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20 September 2023, Volume 21 Issue 5 Previous Issue    Next Issue

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Application prospect of tumor treating fields technology in head and neck cancer LI Chen-xi, GONG Zhong-cheng, ZHAO Hua-rong, DING Ming-chao, LIU Hui 2023, 21 (5):  425-431.  doi: 10.19438/j.cjoms.2023.05.001 Abstract ( 306 )   PDF (1218KB) ( 127 )   In recent years, major breakthroughs have been made in the treatment of malignant tumours with research and development progress of immunologic agents and molecular targeted drugs, but it is still the main cause of global disease death. Tumour treating fields (TTFields) is a new non-invasive approach to cancer treatment. TTFields can provide a kind of low-intensity (1-3 V/cm), intermediate frequency (100-300 kHz) alternating electric fields delivered locally to the tumour, which can destroy the chromosome segregation of mitotic tumour cells and induce dielectrophoresis to arise cell structure disturbance and apoptosis. The sensitive parameters of TTFields for normal and cancerous cells are different, but TTFields has no effect on quiescent cells. Hence, it has the advantages of fewer side effects and less trauma, and has great potential. Additionally, its efficacy and safety have been verified in phase III clinical trials of glioblastoma multiforme. Some clinical trials on TTFields have also been carried out in other kinds of solid tumours. This article reviewed the latest research progress of TTFields, expounding its micromechanism and discussing its application prospects in head and neck cancer. References | Related Articles | Metrics

Original Articles

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Simulation analysis and experimental research of 3D printing self-positioning titanium mesh ZHANG Jia-yuan, YU De-dong, JI Min, LIN Hai-yan 2023, 21 (5):  432-438.  doi: 10.19438/j.cjoms.2023.05.002 Abstract ( 155 )   PDF (1859KB) ( 86 )   PURPOSE: To validate the feasibility of 3D printing self-positioning individual titanium mesh, establish an efficient standardized self-positioning titanium mesh simulation model and perform fracture simulation analysis. METHODS: A standard self-positioning titanium mesh model was built by using 3D modeling design software SolidWorks. The details of the connection between the two ends of the titanium mesh and the locating wing were highlighted. Simulation software ANSYS Workbench was used to conduct fracture simulation analysis on the standardized self-positioning titanium mesh model indicated above, including deformation, strain, stress. Self-positioning titanium mesh for 3D printing was standardized and mechanical performance tests were performed. To verify the viability of the simulation model establishment, compare the fracture simulation analysis results were compared with mechanical performance test results, and the rationality of the self-positioning titanium mesh design and the feasibility of clinical application based on the results were further objectively evaluated. RESULTS: The mechanical test results were basically consistent with the simulation results, with an error of 13.4%-14.5%. According to the results of fracture simulation, the maximum equivalent total strain for a 40 N vertical load on titanium mesh was 4.275 2e-003; for a 45°bending force on the locating wing, the maximum equivalent total strain was 1.133 4e-002, less than the fracture strain (0.17) for TC4 titanium alloy material. In both cases, the maximum deformation was 0.190 55 mm and 1.111 80 mm. CONCLUSIONS: It is successful to create a standard self-positioning titanium mesh simulation model. An extensive analysis of the model's fracture simulation results revealed that titanium mesh would not fracture or deform excessively at the connection when subjected to a 40 N load coming from different directions, and the maximum deformation was within acceptable limits. Strong practicality exists for self-positioning individual titanium mesh. References | Related Articles | Metrics

