavoneon decreased the number osteoclast in BMMs induced by RANKL (P<0.05). Moreover, the mRNA level of NFATc1, MMP9, Trap and Ctsk of in mBMMs treated with 1 μmol/L and 100 nmol/L soybean isoflavoneon decreased significantly in comparison with the control group. CONCLUSIONS: Soybean isoflavoneon inhibits osteoclastic differentiation of mBMMs. References | Related Articles | Metrics

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Effects of propofol on proliferation, migration, invasion and apoptosis of human pharyngeal squamous cell carcinoma FADu cell line WANG Yue, LAO Wei, SUN Yu 2021, 19 (3):  201-204.  doi: 10.19438/j.cjoms.2021.03.003 Abstract ( 229 )   PDF (1085KB) ( 221 )   PURPOSE: To study the potential mechanism of propofol on proliferation, migration, invasion and apoptosis of human pharyngeal squamous cell carcinoma FADu cell line. METHODS: Different concentrations of propofol (0, 5, 10, 20 μg/mL) were used to treat FADu cell line. CCK-8 toxicity test and plate clone test were used to test cell proliferation ability. The ability of lateral migration was detected by wound healing assay. Transwell assay was used to detect the ability of longitudinal migration and invasion. The expression of Bcl-2,Bax and Cleaved Caspase-3 was detected by Western blot. SPSS 18.0 software package was used to analyze the data. RESULTS: Cytotoxicity test showed that the survival rate of FADu cell line decreased in a time and concentration dependent manner (P<0.01) after treatment with different concentrations of propofol. The results of plate clonal assay showed that cell proliferation decreased with the increase of propofol concentration(P<0.01). Wound healing assay showed that the lateral migration ability of cells treated with propofol of 10 and 20 μg/mL was significantly different from that of the control group (P<0.05). Transwell test showed that propofol effectively inhibited the ability of longitudinal migration and invasion (P<0.001) in a concentration dependent manner. Western blot analysis showed that the expression of Bcl-2 decreased and the expression of Bax and Cleaved Caspase-3 increased significantly(P<0.01). CONCLUSIONS: Propofol inhibits the proliferation, migration and invasion of FADu cells, and promotes apoptosis by inhibiting Bcl-2/Bax pathway. The mechanism may be through promoting the expression of Caspase-3. References | Related Articles | Metrics

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Effects of small molecule biochanin A on osteogenic differentiation of human dental pulp stem cells XIE Xin-ru, RAN Xue-hui, XU Wei-feng, LIU Xiu-ming, ZHANG Xiang-kai, CAO Ling-yan, ZHANG Shan-yong 2021, 19 (3):  205-212.  doi: 10.19438/j.cjoms.2021.03.004 Abstract ( 318 )   PDF (1370KB) ( 280 )   PURPOSE: To study the effects of different concentrations of biochanin A (BCA) on osteogenic differentiation of human dental pulp stem cells (hDPSCs) and its related molecular mechanisms. METHODS: Primary human dental pulp stem cells were isolated and cultured by tissue explant method, cell phenotypes were identified by flow cytometry. Effects of different concentrations of BCA on proliferation of hDPSCs were detected by CCK-8 method, and effects of different concentrations of BCA on osteogenic differentiation of hDPSCs were analyzed by q-PCR, alkaline phosphatase (ALP) staining, and alizarin red staining. Finally, the influence of BCA on MAPK signaling pathway during osteogenic differentiation of hDPSCs was investigated through Western blot. SPSS 16.0 software package was used for statistical analysis of the data. RESULTS: hDPSCs obtained in the experiment were conformed to have the characteristics of mesenchymal stem cells by flow cytometry. CCK-8 results showed that BCA below 25 μmol/L had no effect on cell activity of hDPSCs, while over 30 μmol/L BCA inhibited the proliferation of hDPSCs. 10 μmol/L BCA significantly increased the expression of osteogenic-related genes ALP, COL-1, OPN and OCN. The staining of ALP and alizarin red was also more obvious than that of the control group and the other concentration groups. Western blot displayed that BCA activated P38/MAPK signaling pathway, but had no obvious effect on ERK and JNK pathway. CONCLUSIONS: Tissue explant method can obtain hDPSCs with higher purity. BCA may promote osteogenic differentiation of hDPSCs by activating P38/MAPK signaling pathway. References | Related Articles | Metrics

