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20 January 2018, Volume 16 Issue 1 Previous Issue    Next Issue

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Study on Twist1 promoting epithelial-mesenchymal transition and drug-resistance in tongue squamous cell carcinoma LIU Mo, RUAN Yi, LI Jing-song, HUANG Hong-zhang 2018, 16 (1):  1-5.  doi: 10.19438/j.cjoms.2018.01.001 Abstract ( 416 )   PDF (3622KB) ( 145 )   PURPOSE: The aim of this study was to investigate the mechanism of Twist1 regulating epithelial-mesenchymal transition (EMT) and cisplatin-resistance in tongue squamous carcinoma cells. METHODS: TSCC CDDP resistant cell line CAL27/CDDP was transfected with Twist1 siRNA. Western blot and immunofluorescence staining were used to detect the expression of E-cadherin and Vimentin; Western blot was used to detect the expression of Twist1 and Slug; Transwell assay and scratch test were used to detect the invasion and migration capabilities; MTT was used to analyze the half maximal inhibitory concentration (IC50) values. One-way ANOVA was used to analyze the results with SPSS 17.0 software package. RESULTS: Twist1 siRNA transfection reversed EMT phenotype of CAL27/CDDP. The expression of E-cadherin was up-regulated and the expression of Vimentin, Twist1 and Slug was down-regulated. The motility was significantly decreased. The IC50 of CAL27/CDDP decreased by 41.75%±5.10%（P<0.01). CONCLUSIONS: Twist1 promotes EMT and CDDP drug-resistance in TSCC. References | Related Articles | Metrics

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Establishment of zebrafish model via TIE2-R849W and exploration of its role in hereditary venous malformations DU Zhong, MA Hai-long, ZHANG Ling, ZHENG Jia-wei, WANG Yan-an 2018, 16 (1):  6-11.  doi: 10.19438/j.cjoms.2018.01.002 Abstract ( 475 )   PDF (4318KB) ( 496 )   PURPOSE: To explore the role of TIE2-R849W, a mutation related to hereditary venous malformations, via establishing a novel zebrafish model. METHODS: Through the designment and synthesis of TIE2-R849W expression plasmid, translated mRNA was microinjected into fli1a: EGFP fertilized eggs, which were used to establish a TIE2-R849W over-expression model. Under fluorescence microscope, the developmental change of caudal vein plexus (CVP) was recorded and quantitatively compared. Using RNA extracted from zebrafish, target genes were tested by real-time quantitative PCR (qRT-PCR). The existing gene chip was analyzed to further verify the results. Statistical analysis was performed with GraphPad Prism 5. RESULTS: Based on observed phenotypes of TIE2-R849W over-expression zebrafish, TIE2-R849W significantly affected the development of the caudal venous plexus, which displayed a significant decrease in the number and area of sinus. According to the results of qRT-PCR, upregulation of pik3r2 and foxo1b could be induced by TIE2-R894W over-expression. At the same time, except for significantly up-regulated egfl7, expression of nr2f2, nr2f1a and s1pr1 had no significant difference from the control. In contrast to in vitro chip analysis, tie2, pik3r2, foxo1b and egfl7 showed consistent high expression in individual mutant group. CONCLUSIONS: TIE2-R849W associated with hereditary venous malformations could induce abnormal development of zebrafish CVP, which implies a possible relationship between VM and egfl7. References | Related Articles | Metrics

