The expression and significance of astrocyte elevated gene-1 in salivary gland tumors

China Journal of Oral and Maxillofacial Surgery ›› 2014, Vol. 12 ›› Issue (1): 35-38.

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The expression and significance of astrocyte elevated gene-1 in salivary gland tumors

CHEN Chui-shi¹, HUANG Zhi-quan¹, LI Hai-gang¹

1.Department of Stomatology, Shenzhen Longgang Central Hospital. Shenzhen 518116; 2. Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University. Guangzhou 510120, Guangdong Province, China; 3. Department of Pathology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University. Guangzhou 510120, Guangdong Province, China

Received:2013-05-15 Revised:2013-07-17 Online:2014-02-10 Published:2014-02-10
Supported by:
Supported by National Natural Science Foundation of China(81101592) and Natural Science Foundation of Guangdong Province (S2013010014794).

Abstract

Abstract: PURPOSE: To explore the expression and significance of astrocyte elevated gene-1 (AEG-1) in salivary gland tumors. METHODS: The expression of AEG-1 was detected by immunohistochemistry in salivary gland tumors (including pleomorphic adenoma, mucopidermoid carcinoma, and adenoid cystic carcinoma), as well as 15 cases of normal salivary gland tissue. SPSS 10.0 software package was used for statistical analysis. RESULTS: AEG-1 expression in tumor tissue was significantly higher than that in normal salivary gland tissue (P=0.001). AEG-1 expression in malignant tumors was significantly higher than that in pleomorphic adenoma (P=0.033). The expression of AEG-1 was related to tumor stage in malignant tumors (P=0.035). CONCLUSIONS: The expression of AEG-1 may contribute to salivary gland tumor development and malignant potentiality.

Key words: Astrocyte elevated gene-1, Salivary gland tumor, Immunohistochemistry

CHEN Chui-shi, HUANG Zhi-quan, LI Hai-gang. The expression and significance of astrocyte elevated gene-1 in salivary gland tumors[J]. China Journal of Oral and Maxillofacial Surgery, 2014, 12(1): 35-38.

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The expression and significance of astrocyte elevated gene-1 in salivary gland tumors

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