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Effects of raloxifene on fracture healing and OPG/RANKL/RANK system in rats with osteoporotic jaw fracture LI Jian-ping, LIU Pei, GAO Xue-ge, SHI Yan-ping 2021, 19 (3):  213-216.  doi: 10.19438/j.cjoms.2021.03.005 Abstract ( 245 )   PDF (899KB) ( 255 )   PURPOSE: To investigate the effects of raloxifene on fracture healing and osteoprotegerin (OPG) / receptor activator of NF-κB ligand (RANKL) / receptor activator of NF-κB (RANK) system in rats with osteoporotic jaw fracture. METHODS: SPF SD rats were used to establish an osteoporotic jaw fracture model. After successful establishment of the model, 12 mg/kg raloxifene were administered intragastrically for 4 weeks. X-ray film was taken to check the fracture healing. Bone mineral density (BMD) was measured by dual energy X-ray absorptiometry. H-E staining was used to examine the morphology of callus. Western blot was used to detect the expression of OPG, RANKL and RANK. SPSS 22.0 software package was used for data analysis. RESULTS: The fracture line recovery of the raloxifene group was better than that of the model group 2 and 4 weeks after surgery. H-E staining showed more bone trabecula and bone matrix-like masses in the callus area than the model group, which was similar to that in blank control group 4 weeks after operation. The BMD and relative expression of OPG protein in raloxifene group were significantly higher than those in model group at 2 and 4 weeks after operation, and the relative expression of RANKL and RANK protein were significantly lower than those in model group (P<0.05), which were similar to those in blank control group 4 weeks after operation (P>0.05). CONCLUSIONS: Raloxifene can regulate OPG/RANKL/RANK system and promote fracture healing in rats with osteoporotic jaw fracture. References | Related Articles | Metrics

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Stathmin expression correlated with the long-term survival benefit from TPF induction chemotherapy in patients with locally advanced oral squamous cell carcinoma TAN Yi-ran, ZHAO Tong-chao, WANG Li-zhen, LI Jiang, JU Wu-tong, ZHU Dong-wang, ZHANG Zhi-yuan, ZHONG Lai-ping 2021, 19 (3):  217-221.  doi: 10.19438/j.cjoms.2021.03.006 Abstract ( 288 )   PDF (999KB) ( 219 )   PURPOSE: This study analyzed the role of Stathmin as a predictive biomarker on the long-term benefit of TPF induction chemotherapy based on a 11-year follow-up results. METHODS: Long-term follow-up results of 256 oral squamous cell carcinoma (OSCC) patients enrolled in the TPF induction chemotherapy trial were collected. Tumor biopsy specimens were collected for Stathmin immunohistochemical staining and scoring. Subgroup prognosis was analyzed according to the Stathmin expression. Stathmin and other baseline characteristics were analyzed by univariate, multivariate, and Cox regression model with SPSS 13.0 software package. RESULTS: Stathmin expression predicted the response of TPF induction chemotherapy in OSCC patients. OSCC patients with lower Stathmin expression benefited from TPF induction chemotherapy, while OSCC patients with higher Stathmin expression did not benefit from TPF induction chemotherapy. Stathmin expression was an independent predictor of long-term prognosis. CONCLUSIONS: Stathmin is an independent biomarker for predicting the efficacy of TPF induction chemotherapy in OSCC. Subsequent clinical studies based on Stathmin screening will be meaningful for choice of TPF induction chemotherapy in OSCC. References | Related Articles | Metrics

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Angulated screw channel restored with monolithic zirconia vs. porcelain-fused-to zirconia implant crowns: a prospective clinical trial in split-mouth design YANG Lu-peng, FAN Lin-feng, SHI Jun-yu, ZHANG Xiao, GU Ying-xin, ZHANG Chu-nan 2021, 19 (3):  222-225.  doi: 10.19438/j.cjoms.2021.03.007 Abstract ( 393 )   PDF (832KB) ( 256 )   PURPOSE: The objective of the present study was to compare the clinical performance of angulated screw channel restored with monolithic zirconia and porcelain-fused-to-zirconia implant crowns. MOTHODS: In a prospective, clinical, split-mouth trial, bilateral premolar or molar single gaps in 13 patients were restored with angulated screw channel with either monolithic (experimental group) or porcelain-fused-to-zirconia (control group). Patient's subjective evaluation, technical complications and crestal bone level change were recorded during a follow-up period of 12 months. SAS 9.4 software was used for statistical analysis. RESULTS: No implant was lost during the follow-up period. Of the crowns in esthetic appearance, there were 10 (excellent)/3(acceptable) in the experimental group and 12 (excellent)/1(acceptable) in the control group (P>0.05). Of the crowns in function, there were 12(excellent)/1(acceptable) in the experimental group and 11(excellent)/2(acceptable) in the control group (P>0.05). Changes in bone crest level seemed to have no correlation with either monolithic crowns or porcelain fused to zirconia crowns（P>0.05）. CONCLUSIONS: Within the limits of our study, over a 12-month follow-up, angulated screw channel restored with monolithic and porcelain-fused-to-zirconia implant crowns shows comparable clinical and radiological results. References | Related Articles | Metrics