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Relationship of HER2 gene amplification to clinicopathological characteristics and prognosis of salivary gland malignant pleomorphic adenoma XIA Liang, WANG Yang, HU Yu-hua, GU Ting, LI Jiang, SHI Hui-min, TIAN Zhen 2018, 16 (1):  12-19.  doi: 10.19438/j.cjoms.2018.01.003 Abstract ( 554 )   PDF (6357KB) ( 285 )   PURPOSE: To investigate HER2 gene overexpression or amplification in human salivary malignant pleomorphic adenoma (MPA), and analyze the association between HER2 and tumor clinicopathological characteristics, as well as prognosis, in order to assess its potential as a therapeutic target. METHODS: The expression of HER2 protein was detected by immunohistochemistry in 140 patients with MPA, and the amplification of HER2 gene was determined by fluorescence in situ hybridization for HER2 2+ cases. The clinicopathological data of 140 patients were reviewed. The correlation between HER2 gene amplification and clinicopathological features and prognosis of MPA patients was analyzed using SPSS 16.0 software package. RESULTS: The positive rate of HER2 in 140 patients with MPA was 25%. The positive rate of HER2 in adenocarcinoma subtype of MPA was 40.5% (32/79), which was significantly higher than that of myoepithelial carcinoma subtype MPA (4.9%, 3/61, P<0.05). HER2 positive staining was significantly correlated with gender, histological grade and N stage. Survival analysis showed that overall survival and disease-specific survival were lower in HER2 positive patients. CONCLUSION: Overexpression and amplification of HER2 gene is significantly correlated with the malignant subtype of MPA tumor cells, and suggests a poor prognosis in patients with MPA. References | Related Articles | Metrics

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Effect of interferon inducible protein-10 on proliferation and apoptosis of tongue squamous cancer cell CHU Hong-xing, JIA Bo, ZHANG Zhao-qiang, WANG Zhi-ping, CHEN Jun, ZHENG Xiang-huai, SUN Xiang, ZHAO Jian-jiang 2018, 16 (1):  20-24.  doi: 10.19438/j.cjoms.2018.01.004 Abstract ( 290 )   PDF (3456KB) ( 208 )   PURPOSE: To investigate the influence of interferon inducible protein-10 (IP-10) on proliferation, apoptosis of tongue squamous cancer cell CAL-27 , and the relation with CXCR3A, CXCR3B gene expression. METHODS: CAL-27 cells were divided into 3 experimental group and 1 control group. The experimental groups were treated with 10 ng/mL, 20 ng/mL, and 40 ng/mL IP-10, respectively; while the control group was not stimulated. CCK 8 was used to test cell proliferation after being stimulated for 12, 24, 48, and 72 h; Flow cytometry was used to detect cell apoptosis after being stimulated for 24 h. Q-PCR was used to detect CXCR3A, CXCR3B mRNA expression after being stimulated for 12, 24, 48 and 72 h, respectively. SPSS 16.0 software package was used for statistical analysis. RESULTS: IP-10 with 3 kinds of concentration promoted CAL-27 cell proliferation (P<0.05) at 12, 24 h. At 48h, only 40 ng/mL of IP-10 promoted CAL-27 cell proliferation (P<0.01). At 72 h, IP-10 with 3 kinds of concentration had no effect on CAL-27 cell proliferation (P>0.05). After 24 h, CAL 27 cell proliferation in 3 experimental groups decreased compared with the control group. At 24 h, cell apoptosis rate in 3 experimental groups was 3.377%±0.575%, 6.867%±2.848%, 5.317%±2.794%, respectively. There was significant difference between the control group (P<0.05), but no significant difference between the experimental groups (P>0.05). At 12, 24, 48, 72 h, CXCR3A mRNA expression was 0.0130±0.0007, 0.0274±0.0005, 0.0204±0.0011 and 0.0174±0.0006 respectively; there was significant difference between groups (P<0.05). CXCR3B mRNA expression was 0.0124±0.0015, 0.0209±0.0016, 0.0297±0.0013 and 0.0386±0.0010, respectively; there was significant difference between groups (P<0.05). CONCLUSIONS: IP-10 can not only promote CAL-27 proliferation, but also induce its apoptosis. As time goes on, cell proliferation decreased, CXCR3A mRNA expression increased first and then decreased, while CXCR3B mRNA expression increased gradually. CXCR3A, CXCR3B may participate in regulation of tongue squamous cancer cell proliferation and apoptosis induced by IP-10. References | Related Articles | Metrics

