Research progress of regulating endothelial cell related arteriovenous differentiation

doi:10.19438/j.cjoms.2021.01.016

Abstract

Abstract: ] Arteriovenous differentiation is a regulated programmatically biological process that involves multi-genetics and multi-factors. The regulation of differentiation of arteriovenous endothelial cells(EC) is one of the most critical prerequisites for this process. Hedgehog, VEGF, Notch, COUP-TF Ⅱand other vascular development-related signaling pathways participate in regulating the differentiation of endothelial cells. However, the expression levels and functions of above molecules in this process are variant. In addition, hemodynamic is also an indispensable factor for arteriovenous endothelial differentiation. This article reviewed progression of arteriovenous differentiation of vascular endothelial cell in recent years, from aspects of molecular markers, related signaling pathways, and hemodynamics of arteriovenous endothelial cells.

Key words: Arteriovenous differentiation, Endothelial cell, Notch, VEGF, Hemodynamic

CLC Number:

R739.8

YOU Yuan-he, DU Zhong, LIU Jia-liang, ZHENG Jia-wei, WANG Yan-an. Research progress of regulating endothelial cell related arteriovenous differentiation[J]. China Journal of Oral and Maxillofacial Surgery, 2021, 19(1): 82-87.

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