Risk factor analysis of postoperative venous thromboembolism in elderly patients with oral cancer

doi:10.19438/j.cjoms.2024.03.005

Abstract

Abstract: PURPOSE: To investigate the risk factors of postoperative venous thromboembolism(VTE) in elderly patients with oral cancer. METHODS: Retrospective collection and evaluation of the relevant risk factors for postoperative VTE in 219 elderly patients undergoing oral cancer treatment at Sun Yat-sen Memorial Hospital of Sun Yat-sen University from October 2016 to October 2021 were conducted. A total of 219 cases were included, and both univariate and multivariate logistic regression analysis were used to identify the risk factors for postoperative VTE in elderly oral cancer patients with SPSS 25.0 software package. RESULTS: Among the 219 patients, 55 developed VTE after surgery, accounting for 25.11%. Univariate analysis indicated that age, gender, hemoglobin(HGB), fibrinogen(FIB), D-dimer, surgical duration, and postoperative use of low molecular weight heparin (LMWH) were significantly associated with postoperative VTE (P<0.05). Multivariate logistic regression analysis revealed that age >70 years, female gender, and surgical duration >340 min were risk factors for postoperative VTE. Prophylactic use of LMWH was found to reduce the risk of VTE. CONCLUSIONS: Patients' age and surgical duration are independent risk factors for postoperative VTE in elderly patients with oral cancer. For patients without contraindications to anticoagulation, postoperative prophylactic use of LMWH can significantly reduce the incidence of VTE. Necessary postoperative VTE prevention measures should be taken for female patients over 70 years of age with surgical durations exceeding 340 min.

Key words: Venous thromboembolism, Oral cancer, Elderly, Reconstructive surgery, Risk factors

CLC Number:

R739.8

HONG Lei, CHEN Wei-liang. Risk factor analysis of postoperative venous thromboembolism in elderly patients with oral cancer[J]. China Journal of Oral and Maxillofacial Surgery, 2024, 22(3): 233-238.

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