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20 March 2021, Volume 19 Issue 2 Previous Issue    Next Issue

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Effects of silencing Icmt on the proliferation, apoptosis, and cell cycle of CAL-27 and SCC-4 cells CHEN Zheng-gang, WANG Qi-min, TONG Lei, WANG Yun-ying, XU Xiao-na, WANG Ying, HAN Hong-yu, SHENG Shan-gui, WANG Shao-ru 2021, 19 (2):  97-104.  doi: 10.19438/j.cjoms.2021.02.001 Abstract ( 327 )   PDF (5803KB) ( 230 )   PURPOSE: This study was aimed to explore the effects and regulatory mechanisms of silencing Icmt on cell proliferation, apoptosis, and cell cycle of cell line CAL-27 and SCC-4 in vitro. METHODS: Three siRNAs were designed and constructed for Icmt gene sequence, and then transfected into CAL-27 and SCC-4 cells to silence Icmt expression. The tested cells were divided as follows: RNA interference groups including Icmt-siRNA-1, Icmt-siRNA-2, and Icmt-siRNA-3, negative control group, and blank control group. The mRNA and protein expression of Icmt and K-Ras were examined by real-time PCR and Western blot, respectively. The expression of Cyclin D1, p21, Akt, and p-Akt were ex-amined by Western blot. The proliferation abilities of CAL-27 and SCC-4 cells were determined by cell counting kit-8 assay. Cell cycle analysis and apoptosis abilities of CAL-27 and SCC-4 cells were detected by flow cytometry. Statistical analysis and presentation was performed using GraphPad Prism 8.2.1 software. RESULTS: The expression of Icmt mRNA and protein in CAL-27 and SCC-4 cells was reduced significantly after Icmt siRNAs were transfected (P<0.05). No significant difference in K-Ras mRNA and protein expression was detected(P>0.05), but the expression of K-Ras membrane protein was decreased significantly compared with the negative control group and the blank control group (P<0.05). Cyclin D1 expression was decreased, whereas p21 expression was increased significantly. The expression of Akt was invariant (P>0.05), but the expression of p-Akt was significantly decreased (P<0.05). The cell cycle was altered in G1/S, the growth-proliferative activity was inhibited and apoptosis was significantly induced (P<0.05). CONCLUSIONS: Silencing Icmt can effectively reduce the proliferation and induce apoptosis of CAL-27 and SCC-4 cells by affecting K-Ras membrane targeting localization, and then negatively regulating cell cycle and down-regulating K-Ras /PI3K/Akt/mTOR signaling pathway. References | Related Articles | Metrics

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The effect of dietary nitrate on rat dorsal random flap and its mechanism PANG Bao-xing, BU Ling-xue, JIA Mu-yun, YUAN Rong-tao, SHANG Wei 2021, 19 (2):  105-109.  doi: 10.19438/j.cjoms.2021.02.002 Abstract ( 286 )   PDF (3919KB) ( 206 )   PURPOSE: To investigate the effect of oral nitrate on the survival of rat dorsal random flap, and to explore its potential mechanism by taking nitrate-nitrite-NO pathway as the breakthrough point. METHODS: Twenty-four healthy adult male Wistar rats were randomly divided into 3 groups (n=8). Modified McFarlane rat dorsal random skin flap was used to make the model. The experimental group was given 0.5 mmol/L sodium nitrate 7 days before operation and daily after operation, while the control group was given the same amount of sodium chloride daily, and the blank group was given distilled water daily. The survival area of the flap was observed on the 7th postoperative day. On the 7th day after operation, the contents of serum nitrate and nitrite in rats were detected, and the levels of TNF-α and IL-6 in serum were further detected. Meanwhile, histological changes of skin flap were observed and the levels of malondialdehyde(MDA) and superoxide dismutase(SOD) were analyzed in flap tissue samples. The data were analyzed with SPSS software package. RESULTS: The survival area of the flap in the experimental group was significantly higher than that in the control group on the 7th day after operation, and the serum nitrate and nitrite contents were significantly higher than those in the control group. At the same time, H-E staining found that nitrate reduced the histological damage of the flap. Through observation of the expression of serum TNF-α and IL-6, it was found that nitrate reduced inflammatory reaction. In addition, the oxidative stress marker MDA was reduced, while the activity of SOD was restored after nitrate treatment. CONCLUTIONS: Oral nitrate can improve the survival area of random flap in rats. The mechanism is associated by promoting angiogenesis and reducing circulating inflammatory factors through nitrate-nitrite - NO pathway. References | Related Articles | Metrics

