Osteogenic role of bone substitute in maxillary sinus augmentation and simultaneous implantation

doi:10.19438/j.cjoms.2023.03.002

Abstract

Abstract: PURPOSE: To explore whether it is necessary to implant bone substitute materials for maxillary sinus augmentation and simultaneous implantation, and to compare the osteogenic role of different bone substitutes. METHODS: Twelve New Zealand white rabbits (3-month, male) were used for maxillary sinus augmentation and simultaneous implantation, and 24 maxillary sinuses in 12 rabbits were randomly divided into 4 groups(n=6): blood clot group, blank liposome-hydrogel group, medicine-loaded liposome-hydrogel group, and bone allograft group. At 3 months, all samples were entirely taken and the effects of different bone substitutes on promoting bone regeneration were evaluated by micro-CT, H-E staining, Masson staining, immunohistochemistry (IHC), and H-E staining of bone tissue grinding slices. RESULTS: Micro-CT, H-E staining and Masson staining displayed that there were different degrees of new bone formation around the implants in 4 groups. Compared to blood clot group, more new bone formation was observed in blank liposome-hydrogel group. Compared with blood clot group and blank liposome-hydrogel group, more new bone formation was observed in medicine-loaded liposome-hydrogel group and bone allograft group. Moreover, compared to bone allograft group, more new blood vessels were observed in bone matrix in medicine-loaded liposome-hydrogel group. IHC showed the expression of angiogenesis indexes in medicine-loaded liposome-hydrogel group was highest in 4 groups. The expression of osteogenic indexes in medicine-loaded liposome-hydrogel group and bone allograft group was higher than other groups. H-E staining of bone tissue grinding slices showed that the osseointegration of the implants was good. The medicine-loaded liposome-hydrogel group had more bone surrounding the implants. CONCLUSIONS: Using bone substitute in maxillary sinus augmentation surgery and simultaneous implantation not only maintains the height of maxillary sinus mucosa, but also improves the efficiency of osteogenesis. Compared to bone allograft, medicine-loaded liposome-hydrogel with injectability is more suitable for irregular bone defect by minimally invasive filling. Medicine-loaded liposome-hydrogel effectively promotes angiogenic bone regeneration by steady drug release.

Key words: Maxillary sinus augmentation, Dental implant, Bone substitute, Bone regeneration, Rabbit

CLC Number:

R782.1

WANG He-jing, ZHANG Cai-xin, XUN Xing-xiang, HAN Lin-zi, YAN Ting-ting, XU Xiao, YUAN Rong-tao. Osteogenic role of bone substitute in maxillary sinus augmentation and simultaneous implantation[J]. China Journal of Oral and Maxillofacial Surgery, 2023, 21(3): 218-224.

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