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Clinical analysis of 300 cases of autotransplantation HOU Rui, XU Guang-jie, HUI Xiao-yong, YANG Xia, ZHANG Lin-lin, WANG Xiao-nan, ZHANG Xin-qing, ZHONG Liang-yan, HU Man 2018, 16 (1):  25-28.  doi: 10.19438/j.cjoms.2018.01.005 Abstract ( 981 )   PDF (2868KB) ( 422 )   PURPOSE: To analyze the clinical effect of autotransplantation in a larger sample. METHODS: Three hundred patients with autotransplanted teeth in recent 5 years were analyzed from patient's gender, age, position of receptor and donor tooth, the illness or missing condition of receptor, surgical type, intraoperative guided bone regeneration, root canal therapy and postoperative follow-up, outcomes. RESULTS: Among 300 patients with autotransplantated teeth, there were 120 men and 180 women, aged from 17 to 62 years old (average 32±9.18). There were 45 maxillary first molars, 28 maxillary second molars, 104 mandibular first molars, and 123 second mandibular molars, and mandibular molar accounted for 75.67%. Seventy-four were residual roots, 116 were residual crown, 35 had odontagma, 16 had periapical periodontitis, 19 had root absorption, 19 had decay and endodontic perforation, 21 had missing teeth for a long time. One hundred and forty-two teeth were from the third maxillary molars, 158 from the third mandibular molar. One hundred and ninety-one cases had simultaneous surgery, and 109 had delayed operation. Forty cases received highly concentrated growth factors blood fibrin (CGF), 64 received CGF combined with bone filling materials, 2 received biological membrane and bone filling material, 5 received bone filling materials. Twenty-three cases had vital pulp without root canal therapy, 3 cases had root canal retrofilling, and 274 cases had postoperative root canal therapy. The follow-up period ranged from 6 months to 5 years. The overall success rate was 86.67%, survival rate was 96.67%, and failure rate was 3.33%. CONCLUSIONS: As an ideal method of replacing missing tooth defect, autotransplantation is simple, fast, effective, and biocompatible, which is worthy of wide application. References | Related Articles | Metrics

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Early regenerated buccal bone remodeling following dental implant surgery with guided bone regeneration in the esthetic area using bone xenografts ZHANG Chu-nan, NI Jie, MO Jia-ji, QIAO Shi-chong, WANG Bei, GU Ying-xin 2018, 16 (1):  29-33.  doi: 10.19438/j.cjoms.2017.06.006 Abstract ( 530 )   PDF (4018KB) ( 486 )   PURPOSE: To investigate early regenerated buccal bone remodeling following dental implant surgery with guided bone regeneration (GBR) in the esthetic area using bone xenografts. METHODS: From September 2015 to April 2016, 23 dental implants in the maxillary anterior region with simultaneous GBR using bone xenografts were included in the study. Cone-beam CT (CBCT) was acquired before operation, once the operation was finished and 6 months after surgery. Mucosal thickness (>2 mm or ≤2 mm), types of bone quality and different membranes used were also identified. The buccal bone width perpendicular to implant long axis was taken 2 mm below the implant shoulder, midpoint and apical point of implant body at 3 intervals: the mesio-distal midpoint of the implant and 1mm mesial and distal to the the midpoint. Standardized measurements were taken to record alveolar height, width and undercut depth from preoperative CBCT scans. The data were analyzed using SPSS 21.0 software package. RESULTS: Loss in width of augmented bone after 6 months of healing was (0.70±0.59) mm, (0.85±0.72) mm and (0.55±0.51) mm. Bone absorption rate was 23.07%, 18.53% and 12.97%, respectively. The variables "undercut" and "age" had significant influences on bone graft resorption (P<0.05). Multiple linear stepwise regression analysis revealed that only undercut was the independent risk factor for bone resorption among all variables (P<0.05). CONCLUSIONS: Early regenerated buccal bone remodeling occurs following dental implant surgery with GBR in the esthetic area. Undercut depth and patient age have a significant effect on graft resorption. Consequently, with deeper undercut, decreased resorption could be expected for regenerated buccal bone. References | Related Articles | Metrics