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Expression and significance of ribosomal protein L29 in tongue squamous cell carcinoma KONG Xian-chen, JIANG Xiao-dong, LU Xin, YU Wen-yi, XUE Jiao, ZHANG Peng, ZHAO Lu, YUAN Rong-tao 2021, 19 (2):  110-115.  doi: 10.19438/j.cjoms.2021.02.003 Abstract ( 399 )   PDF (4546KB) ( 162 )   PURPOSE: To investigate the expression and significance of ribosomal protein L29 (RPL29) in human tongue squamous cell carcinoma (TSCC). METHODS: SP method of immunohistochemistry was carried out to detect the expression of RPL29 in cancer tissues and adjacent tissues of 52 TSCC patients. CAL-27 cells were transfected with RPL29-siRNA. RPL29 protein and mRNA levels were detected using Western blot and RT-PCR. Transwell invasion assay was performed to assess the invasion ability of CAL-27 cells. SPSS 21.0 software package was used for statistical analysis. RESULTS: The expression of RPL29 in TSCC was significantly higher than that in paracancerous tissues. RPL29 over-expression was found to be associated with cervical lymph node metastasis（P<0.05）,but not with age,gender,smoking history,alcohol drinking history, pathological type and T stage(P>0.05). After transfecting RPL29-siRNA into CAL-27 cells, the ability of invasion was significantly decreased. CONCLUSIONS: The expression of RPL29 in TSCC was significantly increased and its expression level was significantly different from that in patients with or without lymph node metastasis. The invasive ability of CAL-27 cells was significantly inhibited after transfection with RPL29-siRNA. RPL29 may play an important role in the processes of invasion and metastasis of TSCC. References | Related Articles | Metrics

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Comparison of reconstruction outcomes of through-and-through buccal defects involving the labial commissure following tumor resection with 4 pedicled local flaps HONG Lei, CHEN Wei-liang, YUAN Kai-fang, ZHOU Bin, CHEN Rui 2021, 19 (2):  116-120.  doi: 10.19438/j.cjoms.2021.02.004 Abstract ( 492 )   PDF (3870KB) ( 377 )   PURPOSE: The purpose of this study was to evaluate the outcomes of reconstruction of through-and-through buccal defects involving the labial commissure following tumor resection with 4 pedicled local flaps. METHODS: This study evaluated 35 patients with buccal squamous cell carcinoma(SCC) involving the labial commissure who received Abbe-Estlander (A-EF), folded extended supraclavicular fasciocutaneous island(SFIF), folded pectoralis major muscle (PMMF), or folded extended vertical lower trapezius island myocutaneous(TIMF) flap for reconstruction of through-and-through buccal defects. The results were analyzed with SPSS 20.0 software package. RESULTS: The A-EF and SFIF group differed significantly (P<0.05) from the PMMF and TIMF groups in terms of tumor clinical stage and type of treatment. The esthetic results, orbicularis oris function, and speech function were significantly better in A-EF group than in SFIF, PMMF, and TIMF group(P<0.05). At the final follow-up, 4(80.0%) patients in A-EF group, 7(87.5%) in SFIF group, 5 (55.6%) in PMMF group, and 5(38.4%) in the TIMF group were alive with no disease; one (20.0%), 1(12.5%), 2(22.2%), and 4(30.8%) patients, respectively, were alive with disease, and 2(22.2%) patients in PMMF group and 4(30.8%) in TIMF group died of local recurrence or distant metastases between 9 and 38 months. CONCLUSIONS: A-EF is suitable for reconstructing defects of clinical stage Ⅱ disease, SFIF for clinical stage Ⅱ or Ⅲ disease, PMMF for clinical stage Ⅲ or Ⅳ, and TIMF for clinical stage rCS Ⅲ or rCS Ⅳ disease. References | Related Articles | Metrics

