Effect of blood glucose control on the stability of implant and the indexes of blood inflammation in patients with type 2 diabetes mellitus

doi:10.19438/j.cjoms.2017.06.011

Abstract

Abstract: PURPOSE: To investigate the effect of blood glucose control on the stability of the implant and the indexes of blood inflammation in type 2 diabetes mellitus. METHODS: From July 2014 to July 2015, 30 patients with type 2 diabetes undergoing dental implantation were chosen as the experimental group, while 30 patients with normal blood glucose who underwent dental implantation were chosen as control group. Blood glucose control level, implant stability and blood inflammatory markers were compared between the two groups using SPSS 18.0 software package. RESULTS: Preoperatively inflammatory markers were not significantly different (P>0.05) between the two groups; 24 h postoperatively, inflammatory indexes in the experimental group were significantly higher than those in the control group (P<0.05); postoperative ISQ decreased rapidly and then raised, but no difference was found at each time point in 2 groups (P>0.05); maximum decrease of ISQ in patients with blood glucose >7.5% was lower than in patients with blood glucose less than or equal to 7.5%, and the recovery time of ISQ was significantly longer. CONCLUSIONS: The level of blood glucose control in type 2 diabetes mellitus is closely related to the stability of dental implant and the indexes of blood inflammation.

Key words: TMJ anchorage surgery, Condyle of mandible, Anchoring nail, Anchoring line, Analysis of pullout force

CLC Number:

R782.1

ZHANG Xiao-dong, LIU Xi, ZHANG Min-zhu, WANG Min, ZHU Kun. Effect of blood glucose control on the stability of implant and the indexes of blood inflammation in patients with type 2 diabetes mellitus[J]. China Journal of Oral and Maxillofacial Surgery, 2017, 15(6): 488-492.

References

[1] 郑强, 陈凰, 朱卉, 等. 一次完成微创式全口种植牙手术并行螺丝固位托牙式全口固定义齿即刻修复即刻负重技术的临床研究 [J]. 中国药物与临床, 2014, 14(12): 1629-1632.
[2] 董刚, 徐欣, 田燕, 等. 2型糖尿病患者血糖控制水平与种植牙愈合的关系 [J].吉林大学学报(医学版), 2013, 39(1): 143-147.
[3] Sunyung L, Mija K, Sunja K. Effects of low glycemic index nutrition education on the blood glucose control in patients with type 2 diabetes mellitus [J]. Korean J Nutr, 2010, 43(1): 46-56.
[4] 邬琪, 冷颖, 段昌华, 等. 2型糖尿病血糖控制水平对种植体稳定性和血液炎症指标的影响[J]. 口腔疾病防治, 2016, 24(8): 487-490.
[5] 林保莹. 重度牙周炎伴糖尿病的牙周与种植治疗 [J]. 中华口腔医学杂志, 2013, 48(5): 311-316.
[6] Buehler AM, Cavalcanti AB, Berwanger O, et al. Effect of tight blood glucose control versus conventional control in patients with type 2 diabetes mellitus: a systematic review with meta-analysis of randomized controlled trials[J]. Cardiovasc Ther, 2013, 31(3): 147-160.
[7] Gökçe C, Aycankaya Ö, Yula E, et al. The effect of blood glucose regulation on the presence of opportunistic Demodex folliculorum mites in patients with type 2 diabetes mellitus [J]. J Int Med Res, 2013, 41(5): 1752-1758.
[8] 刘乃彬, 焦铁军, 王洪亮, 等. 血糖波动对2型糖尿病大鼠种植体骨结合的影响 [J]. 中华临床医师杂志(电子版), 2013, 7(5): 2073-2076.
[9] 吴嵩, 陈宝琪, 夏阳, 等. 老年糖尿病患者牙周重度破坏后种植研究 [J]. 现代生物医学进展, 2014, 14(29): 5691-5694.
[10] Kempf K, Tankova T, Martin S. Long-term effects of self-monitoring of blood glucose on glucometabolic control in patients with type 2 diabetes mellitus: Follow up data from ROSSO-in-praxi international 2009 [J]. Diabetes Technol Ther, 2011, 15(1): 89-96.
[11] Eto T, Inoue S, Kadowaki T. Effects of once-daily teneligliptin on 24-h blood glucose control and safety in Japanese patients with type 2 diabetes mellitus: a 4-week, randomized, double-blind, placebo-controlled trial [J]. Diabetes Obes Metab, 2012, 14(11): 1040-1046.
[12] 黄晓斌, 张继伟. Ⅱ型糖尿病患者使用种植牙修复牙列缺损的临床疗效 [J]. 医学信息, 2014, 27(21): 279-280.
[13] 刘乃彬. 血糖波动对2型糖尿病大鼠种植体骨结合影响的实验研究[D]. 西安: 第四军医大学, 2013.
[14] Oates TW Jr, Galloway P, Alexander P, et al. The effects of elevated hemoglobin A(1c) in patients with type 2 diabetes mellitus on dental implants: Survival and stability at one year [J]. J Am Dent Assoc, 2014, 145(12): 1218-1226.
[15] Juncar RI, Juncar M, Gligor FO, et al. Effect of masticatory forces transmitted by dental implants on the mandibular bone of patients with type 2 diabetes mellitus [J]. Rom J Diabetes Nutr Metab Dis, 2015, 22(4):419-424.
[16] 丁少华, 邹廷前, 李敬, 等. 糖尿病患者种植牙5例临床观察 [J]. 临床口腔医学杂志, 2013, 29(12): 33-34.
[17] 李亚男, 刘洪臣. 糖尿病患者种植修复的全身与局部处理 [J]. 口腔颌面修复学杂志, 2014, 16(2): 126.
[18] Auyeung L, Wang PW, Lin RT, et al. Evaluation of periodontal status and effectiveness of non-surgical treatment in patients with type 2 diabetes mellitus in Taiwan for a 1-year period [J]. J Periodontol, 2012, 83(5): 621-628.
[19] Mankovsky B, Urbanovych A. The content of blood leptin and activity of systemic inflammatory response in patients with type 2 diabetes mellitus depending on weight and length of the process [J]. Int J Physiol Pathophysiol, 2015, 6(3): 213-219.