Research progress on the mechanism of mitochondrial dysfunction in the pathogenesis and progression of hemangiomas

doi:10.19438/j.cjoms.2026.02.013

Abstract

Abstract: Hemangioma is a common vascular tumor caused by the abnormal proliferation of vascular endothelial cells; its rapid early growth can lead to disfigurement and functional impairment. The precise pathogenesis remains incompletely understood. Recent studies show that mitochondrial dysfunction is not only closely associated with abnormal endothelial-cell proliferation, but also plays a pivotal role in the initiation and progression of hemangioma. This article focused on elaborating the risk factors of hemangioma, the pathogenesis related to mitochondria, as well as prevention and treatment, providing new insights and theoretical basis for the research on the pathological mechanism of hemangioma and the formulation of noval clinical treatment strategies.

Key words: Hemangioma, Vascular endothelial cell, Mitochondrial dysfunction, Risk factors, Abnormal proliferation

CLC Number:

R739.8

Ma Ruoyan, Wang Junbin, Zhen Lixiao, Zhou Yuncai, Liu Xuejian. Research progress on the mechanism of mitochondrial dysfunction in the pathogenesis and progression of hemangiomas[J]. China Journal of Oral and Maxillofacial Surgery, 2026, 24(2): 176-184.

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