Current research progress of EGFL7 in angiogenesis regulation

doi:10.19438/j.cjoms.2019.04.021

Abstract

Abstract: Epidermal growth factor-like domain-containing protein 7 (EGFL7), a member of the epidermal growth factor (EGF)-like protein family, is a potent angiogenic factor expressed in endothelial cells. The findings from present studies suggest that EGFL7 can influence different aspects related to the angiogenesis process, such as embryogenesis, tumorigenesis, wound healing, cardiovascular diseases, etc. From the point of angiogenesis regulation, we reviewed the expression profiles, animal models, endothelial phenotypes and molecular mechanisms of EGFL7, which would provide a novel insight into further researches or targeted therapies.

Key words: EGFL7, Angiogenesis, Animal model, NOTCH, Integrin

CLC Number:

R543

DU Zhong, LIU Jia-liang, ZHENG Jia-wei, WANG Yan-an. Current research progress of EGFL7 in angiogenesis regulation[J]. China Journal of Oral and Maxillofacial Surgery, 2019, 17(4): 377-381.

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