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10 February 2014, Volume 12 Issue 1 Previous Issue    Next Issue

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Editorial

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Overview of current pharmacotherapy for infantile hemangiomas ZHENG Jia-wei, MA Kun-ning, ZHANG Ling 2014, 12 (1):  1-6.  Abstract ( 538 )   HTML ( 5 )   PDF (893KB) ( 927 )   Infantile hemangiomas (IH) are the most common tumors of infancy and childhood. 60% of them are localized in the head and neck region. They may impinge on vital structures, ulcerate, bleed, cause high-output cardiac failure or significant disfigurement if left untreated. The traditional treatment methods include drug therapy, laser therapy and surgery, with drug therapy being the mainstay of treatment. The medications most commonly used to treat IH are corticosteroids, beta-adrenergic blocker, pingyangmycin, interferon alfa, imiquimod, and etc. For function- and life-threatening infantile hemangioma, some anti-cancer agents like vincristine may be used as an effective alternative option. This succinct review summarized current pharmacotherapeutic therpy of IH, especially the properties and effectiveness of various beta-adrenergic antagonists in the management of IH. References | Related Articles | Metrics

Basic Research Articles

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Study on behaviors of the growing rabbit condylar chondrocytes in vitro HUANG Lin-jian, ZHANG Xiu-li, LI Miao-ran, LI Hui, DENG Ya-wei, CAI Xie-yi 2014, 12 (1):  7-12.  Abstract ( 394 )   HTML ( 0 )   PDF (2120KB) ( 407 )   PURPOSE: To establish the growing rabbit condylar chondrocyte culture model in vitro, and to study its biological characteristics. METHODS: Condylar cartilage was aseptically dissected from the temporomandibular joint of 4-week old New Zealand white rabbit. Chondrocytes were obtained using enzyme digestion at the interval of 4 h and 12 h. Then they were cultured in vitro and subcultivated until the 10th passage. The chondrocytes were analysed by inverted microscope, toluidine blue staining, alcian blue staining and immunocytochemical staining. Condylar chondrocytes growth curve was made with the method of cell counting. Western blot was used to analyse the expression of collagen type Ⅱ, collagen type Ⅹ and SOX9. SPSS13.0 software package was used for statistical analysis. RESULTS: Condylar chondrocytes of rabbits were spindle-shape or polygon shape and displayed cobble-stone morphology. Following the increase of subcultures, the chondrocytes changed morphologically into fibroblast-like cells. The condylar chondrocytes staining was positive in the slides of cells, and the growth curve showed that condylar chondrocytes had a typical S shape.Western blot showed that the expression of collagen type Ⅱ, collagen type Ⅹ and SOX9 was not significantly different between condylar chondrocytes collected at 4 h and those at 12 h. CONCLUSIONS: It is a simple and effective way to culture condylar chondrocytes in vitro in this study. The results confirm that the tendency of dedifferentiation would occur after passage 3 which may lose its nature traits. The chondrocytes cultured from passage 0 to passage 2 in vitro are stable and suitable for subsequent research. References | Related Articles | Metrics