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Effect of continuous oral anticoagulant therapy on the risk of postoperative bleeding events in patients undergoing extraction of complication teeth HAO Xin-he, GAO Chao, SHEN Mo-lun, YE Hu, ZHAO Jun, CHU De-qiang, ZHAI Qin-kai 2021, 19 (3):  226-229.  doi: 10.19438/j.cjoms.2021.03.008 Abstract ( 610 )   PDF (755KB) ( 245 )   PURPOSE: To investigate the incidence of bleeding events after surgical tooth extraction in patients without withdrawal of oral anticoagulant therapy. METHODS: This prospective cohort study included 51 patients who were treated with oral anticoagulants undergoing surgical dental extractions from July 2020 through September 2020. Surgical extraction referred to a procedure requiring the elevation of a mucoperiosteal flap and/or an osteotomy. The primary predictor variables were the kinds of anticoagulant drugs, including warfarin and aspirin. The primary outcome measurement was the incidence of bleeding events after surgical dental extraction. Chi-square test was used for statistical analysis with SPSS 17.0 software package. RESULTS: Twenty-six patients taking warfarin showed 9(34.6%) bleeding episodes and 25 patients receiving aspirin presented 10 (40%) bleeding episodes 30 minutes after tooth extractions, with a total of 19(37.3%) bleeding cases(P=0.691). Bleeding complications occurred in 4 patients(15.4%) in the warfarin group and 4 patients(16%) in the aspirin group respectively, at 1 hour after tooth extractions, with a total of 8 (15.7%) bleeding complications(P=0.952). Two patients（3.9%） developed delayed bleeding more than 24 hours after operation, both underwent molar extraction while taking warfarin(P=0.157). CONCLUSIONS: No significant difference was observed between patients with bleeding after surgical extractions. It is more likely to have delayed bleeding more than 24 hours after operation in patients taking warfarin undergoing molar extraction. References | Related Articles | Metrics

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Application of different anesthesia methods in facial nerve monitoring during parotid gland surgery LIU Jin-xing, HUANG Hui-min, DONG Xiang, LAO Wei, SHI Wei 2021, 19 (3):  230-233.  doi: 10.19438/j.cjoms.2021.03.009 Abstract ( 436 )   PDF (755KB) ( 221 )   PURPOSE: To compare the effects of intravenous inhalation anesthesia and total intravenous anesthesia in facial nerve monitoring without muscle relaxant during resection of parotid tumors. METHODS: Seventy patients with parotid tumors undergoing facial nerve monitoring surgery were randomly divided into 2 groups, with 35 cases in each group. After cisatracurium administration, maintenance of anesthesia was performed by sevoflurane plus remifentanil and propofol in group sevofurane(S) and propofol plus remifentanil in group vein(V). Train-of-four ratio (TOF) was monitored and block work time, recovery time of deep blockade T1, T1 50% and TOF 90% were recorded. Electrophysiological monitor was connected and the success rates of facial nerve monitoring in the recovery time of T1 50% were compared. The response of body movement, usage of vasoactive agents and extubation time were also recorded. SPSS 20.0 software package was used for data analysis. RESULTS: There was no significant difference in time of block work and recovery time of deep blockade between two groups(P>0.05). Recovery time of T1 50% and TOF 90% in group S were significantly longer than those in group V (P<0.05). All patients underwent electrophysiological monitor successfully in the recovery time of T1 50%. Two patients in group V had weak body movements during operation,and patients in both groups had no cardiovascular drug treatments. There was no significant difference between the two groups in time of extubation(P>0.05). CONCLUSIONS: The two methods in facial nerve monitoring without muscle relaxant during resection of parotid tumors are completely possible and effective. Sevoflurane can enhance the muscle relaxation of cisatracurium and the patients undergoing total intravenous anesthesia can receive electrophysiological signals of facial nerve earlier. Intravenous inhalation anesthesia provides lower movements. References | Related Articles | Metrics

