Expression and clinical significance of CCL2 and CCR2 in salivary adenoid cystic carcinoma

doi:10.19438/j.cjoms.2019.04.005

Abstract

Abstract: PURPOSE: To investigate the expression of CCL2 and CCR2 in salivary adenoid cystic carcinoma (SACC) and to find out its correlation with clinicopathological characteristics. Methods: Immunohistochemical staining was used to detect the expression of CCL2 and CCR2 in 60 primary SACC cases and 12 normal salivary gland tissues and analyze the correlation with clinicopathological characteristics. The results and clinicopathological data were statistically analyzed by SPSS 17.0 software package with χ² test, Wilcoxon rank sum test, and Spearman's rank correlation coefficient test. Results: High expression of CCL2(91.7%) and CCR2 (88.3%) was found in SACC cases compared with normal ones. The expression of CCL2 and CCR2 was significantly associated with histopathological stages, perineural invasion and distant metastasis (P<0.05), but there was no significant correlation with age, sex, and clinical stages (P>0.05). Conclusions: The expression of CCL2 and CCR2 is closely associated with clinicopathological characteristics of SACC. Detection of the expression of CCL2 and CCR2 may have great value in the diagnosis and clinicopathlogical study.

Key words: CCL2, CCR2, Salivary adenoid cystic carcinoma, Perineural invasion

CLC Number:

R739.8

XU Bo-ya, YANG Zi-hui, WANG Jun, LEI De-lin, YANG Xin-jie. Expression and clinical significance of CCL2 and CCR2 in salivary adenoid cystic carcinoma[J]. China Journal of Oral and Maxillofacial Surgery, 2019, 17(4): 311-315.

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