Study on the role of PRF combined with preformed titanium mesh in implant restoration of severe horizontal defects in maxillary anterior alveolar ridge

doi:10.19438/j.cjoms.2026.01.009

Abstract

Abstract: PURPOSE: To explore the application effect of platelet-rich fibrin(PRF) combined with preformed titanium mesh in the implant restoration of severe horizontal defects of the maxillary anterior alveolar ridge. METHODS: A total of 64 patients who underwent implant restoration for severe horizontal defects of the maxillary anterior alveolar ridge in Xi'an Labor Union Hospital from January 2021 to January 2024 were selected and randomly divided into a control group and an experimental group, with 32 cases in each group. In the control group, preformed titanium mesh was placed over the bone defect area after implantation; in the experimental group, PRF was applied in combination with the treatment used in the control group. The implant success rate, changes in alveolar bone morphology (alveolar bone volume increment, height increment, width increment), periodontal health status, red aesthetic score, occlusal and masticatory functions were compared between the two groups after 12 months, and complications were recorded. RESULTS: The implant success rate was 100% in both groups. The postoperative alveolar bone volume increment, height increment, and width increment in the experimental group were significantly higher than those in the control group(P<0.05). The periodontal status and anterior tooth aesthetics in the experimental group were significantly better than those in the control group(P<0.05), and the occlusal and masticatory abilities were significantly higher than those in the control group (P<0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05). CONCLUSIONS: PRF combined with preformed titanium mesh can significantly improve bone increment effect in severe horizontal defects of the maxillary anterior alveolar ridge, enhance periodontal health and aesthetic appearance, and strengthen occlusal and masticatory functions, with good safety.

Key words: Platelet-rich fibrin, Preformed titanium mesh, Maxillary anterior alveolar ridge defect, Implant restoration, Bone increment

CLC Number:

R782.1

Zhang Wentao, Xin Dan, Pang Lifeng. Study on the role of PRF combined with preformed titanium mesh in implant restoration of severe horizontal defects in maxillary anterior alveolar ridge[J]. China Journal of Oral and Maxillofacial Surgery, 2026, 24(1): 54-58.