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Clinical study of serum hepcidin and ferritin for ventilator-associated pneumonia after oral and maxillofacial surgery WANG Ye, HU Rong, WANG Yuan, HUANG yan 2021, 19 (3):  234-237.  doi: 10.19438/j.cjoms.2021.03.010 Abstract ( 332 )   PDF (756KB) ( 157 )   PURPOSE: To investigate the changes and clinical significance of serum hepcidin and ferritin in patients with ventilator-associated pneumonia(VAP) after oral and maxillofacial surgery. METHODS: One hundred and ninety-six patients who underwent ventilator treatment after oral and maxillofacial surgery from January 2017 to December 2019 in Shanghai Ninth People's Hospital were selected. The patients were categorized into VAP group(n=100) and non-VAP group (n=96). VAP patients were divided into low-risk, intermediate-risk and high-risk subgroup, according to Acute Physiology and Chronic HealthⅡ(APACHEⅡ) score. The level of serum procalcitonin (PCT), hepcidin and ferritin was detected. SPSS 23.0 software package was used for statistical analysis. RESULTS: The hospitalization time and mechanical ventilation time of VAP group were significantly higher than those of non-VAP group (P<0.05). The PCT level and APACHEⅡ score of VAP group were (2.13±0.95)ng/mL and (23.68±6.70) points, which were both significantly higher than those in non-VAP group: (0.87±0.46)ng/mL and (17.22±5.19) points(P<0.05). The serum level of ferritin, hepcidin and ratio of ferritin/hepcidin in VAP group was (217.79±62.38) ng/mL, (57.62±9.60) ng/mL and 3.79±0.93, which was significantly higher than those in non-VAP group:(181.55±54.02) ng/mL,(50.58±8.52) ng/mL and 3.11±0.86, respectively (P<0.05）. The serum level of ferritin, hepcidin and ratio of ferritin/hepcidin in VAP patients in the low-risk subgroup, intermediate-risk subgroup and high-risk subgroup gradually increased (P<0.05). Spearman correlation analysis found that the severity of VAP was positively correlated with serum PCT, hepcidin, ferritin, and ferritin/hepcidin ratio (r=0.772, 0.811, 0.873, 0.898; P<0.05). CONCLUSIONS: Serum hepcidin and ferritin were significantly elevated in VAP patients, which can be used to evaluate the severity of VAP patients. References | Related Articles | Metrics

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Survival analysis of 68 HPV related oropharyngeal squamous cell carcinoma based on the new clinical staging system KONG Yu, YANG Xiao-chen, TAO Yue-qin, ZHOU Kai, LIN Zhi-hao, HOU Feng, FENG Yuan-yong, CHEN Yun-qing, JIANG Yan-xia, SONG Kai, SHANG Wei 2021, 19 (3):  238-243.  doi: 10.19438/j.cjoms.2021.03.011 Abstract ( 668 )   PDF (928KB) ( 217 )   PURPOSE: To compare the detection rate of human papillomavirus (HIV) associated oropharyngeal squamous cell carcinoma (SCC) with 3 methods, including brush cytology of oropharynx, P16 immunohistochemistry (IHC) and HPV polymerase chain reaction (PCR), evaluate the prognosis of patients with HPV positive based on the new and old TNM staging system, in order to provide clinical evidence to guide the precise diagnosis and treatment of HPV-related oropharyngeal SCC. METHODS: The results of brush cytology, P16 IHC and PCR in 171 patients with oropharyngeal SCC were analyzed and compared. The clinical and pathological data of 68 patients with HPV associated oropharyngeal SCC were collected,according to the new and old TNM staging system, the degradation situation was determined, the survival rate of patients at each stage, and the prognosis of patients with the new and old TNM stages was analyzed with SPSS 22.0 software package. RESULTS: The positive rates of HPV detected by P16 IHC, brush cytology and PCR were 25.7%, 14.6% and 24.0%, respectively. There was significant difference between brush cytology and other two methods (P =0.000), but there was no significant difference between IHC and PCR (P=0.205). Sixty-eight patients with HPV positive oropharyngeal SCC were classified according to the 7th and 8th edition of TNM staging system, they were 3 and 42 in stage Ⅰ, 7 and 14 in stage Ⅱ, 17 and 9 in stage Ⅲ, and 41 and 3 in stage Ⅳ, respectively. The 3-year survival rates of patients in the 7th and 8th edition of staging system was compared, stage Ⅰ was 100.0% and 89.7%(P=0.672), stage Ⅱ was 68.6% and 61.9% (P=0.961), stage Ⅲ was 66.8% and 37.0% (P=0.043), IV stage was 74.8% and 0.00% (P=0.000), respectively. The survival rates of early stage patients (stagesⅠandⅡ) in the 7th and 8th edition of staging system were 78.8% and 82.7% (P=0.585), and the survival rates of advanced patients (stage Ⅲ and Ⅳ) were 71.2% and 27.8% (P=0.000), respectively. According to the 7th edition of staging system of HPV positive patients, the survival rates of early and late patients were 78.8% and 71.2% (P=0.982). According to the 8th edition of staging system, the survival rates of early and late patients were 82.7% and 27.8%, respectively (P=0.000). CONCLUSIONS: Brush cytology test should not be used as a standard for the diagnosis of HPV positive oropharyngeal SCC. P16 IHC and PCR have their advantages and disadvantages, and should be selected according to the individual situation. For patients with HPV positive oropharyngeal SCC, the new staging system is more consistent with the actual clinical situation, the prognostic stratification is clearer, and it can better guide clinical decision-making and is worthy of clinical application References | Related Articles | Metrics