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Establishment and histological evaluation of traumatic temporomandibular joint model in goat LI Ling-zhi, WANG Li-zhen, HE Dong-mei, YANG Chi 2014, 12 (1):  13-19.  Abstract ( 523 )   HTML ( 1 )   PDF (1021KB) ( 640 )   PURPOSE: To establish traumatic temporomandibular joint model in goat, and evaluate the histopathological changes. METHODS: According to the clinical traumatic type, 16 adult goats’ bilateral joints were randomly divided into 4 groups following surgical procedures. Disc displacement without reduction (DD): the attachment of disc was severed, and pulled anteriorly; the disc was fixed in the root of coronoid process. Condylar cartilage defect (CCD): the inferior compartment of TMJ was open to grind off lateral 1/3 condylar cartilage. Disc displacement and condylar cartilage defect (DD+CCD): the above two METHODS were used. Blank control group(C): nothing was done in TMJ. The TMJs were removed and observed 2 weeks and 1 month after surgery. The histopathological score of condylar cartilage was observed and was statistically analysed between each two groups (4 groups) with SPSS 17.0 software package. RESULTS: DD+CCD showed fibrous adhesion and coarse condylar cartilage; histologically, the composition of condylar cartilage was in disorder; and matrix proteoglycan decreased at 2-week and 1-month. Partial cartilage desquamation and fibrous adhesion exacerbated at 1-month. DD showed disordered cartilage composition, intact superfacial zone, little angiogenesis and proteoglycan degradation at 2-week and 1-month. CCD showed fibrosis between disc and defective cartilage in defective condyle, and the remnant cartilage composition and proteoglycan were normal at 2-week and 1-month. Cartilage degeneration was more serious at 1-month than 2-week in each group; and cartilage score was significantly different (P<0.05)in the following order: DD+CCD(11.75±0.75),DD(8.75±0.25),CCD(1.75±0.85),and C(0.00±0.00). CONCLUSION: Three traumatic TMJ models in goat were successfully established. The degeneration of cartilage in DD+CCD was most severe, and CCD was the mildest. References | Related Articles | Metrics

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A model of vascularized nerve graft for facial nerve repair in rabbit ZHU Yun, LIU Sheng-wen, LI Guang-hui, TIAN Zhen, ZHANG Chen-ping, YANG Wen-jun 2014, 12 (1):  20-24.  Abstract ( 293 )   HTML ( 0 )   PDF (1258KB) ( 303 )   PURPOSE: To develop a new vascularized nerve graft model for facial nerve repair. METHODS: Fifteen New Zealand white rabbits were used in this study. The great auricular nerve of ear was designed as a vascularized graft to serve as a model. VNG group (n=6) received vascularized facial nerve graft, FNG group (n=6) received free nerve graft, control group (n=3) were blank rabbits. The results were evaluated with analysis of facial performance, histological and immunohistochemical studies and electrophysiological monitoring. SPSS 13.0 software package was used for data analysis. RESULTS: At 4-month following facial nerve repair, facial nerve function recovery was observed and analyzed, VNG group was better than FNG group. Through the 20mm facial nerve graft, regenerated nerve fibers were seen, good vascularation facilitated more axons regeneration. CONCLUSIONS: This study demonstrates a new feasibility of vascularized nerve graft in a rabbit model. It has obvious operability and reliability compared with the other models, and the model is useful for future investigation in facial nerve repair. References | Related Articles | Metrics

Clinical Articles

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The current status of speech therapy for cleft patients in 42 medical institutions in China YANG Yang, JIANG Li-ping, LIU Qiong, WANG Guo-min 2014, 12 (1):  25-29.  Abstract ( 452 )   HTML ( 2 )   PDF (674KB) ( 306 )   PURPOSE: To investigate the current status and affecting factors of speech therapy for cleft palate patients in China. METHODS: Questionnaires were sent to speech therapists in 42 facilities from 28 provinces in China, regarding the setup, equipment and establishment time of speech clinic, patient number, the experience and qualification of the therapists, the charge for each session, and the course of therapy. RESULTS: All 42 facilities had surgical wards for cleft patients, but only 36 had speech clinics, 75% of which were established less than 5 years. The patient number was less than 10 patients per week in average. The equipment was poorer and the charge for each session was low. The course of therapy was less than 20 times. About two thirds of the speech therapists came from nurses, others were part-time therapists by surgeons. The main training method was short-term fellowship. Considering the basic conditions of China as a developing country, the affecting factors were the lack of awareness of the importance of speech therapy, lack of regulations and qualifications for speech therapists, long course of therapy, and high additional costs. CONCLUSIONS: Speech therapy for cleft patients started late in China, with no departments of speech pathology, systematic training program and professional degrees, and lack of professional equipment and follow-up. More attention and investment are needed to promote normative and rapid development of speech therapy in China. References | Related Articles | Metrics

Orginal Article

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Current literature 2014, 12 (1):  29-29.  Abstract ( 269 )   HTML ( 0 )   Related Articles | Metrics