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The impact of mitochondrial topoisomerase I expression in head and neck squamous cell carcinoma ZHAI Pei-song, TONG Tong, LIU Chun, MA Hai-long, ZHANG Jian-jun 2023, 21 (5):  439-445.  doi: 10.19438/j.cjoms.2023.05.003 Abstract ( 129 )   PDF (1598KB) ( 49 )   PURPOSE: To analyze the correlation between mitochondrial topoisomerase I (TOP1MT) and the clinicopathological characteristics of head and neck squamous cell carcinoma(HNSCC), and to explore its impact on cisplatin resistance in HNSCC. METHODS: The correlation between TOP1MT and clinicopathological characteristics was analyzed by combining the information of 83 clinical patients with the results of immunohistochemical staining and real-time fluorescence quantitative PCR(qRT-PCR). The effect of TOP1MT on proliferation and migration of HNSCC cells with cisplatin treatment was analyzed by in vitro experiments. SPSS 26.0 software package was used for statistical analysis. RESULTS: High expressed TOP1MT was related to tumor size, clinical stage, overall survival, efficacy of TPF regimen, and worse prognosis of HNSCC patients, and the survival probability of patients with high expression of TOP1MT was significantly lower than that of patients with moderate and low expression. In vitro experiments showed that overexpression of TOP1MT significantly promoted the migration and proliferation of HNSCC cells HN30 and HN4 with 20 μmol/L cisplatin treatment. CONCLUSIONS: High expression of TOP1MT in HNSCC indicates insensitivity to chemotherapy and decreased overall survival. The experiment confirmed that TOP1MT promotes HNSCC development and may act as a potential target for clinical therapy. References | Related Articles | Metrics

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The role and mechanism of miR-93-5p in osteogenic differentiation of rabbit bone marrow mesenchymal stem cells mediated by total flavonoids of rhizoma drynariae SHEN Xiao-jing, LI Lin-lin, LU Yao, WANG Le-wei, YUAN Rong-tao, GUO Qing-yuan, ZHAO Peng 2023, 21 (5):  446-451.  doi: 10.19438/j.cjoms.2023.05.004 Abstract ( 130 )   PDF (1258KB) ( 53 )   PURPOSE: To investigate the role of miR-93-5p in osteogenic differentiation of rabbit bone marrow mesenchymal stem cells (rBMSCs) mediated by total flavonoids of rhizoma drynariae(TFRD). METHODS: The osteogenic differentiation of rBMSCs was induced by osteogenic medium. The osteogenic and adipogenic differentiation of rBMSCs were detected by Alizarin red S and oil red O staining, respectively. The expression of miR-93-5p was detected by fluorescence quantitative PCR (qPCR), and the expression level of FZD6, ALP, Runx2 and WNT pathway related proteins (Dishevelled and β-catenin) was detected by Western blotting. The binding of miR-93-5p and FZD6 was tested by double-luciferase reporter gene analysis. The data were analyzed with SPSS 22.0 software package. RESULTS: Compared with the control group, TFRD promoted the osteogenic differentiation of rBMSCs, inhibited the expression of miR-93-5p, and promoted the expression of FZD6 and osteogenic related genes ALP and Runx2. Double-luciferase reporter gene analysis showed that FZD6 was the downstream target gene of miR-93-5p. Overexpression of miR-93-5p inhibited the osteogenic differentiation of rBMSCs and the protein expression of FZD6, ALP and Runx2, while overexpression of FZD6 reversed the inhibitory effect of miR-93-5p. Treatment of rBMSCs with WNT pathway inhibition (KYA1797K) could reverse the promoting effect of TFRD on osteogenic differentiation, resulting in reduced osteoblast differentiation and downregulation of ALP, Runx2 and WNT pathway related proteins (Dishevelled and β-catenin). CONCLUSIONS: TFRD promote the osteogenic differentiation of rBMSCs by downregulating miR-93-5p and upregulating FZD6 to activate the WNT signaling pathway, which contributes to the osseointegration of dental implant. References | Related Articles | Metrics