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Clinical efficacy of intra-articular ozone gas bath therapy combined with physiotherapy on temporomandibular anterior disc displacement without reduction YANG Ping-ping, XI Peng, WANG Jing, GUO Jin-jin, SHENG Guang, MAIMAITITUXUN Tuerdi 2021, 19 (2):  121-125.  doi: 10.19438/j.cjoms.2021.02.005 Abstract ( 317 )   PDF (3650KB) ( 187 )   PURPOSE: To explore the clinical efficacy of intra-articular ozone gas bath therapy combined with physiotherapy on temporomandibular anterior disc displacement without reduction(ADDwoR). METHODS: Fifty-four patients diagnosed with ADDwoR were randomized into the experimental group (27 cases) and control group (27 cases). Patients in the two groups respectively underwent intra-articular ozone gas bath and sodium hyaluronate(SH) injection, once a week for 3 weeks, simultaneously combined with physical therapy modalities which included patients education, mandibular manipulation technique, passive training with open mouth. The visual analogue scale (VAS) of pain, mandibular movements, and efficiency of the two groups were assessed after 1, 3 months of follow-up. SPSS 21.0 software package was used for data analysis. RESULTS: The pain intensity and mandibular movements improved significantly compared to these of pre-treatment in both groups (P<0.05), with no significant intra-group difference (P>0.05). There was no significant difference in the total effective rate between the two groups (P>0.05). CONCLUSIONS: Intra-articular ozone gas bath therapy combined with physiotherapy can provide symptomatic relief on ADDwoR, similar to the efficacy of SH combination; however, it could be a cheaper clinical alternative. References | Related Articles | Metrics

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Clinical analysis of 49 cases with coronectomy for extraction of impacted wisdom tooth contacting inferior alveolar nerves YUE Wei, LI Hong-quan, ZHAO Chu-xin, WANG Guo-rui 2021, 19 (2):  126-131.  doi: 10.19438/j.cjoms.2021.02.006 Abstract ( 532 )   PDF (4205KB) ( 463 )   PURPOSE: The clinical suitable range of coronectomy for extraction of impacted wisdom tooth contacting inferior alveolar nerves was comprehensively analyzed by the correlation between the root movement distances and rates of mandibular wisdom tooth, with age, gender, number of roots, impacted angle and the characteristics of new bone formation. METHODS: In 49 patients with root compression of mandibular canal determined by cone-beam CT (CBCT), the root movement distances were measured and the characteristics of root movement rates was proposed; the relationship between rates of root movement and age, gender, root morphology was analyzed, and the appropriate equation of root movement rate was formulated. The application range of coronectomy was determined by the formula of root movement rate combined with clinical operation. RESULTS: The safe distance and the time of residual root extraction could be predicted for the vertically impacted and proximally impacted single wisdom tooth with the fitting equation D=K×（7×10-8x2-8×10-5x+0.0239）x·sinθ1 within 200 days; the second stage of residual root extraction should be controlled in 90 days for the mesioangular impaction, impacted wisdom tooth with multiple-root. The reachable safe distance of the predicted root movement can be used as the main basis for the application of coronectomy to wisdom tooth contacting inferior alveolar nerves. CONCLUSIONS: Estimating the maximum distance of root movement is the main indicator to evaluate the application scope of coronectomy, the formula should be used and pre-judged in accordance with different situations in order to improve the success rate of coronectomy. References | Related Articles | Metrics