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Effect of different anesthetic maintenance drugs on serum homocysteine concentration in infants undergoing long-term operation QIU Lin, LI Jing-jie, ZHANG Ling, JIANG Chao 2021, 19 (3):  244-247.  doi: 10.19438/j.cjoms.2021.03.012 Abstract ( 277 )   PDF (756KB) ( 150 )   PURPOSE: To compare the effect of three different general anesthetic maintenance drugs: propofol intravenous, sevoflurane inhalation and propofol intravenous injection combined with sevoflurane in halation, on serum homocysteine (Hcy) concentration in infants undergoing long-term operation. METHODS: Fifty-one children aged 8-24 months with operation time more than 3 hours were randomly divided into three groups: group P（propofol intravenous injection), group S（sevoflurane inhalation) and group C（propofol intravenous injection combined with sevoflurane inhalation).All the infants underwent rapid induction transoral endotracheal intubation, and the dosage of anesthesia maintenance drugs in each group was adjusted according to the depth of anesthesia during operation. Venous blood was collected at the beginning of the operation (T0) and immediately after the end of the operation (T1), to determine the serum hcyconcentration(Hcy). Preoperative and postoperative Hcy concentrations and their changes in each group were compared. Statistical analysis was performed using SPSS 21.0 software package. RESULTS: Compared with the preoperative period, HR of the infants in all three groups were significantly decreased (P<0.05), but there was no significant difference in NIBP and SpO2.Compared with preoperative level, serum Hcy concentration of group C decreased significantly after operation(P<0.01), while there was no significant difference between group S and group P. There was no significant difference between the three groups in Hcy concentration at T0 and T1(P>0.05). CONCLUSIONS: Propofol and sevoflurane alone or combined with anesthesia maintenance in infants with long-term operation has little effect on serum Hcy concentration. References | Related Articles | Metrics

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Impact of metal artifact reduction algorithms on dosimetry of postoperative radiotherapy for head and neck cancer patients with titanium plate implantation LAO Zheng, BI Fan, FAN Wen-hui, HU Hai-sheng, TU Wen-yong, SHI Hui-feng 2021, 19 (3):  248-252.  doi: 10.19438/j.cjoms.2021.03.013 Abstract ( 325 )   PDF (817KB) ( 195 )   PURPOSE: To explore the value of metal artifact reduction(MAR) algorithms on radiotherapy dose calculation by comparing the CT values and radiation doses before and after MAR. METHODS: Twenty head and neck cancer patients admitted to Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine during Oct 2019 to March 2020 were selected. All of them underwent mandibular reconstruction with titanium plate implantation before radiotherapy. Their CT simulation scans and the images after MAR were collected. The organs at risk(OAR) were contoured by auto-segmentation software on CT images after MAR and the contouring was duplicated to original CT scan, with both the CT values of OAR recorded. Two 40 cm×40 cm opposite irradiated fields were planned with anterior margin of the second cervical vertebra set as central point, and then dose calculations were collected for paired t test with SPSS 21.0 software package. RESULTS: The average CT values of all the organs and tissue changed significantly after MAR based on MAR algorithms, compared with the original planning CT images. The average rate of change was 26.29%, with a range from 5.04%-127.19%.There was significant difference in average CT values of organs between before and after MAR except for larynx, bilateral parotid glands, pharyngeal tonsil, pituitary gland and thyroid gland. There was no significant difference in radiation dose change between the two groups, with the exception of oral cavity. CONCLUSIONS: MAR algorithms can effectively reduce metal artifacts on CT scans, but the CT values were also significantly changed, which inevitably influenced the dose calculation. It is suggested that CT images after MAR could be performed as references for target area contouring, but not suitable for dose calculation for planning of radiotherapy. References | Related Articles | Metrics