References

[1] 欧阳思远, 邸萍.自体骨块移植术在重度牙槽嵴缺损重建中的临床应用[J]. 中华口腔医学杂志, 2024, 59(7): 745-750.
Ouyang SY, Di P.Application of autogenous block bone graft in the reconstruction of severe alveolar crest defect[J]. Chinese Journal of Stomatology, 2024, 59(7): 745-750.
[2] Kapare K, Gopalakrishnan D, Kathariya R, et al.Evaluation of efficacy of a novel resorbable collagen membrane for root coverage of Miller's Class Ⅰ and Class Ⅱ recession in the maxillary anteriors and premolars[J]. J Indian Soc Periodontol, 2016, 20(5): 520-524.
[3] 乐柯, 董衡, 陈力, 等. 应用三维预成型钛网在上颌前牙区骨增量疗效的临床研究[J]. 口腔医学研究, 2020, 36(5): 481-485.
Le K, Dong H, Chen L, et al.Effect of three-dimensional pre-formed titanium mesh in maxillary anterior region[J]. Journal of Oral Science Research, 2020, 36(5): 481-485.
[4] Song P, He D, Ren S, et al.Platelet-rich fibrin in dentistry[J]. J Appl Biomater Funct Mater, 2024, 22: 22808000241299588.
[5] 曹采方. 临床牙周病学 [M]. 北京: 北京大学医学出版社, 2006: 307.
Cao CF.Clinical periodontology [M]. Beijing: Peking University Medical Press, 2006: 307.
[6] Yu J, Liu X, Li D, et al.Observation of the clinical effect of immediate implantation and delayed implantation in the maxillary and maxillary molars[J]. Afr Health Sci, 2023, 23(2): 597-605.
[7] Fürhauser R, Mailath-Pokorny G, Haas R,et al.Immediate restoration of immediate implants in the esthetic zone of the maxilla via the copy-abutment technique: 5-year follow-up of pink esthetic scores[J]. Clin Implant Dent Relat Res, 2017, 19(1): 28-37.
[8] Wang W, Li X, Mei D, et al.Autogenous solid dentin for horizontal ridge augmentation with simultaneous implantation in a severe bone defect: a 3.5-year follow-up clinical report[J]. J Prosthet Dent, 2025, 133(4): 948-953.
[9] Lee SR, Jang TS, Seo CS, et al.Hard tissue volume stability effect beyond the bony envelope of a three-dimensional preformed titanium mesh with two different collagen barrier membranes on peri-implant dehiscence defects in the anterior maxilla: a randomized clinical trial[J]. Materials (Basel), 2021, 14(19): 5618.
[10] 阎旭, 芈大卫, 赵明, 等. 预成型钛网联合浓缩生长因子膜修复31例前牙种植区骨量不足的疗效分析[J]. 上海口腔医学, 2022, 31(4): 406-409.
Yan X, Mi DW, Zhao M, et al.Effect of preformed titanium mesh combined with concentrated growth factor membrane on implant restoration of insufficient bone mass in anterior teeth of 31 consecutive cases[J]. Shanghai Journal of Stomatology, 2022, 31(4): 406-409.
[11] Pavlovic V, Ciric M, Jovanovic V, et al.Platelet-rich fibrin: basics of biological actions and protocol modifications[J]. Open Med (Wars), 2021, 16(1): 446-454.
[12] 吕晔, 李泓运, 陈青. 预成型钛网联合胶原膜及PRF在前牙牙槽嵴严重骨缺损种植中的应用[J].中国美容医学, 2024, 33(9): 126-129.
Lyu Y, Li HY, Chen Q.Application effect of preformed titanium mesh combined with collagen membrane and PRF in patients with severe bone defects of anterior alveolar ridge[J]. Chinese Journal of Aesthetic Medicine, 2024, 33(9): 126-129.
[13] Kornsuthisopon C, Pirarat N, Osathanon T, et al.Autologous platelet-rich fibrin stimulates canine periodontal regeneration[J]. Sci Rep, 2020, 10(1): 1850.
[14] Shashank B, Bhushan M.Injectable platelet-rich fibrin (PRF): the newest biomaterial and its use in various dermatological conditions in our practice: a case series[J]. J Cosmet Dermatol, 2021, 20(5): 1421-1426.
[15] Araújo CRG, Araújo RC, Araújo CG, et al.Bone regeneration in the anterior maxilla with titanium mesh and advanced-platelet-rich fibrin: a case report with 2-year follow-up[J]. J Oral Implantol, 2024, 50(5): 514-518.
[16] 张运, 王彦梅, 何家才. 富血小板纤维蛋白联合骨替代材料应用于牙槽嵴位点保存术的临床效果[J]. 口腔疾病防治, 2020, 28(6): 361-366.
Zhang Y, Wang YM, He JC.Clinical effect of platelet-rich fibrin combined with bone substitute in alveolar ridge preservation[J]. Journal of Prevention and Treatment for Stomatological Diseases, 2020, 28(6): 361-366.
[17] Kelm RC, Ibrahim O.Utility of platelet-rich plasma in aesthetics[J]. Clin Dermatol, 2022, 40(1): 19-28.
[18] Buzayan MM, Mahdey HM, Ning CJ.A new approach for better anterior esthetic using platelet-rich fibrin as sole graft material combined with ovate design dental bridge[J]. J Indian Prosthodont Soc, 2020, 20(2): 219-223.
[19] Li S, Zhao J, Xie Y, et al.Hard tissue stability after guided bone regeneration: a comparison between digital titanium mesh and resorbable membrane[J]. Int J Oral Sci, 2021, 13(1): 37.
[20] Kurtis B, Sahin S, Gürbüz S, et al.Vertical bone augmentation with customized CAD/CAM titanium mesh for severe alveolar ridge defect in the posterior mandible: a case letter[J]. J Oral Implantol, 2023, 49(2): 147-156.
[21] 曾令紫, 莫安春. 富血小板纤维蛋白在口腔种植中的应用进展[J]. 中国口腔颌面外科杂志, 2023, 21(5): 518-521.
Zeng LZ, Mo AC.Progress on application of platelet-rich fibrin in dental implantology[J]. China Journal of Oral and Maxillofacial Surgery, 2023, 21(5): 518-521.
[22] Shetye AG, Rathee M, Jain P, et al.Effect of advanced platelet-rich fibrin and concentrated growth factor on tissues around implants in maxillary anterior region[J]. J Indian Prosthodont Soc, 2022, 22(2): 169-178.
[23] Latalski M, Walczyk A, Fatyga M, et al.Allergic reaction to platelet-rich plasma (PRP): case report[J]. Medicine (Baltimore), 2019, 98(10): e14702.