Application of whiskers in bone tissue engineering

doi:10.19438/j.cjoms.2024.05.015

Abstract

Abstract: Whiskers are micro-nano sized short fibers grown from high-purity single crystals, and their excellent physicochemical and biological properties show great potential for application in bone tissue engineering BTE. In this paper, the classification, growth mechanism, preparation methods and characteristics of whiskers were reviewed, and their application in BTE was discussed. The research direction and application prospect of whisker in bone tissue engineering were also discussed.

Key words: Whiskers, Composite material, Biomaterials, Bone tissue engineering

CLC Number:

R782

LI Li-li, LIU Xiao-ming, ZHANG Yuan, WU Feng, GE Xue-jun, TIAN Zhi-qiang. Application of whiskers in bone tissue engineering[J]. China Journal of Oral and Maxillofacial Surgery, 2024, 22(5): 499-504.

References

[1] Roohani I, Yeo GC, Mithieux S, et al.Emerging concepts in bone repair and the premise of soft materials[J]. Curr Opin Biotechnol, 2022, 74: 220-229.
[2] Moghaddam A, Bahrami M, Mirzadeh M, et al.Recent trends in bone tissue engineering: a review of materials, methods, and structures[J]. Biomed Mater, 2024, 19(4): 042007.
[3] Ding W, Ge Y, Zhang T, et al.Advanced construction strategies to obtain nanocomposite hydrogels for bone repair and regeneration[J]. NPG Asia Mater, 2024, 16(1): 14.
[4] Peng HR, Zhao Q, Xiao T, et al.Preparation and properties of magnesium/strontium modified hydroxyapatite whisker bone tissue engineering scaffold[J]. Mater Lett, 2024, 361: 135922.
[5] Liu Z, Tian G, Liu L, et al.A 3D-printed PLGA/HA composite scaffold modified with fusion peptides to enhance its antibacterial, osteogenic and angiogenic properties in bone defect repair[J]. J Mate Res Technol, 2024, 30: 5804-5819.
[6] Yu ZH, Yuan Z, Xia C, et al.High temperature flexural deformation properties of engineered cementitious composites (ECC) with hybrid fiber reinforcement[J]. Res App Mater Sci, 2020, 2(2): 17-26.
[7] Li Y, Tang S, Luo Z, et al.Chitin whisker/chitosan liquid crystal hydrogel assisted scaffolds with bone-like ECM microenvironment for bone regeneration[J]. Carbohydr Polym, 2024, 332: 121927.
[8] Li Z, Pan D, Han Z, et al.Boron nitride whiskers and nano alumina synergistically enhancing the vertical thermal conductivity of epoxy-cellulose aerogel nanocomposites[J]. Adv Compos Hybrid Mater, 2023, 6(6): 224.
[9] Chen J, Zhu Z, Chen J, et al.Photocurable liquid crystal hydrogels with different chargeability and tunable viscoelasticity based on chitin whiskers[J]. Carbohydrate Polym, 2023, 301(Pt A): 120299.
[10] Zhao R, Chen S, Yuan B, et al.Healing of osteoporotic bone defects by micro-/nano-structured calcium phosphate bioceramics[J]. Nanoscale, 2019, 11(6): 2721-2732.
[11] 张雪. 硼酸镁及硼酸铝晶须的制备及其机理研究[D].沈阳: 东北大学, 2018.
Zhang X.Research on the synthesis and mechanism of magnesium borate and aluminum borate whiskers[D]. Shenyang: Northeast University, 2018.
[12] Wang T, Jiang W, Liu J, et al.Simple and novel synthesis of zirconia whiskers from a phosphate flux[J]. Ceram Int, 2019, 45(4): 4514-4519.
[13] Wu H, Guo A, Kong D, et al.Nacre-like carbon fiber-reinforced biomimetic ceramic composites: fabrication, microstructure, and mechanical performance[J]. Ceram Int, 2024, 50(14): 25388-25399.
[14] Ji S, Zhang S, Wang Z, et al.High-impact performance and thermal properties of polyimine nanocomposites reinforced by silicon carbide nano-whiskers[J]. Mater (Basel), 2023, 16(13): 4587.
[15] Liu Z, Wang S, Pan S, et al.Preparation, growth mechanism, and application of Mg₂B₂O₅ whiskers: a review[J]. Prog Cryst Growth Character Mater, 2023, 69(2): 100602.
