Primary intraosseous squamous cell carcinoma of the mandible: clinical, pathological and prognosis analysis of 34 consecutive cases

doi:10.19438/j.cjoms.2018.03.012

Abstract

Abstract: PURPOSE: To analyze the clinical and pathological features as well as the prognostic factors for primary intraosseous squamous cell carcinoma of the mandible. METHODS: A retrospective study for primary intraosseous squamous cell carcinoma patients treated in our hospital from 2010 to 2015 was executed. The clinical, radiological, pathological, treatment information and follow up records were collected. Statistical analysis was performed with SPSS 17.0 software package. RESULTS: There were a total of 36 patients treated in the given time period, among them 34 were followed-up: 22 were male and 12 were female; 23 were within the age group of 31-60 years old, 11 were above 60 years old. Thirteen had smoking history, 4 had previous alcohol hobby. The median tumor size was 4 cm while 21 was < 4 cm and 13 was >4 cm. Nine had positive cervical lymph nodes in final pathological results, no positive surgical margin was found. Twenty-eight received postoperative radiotherapy, 9 died of locoregional recurrence or metastasis during follow-up. CONCLUSIONS: Surgery is the main approach for treating primary intraosseous squamous cell carcinoma of the mandible. Tumors outside the body of mandible, positive cervical lymph node were related to high rate for locoregional recurrence. Patients with previous alcohol hobby seemed to have high possibility of tumor metastasis postoperatively. Tumor size > 4 cm significantly reduces overall survival rate.

Key words: Primary intraosseous squamous cell carcinoma, Mandible, Prognostic factor, Locoregional recurrence, Metastasis

CLC Number:

R739.8

KUDUSI·Keyimu, CHEN Yi-ming, XU Qian, JI Tong.. Primary intraosseous squamous cell carcinoma of the mandible: clinical, pathological and prognosis analysis of 34 consecutive cases[J]. China Journal of Oral and Maxillofacial Surgery, 2018, 16(3): 253-258.

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