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Effect of rhizoma drynariae flavones on alveolar bone quality in patients with osteoporosis YANG Feng, SUN Yu-hua, LV Zhong-jing, LIU Dian-bin, QIN Ying, XIAO Li-ting, SUN Jin-hu 2018, 16 (1):  34-40.  doi: 10.19438/j.cjoms.2018.01.007 Abstract ( 572 )   PDF (5282KB) ( 316 )   PURPOSE: To evaluate the influence of rhizoma drynariae flavones on the height, thickness, bone mineral density of alveolar bone and width of the alveolar crest for osteoporosis patients with dentition defect or edentulous jaw. METHODS: Forty-six patients who met the inclusion criteria were randomly divided into 2 groups, the experimental group and the control group, 23 cases in each group. Cone-beam CT was performed for each patient before administration and 1 month, 3 months and 6 months after administration, respectively. Anatomage invivo 5 software was used to measure and observe the changes of alveolar bone height, thickness, bone mineral density and alveolar crest width. SPSS 17.0 software package was used for statistical analysis. RESULTS: In the control group, bone mineral density of cortical bone in the buccal (labial) side of the alveolar bone was significantly higher than that of the experimental group 1 months after administration (P<0.05). In the experimental group, bone mineral density of the buccal (labial) cortical bone was significantly higher than that of the control group 3 and 6 months after administration (P<0.05). Compared with the experimental group, the width of the alveolar crest and the thickness of cortical bone in the buccal (labial) side of the alveolar bone increased significantly 3 months after administration in the control group(P<0.05), yet there was no significant difference between the 2 groups at the end of 6 months (P>0.05). No significant difference was found on the thickness of cortical bone in the buccal (labial) side, cortical bone in the palatal(lingual) side and cancellous bone of the basal bone between the 2 groups at different time points (P>0.05). CONCLUSIONS: Rhizoma drynariae flavones can significantly increase bone mineral density of the alveolar bone in osteoporosis patients, which is superior to that of alendronate in increasing bone mineral density of cortical bone in the buccal (labial) side of the alveolar bone. Furthermore, rhizoma drynariae flavones can increase the thickness of cortical bone in the buccal (labial) side of the alveolar bone in patients with osteoporosis, but it has little effect on the width of alveolar crest and the height of alveolar bone. References | Related Articles | Metrics

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A modified tragus incision with vascular-guided multilayer approach to temporomandibular joint JIAO Zi-xian, WANG Xiang-yu, ZHANG Xiao-hu, YANG Chi 2018, 16 (1):  41-43.  doi: 10.19438/j.cjoms.2018.01.008 Abstract ( 1140 )   PDF (2074KB) ( 307 )   PURPOSE: To introduce a modified surgical approach for treating temporomandibular joint (TMJ) disc displacement using tragus incision with vascular-guided multilayer approach and evaluate its clinical outcome. METHODS: Six patients (7 joints) were selected in this study. All patients were diagnosed as stage IV-V of TMJ internal derangement according to Wilkes-Bronstein staging system. All patients underwent open surgery for TMJ disc repositioning and fixation using the modified tragus incision with vascular-guided multilayer approach. TMJ MRI was performed 4 days postoperatively. RESULTS: Good surgical field exposure was obtained and TMJ disc were well replaced in all operations. Postoperative MRI showed satisfactory position of the TMJ disc. The function of facial nerve was well preserved in all patients. CONCLUSIONS: The modified tragus incision with vascular-guided multilayer approach is one of the ideal methods for TMJ open surgery to treat anterior disc displacement. References | Related Articles | Metrics

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Application of 3D printing design and endoscope in reduction and fixation of fractures of zygoma and zygomatic arch XU Bing-bing, LI Ya-nan, LAI Qing-guo, TANG Xiao-peng, CI Jiang-bo, XUE Run-qi, ZOU Bin, XING Hong-yu 2018, 16 (1):  44-47.  doi: 10.19438/j.cjoms.2018.01.009 Abstract ( 415 )   PDF (3240KB) ( 331 )   PURPOSE: To evaluate the feasibility and effect of 3D printing design and endoscope in reduction and fixation of fractures of zygoma and zygomatic arch. METHODS: Four patients diagnosed as B type fractures of zygoma and zygomatic arch with limited mouth opening and facial depression were included. After CT scanning data were tranformed into STL type, the fracture model and mirror-imaged model were printed. Preoperative design and premolding of titanium plates were completed on the models. Through a small preauricular incision and tunnel on the zygomatic arch, reduction and fixation of fractures of zygoma and zygomatic arch were performed under endoscope. RESUITS: All patients achieved symmetrical face and normal mouth opening. Facial scar was not obvious and there was no complication such as infection and nerve damages. CONCLUSIONS: 3D printing design reduces the difficulty of endoscopic surgery in reduction and fixation of fractures of zygoma and zygomatic arch and improves the precision of operation. This method avoided coronal incision and achieved cosmetic results with minimal invasion. References | Related Articles | Metrics