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Neoadjuvant chemotherapy in head and neck osteosarcoma: a retrospective study in single institute DAI Zhen-lin, AHMED·Abdelrehem, CHEN Yi-ming, WANG Yi, JI Tong 2021, 19 (2):  132-137.  doi: 10.19438/j.cjoms.2021.02.007 Abstract ( 372 )   PDF (4111KB) ( 251 )   PURPOSE: To analyze the outcome of neoadjuvant chemotherapy in the treatment of head and neck osteosarcoma. METHODS: A retrospective study of head and neck osteosarcoma patients treated from 2007 to 2015 was conducted. The clinical, radiological, pathological, treatment information and follow-up records were collected. Statistical analysis was performed with SPSS 17.0 software package. RESULTS: One hundred and fifty-seven patients were included, with a 5-year overall survival rate (OS) of 50.96%. Sixty-eight were male, 89 were female. Fifty-one were aged less than 30 years old, 85 were within 31-60 years old, 21 were more than 61 years old. Ninety-one had tumor in the mandible while 66 in the maxilla and skull base. One hundred and forty-one were high-grade osteosarcoma, 8 were low-grade osteosarcoma, 8 were unknown differentiated. Fifty-four had tumor > 4 cm and 103 ≤4 cm in diameter. Seven had positive surgical margin. Sixty-five were treated with surgery alone, 15 had surgery and chemotherapy, 23 had surgery combined with chemoradiotherapy, 54 had surgery and radiotherapy. Univariate analysis showed that distant metastasis were related with maxillary and skull base tumors (P=0.022), high-grade osteosarcoma (P=0.011) and positive margin (P=0.031). Osteosarcoma of the mandible(P=0.032), negative margin (P=0.006) were correlated with overall survival. Surgical margin (P=0.007) was associated with disease free survival. Multivariate analysis showed that tumor region (P=0.034), surgical margin (P=0.006), chemotherapy (P=0.025) and pathological subtype (P=0.012) were correlated with OS. Positive margin (P=0.002) and without adjuvant radiotherapy(P=0.005) were associated with local recurrence. CONCLUSIONS: Negative surgical margin is important for good prognosis. Chemotherapy (neoadjuvant chemotherapy and adjuvant chemotherapy) can improve the OS of patients with head and neck osteosarcoma References | Related Articles | Metrics

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Effect of depth of invasion of oral squamous cell carcinoma on improving TNM staging and prognostic evaluation ZHOU Kai, LI Heng-yong, QI Xiao-jie, GE Sheng-you, KONG Yu, SONG Kai, FENG Yuan-yong, HOU Feng, SHI Hai-lei, JIANG Yan-xia, SHANG Wei 2021, 19 (2):  138-145.  doi: 10.19438/j.cjoms.2021.02.008 Abstract ( 713 )   PDF (5291KB) ( 563 )   PURPOSE: To analyze and compare the significance of the American Joint Committee on Cancer (AJCC) eighth edition and seventh edition of TNM staging system in clinical treatment decision-making, prognosis stratification and improving the accuracy of prognosis evaluation of oral cancer. METHODS: A retrospective cohort study of patients with oral squamous cell carcinoma(OSCC) from 2009 to 2015 was performed, and AJCC seventh and eighth edition of staging systems was applied to all patients. Overall survival and disease-specific survival were analyzed by Kaplan-Meier analysis and Log-rank test with SPSS 26.0 software package. Concordance index and Akaike information criterion was used to calculate the system's prognostic accuracy. RESULTS: In total, 570 patients were followed up with a median follow-up age of 64 years. The median follow-up peroid was 38 months. The tumor stage of 146 (25.61%) patients was changed by depth of invasion and extranodal extension. Overall survival and disease-specific survival model analysis of T stage and TNM stage showed that the Akaike information criterion of AJCC eighth edition staging systems was significantly lower than the seventh edition and concordance index was significantly higher than the seventh edition(P<0.05). CONCLUSIONS: Depth of invasion and extranodal extension were added to the TNM staging of oral cancer in the AJCC eighth edition of staging systems. These two indices have changed the pathological stages of many patients according to the original standard staging. The results showed that when depth of invasion is 6.25 mm, it can well predict cervical lymph node metastasis, and is also the optimal cut-off for predicting overall survival and disease-specific survival. The new staging system has more guiding significance for clinical decision-making and prognosis evaluation of oral cancer patients, especially for advanced patients. References | Related Articles | Metrics