Clinical Articles

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Correction of facial asymmetry deformity using modified BSSRO and fixation method HUANG Li, LIU Zhi-xu, ZHANG Lei, SHEN Shun-yao, WANG Xu-dong 2014, 12 (1):  30-34.  Abstract ( 404 )   HTML ( 1 )   PDF (1071KB) ( 351 )   PURPOSE: To investigate the clinical application of reserving the proximal bone segment in the concave side, and osteosynthesis with three bicortical titanium screws placed in a triangular shape for stabilization during bilateral sagittal split ramus osteotomy (BSSRO) for correction of facial asymmetry deformity. METHODS: Between January 2013 and July 2013, 8 adult patients with lateroprognathism in Shanghai Ninth People’s Hospital underwent orthognathic surgery. The asymmetry in the masseter region was evaluated based on clinical examination and three-dimension CT examination. After regular maxillary LeFort I osteotomy and BSSRO, the proximal bone segment in the hypertrophy side was resected and fixed using four-hole mini-titanium plate whereas the proximal bone segment in the concave side was reserved, and osteosynthesis with three bicortical titanium screws placed in a triangular shape for stabilization. The security and validity of the method were evaluated based on the examination of facial symmetry 3 months after operation：the face asymmetry was measured on postero-anterior(P-A) cephalogram. The data was compared before and after surgery with paired t test using SPSS 20.0 software package. RESULTS: The facial asymmetry in all 8 patients was effectively corrected, and radiographic facial asymmetry was found obviously decreased (P<0.05) and no complications were noted. CONCLUSIONS: Reserving the proximal bone segment in the concave side, and fixed with three bicortical titanium screws placed in a triangular shape could effectively and safely correct the facial asymmetry deformity. References | Related Articles | Metrics

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The expression and significance of astrocyte elevated gene-1 in salivary gland tumors CHEN Chui-shi, HUANG Zhi-quan, LI Hai-gang 2014, 12 (1):  35-38.  Abstract ( 339 )   HTML ( 0 )   PDF (1672KB) ( 233 )   PURPOSE: To explore the expression and significance of astrocyte elevated gene-1 (AEG-1) in salivary gland tumors. METHODS: The expression of AEG-1 was detected by immunohistochemistry in salivary gland tumors (including pleomorphic adenoma, mucopidermoid carcinoma, and adenoid cystic carcinoma), as well as 15 cases of normal salivary gland tissue. SPSS 10.0 software package was used for statistical analysis. RESULTS: AEG-1 expression in tumor tissue was significantly higher than that in normal salivary gland tissue (P=0.001). AEG-1 expression in malignant tumors was significantly higher than that in pleomorphic adenoma (P=0.033). The expression of AEG-1 was related to tumor stage in malignant tumors (P=0.035). CONCLUSIONS: The expression of AEG-1 may contribute to salivary gland tumor development and malignant potentiality. References | Related Articles | Metrics

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Analysis of the mandibular condylar fracture type leading to temporomandibular joint ankylosis in adults CAI Yi-hua, LU Chuan, HE Dong-mei, YANG Chi 2014, 12 (1):  39-44.  Abstract ( 397 )   HTML ( 5 )   PURPOSE：To analyze the mandibular condylar fracture type leading to temporomandibular joint ankylosis in adults. METHODS: Patients diagnosed with ankylosis caused by condylar fracture who had CT scans from injury to ankylosis in our department from 2010 to 2012 were reviewed. According to the relationship between the mandibular stump of the ramus and TMJ fossa, the condylar fractures were divided into 3 grades. Grade 0: the stump of the ramus was in the fossa without contact to it; Grade 1: the stump of the ramus was in the fossa with contact to it; Grade 2: the stump of the ramus was superolaterally displaced out of the fossa. The type of condylar fracture, the degree of fracture fragment displacement, the position of the disc and other fractures of the mandible were also analyzed for ankylosis development. RESULTS: Thirteen patients with 24 joints had completed CT scans diagnosed with TMJ ankylosis caused by condylar fracture were included in the study. The types of the condylar fracture caused to ankylosis were all intracapsular fractures with type B fracture accounting for 70%. Among the relationship between the stump of the ramus and TMJ fossa, grade 0 in 0 joint; grade 1 in 10 joints, accounting for 41.7%; grade 2 in 14 joints, accounting for 58.3%. The discs were all displaced with the fracture fragment and ruptured in the posterior band in grades 1 and 2. There were 77% of the condylar fractures had combined symphysis fracture which caused widening of the mandibular arch. CONCLUSION: The relationship between the ramus stump and TMJ fossa plays an important role in the prognosis of condylar fracture. Grade 0 is less easy to cause ankylosis; grade 1 is easy to cause ankylosis and is the relative indication for surgery; grade 2 is most likely to cause ankylosis and is the absolute indication for surgery. Other risk factors are type B intracapsular condylar fracture and combined mandibular fracture with arch widening. References | Related Articles | Metrics