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Minimally invasive extraction of impacted mandibular third molar compressing the inferior alveolar nerve: a comparison of three techniques WANG Yong, XU Ying, YANG Chi, GE Jing, CHI Zheng-bin 2018, 16 (1):  48-51.  doi: 10.19438/j.cjoms.2018.01.010 Abstract ( 649 )   PDF (3176KB) ( 467 )   PURPOSE: Extraction of impacted mandibular third molar compressing inferior alveolar nerve(IAN) is highly related to inferior alveolar nerve injury. The aim of this study was to compare the incidences of IAN injury in orthodontic traction, coronectomy and piezosurgery for the impacted mandibular third molar removal. METHODS: After examination of panoramic radiography and cone-beam computed tomography(CBCT), sixty patients with impacted mandibular third molar compressing the IAN were enrolled in this study. Orthodontic traction, coronectomy and piezosurgery were carried out in 20 patients, respectively. Signs of postoperative neurosensory impairment were recorded. RESULTS: No sign of neurosensory impairment was observed in patients undergoing orthodontic traction or coronectomy. One patient (5%) undergone piezosurgery had postoperative lower lip numbness, and recovered within 1 month after drug treatment. CONCLUSIONS: Orthodontic traction, coronectomy and piezosurgery can reduce the incidence of nerve injury during removal of impacted mandibular third molar compressing IAN. References | Related Articles | Metrics

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Clinical observation of fibrin glue combined with pingyangmycin for the embolism and sclerotherapy of cervicofacial arteriovenous malformations YAN Zhi-wei, ZHANG Chun-yi, GUO Jun, YANG Xia, WANG Wei-qi, Yang Tao, SUN Mo-yi, YANG Yao-wu 2018, 16 (1):  52-55.  doi: 10.19438/j.cjoms.2018.01.011 Abstract ( 359 )   PDF (3305KB) ( 286 )   PURPOSE: To observe and evaluate the outcome of fibrin glue (FG) combined with pingyangmycin (PYM) for treatment of selected cervicofacial arteriovenous malformation (AVM). METHODS: Twenty-two patients with cervicofacial AVM were chosen and treated by embolism and sclerotherapy of FG combined with PYM from December 2012 to December 2016. Of the 22 cases, 15 underwent a direct percutaneous puncture of the nidus and injection of FG combined with PYM solely; 2 underwent an injection of FG combined with PYM into the facial artery in addition to direct injection in lesion. Six underwent surgical excision of the redundant fibrous connective tissue and residual lesions after the embolism and sclerotherapy. To observe the vital signs and symptoms after treatments. The therapeutic effect was evaluated by physical examination, ultrasonography with Doppler, computed tomography (CT) scan, and CT angiography. The follow-up time was from 6 months to 36 months(mean 18 months). RESULTS: Of 22 patients, 17 were male and 5 were female, ranging in age from 19~74 years（mean,28 years）. Eighteen of 22 lesions (81.8%) showed greater than 90% reduction, whereas another 4 (18.2%) exhibited greater than 50% reduction. Transient white or cyan purple alteration in the skin occurred during the course treatment, indicating tissue ischemia or obstruction of draining veins. Superficial skin necrosis occurred and thin crust formed in forehead of 1 patient, and superficial mucous ulcer occurred in 2 patients and healed on its own. Three patients were found to continue growth during follow-up. CONCLUSIONS: Application of fibrin glue combined with PYM for the embolism and sclerotherapy of selected cervicofacial AVM appears to be safe and effective. It offers broad prospects especially for the treatment of locally expanded AVM. References | Related Articles | Metrics

