Research on the preventive effect of lutein on traumatic temporomandibular joint ankylosis of rabbits

doi:10.19438/j.cjoms.2024.03.002

Abstract

Abstract: PURPOSE: To explore the effect of lutein on traumatic temporomandibular joint ankylosis. METHODS: Sixteen New Zealand white rabbits were randomly divided into blank control group and lutein intervention group (experimental group). The traumatic temporomandibular joint ankylosis model was established in all experimental animals under the premise of protecting the joint capsule. Postoperatively, the experimental group was given oral lutein 10 mg·kg^-1·d^-1 for 4 consecutive weeks. The maximum mouth opening, body weight, histology, imaging and bone metabolism indexes were compared between the two groups. GraphPad Prism 9.4.0 software package was used for data analysis. RESULTS: The body weight, mouth opening, serum osteocalcin concentration, condylar surface area and volume measured by CT in the experimental group were significantly higher than those in the control group after operation(P<0.05). Histomorphological observation showed that braid bone and new bone could be seen at the condylar stump of the two groups of experimental animals, sometimes chondrometaplasia could be seen in the fibers, occasionally granulation tissue and long-standing bleeding could be seen. The experimental group had thickening fibrous layer of the condyle, active cell proliferation, and a more pronounced cellular hierarchy. CONCLUSIONS: Lutein has certain preventive effect on traumatic temporomandibular joint ankylosis, and its mechanism of action may be related to its ability to promote bone formation and increase serum osteocalcin concentration.

Key words: Lutein, Traumatic temporomandibular joint ankylosis, Animal models, Rabbit

CLC Number:

R782.6

MI Na, AN Wei, JIN Xue-mei, XIE Shuai, YAO Zhi-tao. Research on the preventive effect of lutein on traumatic temporomandibular joint ankylosis of rabbits[J]. China Journal of Oral and Maxillofacial Surgery, 2024, 22(3): 216-221.

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