Experimental study on the guided tissue regeneration membrane promoting bone formation in rabbit mandibular distraction osteogenesis

Abstract

Abstract: PURPOSE : To investigate the promotive effect of guided tissue regeneration membrane (GTRM) in rabbit mandibular distraction osteogenesis (DO). METHODS : Twenty New Zealand’s white rabbits were randomly divided into 2 groups with ten in each, and then mandibular distraction osteogenesis model in rabbits was established. In group A, only DO was performed on one side of the mandible; in group B, the distraction device was positioned and fixed on the mandible with GTRM inside wrapped around the distraction zone. Half of the animals randomly chosen from each group were sacrificed at the end of week 2 and 6 throughout the consolidation phase. The mandibular samples were taken out for X-ray and histologic examinations. The data was analyzed with SPSS 11.0 software package. RESULTS: Radiological and histological study confirmed that group B showed better bone formation than group A (P<0.05) at the end of 2nd and 6th week consolidation. CONCLUSION : GTRM could effectively promote bone regeneration in rabbit mandibular DO.

Key words: Guided tissue regeneration membrane, Distraction osteogenesis, Mandible, Rabbit

CLC Number:

R782.2

TANG Xiao-peng, YUAN Kui-feng, LAI Qing-guo, YANG Zhong-jun, CI Jiang-bo. Experimental study on the guided tissue regeneration membrane promoting bone formation in rabbit mandibular distraction osteogenesis[J]. China Journal of Oral and Maxillofacial Surgery, 2014, 12(6): 492-497.

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