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Application of digital guide in the osteotomy of benign lesions in mandible with preservation of the inferior alveolar neurovascular bundle: report of one case HUANG Dong, HE Dong-mei, YANG Chi, CHEN Min-jie, YUAN Jian-bing, BAI Guo, CHEN Zhuo-zhi 2014, 12 (1):  45-50.  Abstract ( 509 )   HTML ( 0 )   PDF (2284KB) ( 916 )   PURPOSE: To discuss the application of digital guide in the treatment of benign lesions in mandible with preservation of the inferior alveolar neurovascular bundle, and to evaluate its effect. METHODS: Preoperative planning based on CT data of a patient with mandibular ossifying fibroma (OF) was done using ProPlan CMF 1.3. The mandibular canal on the affected side was segmented, and a special digital guide was made to guide the osteotomy 2 mm below the canal to preserve the inferior alveolar neurovascular bundle, and mirrored mandible was used to help the positioning of the reconstruction plate. The design and the postoperative CT was merged using the software to evaluate the accuracy of osteotomy, the sensation of lower lip and the pulp vitality were measured to evaluate the function of the inferior alveolar nerve. SPSS 17.0 software package was used for statistical analysis. RESULTS: The operation successfully removed the affected mandible and preserved the inferior alveolar neurovascular bundle. The costochondral flap was positioned accurately according to the guide. Follow-up results showed good facial symmetry, existence of the sensation in lower lip and no significant difference between the pulp vitality on both sides. CONCLUSIONS: The application of digital guide can help resection of mandibular benign lesions, as well as preserving the inferior alveolar neurovascular bundle and guiding the reconstruction procedure. It is a useful technique for functional surgery. References | Related Articles | Metrics

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Oral medication controlled hypotension in hypertensive patients before tooth extraction：A randomized double-blinded clinical study HOU Rui, WU Fang, HE Li-sheng, ZHANG Lin-lin, LIU Zhuo 2014, 12 (1):  51-55.  Abstract ( 441 )   HTML ( 0 )   PDF (864KB) ( 405 )   PURPOSE: To compare the changes of blood pressure and heart rate in patients with hypertension who took different oral medications to control hypertension before tooth extraction and to find a way to better control hypertension around tooth extraction. METHODS: Ninety patients with hypertension undergoing controlled hypotension medication were given three different drugs randomly, including diazepam, nifedipine and diazepam combined with nifedipine. Blood pressure and heart rate during extraction were recorded in detail. The data was analyzed with SPSS17.0 software package for either t test or Chi-square test. RESULTS: Changes of perioperative blood pressure and heart rate was relatively stable after controlled hypotension medication. Difficulty and time during tooth extraction were charged slightly in both diazepam group and diazepam combined with nifedipine group, but significantly in nifedipine group. There was no significant change in heart rate in all groups. CONCLUSION: Controlled hypotension by oral medication before extraction could lower the blood pressure well. Combined medications can better ensure the safety of patients with hypertension during tooth extraction. References | Related Articles | Metrics