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Endoscopy-assisted transoral versus endoscopy-assisted transcervical minimal incision plus mandibular osteotomy approach in resection of large parapharyngeal space tumors HUANG Zhuo-shan, ZHANG Da-ming, CHEN Wei-liang, HUANG Zhi-quan, FAN Song 2018, 16 (1):  56-59.  doi: 10.19438/j.cjoms.2018.01.012 Abstract ( 484 )   PDF (2811KB) ( 415 )   PURPOSE: To evaluate the outcome of endoscopy-assisted transoral(ETO) approach for resection of parapharyngeal space tumors compared to endoscopy-assisted transcervical minimal incision plus osteotomy of the vertical ramus outside the mandibular foramen approach(ETC+MO). METHODS: Twenty-three consecutive patients (15 males, 8 females) who underwent resection of large parapharyngeal space tumors via ETO approach or ETC+MO approach were analyzed retrospectively. RESULTS: The tumors in ETO group were benign; there were 2 patients with adenoid cystic carcinoma and 1 patient with recurrent pleomorphic adenoma in ETC+MO group. All tumors were removed completely without rupture. No major complications developed in any patient. Temporary facial paresis occurred in 1 patient in the ETC+MO group, which resolved spontaneously within 8 weeks. The cosmetic effects of all patients in ETO groups and 10 patients in ETC+MO groups were excellent. Patients were followed up for 7-26 months, no recurrence was encountered. CONCLUSIONS: ETO and ETC+MO approach in resection of large parapharyngeal space tumors are feasible and safe, which can achieve excellent aesthetic and functional results. ETO approach can shorten hospitalized time and avoid the risk of marginal mandibular nerve injury and ETC+MO approach may be used in resection of malignant or recurrent parapharyngeal space tumors. References | Related Articles | Metrics

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Diagnosis and treatment of descending necrotizing mediastinitis in 111 patients QU Lu-yao, JIANG Bin, QIAN Wen-tao, CAI Xie-yi, ZHANG Wei-jie, LIANG Xiang, GUAN Xin 2018, 16 (1):  60-63.  doi: 10.19438/j.cjoms.2018.01.013 Abstract ( 392 )   PDF (3251KB) ( 413 )   PURPOSE: To explore the clinical manifestation and early diagnosis and treatment of descending necrotizing mediastinitis, in order to decrease its mortality. METHODS: We retrospectively reviewed 111 patients with DNM who were treated in Shanghai Ninth People's Hospital from January 2013 to October 2016. The clinical data were recorded,including sex, age, comorbidities, original infections, imaging results, microbiological examination, treatment, and outcomes. RESULTS: A total of 111 patients were collected in the study, with an average age of 56.6±12.5 years. The male-to-female ratio was 5.6∶1. The main source of infection was odontogenic infection, followed by glandular infection. There were 52 patients (46.8%) with comorbidities, with diabetes mellitus being the most common. The main pathogen was Streptococcus. All patients received antibiotic therapy and drainage for abscess in cervical region. 106 patients underwent mediastinal drainage with transcervical incision, and 9 patients underwent thoracotomy. The mortality rate was 6.3%. CONCLUSIONS: Chest CT is an effective tool for early diagnosis of descending necrotizing mediastinitis. At the same time, early efficacious antibacterial treatment, aggressive surgical debridement and supportive therapy are the key factors in reducing mortality of descending necrotizing mediastinitis. References | Related Articles | Metrics

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Study about the relationship between the structural features of adult temporomandibular joint osteoarthritis and Helkimo index by cone-beam CT ZHANG Xin-yun, LI Chan, LI Hong-fa 2018, 16 (1):  64-68.  doi: 10.19438/j.cjoms.2018.01.014 Abstract ( 461 )   PDF (3492KB) ( 490 )   PURPOSE: Use of cone-beam computer tomography (CBCT) to investigate the relationship between clinical symptoms, signs of adult temporomandibular joint osteoarthritis(TMJOA) and the imaging changes in order to provide reference for clinical diagnosis. METHODS: Eighty-one cases with CBCT images and clinical data were selected. Craniofacial items and TMJ images were measured by using Invivo 5 software and recorded. The final data were analyzed with SPSS 22.0 software package for Spearman rank correlation analysis. RESULTS: A significant correlation was found between Helkimo index and TMJ bony changes in condyle and glenoid fossa (P<0.01). However, no relationship with TMJ space changes was displayed (P>0.05). CONCLUSIONS: Use of CBCT to observe TMJOA bony changes (include mandibular condyle, joint fossa) is helpful for the diagnosis and judgment of disease severity, but not for displaying temporomandibular joint space changes. References | Related Articles | Metrics