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Comparison of two early warning scoring methods in evaluating the condition and risk of patients with odontogenic descending necrotizing mediastinitis LI Li, SHEN Ping, JI Ping-ping, YANG Zhi-yang, HOU Li-li 2021, 19 (2):  146-150.  doi: 10.19438/j.cjoms.2021.02.009 Abstract ( 272 )   PDF (3542KB) ( 280 )   PURPOSE: To compare the application value of modified early warning score (MEWS) and corrected MEWS in patients with descending necrotizing mediastinitis. METHODS: A retrospective analysis of the clinical data of 65 patients with descending necrotizing mediastinitis treated from July 2018 to December 2019 was performed, and whether the patient developed severe disease was used as the observation index. The patients were evaluated with MEWS and corrected MEWS respectively, and the sensitivity and specificity of the two scoring methods to assess the severity of disease and prognosis were compared. SPSS 22.0 software package was used for statistical analysis. RESULTS: Both scoring scales had a moderate degree of resolution in predicting the severity of the patient's disease, the corrected MEWS score was significantly higher than the MEWS score (Z=2.257, P=0.024), the area under the ROC curve of MEWS was 0.669 (95% CI: 0.538-0.800, P=0.023), and the area under the ROC curve of the corrected MEWS was 0.818 (95% CI: 0.718-0.917, P=0.000). CONCLUSIONS: The corrected MEWS scoring can more effectively reflect the severity of the patient's condition at the time of admission, which is helpful for nurses to find out the potential disease risk of patients in the early stage, do a good job in emergency treatment in time, thus having important clinical significance for improving the safety of patients' medical care. References | Related Articles | Metrics

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Analysis of accuracy and operation time of domestic digital dynamic navigation and static guide in oral implant surgery WU Yu-peng, MEI Dong-mei, ZHANG Qi, WANG Wen-xue, ZHAO Bao-dong 2021, 19 (2):  151-155.  doi: 10.19438/j.cjoms.2021.02.010 Abstract ( 456 )   PDF (4269KB) ( 349 )   PURPOSE: To evaluate the accuracy and operation time of domestic digital dynamic navigation and digital static guide in oral implant surgery. METHODS: Patients who were subjected to implant surgery at Department of Implantology, Affiliated Hospital of Qingdao University from September, 2018 to December, 2019 were selected. The patients were randomly divided into digital dynamic navigation group (n=21) and static guide group (n=19). The operation time of 2 groups was recorded, the linear deviation of the entry, apex point and angle in 2 groups were measured as well. The data was statistically analyzed using SPSS 25.0 software package. RESULTS: The average operation time of group 1 was 23.2 min, and that of group 2 was 14.5 min. The mean (SD) discrepancies of group 1 were (0.74±0.3) mm for entry point and (0.78±0.31) mm at the apex, the mean angle discrepancy was (2.45±1.26)° from actual vs planned implant positions. The mean (SD) discrepancies of group 2 were (0.79±0.39) mm for entry point and (0.78±0.35) mm at the apex, the mean angle discrepancy was (2.44±1.07)° from actual vs planned implant positions. There was no significant difference between the 2 groups in the measurement of the entry, apex point and angle of implants(P>0.05). CONCLUSIONS: There is no significant difference between the domestic dynamic navigation system and the static guide in the accuracy of assisting oral implant surgery. The operation time of the former in single tooth loss cases is longer than that of the latter. The indications of dynamic navigation are wider than that of static navigation, and need to be chosen according to specific conditions. References | Related Articles | Metrics

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Machine learning based analysis and prediction of curative effect after extraction of wisdom teeth WEN Zhen-yu, GUO Wen-jin, FENG Ai-min, LI Long-de, WEN Shi-sheng 2021, 19 (2):  156-162.  doi: 10.19438/j.cjoms.2021.02.011 Abstract ( 355 )   PDF (4526KB) ( 230 )   PURPOSE: To analyze and predict the occurrence of postoperative complications after extraction of wisdom teeth by machine learning algorithms, to provide scientific basis for targeted treatment and early prevention of complications of pericoronitis. METHODS: From January 2018 to December 2018, 467 patients with pericoronitis of wisdom teeth who were treated in the Department of Stomatology of the First People's Hospital of Jiayuguan City, Gansu Province were selected. Among them, 373 patients served as training set and 94 patients served as test set. Feature selection and data were completed through detection of digital panoramic tomography combined with doctor’s treatment plan and patients’ follow-up results. By calculating Gini importance of each feature, all features were sorted by importance, then all features were analyzed and the selection was completed. Seven machine learning algorithms were used to establish a complication predicting model, which was trained on the training set until the result converged. The final algorithm was determined by the accuracy and F1 score of 10-fold cross-validation. RESULTS: A 467×16-dimensional dataset containing 15 feature attributes and 1 classification attribute were established. Random forest was finally selected as the core algorithm to complete the complication predicting model after testing. The accuracy of the final model was 89% and F1 weighted average score was 88%. CONCLUSIONS: Machine learning algorithm can effectively analyze the relationship between case features and curative effect after extraction of wisdom teeth as well as predicting complications, which has high clinical practicability. References | Related Articles | Metrics