[16] Wagner RS, Ellis WC.Vapor-liquid-solid mechanism of single crystal growth[J]. Appl Phys Lett, 1964, 4(5): 89-90.
[17] Qi X, Luo X, Zhang L, et al.In situ synthesis and interfacial bonding mechanism of SiC in MgO-SiC-C refractories[J]. Inter J Appl Ceram Technol, 2022, 19(5): 2723-2733.
[18] Yasue H, Yoshimura M, Sumida H, et al.Localization and mechanism of secretion of B-type natriuretic peptide in comparison with those of A-type natriuretic peptide in normal subjects and patients with heart failure[J]. Circulation, 1994, 90(1): 195-203.
[19] Lu D, Cheng S, Zhang L, et al.Effect of holding time on SiC whiskers growth of SiCw/SiC composites based on SLS technology and their mechanical properties[J]. Ceram Int, 2022, 48(22): 33019-33027.
[20] Li J, Zhang F, He P, et al.Electromagnetic wave absorption property of SiC whiskers regulated by stacking faults and SiC@SiO₂ core-sheath microstructure[J]. J Mater Res Technol, 2023, 24: 995-1004.
[21] Zadorozhnaya LA, Tarasov AP, Volchkov IS, et al.Morphology and luminescence of flexible free-standing ZnO/Zn composite films grown by vapor transport synthesis[J]. Mater (Basel), 2022, 15(22): 8165.
[22] Zhang T, Liu J, Qi J, et al.Biosafety and chemical solubility studies of multiscale crystal-reinforced lithium disilicate glass-ceramics[J]. J Biomed Mater Res B Appl Biomater, 2024, 112(3): e35400.
[23] Zhang C, Wu W, Hu H, et al.Preparation of SiO₂/Si₃N₄ws/PU reinforced coating and its reinforcement mechanism for SLS-molded TPU materials[J]. J Appl Polym Sci, 2023, 140(35): e54355.
[24] Wu Y, Zhang QP, Zhou D, et al.One-dimensional lead borate nanowhiskers for the joint shielding of neutron and gamma radiation: controlled synthesis, microstructure, and performance evaluation[J]. Cryst Eng Comm, 2017, 19(48): 7260-7269.
[25] Mu Y, Yan L, Liu P, et al.High-temperature-resistant ZrO₂ coating with SiC-whisker-enhanced interfacial bonding strength and improved emissivity for flexible silica fibre fabric[J]. Ceram Int, 2023, 49(4): 6825-6833.
[26] Wei D, Sun H, Zhang M, et al.Mapping the technological trajectory of inorganic nanomaterials in the cancer field[J].J Nano Res, 2024, 26(4): 66.
[27] Abdikakharovich SA, Rauf MA, Khattak S, et al.Exploring the antibacterial and dermatitis-mitigating properties of chicken egg white-synthesized zinc oxide nano whiskers[J]. Front Cell Infect Microbiol, 2023, 13: 1295593.
[28] Wang J, Lei J, Hu Y, et al.Calcium silicate whiskers-enforced poly(ether-ether-ketone) composites with improved mechanical properties and biological activities for bearing bone reconstruction[J]. Macromol Biosci, 2022, 22(12): e2200321.
[29] Kumar A, Dixit K, Sinha N.Fabrication and characterization of additively manufactured CNT-bioglass composite scaffolds coated with cellulose nanowhiskers for bone tissue engineering[J]. Ceram Int, 2023, 49(11, Part A): 17639-17649.
[30] Liu K, Li L, Chen J, et al.Bone ECM-like 3D printing scaffold with liquid crystalline and viscoelastic microenvironment for bone regeneration[J]. ACS Nano, 2022, 16(12): 21020-21035.
[31] Liu K, Zhu L, Tang S, et al.Fabrication and evaluation of a chitin whisker/poly(l-lactide) composite scaffold by the direct trisolvent-ink writing method for bone tissue engineering[J]. Nanoscale, 2020, 12(35): 18225-18239.
[32] Peng H, Ling T, Zhang Y, et al.Nanowhiskers orchestrate bone formation and bone defect repair by modulating immune cell behavior[J]. ACS Appl Mater Inter, 2023, 15(7): 9120-9134.
[33] Qi F, Gao X, Wang C, et al.In situ grown silver nanoparticles on tetrapod-like zinc oxide whisker for photocatalytic antibacterial in scaffolds[J]. Mater Today Sustain, 2022, 19: 100210.