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Screening of hub genes in tongue squamous cell carcinoma based on bioinformatics analysis ZENG Hui, JIANG Hua-xiang, HU Yan-chang, YANG Feng-rui, WANG Jun 2023, 21 (5):  452-460.  doi: 10.19438/j.cjoms.2023.05.005 Abstract ( 211 )   PDF (1893KB) ( 81 )   PURPOSE: To screen hub genes for tongue squamous cell carcinoma(TSCC) by bioinformatic methods and explore their potential functional and pathway mechanisms associated with TSCC progression. METHODS: The microarray datasets GSE13601 was analysed to screen out the differentially expressed genes. The database for Annotation, Visualization, and Integrated Discovery (DAVID) was used for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. STRING database was used to construct protein interaction networks, and the abnormal expression of key genes in TSCC was assessed by sequencing data from The Cancer Genome Atlas (TCGA) database. RESULTS: A total of 101 differentially expressed genes and 20 key genes were screened, and further studies revealed that key genes such as MYH2, MYLPF, NEB, ACTN2, DES and TMP2 affected the survival rate of TSCC patients, and the expression of MYH2, MYLPF, ACTN2, DES, TPM2, TNNC1, MYL1, MYH7 and TNNI2 correlated with the clinical stage of TSCC. CONCLUSIONS: MYH2, MYLPF, NEB, ACTN2, DES, TMP2, TNNC1, TPM2, MYH7 and TNNI2 may participate in the development of TSCC and have the potential to become biomarkers and therapeutic targets for TSCC. References | Related Articles | Metrics

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An experimental study of pathogenesis similarity between traumatic temporomandibular joint ankylosis and heterotopic ossification CHEN Yun-liang, MAN Cheng, LI Xiao-yu, WU Jing, WEI Liu-qiong, LI Wen-long 2023, 21 (5):  461-466.  doi: 10.19438/j.cjoms.2023.05.006 Abstract ( 144 )   PDF (2827KB) ( 59 )   PURPOSE: To investigate whether the pathogenesis of heterotopic ossification(HO) was similar to traumatic temporomandibular joint ankylosis(TMJA), and to provide new ideas for the prevention and treatment of TMJA. METHODS: Thirty cases of elbow, hip and knee joint HO and 30 cases of traumatic TMJA were selected. The bone samples of joint area and surrounding area were collected and preserved as experimental group A (group A) and experimental group B (group B) respectively. Five normal and complete coracoids were collected as the control group(group C). Structural forms of bone specimens were detected by H-E staining and expressions of BMP-2, BMP-4, CD34+ in the three groups were detected by immunohistochemical assay. Imaging data were used to compare the imaging features of group A and group B. SPSS 17.0 software package was used for data analysis. RESULTS: The histological structure and imaging features of group A and group B were basically the same. Immunohistochemistry showed that the positive expressions of BMP-2, BMP-4 and CD34+ in group A and group B were significantly stronger than those in group C (P<0.05). CONCLUSIONS: Traumatic TMJA and HO have similar pathogenesis. References | Related Articles | Metrics

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Prognosis of adenoid cystic carcinoma in head and neck region: a single-centre experience CHENG Yu-tian, XU Le, MA Li, WU Hai-wei, CHEN Zhan-wei, ZOU Hu-wei, ZHANG Tian-qi, LIU Gui-jun, LIU Zhen-xing, YIN Chang-wei, LI Wen-gang, ZHANG Shi-zhou, HUANG Sheng-yun, ZHANG Dong-sheng 2023, 21 (5):  467-471.  doi: 10.19438/j.cjoms.2023.05.007 Abstract ( 199 )   PDF (511KB) ( 75 )   PURPOSE: To explore the prognostic factors of adenoid cystic carcinoma (ACC) in head and neck region by analyzing associated clinical characters. METHODS: A total of 188 patients with ACC in head and neck region were enrolled, and the follow-up was carried out by outpatient review or telephone. Kaplan-Meier method was used to assess the survival rates, and Cox regression analysis was used to identify the associated prognostic factors with SPSS 26.0 software package. RESULTS: The overall survival rate of 188 patients was 76.6%, of which 13.3% died of recurrence and 10.1% died of distant metastasis. The rate of local recurrence and distant metastasis were 23.9% and 10.1%, of which the survival rate was 42.2% and 68.4%, respectively. Cox regression analysis revealed that age, T stage, N stage, and regimens were significantly associated with survival of ACC. CONCLUSIONS: In ACC, age, T stage, N stage, and regimen were independent prognostic factors of survival, age and nerve invasion were independent prognostic factors of recurrence, and N stage was independent prognostic factor of distant metastasis. References | Related Articles | Metrics

