Prognostic factors of oral tongue squamous cell carcinoma: a retrospective study of 638 cases

doi:10.19438/j.cjoms.2021.05.012

Abstract

Abstract: PURPOSE: To investigate the impact of clinical and pathological characteristics on survival of patients with oral tongue squamous cell carcinoma （OTSCC）, and to analyze the factors predicting survival outcome. METHODS: A retrospective analysis of 638 patients diagnosed with OTSCC at Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine from January 2003 to December 2013 was performed. Details on patient characteristics and tumor characteristics were recorded by retrospective review of patients' charts. Survival data acquisition was retrieved from Shanghai registry database of resident cancer by Shanghai Center for Disease Control and Prevention. Standard descriptive statistics were used to summarize patient demographic and disease-related data. Pearson Chi-square, Kaplan-Meier, Log-rank test, and Cox proportional hazards regression analysis were performed with Stata/SE 10.0 software package, and only variables with P<0.05 in univariate analysis were included in multivariable regression models. RESULTS: The 1-year, 3-year, and 5-year overall survival of 638 patients were 83.52%, 68.98% and 63.33%, respectively. Univariate analysis indicated that age> 60 years, males below 60 years, base of tongue, higher T stage, N stage were predictors of poor outcome. In multivariate analysis, several predictors of compromised overall survival were T stage, N stage and histopathological grade. T stage and N stage were strong independent predictors of poorer overall survival. CONCLUSIONS: Age, sex, lesion, T stage, N stage and histopathologic grading are prognostic factors for OTSCC patients.

Key words: Oral tongue squamous cell carcinoma, Overall survival, Prognostic factor, Cox proportional hazards model

CLC Number:

R739.8

YE Chen, CAI Yun, ZHAO Xiao-mei, ZHANG Chen-ping, ZHAO Nai-qing. Prognostic factors of oral tongue squamous cell carcinoma: a retrospective study of 638 cases[J]. China Journal of Oral and Maxillofacial Surgery, 2021, 19(5): 449-455.

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