PUMA expression and its clinical significance in tongue squamous cell carcinoma

Abstract

Abstract: PURPOSE: To investigate the expression of PUMA (p53 up-regulated modulator of apoptosis) in tongue squamous cell carcinoma (TSCC), tongue tissues adjacent to cancer and normal tongue tissues, and to explore its clinical significance. METHODS: The expression of PUMA in resected samples from TSCC, tongue tissues adjacent to cancer and normal tongue tissues were detected by immunohistochemistry. The relationships between the expression of PUMA and the TNM staging, cell differentiation, and lymph node metastasis were analysed respectively. SPSS 17.0 software package was used for statistical analysis. RESULTS: Immunohistochemical studies demonstrated that PUMA expression was lower in TSCC (36.67%) than in tongue tissues adjacent to cancer(53.85%) and normal tongue tissues(80.00%). There was significant difference of PUMA expression in lymph node metastasis and lymph node without metastasis(P<0.05). The expression of PUMA in TSCC had no relation with age, gender, clinical stages, and the degree of cell differentiation(P>0.05). CONCLUSIONS: The results indicated that PUMA expression in TSCC is correlated with the pathogenesis and development of TSCC and lymph node metastasis and maybe a new promising target for treatment of TSCC.

Key words: p53 up-regulated modulator of apoptosis, Tongue squamous cell carcinoma, Immunohistochemistry

CLC Number:

R739.8

LIU Bin, JIANG Fang-fang, YU Dong-sheng, LIU Zi-feng, ZHAO Wei. PUMA expression and its clinical significance in tongue squamous cell carcinoma[J]. China Journal of Oral and Maxillofacial Surgery, 2014, 12(2): 121-125.

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