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Clinical and radiographic analysis of 20 patients of congenital infiltrating lipomatosis of the face XU Gui-song, YANG Gong-xin, YOU Yuan-he, TIAN Zhuo-wei, XIAO Meng, DU Zhong, WANG Yan-an 2023, 21 (5):  472-478.  doi: 10.19438/j.cjoms.2023.05.008 Abstract ( 150 )   PDF (1621KB) ( 69 )   PURPOSE: To summarize and analyze the clinical and radiographic characteristics of congenital infiltrating lipomatosis of the face (CILF). METHODS: Clinical and radiographic data of patients diagnosed with CILF were collected and retrospectively analyzed. Statistical analysis of characteristic radiographic changes was performed using GraphPad Prism 5.0 software package. RESULTS: Twenty patients diagnosed with CILF were included in the study(male to female ratio was 1:1). All suffered from hemifacial hypertrophy since birth, and showed features of hemifacial fatty infiltration thickening(cheek, temporal region, palatal mucosa, masseter space, etc.), deformity of maxillary tuberosity, abnormal mandibular density, etc. Compared with the healthy side, there were significant differences in soft tissue thickening and bone density(P<0.05). According to the distribution pattern of the trigeminal nerve, the frontal branch-related region was rarely affected, while the superior (80%-100%) and mandibular(25%-100%) branches had strong potential correspondence with CILF. CONCLUSIONS: CILFs have unique clinical and imaging features which are of great significance for early diagnosis and follow-up. Furthermore, CILFs are closely related to the controlled area of the superior and mandibular branches of the trigeminal nerve, suggesting that CILF may be related to early neural development. References | Related Articles | Metrics

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Study on risk model for postextraction bleeding of mandibular third molars WANG Jian-rong, SUN Jing, ZHAO Shu-hong, SHANG Jiang 2023, 21 (5):  479-485.  doi: 10.19438/j.cjoms.2023.05.009 Abstract ( 243 )   PDF (987KB) ( 174 )   PURPOSE: To explore the risk factors of bleeding after mandibular third molar extraction and establish a prediction model to provide reference for clinical decision-making. METHODS: Clinical data of 610 cases of mandibular third molar extraction were collected for the study. Association of postextraction bleeding with the patient demographic variables (gender), tooth variables(position, impacted angle) and other variables (periodontitis, intraoperative anesthetic drugs, flap, postoperative treatment, hemostatic materials, patient compliance). SAS 9.4 software package was used to analyze the data. RESULTS: The incidence of postextraction bleeding was 10.33% in 610 patients after mandibular third molars extraction, and 63 patients had postextraction bleeding. Multivariate logistic regression analysis showed that the position, impacted angle, flap, postoperative treatment, patient compliance were independent risk factors for postextraction bleeding of mandibular third molars. The results showed that the prediction model had good differential validity(AUC=0.916), high calibration degree (P=0.605), and certain clinical application value. CONCLUSIONS: The position, impacted angle, flap, postoperative treatment and patient compliance are not only risk factors for postextraction bleeding, but also predictive factors for predictive models. References | Related Articles | Metrics

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Evaluation of nasal protection effect of transnasal tracheal intubation fixator in patients with general anesthesia in oral and maxillofacial surgery XU Xin, XIA Ming, JIN Chen-yu, ZHOU Ren, XU Hui 2023, 21 (5):  486-490.  doi: 10.19438/j.cjoms.2023.05.010 Abstract ( 144 )   PDF (895KB) ( 65 )   PURPOSE: To investigate the effectiveness of nasal protection for patients undergoing oral and maxillofacial surgery with transnasal tracheal intubation fixator. METHODS: A total of 43 oral and maxillofacial surgery patients with general anesthesia were selected and divided into 2 groups: experimental group(n=22) and control group(n=21). After anesthesia induction, nasal tracheal intubation was performed. The transnasal tracheal intubation fixator was used in the experimental group, and the conventional method was used in the control group. The nasal pressure after fixation of tracheal catheter, the time used for fixation of tracheal catheter, the postoperative nasal comfort score and the occurrence of pressure injury were recorded. SPSS 27.0 software package was used for statistical analysis of the data. RESULTS: There was no significant difference in the nasal pressure of the tracheal catheter after fixation between the two groups(P=0.135), the pressure of the experimental group was (1.30±0.19)N, and that of the control group was (1.19±0.30)N. The time of tracheal tube fixation in the experimental group was 39.50 s, which was significantly less than that in the control group (119.00 s, P<0.001). The nasal comfort score of the experimental group was 1.00 points after 24 h, which was significantly lower than that of the control group (2.00 points, P<0.01). There was no significant difference in the incidence of stress injury between the two groups (P=0.215). CONCLUSIONS: Compared with traditional fixation of nasal catheter, the use of transnasal tracheal intubation fixator for patients with oral and maxillofacial surgery has no significant changes in the value of nasal catheter pressure after fixation of tracheal catheter, but it can shorten the time required by surgeons to fix the nasal catheter and reduce the nasal comfort score 24 h after surgery. References | Related Articles | Metrics