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Comparison of effects between short and standard mini dental implants for mandibular overdentures GUO Su-wei, WANG Hong-yan, ZHAO Xiang-he 2021, 19 (3):  253-257.  doi: 10.19438/j.cjoms.2021.03.014 Abstract ( 455 )   PDF (799KB) ( 191 )   PURPOSE: To investigate 1 year follow-up results of short mini dental implant (MDI) and conventional-size MDI for mandibular overdentures, and to provide reference for clinical application. METHODS: Thirty edentulous patients undergoing short MDI and 30 edentulous patients undergoing standard MDI were enrolled. The baseline data, clinical peri-implant indicators, implant survival and success rate, implant complications and patient satisfaction were compared between the two groups. SPSS 20.0 software package was used for statistical analysis. RESULTS: The marginal bone loss (MBL) and probing depth(PD) of short MDI group 1 year after implantation were less than those in standard MDI group, but with no significant difference(P>0.05). The modified plaque index (MPI) and modified bleeding index (MBI) 1 year after implantation in short MDI group were significantly less than those in standard MDI group(P<0.05). The 1-year implant survival rate and success rate of short MDI group were higher than those of standard MDI group, but with no significant difference(P>0.05). The total incidence of complications in standard MDI group was significantly higher than that in short MDI group(P<0.05). The satisfaction rate of short MDI group was significantly higher than that of standard MDI group in terms of implant stability, chewing function, speech, comfort and aesthetics(P<0.05). CONCLUSIONS: Application of short MDI for mandibular overdentures in edentulous patients with severely atrophied alveolar ridges has higher clinical effect and satisfaction rate. References | Related Articles | Metrics

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Comparison of effects between short and standard mini dental implants for mandibular overdentures GUO Su-wei, WANG Hong-yan, ZHAO Xiang-he 2021, 19 (3):  253-257.  doi: 10.19438/j.cjoms.2021.03.014 Abstract ( 1 )   PDF (799KB) ( 17 )   PURPOSE: To investigate 1 year follow-up results of short mini dental implant (MDI) and conventional-size MDI for mandibular overdentures, and to provide reference for clinical application. METHODS: Thirty edentulous patients undergoing short MDI and 30 edentulous patients undergoing standard MDI were enrolled. The baseline data, clinical peri-implant indicators, implant survival and success rate, implant complications and patient satisfaction were compared between the two groups. SPSS 20.0 software package was used for statistical analysis. RESULTS: The marginal bone loss (MBL) and probing depth(PD) of short MDI group 1 year after implantation were less than those in standard MDI group, but with no significant difference(P>0.05). The modified plaque index (MPI) and modified bleeding index (MBI) 1 year after implantation in short MDI group were significantly less than those in standard MDI group(P<0.05). The 1-year implant survival rate and success rate of short MDI group were higher than those of standard MDI group, but with no significant difference(P>0.05). The total incidence of complications in standard MDI group was significantly higher than that in short MDI group(P<0.05). The satisfaction rate of short MDI group was significantly higher than that of standard MDI group in terms of implant stability, chewing function, speech, comfort and aesthetics(P<0.05). CONCLUSIONS: Application of short MDI for mandibular overdentures in edentulous patients with severely atrophied alveolar ridges has higher clinical effect and satisfaction rate. References | Related Articles | Metrics

Clinical Reports

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Clinical analysis of intraosseous curettage combined with decompression in the treatment of mandibular solid ameloblastoma: report of 24 consecutive cases HE Jie, TIAN Zhuo-wei, HU Yong-jie, WANG Yan-an 2021, 19 (3):  258-261.  doi: 10.19438/j.cjoms.2021.03.015 Abstract ( 1241 )   PDF (915KB) ( 300 )   PURPOSE: To evaluate the effect of intraosseous curettage combined with decompression using for mandibular solid ameloblastoma treatment. METHODS: Twenty-four cases with unilocular or multilocular solid ameloblastoma of the mandible received intraosseous curettage combined with decompression from Jan. 2017 to Dec. 2018. The primary evaluation parameter was the percentage of the residual cyst area within 1-year follow-up after surgery. RESULTS: A total of 24 cases were included in this study. After 12-24 months of consecutive follow-up, the tumor cavities shrank to different extent without recurrence and osteogenesis was good. Compared with preoperative panorama and CT scan, six cases were ranked as no response (stable), ten were partial response and the remaining eight cases were classified as complete response. The overall efficiency was 75.0%. CONCLUSIONS: Intraosseous curettage combined with decompression is an effective therapeutic method for solid ameloblastoma of the mandible. References | Related Articles | Metrics

