Gingival metastasis from rectal adenocarcinoma: A case report and literature review

doi:10.19438/j.cjoms.2020.04.019

Abstract

Abstract: Rectal adenocarcinoma rarely metastasizes to the gingiva. An unusual case of an 81-year-old woman with gingival metastasis originating from the rectal adenocarcinoma two years after colon carcinoma resection was presented. The diagnosis was confirmed by histopathologic examination and immunohistochemical analysis. Because oral metastases are rare and often mimic much more common benign lesions, they should be considered as a possibility in differential diagnosis. Careful examination with a high degree of clinical suspicion, as well as a multidisciplinary approach is suggested.

Key words: Rectal adenocarcinoma, Metastasis, Gingiva

CLC Number:

R782

SHE Yang-yang, LIN Yi-jia, LIU Zhi-yong, CHEN Jie-yu, CHEN Xue-ying, GE Ya-ping. Gingival metastasis from rectal adenocarcinoma: A case report and literature review[J]. China Journal of Oral and Maxillofacial Surgery, 2020, 18(4): 381-384.

References

[1] Colombo P, Tondulli L, Masci G, et al.Oral ulcer as an exclusive sign of gastric cancer: report of a rare case[J]. BMC Cancer, 2005, 5: 117.
[2] Hirshberg A, Shnaiderman-Shapiro A, Kaplan I, et al.Metastatic tumours to the oral cavity-pathogenesis and analysis of 673 cases[J]. Oral Oncol, 2008, 44(8): 743-752.
[3] Hirshberg A, Buchner A.Metastatic tumours to the oral region, an overview[J]. Eur J Cancer B Oral Oncol, 1995, 31B(6): 355-360.
[4] Soares AB, Thomaz LA, Duarte MT, et al.Metastatic adenocarcinoma of the colon: early manifestation in gingival tissue[J]. Head Neck Pathol, 2011, 5(2): 140-143.
[5] Hatziotis JC, Constantinidou H, Papanayotou PH.Metastatic tumors of the oral soft tissues. Review of the literature and report of a case[J]. Oral Surg Oral Med Oral Pathol, 1973, 36(4): 544-550.
[6] Rentschler RE, Thrasher TV.Gingival and mandibular metastases from rectal adenocarcinoma: case report and 20 year review of the English literature[J]. Laryngoscope, 1982, 92(7 Pt 1): 795-797.
[7] 宋永浩. 直肠癌术后牙龈转移1例[J]. 中国肿瘤临床, 1998, 25(11): 54.
[8] 马云海, 李书聆, 李建生. 直肠癌转移至子宫内膜及牙龈各1例[J]. 中华普通外科杂志, 2003, 18(5): 278.
[9] 马惠文, 邵江河, 余慧青, 等. 直肠癌转移至牙龈1例的报道[J]. 重庆医学, 2012, 41(34): 3688.
[10] Watanabe M, Tada M, Satomi T, et al.Metastatic rectal adenocarcinoma in the mandibular gingiva: a case report[J]. World J Surg Oncol, 2016, 14(1): 199.
[11] Clausen F, Poulsen H.Metastatic carcinoma to the jaws[J]. Acta Pathol Microbiol Scand, 1963, 57: 361-374.
[12] Mantovani A.Molecular pathways linking inflammation and cancer[J]. Curr Mol Med, 2010, 10(4): 369-373.
[13] van der Waal RI, Buter J, van der Waal I. Oral metastases: report of 24 cases[J]. Br J Oral Maxillofac Surg, 2003, 41(1): 3-6.
[14] 巴恩斯, 伊夫森, 里查特, 等. 头颈部肿瘤病理学和遗传学 [M]. 北京: 人民卫生出版社, 2006.
[15] 卿海云, 杨亦萍. 口腔转移性肿瘤14例临床病理分析[J]. 广西医科大学学报, 2010, 27(2): 310-311.
[16] Shan KS, Zhang XP, Wang JS, et al.Usefulness of large-section cytokeratin 20 in the detection of intestinal wall infiltration and mesangial metastasis in patients with middle and lower rectal cancer[J]. J Cancer Res Ther, 2019, 15(2): 437-441.
[17] Bayrak R, Haltas H, Yenidunya S.The value of CDX2 and cytokeratins 7 and 20 expression in differentiating colorectal adenocarcinomas from extraintestinal gastrointestinal adenocarcinomas: Cytokeratin 7-/20+ phenotype is more specific than CDX2 antibody[J]. Diagn Pathol, 2012, 7: 9.
[18] Eberhard J, Gaber A, Wangefjord S, et al.A cohort study of the prognostic and treatment predictive value of SATB2 expression in colorectal cancer[J]. Br J Cancer, 2012, 106(5): 931-938.
[19] Iida T, Sasaki T, Akita H, et al.Metastatic gingival tumor from rectal cancer diagnosed with CDX2[J]. Clin J Gastroenterol, 2009, 2(3): 175-177.
[20] Murugaraj V, Bischoff P, Fasanya S, et al.Metastatic colorectal adenocarcinoma of the jaw-a case report[J]. Oral Surg, 2013, 6(2): 88-90.