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Application of dietary nursing and psychological intervention in patients with oral mucosal ulceration after radiotherapy and chemotherapy for nasopharyngeal carcinoma TANG Feng-rong, WANG Peng, ZHANG Yan 2023, 21 (5):  491-496.  doi: 10.19438/j.cjoms.2023.05.011 Abstract ( 195 )   PDF (746KB) ( 53 )   PURPOSE: To investigate the application of dietary nursing and psychological intervention in patients with oral mucosal ulceration after radiotherapy and chemotherapy for nasopharyngeal carcinoma. METHODS: A total of 120 patients with nasopharyngeal carcinoma undergoing chemoradiotherapy in Zhongshan Hospital, Fudan University(Xiamen Branch) from April 2019 to July 2022 were selected. The patients were divided into control group and intervention group by convenient sampling in non-probabilistic sampling method with 60 cases in each group. The control group was given routine care, and the intervention group administered "one-on-one" education to patients through diet and psychological interventions. The degree of oral mucosal damage, weight index, quality of life score and anxiety score of the 2 groups were compared. SPSS 26.0 software package was used for data analysis. RESULTS: The degree of oral mucosal injury in the intervention group was significantly lower than that in the control group (P<0.05). After 6 months, the weight, quality of life in the intervention group were significantly higher than those in the control group, and the anxiety status in the intervention group was significantly lower than that in the control group(P<0.05). CONCLUSIONS: Dietary care can effectively improve the nutritional status and quality of life of patients with oral mucosal rupture caused by radiotherapy and/or chemotherapy for nasopharyngeal carcinoma. Through psychological intervention, guiding patients to face the disease correctly and relieve their emotions can effectively improve their psychological health. References | Related Articles | Metrics

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Clinical analysis of 7 cases of 125I radioactive seed implant for recurrent palatal minor salivary gland malignancy WANG Shou-peng, LI Sheng-nan, CHEN Lin, GE Liang-yu, LI Meng, MENG Jian 2023, 21 (5):  497-501.  doi: 10.19438/j.cjoms.2023.05.012 Abstract ( 200 )   PDF (969KB) ( 76 )   PURPOSE: To explore the effect of 125I radioactive seed implant for recurrent palatal minor salivary gland malignancy. METHODS: Seven patients with palatal minor salivary gland malignancy who relapsed after surgery and radiotherapy and refused secondary surgery were treated with iodine 125 radioactive seed implant. According to the treatment planning system, iodine 125 radioactive seeds were implanted into the target area during surgery. Prosthesis-like applicators with radioactive seeds were wore according to the patients' conditions after surgery. The patients were followed up at regular intervals after operation and the treatment efficacy and side effects were evaluated. RESULTS: Tumor recurrence was not found in any patient treated after 17 to 62 months of follow-up. All patients did not show obvious radiation-related complications of grade 3 or more. During the follow-up, 1 elderly patient died of systemic disease and temporary mild adverse effects were noted in 3 patients. CONCLUSIONS: For patients with recurrent palatal minor salivary gland malignancy, iodine 125 radioactive seed implant has achieved good short-term efficacy and is a safe, minimally invasive, and effective treatment. References | Related Articles | Metrics

