Expression and significance of CLIC3 in salivary gland mucoepidermoid carcinoma

Abstract

Abstract: PURPOSE: To investigate the expression and significance of chloride intracellular channel protein 3 (CLIC3) in salivary gland mucoepidermoid carcinoma (MEC). METHODS: Immunohistochemical and Western blot method were used to detect the expression of CLIC3 in MEC M3SP2 and MC3 cell lines. Immunohistochemical method was used to detect the expression of CLIC3 in 49 major salivary glands and 18 minor salivary glands MEC tissues. SPSS 13.0 software package was used for statistical analysis. RESULTS: The positive expression rate of CLIC3 in salivary gland MEC tissues was 83.6%, whereas none in normal salivary gland tissues (P<0.01). High expression of CLIC3 was not related to clinicopathological parameters of salivary gland MEC(P>0.05). The expression of CLIC3 protein was positive in MEC M3SP2 and MC3 cell lines. CONCLUSIONS: CLIC3 may play a role in carcinogenesis and progress of salivary gland MEC.

Key words: Chloride intracellular channel protein 3, Salivary gland, Mucoepidermoid carcinoma

CLC Number:

R739.87

WANG Zhi-ming, WEN Hui-yuan, YE Ming, YANG Dong-sheng, ZHANG Wei-qing, PAN Yao, MA Ying. Expression and significance of CLIC3 in salivary gland mucoepidermoid carcinoma[J]. China Journal of Oral and Maxillofacial Surgery, 2016, 14(3): 239-243.

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