Expression of MEG3 long non-coding RNA in tongue squamous cell carcinomas and its clinical significance

Abstract

Abstract: PURPOSE: To examine the MEG3 lncRNA expression in tongue squamous cell carcinomas (TSCC) and correlate it with patients' clinical status. METHODS: The expression of MEG3 lncRNA was examined by quantitative reverse transcription-PCR in 94 TSCC patients and paired adjacent normal tissues (ANTs), and correlated to the pathoclinical status of the patients. The data were analyzed by different methods and scatter plot was made by Graphpad software. RESULTS: The expression of MEG3 lncRNA was significantly decreased in TSCC tissues compared with ANTs (P<0.01). Expression of MEG3 lncRNA was more impaired in advanced TSCCs (Stage Ⅲ-Ⅳ, P<0.01) and were significantly correlated with lymph node metastasis (P<0.05). CONCLUSIONS: Expression of MEG3 lncRNA was attenuated in TSCCs and might correlate with cancer metastasis, which could be served as a potential biomarker of TSCC staging.

Key words: Tongue squamous cell carcinomas, Long non-coding RNA, MEG3, Metastasis

CLC Number:

R739.8

LI Kong-liang, ZHANG Shan-shan, YANG Hong-yu, FANG Zheng-yu. Expression of MEG3 long non-coding RNA in tongue squamous cell carcinomas and its clinical significance[J]. China Journal of Oral and Maxillofacial Surgery, 2016, 14(6): 514-517.

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