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Clinical evaluation of modified temporomandibular joint disc anchor for disc displacement of temporomandibular joint SHEN Da, LIU Jiang-tai, LI Jian 2018, 16 (1):  69-72.  doi: 10.19438/j.cjoms.2018.01.015 Abstract ( 704 )   PDF (3102KB) ( 478 )   PURPOSE: To estimate and analyze the outcome of modified temporomandibular joint disc anchor for disc displacement of temporomandibular joint (TMJ). METHODS: Twenty-four patients (30 joints) who underwent modified temporomandibular joint disc anchor surgery based on Professor Yangchi's criteria between September 2014 and September 2016 were included in this study. The scores for preoperative maximal interincisal opening (MIO), visual analogue scale (VAS) score for pain and magnetic resonance imaging (MRI) before surgery, 6 months after surgery were compared using SPSS17.0 software package. RESULTS: MIO improved from a mean of 23.63±3.31 mm (range: 17-29 mm) preoperatively to 38.00±2.30 mm (range: 32-42 mm) 6 months postoperatively. Twenty-one of 24 patients (87.50%) had MIO≥35 mm after operation, which showed a significant improvement (P <0.05) at 6-month follow-up. VAS improved from a mean of 29.76±23.25(0-80) preoperatively to 3.71±7.91(0-50) 6 months postoperatively (P <0.05).The position of the discs in 29 of 30 (96.67%) TMJs had kept stable on MRI. There was no complication in any case. CONCLUSIONS: Modified temporomandibular joint disc anchor surgery is a reliable and effective procedure for temporomandibular joint dysfunction that improves pain and mouth opening. The position of TMJ discs postoperatively is stable on MRI. References | Related Articles | Metrics

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3D-visualization aided preoperative education prepares patients with better psychological status for orthognathic surgery ZENG Fei-ni, LI Li, YUAN Wei-jun 2018, 16 (1):  73-77.  doi: 10.19438/j.cjoms.2018.01.016 Abstract ( 375 )   PDF (3742KB) ( 242 )   PURPOSE: To determine if 3D-visualization aided preoperative education in patients undergoing orthognathic surgery improves patients' psychological status. METHODS: A total of 240 patients were enrolled in this study, and equally divided into experimental group, and control group. A professionally built 3D-visualization program was used beside regular preoperative education for patients in the experimental group. After preoperative education, basic information, anxiety (SAS) and depression (SDS) were assessed using questionnaire survey. SPSS 17.0 software package was used for statistical analysis. RESULTS: Student's t test showed no difference in patients' age, gender, education background and occupation (P>0.5) in the two groups. Nine and 11 patients suffered from preoperative anxiety and depression respectively in the control group. Patients in the experimental group showed significant decrease in preoperative anxiety with a ratio of 6.7% (P<0.05), and also lower incidence of preoperative depression (8.3% decrease, P<0.05) by Chi-square test. CONCLUSIONS: The results suggest that 3D-visualization aided preoperative education can efficiently correct patients' anxiety and depression before surgery, and prepare patients for orthognathic surgery with better performance. References | Related Articles | Metrics