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Reconstruction of minor defect after resection of tongue squamous cell carcinoma with improved C-type heterogenic acellular dermis matrix ZHOU Yu, YE Mao-chang, LI Rong-xin, WANG Lai-ping. 2014, 12 (1):  56-60.  Abstract ( 395 )   HTML ( 0 )   PDF (1095KB) ( 342 )   PURPOSE: To study the clinical value of reconstruction of minor defect after resection of tongue squamous cell carcinoma which was smaller than 25 mm×25 mm and only involved submucosa or superficial muscle with improved C-type heterogenic acellular dermis matrix. METHODS: Sixty-four cases were selected which underwent improved C-type heterogenic acellular dermis matrix (H-ADM) to reconstruct minor defect after resection of tongue squamous cell carcinoma. All wound surfaces were packaged and fixed with H-ADM. Changes of epithelium converting into mucosa was observed when the package was removed and 1, 2, 7, 14, 28 days, 3, 6, 12 months after surgery. RESULTS: All patients were followed up. Wound surface recovered well, and the most important feature was the para-mucus pseudomembrane after H-ADM degraded. The para-mucus pseudomembrane reached peak at 1-week, then descended gradually and disappeared 2 months later. Wound surface was then covered with indefinite, slightly atrophied and smooth tissues. CONCLUSIONS: H-ADM can obviously promote wound healing after resection of tongue squamous cell cancer; pressure dressing with vaseline indoform gauze also play an important role in wound healing promotion; H-ADM has satisfactory biocompatibility. References | Related Articles | Metrics

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Reverse facial artery-submental artery deepithelialised submental island flap to reconstruct maxillary defects following cancer ablation ZHAO Xin, WU Hong, CHEN Wei-liang, WANG Jian-guang, ZHANG Cui-cui, PAN Chao-bin, HUANG Zhi-quan, ZHAO Xiao-peng 2014, 12 (1):  61-64.  Abstract ( 349 )   HTML ( 0 )   PDF (929KB) ( 329 )   PURPOSE: The present study assessed the reliability of the reverse facial artery-submental artery deepithelialised submental island flap to reconstruct maxillary defects. METHODS: This study included 13 patients (9 men and 4 women; 43-62 years old) with maxillary defects resulting from cancer ablation. Ten patients presented with maxillary gingival squamous cell carcinoma and the remaining 3 cases hard palatal squamous cell carcinomas.The maxilla was resected and the defects were classified as Class 2a. Reverse facial artery submental artery deepithelialised submental island flaps measuring 8-10 cm in length and 4-5 cm in width were used to reconstruct the defects. RESULTS: Twelve of the 13 flaps survived and the success rate was 92.3%. No donor site problems or palsy of the marginal mandibular branch of the facial nerve occurred. The follow up period ranged from 8 to 24 months, one patient died as a result of local tumour recurrence and two patients developed cervical lymph mode metastasis. CONCLUSION: The reverse facial artery submental artery deepithelialised submental island flap is safe, quick and simple to use or elevate. The flap is reliable for reconstructing maxillary defects following cancer ablation. References | Related Articles | Metrics

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Application of celecoxib in analgesia for patients who underwent extraction of impacted tooth WANG Fei, YU Wen-ting, LIANG Yan-can, CHENG Hui-lin, JIAO Jiu-yang, LU Ying-juan, CHEN Wei-liang 2014, 12 (1):  65-68.  Abstract ( 1118 )   HTML ( 1 )   PDF (566KB) ( 326 )   PURPOSE: To evaluate the effect of celecoxib in acute pain relief after extraction of impacted tooth. METHODS: In the randomized, double-blind placebo-controlled trial, 90 patients who underwent extraction of impacted mandibular third molar, were divided into 3 groups based on the use of ccelecoxib, ibuprofen and placebo. Each group had 30 patients. After 4 hours of extraction, patients were given 400 mg celecoxib in the celecoxib group, 400 mg ibuprofen in the ibuprofen group. While in the placebo group, 100 mg vitamin C was administrated. Pain and adverse events were recorded after extraction and application of 3 drugs. Chi-square test and analysis of variance were carried out for comparison between the three groups using SPSS 13.0 software package. RESULTS: There were significant differences in analgesic onset time, PID, PAR, SPID, TOPPAR and overall assessment between celecoxib group, ibuprofen and placebo group (P<0.05). Compared with celecoxib group and ibuprofen group, the analgesic effect was quite the same. 12 h after administration, only the PID of the two groups had significant difference (P<0.05). Within 24 h, there was no significant difference in time to onset of analgesia, PAR, SPID, TOPPAR, and overall assessment (P>0.05). CONCLUSIONS: Celecoxib has distinct analgesic effect in extraction of impacted teeth with acute severe pain. References | Related Articles | Metrics

