The analgesic effects of a lidocaine-loaded transdermal delivery system in orofacial pain

doi:10.19438/j.cjoms.2024.03.003

Abstract

Abstract: PURPOSE: To study the analgesic effect of transdermal drug delivery system loaded lidocaine in orofacial pain model. METHODS: The soluble microneedle patch loaded with lidocaine hydrochloride (Lido/MN) was prepared by microfabrication technology, and its insertion performance and transdermal release ability in vitro were measured. The analgesic effect of Lido/MN was observed in the orofacial formalin-induced pain model and capsaicin induced pain model in rats, and its biological safety was evaluated. SPSS 21.0 software package was used for data analysis. RESULTS: The study demonstrated that Lido/MN exhibited a complete and smooth external morphology, excellent mechanical properties, and skin penetration capability. It could rapidly dissolve and release lidocaine intradermally, exerting a rapid onset of action and providing good local anesthesia. CONCLUSIONS: The use of Lido/MN addresses the issue of slow onset of action in current lidocaine topical formulations, showing promising prospects for further research and clinical significance.

Key words: Dissolvable microneedles, Lidocaine, Non-invasive transdermal delivery, Orofacial analgesia

CLC Number:

R730.6

WANG Ting, LUO Tao, ZHI Yan-kang, SUN Yu. The analgesic effects of a lidocaine-loaded transdermal delivery system in orofacial pain[J]. China Journal of Oral and Maxillofacial Surgery, 2024, 22(3): 222-227.

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