Dental Education

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Evaluation of the implant navigation virtual teaching system for dental undergraduates WEI Hong-bo, ZHOU Ming-hao, LI De-hua 2023, 21 (5):  502-505.  doi: 10.19438/j.cjoms.2023.05.013 Abstract ( 121 )   PDF (763KB) ( 40 )   PURPOSE: To evaluate the impact of implant navigation virtual teaching system on undergraduate teaching effect. METHODS: Twenty right-handed senior (grade 4) dental students with no surgical experience were randomly divided into 2 groups, with 10 students in each group. The experimental group was trained with the implant navigation virtual teaching system, and the control group was trained with the traditional free hand model. The difference in teaching effect between the two groups was compared through the questionnaire survey scale, and the implantation accuracy was evaluated by comparing the planned implant position with the actual implant position. SPSS 17.0 software package was used for data analysis. RESULTS: The implant placement training of the implant navigation virtual teaching system was implemented smoothly. The implant navigation virtual teaching system can significantly improve learning interest, stimulate motivation to continue learning, and improve students' understanding and memory of theoretical knowledge. The error of implantation in the experimental group was (0.856±0.303) mm in the neck, (1.238±0.494) mm in the root, and (3.516±1.673) degrees in the angle; the implant neck error in the control group was (1.218±0.276) mm, the root error was (1.721±0.524) mm, and the angle error was (9.478±4.395) degrees. The implant placement accuracy of the experimental group was significantly higher than that of the control group(P<0.05). CONCLUSIONS: The implant navigation virtual teaching system can significantly improve the effect of implant placement in the undergraduate teaching of dental implantology. References | Related Articles | Metrics

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Exploration of "one body with two wings" teaching approach in the theoretical teaching of oral and maxillofacial surgery SA Guo-liang, YU Zi-li, ZHU Xin-biao, YANG Xue-wen 2023, 21 (5):  506-510.  doi: 10.19438/j.cjoms.2023.05.014 Abstract ( 155 )   PDF (745KB) ( 58 )   PURPOSE: To explore the effectiveness of the "one body with two wings" teaching approach in the teaching reform and innovation of oral and maxillofacial surgery. METHODS: An experimental group consisting of 80 undergraduate students of stomatology in 2019 received offline teaching supplemented by newly recorded massive open online courses (MOOCs) and newly written problem based learning(PBL) cases. A score of 90 or more was considered excellent. The teaching results were evaluated by calculating the excellence rate and questionnaire survey.The scores of 79 dental students of grade 2017 who only accepted traditional offline teaching were used as the control group. SPSS 19.0 software package was used for data analysis. RESULTS: The survey results indicated that most students found that the "one body with two wings" teaching approach was beneficial to their learning of professional courses, and that the coherence of course arrangement and content were critical to its effectiveness. The test scores also showed a significant improvement in the excellent rate of the experimental group compared to the control group in the same period(P<0.01). CONCLUSIONS: The "one body with two wings" teaching approach effectively enhances students' interest in learning, academic performance, and provides new ideas for the innovation and development of oral and maxillofacial surgery teaching. References | Related Articles | Metrics

