Advance in the role and mechanism of pericentrin in development dento-maxillofacial deformities and other malformations

doi:10.19438/j.cjoms.2023.03.013

Abstract

Abstract: Pericentrin (PCNT) is a centrosomal protein that plays an important role in many biological behaviors such as mitosis and meiosis. Mutations in PCNT can cause a variety of dento-maxillofacial deformities, including severe craniofacial dysplasia and malformation of dental development. Although many clinical symptoms that related with PCNT have been reported, the research in the stomatological medical field is still very limited. In order to better understand the clinical manifestations and pathogenesis of PCNT-related craniomaxillofacial deformities, this article reviewed the research progress on the pathogenic mechanism of PCNT published in recent years, and may hopefully provide theoretical basis for future study on the function of PCNT in craniofacial growth and dento-peridontal development.

Key words: Pericentrin, Congenital dento-maxillofacial deformities, Dental developmental deformities, Microcephalic osteodysplastic primordial dwarfism

CLC Number:

R782.2

ZHANG Yun, DAI Qing-gang, WU Yi-qun. Advance in the role and mechanism of pericentrin in development dento-maxillofacial deformities and other malformations[J]. China Journal of Oral and Maxillofacial Surgery, 2023, 21(3): 279-285.

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