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Application of modified vacuum sealing drainage in reconstruction of free flap donor-site defects with full-thickness skin graft YAO Lin, GUO Meng-meng, DENG Zhang, ZENG Wei 2021, 19 (2):  163-166.  doi: 10.19438/j.cjoms.2021.02.012 Abstract ( 330 )   PDF (2939KB) ( 423 )   PURPOSE: To investigate the application value of modified vacuum sealing drainage (VSD) in free flap donor-site defects with full-thickness skin graft in patients with oral cancer. METHODS: Thirty patients with oral cancer underwent free flap reconstruction and treated with modified VSD after full-thickness skin graft, while 20 cases were treated with conventional pressure-packing. SPSS 20.0 software package was used for statistical analysis of the data. RESULTS: The healing time after skin graft of the modified VSD group was significantly shorter than the traditional packing group, and the incidence of infection, edema and wound edge spliting in the modified VSD group was significantly reduced (P<0.05). CONCLUSIONS: Modified VSD has a good effect in the donor area with free skin flap transplantation after oral cancer ablation. It is cost-effective and worthy of clinical application and promotion. References | Related Articles | Metrics

Clinical Reports

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A retrospective study on the prognosis of retaining injured deciduous teeth after intrusive luxation in 26 cases SHENG Kai, LAI Guang-yun, DING Qin, WANG Jun 2021, 19 (2):  167-172.  doi: 10.19438/j.cjoms.2021.02.013 Abstract ( 392 )   PDF (4347KB) ( 217 )   PURPOSE: To analyze the prognosis of retaining injured deciduous teeth after intrusion and the related factors to prognosis. METHODS: This was a retrospective study of patients diagnosed as deciduous tooth intrusion treated from March 2018 to October 2019. According to the inclusive and exclusive criteria, the data of 36 intruded teeth from 26 patients were selected. The occurrence of re-eruption and pulp prognosis were recorded, their relevance to the severity of intrusion and patients' age was evaluated. The data was analyzed using SPSS 23.0 software package. RESULTS: There were 33 teeth treated with watchful waiting policy. 97% re-erupted spontaneously, 54.6% re-erupted completely and 42.4% partially re-erupted. Only one tooth developed ankylosis. During the follow-up period, 42.4% of the observed teeth suffered from pulp necrosis/infection related resorption, and the remaining showed no clinical symptoms. No obliteration was observed among the teeth. Age and the degree of intrusion had no significant influence on tooth re-eruption, but the degree of intrusion had significant influence on pulp prognosis(P<0.05). There were 3 teeth treated with surgical reposition, without preventive pulp treatment, external root resorption happened in all these cases. CONCLUSIONS: For deciduous tooth intrusion, re-eruption can be expected in most watchful waiting cases regardless of age and the intrusion severity, while the prognosis of pulp was correlated with the degree of intrusion. References | Related Articles | Metrics