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A retrospective study comparing CT angiography and ultrasonic doppler prior to vascularized fibular harvest MA Chun-yue, TIAN Zhuo-wei, ZHU Dan, QING Xing-jun 2021, 19 (3):  262-269.  doi: 10.19438/j.cjoms.2021.03.016 Abstract ( 489 )   PDF (1336KB) ( 222 )   PURPOSE: This study was aimed to discuss and propose the necessity of selective use of CT angiography(CTA) before vascularized fibular flap harvest. METHODS: A 10-year retrospective analysis was performed to find the patients with various fibular artery(FA) abnormalities confirmed by CTA or intraoperative findings. Different FA abnormalities and their influences on peri- or intra-operative decisions were summarized. RESULTS: A total of 19 FA anomalies were found either pre- or intra-operatively in 16 patients, with 3 cases having bilateral FA anomalies. FA magna was confirmed in 2 legs, while the majority (13 legs) were with type ⅢA hypoplastic/aplastic posterior tibialis arteries, 4 legs with typeⅢD (low bifurcation). Preoperative color doppler ultrasonography(CDU) only suspected anomalies in 2 legs. Six cases proceeded with using the affected fibulas, within whom vascular grafts were used in 3 for lengthening the pedicle of FA. Two cases changed into soft tissue flaps instead of fibular flap intraoperatively. Reconstructive plans changed preoperatively for the other 8 cases, into soft-tissue free flaps, iliac bone flaps or adjacent flaps for 5, 2 and 1 retrospectively. Local ischemia, partial soleus muscle necrosis and claudication was found in 1 patient. CONCLUSIONS: CTA should be performed selectively for screening contraindications for lengthy fibular flaps when necessary. References | Related Articles | Metrics

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A retrospective study comparing CT angiography and ultrasonic doppler prior to vascularized fibular harvest MA Chun-yue, TIAN Zhuo-wei, ZHU Dan, QING Xing-jun 2021, 19 (3):  262-269.  doi: 10.19438/j.cjoms.2021.03.016 Abstract ( 1 )   PDF (1336KB) ( 27 )   PURPOSE: This study was aimed to discuss and propose the necessity of selective use of CT angiography(CTA) before vascularized fibular flap harvest. METHODS: A 10-year retrospective analysis was performed to find the patients with various fibular artery(FA) abnormalities confirmed by CTA or intraoperative findings. Different FA abnormalities and their influences on peri- or intra-operative decisions were summarized. RESULTS: A total of 19 FA anomalies were found either pre- or intra-operatively in 16 patients, with 3 cases having bilateral FA anomalies. FA magna was confirmed in 2 legs, while the majority (13 legs) were with type ⅢA hypoplastic/aplastic posterior tibialis arteries, 4 legs with typeⅢD (low bifurcation). Preoperative color doppler ultrasonography(CDU) only suspected anomalies in 2 legs. Six cases proceeded with using the affected fibulas, within whom vascular grafts were used in 3 for lengthening the pedicle of FA. Two cases changed into soft tissue flaps instead of fibular flap intraoperatively. Reconstructive plans changed preoperatively for the other 8 cases, into soft-tissue free flaps, iliac bone flaps or adjacent flaps for 5, 2 and 1 retrospectively. Local ischemia, partial soleus muscle necrosis and claudication was found in 1 patient. CONCLUSIONS: CTA should be performed selectively for screening contraindications for lengthy fibular flaps when necessary. References | Related Articles | Metrics

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Application of V-shaped stent in 15 patients with orbital fracture reduction BAI Zheng-qun, LIU Jian-bing, WU Li-fang, SUN Xiao-wei, DONG Yan 2021, 19 (3):  270-272.  doi: 10.19438/j.cjoms.2021.03.017 Abstract ( 311 )   PDF (960KB) ( 178 )   PURPOSE: To investigate the value of self-made "V" shaped stent under nasal endoscope in reduction of interior orbital wall fracture. METHODS: The data of 15 patient with orbital wall fracture from 2014 to 2020 in Dafeng People's Hospita1 were reviewed. The fracture was reduced under endoscope, and "V" shaped stent was used to provide support. The clinical efficacy was evaluated. RESULTS: Fifteen patients obtained excellent results, postoperative follow-up showed that no complications occurred, and the clinical effect was satisfactory. CONCLUSIONS: Satisfactory results can be obtained in the treatment of orbital wall fracture with self-made "V" shaped stent. References | Related Articles | Metrics