Clinical Reports

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Reconstruction of oral and maxillofacial soft tissue defects with superficial inferior epigastric artery flap: report of 3 cases WANG Hong-wei, GUO Bing, MA Chun-yue, LI Xiao-guang, YIN Jian-xin, ZHOU Hui-hong, AI Song-tao, SUN Jian, ZHANG Chen-ping, QIN Xing-jun 2018, 16 (1):  78-83.  doi: 10.19438/j.cjoms.2018.01.017 Abstract ( 449 )   PDF (5138KB) ( 433 )   PURPOSE: To investigate the clinical value of superficial inferior epigastric artery (SIEA) flap in oral and maxillofacial reconstruction. METHODS: Three patients underwent SIEA flap reconstruction. They had malignant tumors in oral cavity with soft tissue defects of the right tongue, left cheek and right mouth floor. All of them received preoperative examinations with color Doppler ultrasound and/or CT angiography to identify the course of SIEA and superficial inferior epigastric vein (SIEV). The planed size and shape of the SIEA flap was transduced to the inguinal region. SIEA and SIEV were dissected proximally and distally until a sufficient pedicle length was obtained. After vascular dissection, the pedicle was clipped. Then, the SIEA flap was transferred to the recipient site and sutured to the soft tissue defect. The reparative effects in recipient sites and complications at the donor sites were evaluated postoperatively. The patients were followed up for 12~14 months. RESULTS: The length of the flap was defined as the largest diameter in the pedicle direction and the width as the largest diameter at right angles to the flap axis. The effective size of the flaps was 9 cm×6 cm, 8cm×5 cm, and 10cm×6cm, respectively. The pedicle length of the SIEA flap was 8-10 cm, the caliber of the SIEA was 0.7-1.0mm. The caliber of the SIEV was 1.8-2.0 mm, the anastomoses between the SIEA and the superficial thyroid artery and the SIEV and one branch of the internal jugular vein were performed under operation microscope. The SIEA flap achieved reperfusion. In all 3 patients, the anastomoses were carried out without complications. Ideal outcome was obtained in the recipient sites. The SIEA flap also had no donor site problems. CONCLUSIONS: SIEA can be tracked by color Doppler and/or CT angiography. Its body surface projection line can also be marked. Therefore, the SIEA flap is easy to harvest. It has a good dimension and tissue quality and can easily be adapted to the soft tissue defect. In comparison with other flaps, it keeps the abdominal wall intact with the scar being hidden. Reconstruction of oral and maxillofacial defect with SIEA flap has several advantages including good functional outcome and low donor site morbidity. References | Related Articles | Metrics

Review Articles

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Research progress of inflammatory myofibroblastic tumor in head and neck region PENG Can-bang, TIAN Zhen, JI Tong 2018, 16 (1):  84-88.  doi: 10.19438/j.cjoms.2018.01.018 Abstract ( 498 )   PDF (3976KB) ( 549 )   Inflammatory myofibroblastic tumor (IMT) is a distinctive mesenchymal neoplasm, composed of myofibroblasts/ fibroblasts, plasma cells, lymphocytes and/or infiltrating eosinophils. It is not common in the head and neck region, which resulted in the lack of standards of treatment and prognosis for the disease. This paper reviewed the current literature on the etiology, clinical features, pathology, treatment and prognosis of IMT in order to facilitate better recognition and treatment of IMT in head and neck region. References | Related Articles | Metrics

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Clinical progress of piezosurgery in oral and maxillofacial surgery SUN Rui, CAI Yu, ZHAO Ji-hong 2018, 16 (1):  89-92.  doi: 10.19438/j.cjoms.2018.01.019 Abstract ( 547 )   PDF (3381KB) ( 632 )   Decades have passed since piezoelectric bone surgery technique was first introduced to oral and maxillofacial surgery, and numerous researches have investigated the various applications and merits of piezosurgery in clinical medicine. Based on a review of recent literatures, this paper demonstrated the basic principles, indications of piezosurgery in oral and maxillofacial surgery in order to provide a reference for oral surgeons. References | Related Articles | Metrics

Case Reports

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Cystic lymphoepithelial hyperplasia of parotid gland in a HIV-positive patient: case report and review of literature ZHENG Kai, NI Xiao-jie, SHI Wu-chao, HU Si-tong, SUN Dian, CHEN Yi-ping, DING Yu-yuan, SHENG Mei-ying, XIAO Can 2018, 16 (1):  93-96.  doi: 10.19438/j.cjoms.2018.01.020 Abstract ( 366 )   PDF (3156KB) ( 460 )   HIV-related cystic lymphoepithelial hyperplasia is a rare disease and its symptom is not typical.Pathological examination and immunohistochemistry can confirm the diagnosis.This paper reported a case of unilateral parotid lymphoepithelial hyperplasia and reviewed the clinical and pathological features, therapy and prognosis. References | Related Articles | Metrics