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Osseous dysplasias of the jaws: review of 39 consecutive cases LIN Wen-qing, ZHANG Xu-hui, GUO Zhen-zhen, HU Yan-ping 2021, 19 (2):  173-176.  doi: 10.19438/j.cjoms.2021.02.014 Abstract ( 485 )   PDF (3074KB) ( 421 )   PURPOSE: A retrospective research was made to evaluate the clinical characteristics, imaging features , treatment results of patients with osseous dysplasia(OD) of the jaws. METHODS: Thirty-nine patients were enrolled. The age, gender, locations of involvement, clinical and imaging features, treatment methods and results were retrospectively analyzed. RESULTS: The age of patients ranged from 15 to 73 years old, with a mean age of 38 years. The male to female ratio was 1∶2.9. The most involved age group was 30-40 years old (19 cases, 48.7%) . Apical regions of the mandibular first and second molars (17 cases, 43.5% ) were the most involved locations. According to the classification of WHO, the most common type was focal OD (31 cases), periapical and florid OD were 5 and 3 cases, respectively. The main type of image characteristics was focal mixed radiopaque-radiolucent lesions (31 cases, 79.4%). The treatment methods were curettage of the lesions, in which root canal therapy was performed in 17 cases, and tooth extraction was performed in 7 cases. The follow-up period was 6 months to 2 years without postoperative complications. CONCLUSIONS: Osseous dysplasia of the jaws often involved the mandibular molar regions in female patients in their mid-thirties. The most common type of imaging characteristics was focal OD. Surgical curettage is indicated when the lesions are associated with clinical symptoms or significant bone expansion. References | Related Articles | Metrics

Clinical Guidelines

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Interpretation of ASCO clinical practice guideline:management of the neck in squamous cell carcinoma of the oral cavity and oropharynx issued in 2019 PAN Meng-qi, LI Zhi-yong, ZHAO Wen-quan 2021, 19 (2):  177-180.  doi: 10.19438/j.cjoms.2021.02.015 Abstract ( 623 )   PDF (2699KB) ( 586 )   In order to provide evidence-based recommendations on the management of the neck with squamous cell carcinoma of the oral cavity and oropharynx, ASCO convened an expert panel to conduct a literature search, which included systematic reviews, meta-analysis, randomized controlled trials, and prospective and retrospective comparative observational studies published from 1990 through 2018. The literature search identified 124 relevant studies to inform this 2019 version. Six clinical scenarios were devised: three for oral cavity cancer and three for oropharynx cancer. Outcomes of interest included survival, regional disease control, neck recurrence, and quality of life. For the indications of high-quality neck dissection, postoperative radiotherapy or chemoradiotherapy, surgery or non-surgical treatment, the adequacy of radiotherapy and chemotherapy alone were discussed. Treatment standards were proposed successively for different clinical cases. Multiple chronic conditions patients,the scope of application and the limitations of this guideline were stated. The 2019 version of ASCO guideline was interpreted in this paper, which has certain guiding significance for diagnosis and treatment of the clinical practice of oral and maxillofacial tumors by surgeons. References | Related Articles | Metrics

Review Articles

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Research advances in augmented corticotomy-assisted surgical orthodontics ZHU Lei, YU Hong-bo 2021, 19 (2):  181-185.  doi: 10.19438/j.cjoms.2021.02.016 Abstract ( 468 )   PDF (3786KB) ( 625 )   Malocclusion is a common clinical disease, requiring orthodontic treatment. However, in some patients, the amount of alveolar bone is insufficient and the root of tooth is exposed, which seriously limits the implement of orthodontic treatment. It is also a challenge for clinicians. Therefore, it is particularly important for patients to increase the amount of alveolar bone and promote teeth movement. Augmented corticotomy-assisted surgical orthodontics can effectively increase the amount of alveolar bone, expand the indications for orthodontic treatment, accelerate teeth movement, shorten treatment period and reduce complications, such as fenestrations and dehiscence. This article reviewed the biological mechanisms and development of augmented corticotomy-assisted surgical orthodontics. References | Related Articles | Metrics

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Treatment of venous malformations in oral and maxillofacial region: clinical experiences, update and challenges WU Hai-wei, YU Miao, ZHENG Jia-wei 2021, 19 (2):  186-192.  doi: 10.19438/j.cjoms.2021.02.017 Abstract ( 842 )   PDF (5917KB) ( 504 )   Venous malformation is one of the most common types of congenital vascular malformations, which can be found in any location in the body. It is still a challenge to diagnose and treat complicated venous malformations, owing to the diversity of the site and range of diseased regions. There are various treatment approaches for venous malformations in oral and maxillofacial region, such as systemic targeted drugs, open surgery, sclerotherapy, cryoablation and laser photocoagulation. Based on the experience and the recent available literatures, this article summarized the current status and recent progress in diagnosis and treatment of venous malformation of oral and maxillofacial region. References | Related Articles | Metrics