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Analysis of articles published in China Journal of Oral and Maxillofacial Surgery over 10 years from 2010 to 2019 ZHANG Hui-hong, LI Xue-lu, XU Ling 2021, 19 (3):  273-277.  doi: 10.19438/j.cjoms.2021.03.018 Abstract ( 224 )   PDF (787KB) ( 166 )   PURPOSE: To analyze the characteristics of articles published in China Journal of Oral and Maxillofacial Surgery(CJOMS) in recent 10 years, and provide references for future development. METHODS: Articles published in China Journal of Oral and Maxillofacial Surgery from 2010 to 2019 were analyzed by bibliometric method, including the number and type of articles, the first authors' local distributions and institutions, the ratio of funding-supported paper, publication delay, impact factor and quoted frequency. RESULTS: From 2010 to 2019, 1107 articles were published in CJOMS, with 275(24.84%) basic researches and 491(44.35%) clinical researches. The total numbers of top 10 distributions and institutions were 998(90.15%) and 734(66.31%), 669（60.43%）papers were supported by various fund projects, 295(26.65%) of them were supported by national projects. The average time of publication delay was 240.86 days(8 months), the impact factors and quoted frequency were increased year by year in the first 5 years, while remained stable in the last 5 years. CONCLUSIONS: CJOMS has high academic standards and influence with strong core group of authors and institutions. References | Related Articles | Metrics

Review Articles

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Synthetic lethality: towards the targeted strategies of head and neck squamous cell carcinoma CHEN Lan, ZHANG Zhi-yuan, SUN Shu-yang 2021, 19 (3):  278-283.  doi: 10.19438/j.cjoms.2021.03.019 Abstract ( 611 )   PDF (775KB) ( 259 )   Synthetic lethality occurs between two genes when loss of function of either gene is viable but loss of function of both genes simultaneously specifically induces cell death. Head and neck squamous cell carcinoma (HNSCC) is a malignant tumor characterized by high-frequency mutations of tumor suppressor genes, and synthetic lethality has the potential to provide a novel therapeutic strategy for HNSCC which lacks of targeted drugs. With the development of RNA interfering and CRISPR/Cas9-mediated gene editing technology, synthetic lethal screening tends to be more accurate and efficient to explore therapeutic approach including screening novel anti-tumor targets at the whole genome region, refining combination drug therapy and reversing tumor immune escape. Considering genetic context significantly influences synthetic lethality, patient-derived xenograft (PDX) model performs as an ideal preclinical model for screening and verifying synthetic lethality, because it can fully reflect tumor heterogeneity and genetic background of patients. References | Related Articles | Metrics

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Vertical control appliance in treatment of skeletal Class Ⅱ hyperdivergent adult patients: review of the literature QU Ran-yi, WANG Xi-jun, JIANG Ling-yong 2021, 19 (3):  284-288.  doi: 10.19438/j.cjoms.2021.03.020 Abstract ( 557 )   PDF (770KB) ( 512 )   The treatment of malocclusion usually directs at protrusion and retrusion. However, both jaw bones and teeth contain three dimensions: sagittal, lateral and vertical direction. Vertical discordance is often be overlooked, and it can also affect sagittal direction. Most vertical excess patients present hyperdivergent facial skeletal type. Vertical excess can also lead to counterclockwise rotation of the mandible, which may cause skeletal Class Ⅱ deformation. In the early years, orthodontic treatments were quite limited, orthognathic surgery was the most common solution for hyperdivergent patients. With the appearance and application of implant anchorage, mini-titanium plates or miniscrews may improve the effect of orthodontic treatments as well as reduce the risk and trauma of some patients with mild to moderate vertical excess. This article aimed to review the recent researches about the application of vertical control in skeletal Class Ⅱ hyperdivergent patients by camouflaged orthodontic treatment or orthognathic surgery with orthodontic treatment, and summarize the effect, stability analysis and therapeutic strategy of borderline cases, in order to provide new insights into clinical diagnosis and treatments, as well as related researches. References | Related Articles | Metrics