Clinical Reports

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Meta-analysis on risk factors for postoperative pulmonary infection in patients with oral cancers CHEN Yu, TAO Ming, LEI Yin-fu, WU He-mei, PENG Xiao-feng, GOU Deng-qun 2023, 21 (5):  511-517.  doi: 10.19438/j.cjoms.2023.05.015 Abstract ( 196 )   PDF (945KB) ( 65 )   PURPOSE: To systematically review the influencing factors of postoperative pulmonary infection in patients with oral cancers. METHODS: The database of PubMed, Web of Science, Embase, Cochrane Library, Scopus, CNKI, Wanfang, VIP, China Biomedical Literature Database were searched through computer for studies on the influencing factors of postoperative pulmonary infection in oral cancer patients, including case-control studies and cohort research, the search time limit was from the establishment of the database to November 1, 2022. RESULTS: Finally, 11 articles were included, with a total of 3 458 patients. Meta-analysis results showed that smoking history[OR=5.88, 95%CI(1.49,23.26), P=0.011], diabetes history[OR=2.64, 95%CI(1.20,17.54), P=0.023], previous radiotherapy history[OR=8.21, 95%CI(1.45,46.468), P=0.017], poor preoperative oral hygiene [OR=10.17, 95%CI(2.14,48.32), P=0.004], operation time[OR=1.34, 95%CI(1.12,1.61), P=0.001], anesthesia time[OR=2.04, 95%CI(1.262,3.298), P=0.004], flap size [OR=1.02, 95%CI(1.008,1.034), P=0.001],flap type[OR=17.71, 95%CI(4.15,75.56), P=0.0001], delayed activity (>4 days)[OR=4.20, 95%CI(1.057,17.074), P=0.04], and postoperative hospital stay[OR=1.14, 95%CI(1.05,1.24), P=0.002] were independent risk factors for postoperative pulmonary infection in patients with oral cancer; age tracheotomy, intraoperative blood loss, mandibular resection, tracheal tube indwelling time, and flap repair were influencing factors for postoperative pulmonary infection in patients with oral cancers. Preoperative serum albumin level[OR=0.79, 95%CI(0.67,0.94), P=0.005] was protective factor for postoperative pulmonary infection in patients with oral cancers. CONCLUSIONS: There are many factors that affect postoperative pulmonary infection in patients with oral cancers. Targeted and individualized intervention should be carried out to prevent the occurrence of pulmonary infection, which is of great significance to promote postoperative rehabilitation of patients with oral cancers. References | Related Articles | Metrics

Review Articles

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Progress on application of platelet-rich fibrin in dental implantology ZENG Ling-zi, MO An-chun 2023, 21 (5):  518-521.  doi: 10.19438/j.cjoms.2023.05.016 Abstract ( 147 )   PDF (505KB) ( 155 )   The three-dimensional structure of platelet-rich fibrin(PRF) enhances the proliferation, migration, differentiation and sustained release of stem cells, and promotes the healing of hard and soft tissues in oral and maxillofacial tissues, making PRF widely used in dental implantology. This review outlines the preparation method, biological characteristics and latest advances of PRF in the field of dental implantology. References | Related Articles | Metrics

Case Reports

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Calcium pyrophosphate dihydrate crystal deposition disease of the temporomandibular joint: case report and literature review DENG Li-ni, CHEN Chuan-jun, WANG Yi, XIANG Xian-wang 2023, 21 (5):  522-525.  doi: 10.19438/j.cjoms.2023.05.017 Abstract ( 212 )   PDF (1308KB) ( 57 )   Calcium pyrophosphate dihydrate crystal deposition disease (CPPD) refers to calcium pyrophosphate crystals deposited in articular fibrocartilage, hyaline cartilage and its surrounding synovium, ligaments, tendons and joint capsules. CPPD is idiopathic in most patients, however, it has been associated with aging, osteoarthritis, gout, hyperparathyroidism and metabolic disorders like hemochromatosis and hypomagnesemia. In this paper, a female patient with CPPD of temporomandibular joint(TMJ) was reported,in which the lesion invaded cranial base, the condyle and disc of TMJ. Surgical procedure was performed to remove the lesion and reconstruct cranial base and TMJ. References | Related Articles | Metrics

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Multiple calcified epithelioma: a case report and gene analysis SONG Jiao-jiao, LU Qian, CAO Zhang, ZUO Jin-hua, WANG Wen-long, MA Xiang-rui, WANG Li 2023, 21 (5):  526-528.  doi: 10.19438/j.cjoms.2023.05.018 Abstract ( 275 )   PDF (879KB) ( 73 )   Calcified epithelioma (CE), also known as pilomatricoma (PM), is an ectodermal benign tumor originating from the outer root sheath cells of hair follicles. Generally, it only occurs in the upper limb trunk and face and neck, and multiple calcified epithelioma is even rarer in clinic. This paper reported a case of multiple calcified epithelioma and carries out related gene detection, and discussed based on related literature, in order to provide some basis for clinical diagnosis and treatment. References | Related Articles | Metrics