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Characteristics of facial asymmetry of patients with juvenile unilateral temporomandibular joint anterior disc displacement XIE Qian-yang, MA Zhi-gui, YANG Chi, CAI Xie-yi 2014, 12 (1):  69-73.  Abstract ( 715 )   HTML ( 5 )   PDF (612KB) ( 520 )   PURPOSE: To study the characteristics of facial asymmetry of adolescent unilateral temporomandibular anterior disc displacement patients, and clarify the relationship of facial asymmetry and disc displacement. METHODS: Consecutive juvenile patient of 10 to 20 year-old with unilateral temporomandibular anterior disc displacement confirmed by magnetic resonance imaging were collected, posteroanterior cephalometric radiographs were taken and measured. SPSS 18.0 software package was employed to analyze the asymmetry of mandible (menton, gonion, condyle), maxilla (anterior nasal spine, zygomatic alveolar ridge) and dentition (the midpoint of the upper and lower dentition) within both left and right disc displacement through one sample t test. RESULTS: One hundred and five cases aging from 10 to 20 years old (mean 16.76 years) with unilateral disc displacement were collected, 67 (63.81%) were diagnosed as mandibular deviation. Patient with unilateral disc displacement displayed decrease of vertical height of ramus, increase of dispersion of gonion on the ipsilateral side, and shift of midline of chin and upper and lower dentition to the same side (P<0.05). There was significant asymmetry of the maxilla in the right disc displacement group (P<0.05), but no asymmetry in the left disc displacement group (P>0.05). CONCLUSION: Teenagers with unilateral anterior disc displacement showed significant facial asymmetry and its characteristics was closely related to the ipsilateral side of disc displacement. Facial asymmetry affected mostly mandible with the chin deviated and overall rotation of mandible to the ipsilateral side. There is a tendency that development of maxilla on the ipsilateral side was affected. References | Related Articles | Metrics

Clinical Reports

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Treatment of oral and maxillofacial fracture with multiple traumas in 47 cases WANG Bing, JIANG Guo-ming, HAN Pei-hui 2014, 12 (1):  74-76.  Abstract ( 378 )   HTML ( 1 )   PDF (466KB) ( 462 )   PURPOSE: To observe the effect of multidisciplinary approach on oral and maxillofacial fracture with multiple traumas. METHODS: Forty-seven patients with oral and maxillofacial fracture and multiple traumas were treated between January 2008 and December 2012. The airway was kept open, the vital signs remained stable, and multiple related injuries were treated via multidisciplinary approach. After open reduction, the fracture was fixed with miniature titanium plate. The patients were instructed to perform postoperative physical exercises. RESULTS: All patients survived after treatment. The curative rate of 47 patients was 95.74%. CONCLUSIONS: Oral and maxillofacial fracture with multiple traumas should be treated multidisciplinary according to the severity of injury. Suitable miniature titanium should be chosen to fix the fracture rigidly based on the type of fracture. References | Related Articles | Metrics

