Effect of concentrated growth factors on goat condylar cartilage defect

Abstract

Abstract: PURPOSE: To investigate the therapeutic effect of concentrated growth factors (CGF) on the healing process of goat condylar cartilage defect. METHODS: Three goats at the age of 6 months (average weight=16 kg) were used in this study. Each animal had bilateral condyle cartilage resected, then autologous venous blood was collected to obtain CGF. CGF was used to cover one side of the condyle cartilage defect, the other side of the condyle cartilage defect was uncovered as control. Gross observation and histological examination were performed 1 month after operation. RESULTS: The condylar surface of the control side was uneven while the experimental condylar surface was smooth, covered by cartilage-like tissues. H-E staining of the control side showed exposed subchondral bone, active bone resorption by osteoclasts and inflammatory reaction. While the control side showed no obvious inflammatory reaction and bone resorption. The bone surface was covered by fibrous tissues. CONCLUSION: CGF can reduce inflammation and bone resorption after cartilage damage. It can also promote fibrous tissue repair to protect the subchondral bone.Supported by Research Fund of Science and Technology Committee of Shanghai Municipality (08DZ2271100, 13XD1402300), Program for Innovative Research Team of Shanghai Municipal Education Commission, Scientific Research Foundation of Ministry of Education for Returned Overseas Scholars, Research Fund of the Ministry of Health (201002017), and Natural Science Foundation of Shanghai Municipality (13ZR1423500).

Key words: Concentrated growth factors, Condyle, Cartilage defect, Cartilage repair

CLC Number:

R782.6

SUN Yu-huan, HE Dong-mei, YANG Chi,SUN Ning-ning, CAI Yi-hua, WANG Li-zhen, ZHANG Ping. Effect of concentrated growth factors on goat condylar cartilage defect[J]. China Journal of Oral and Maxillofacial Surgery, 2014, 12(3): 205-209.

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