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Clinical and pathological characteristics of ameloblastic carcinoma: report of 2 cases and review of literature LIANG Jun, ZHENG Wei-xin, WU Zhen-chan, YOU Yun-hua 2014, 12 (1):  77-81.  Abstract ( 730 )   HTML ( 7 )   PDF (1582KB) ( 626 )   PURPOSE: To analyze the clinical and pathological characteristics of ameloblastic carcinoma. METHODS: Two cases of ameloblastic carcinoma were reported and the relevant literatures were reviewed and analyzed. RESULTS: There were 30 well-documented clinical reports of ameloblastic carcinoma, including 3 retrospective studies and 27 case reports, with 61 patients in total. CONCLUSION: Ameloblastic carcinoma is a rare odontogenic epithelial malignancy with no significant gender differences and non-specific clinical features, the definite diagnosis was depended on pathological examination and immunohistochemical staining. It is easy to infiltrate contiguous tissues, surgical treatment is preferred. The patient’s prognosis is not so good that long-time follow-up is necessary. References | Related Articles | Metrics

Review Article

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The value of preoperative imaging of perforator vasculature for planning perforator flaps HUANG Jian, SUN Jian 2014, 12 (1):  82-86.  Abstract ( 366 )   HTML ( 0 )   PDF (615KB) ( 321 )   Perforator-based microsurgical reconstruction of the compound tissue defect has become the newest method in surgical reconstruction since the introduction of the technique in the late 1980s. Compared with conventional musculocutaneous flap, this approach decreases morbidity of donor site and complication, better preserves muscles. However, the major disadvantage of these flaps is that they can be difficult to harvest. The challenges in flap dissection are a result of the tiny diameter size of perforators and the location, number, and caliber which varies greatly from individuals. Preoperative imaging to assess vascular architecture is vital to improve the success rate, reduce the operative complication, and decrease operating time. The purpose of this article was to review the value of currently available imaging modalities for preoperative planning of perforator vascular architecture, which include hand-held Doppler, color duplex sonography, computer tomography angiography, magnetic resonance angiography and image-guided stereotactic navigation. References | Related Articles | Metrics

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Research progress for peri-implant soft tissue stability in aesthetics area SHI Jun-yu, LAI Hong-chang 2014, 12 (1):  87-90.  Abstract ( 339 )   HTML ( 0 )   PDF (442KB) ( 372 )   Nowadays the esthetic outcome of dental implants treatment has gained more concerns. This paper introduced the objective criteria for peri-implant soft tissue stability, and reviewed the latest studies focusing on peri-implant soft tissue stability in aesthetic area. In addition, the impact of new technologies on peri-implant stability has also been discussed. References | Related Articles | Metrics

Case Reports

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Malignant peripheral nerve sheath tumors of the oral and maxillofacial region: report of a case and review of the literature DONG Rui, TAO Ye, HU Min, CHEN Peng, WANG Gao-fei, LINGHU Da-ke 2014, 12 (1):  91-94.  Abstract ( 359 )   HTML ( 0 )   PDF (814KB) ( 569 )   Malignant peripheral nerve sheath tumor (MPNST) is a rare malignant tumor, even in the head and neck areas. This article reported a case of MPNST in oral and maxillofacial region, and discussed the clinical manifestation of MPNST, histopathological and imaging features, treatment and prognosis with related literature review. MPNST is a kind of high malignant tumor, recurrence rate after surgery is high, local recurrence and distant metastasis is the main cause of death. References | Related Articles | Metrics

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Hemorrhage after tooth extraction due to coagulation factor Ⅺ deficiency: a case report DU Meng, ZHANG Ye 2014, 12 (1):  95-97.  Abstract ( 485 )   HTML ( 0 )   PDF (276KB) ( 346 )   Coagulation factor Ⅺ(factor Ⅺ,FⅪ)deficiency is a kind of hereditary hemorrhagic disease. Lack of FⅪ can cause lack of thrombin and high fibrinolytic activity, which leads to increased bleeding. Bleeding always happens in oral and nasal mucosa with high fibrinolytic activity in patients, and is often associated with trauma and surgery. This paper reported a case treated in China-Japan Friendship Hospital. The patient bled repeatedly after tooth extraction and was controlled with insertion of a tela iodoformum. The final diagnosis of the patient was coagulation factor Ⅺ deficiency and the bleeding was eventually stopped by plasma input. References | Related Articles | Metrics