Advances in study of the role of vascular endothelial growth factor in the pathogenesis of temporomandibular joint osteoarthritis

Abstract

Abstract: Temporomandibular joint osteoarthritis(TMJOA) is a very common disease of temporomandibular joint disorders, which has a high morbidity and results in unbearable sufferings for patients, such as limitation of mouth opening, pain in the TMJ and clicking. The main pathological processes of TMJOA included cartilage degeneration, synovitis and adhesion formation. Vascular endothelial growth factor (VEGF) is one of the most potent angiogenic factors, recently, studies have showed that VEGF was found in the articular disc, condylar cartilage, synovial tissue and synovial fluid in TMJOA, and it is increasingly considered to be an important suspicious factor in the formation of TMJOA. This review summarized the current literature on the studies of VEGF on TMJOA. Supported by National Natural Science Foundation of China (81371168), Natural Science Foundation of Shanghai Municipality (10ZR1418200), Shanghai Pujiang Talent Plan in 2011,The New Hundred Talents Program of Shanghai Jiao Tong University School of Medicine in 2011, The Seventh College Students Innovation Training Project of Shanghai Jiao Tong University School of Medicine (2013052).

Key words: VEGF, Cartilage degeneration, Adhesion formation, Synovitis

CLC Number:

R782.6

XU Wei-feng, ZHANG Shan-yong. Advances in study of the role of vascular endothelial growth factor in the pathogenesis of temporomandibular joint osteoarthritis[J]. China Journal of Oral and Maxillofacial Surgery, 2014, 12(3): 277-280.

References

【1】Nah KS. Condylar bony changes in patients with temporomandibular disorders: a CBCT study. Imaging Sci Dent, 2012, 42(4): 249-253.
【2】顾昕, 谷志远, 周艺群. 血管内皮细胞生长因子在颞下颌关节功能紊乱病中的研究进展 . 国际口腔医学杂志, 2006, 33(4): 278-280.
【3】Tanaka E, Aoyama J, Miyauchi M, et al. Vascular endothelial growth factor plays an important autocrine/paracrine role in the progression of osteoarthritis. Histocbem Cell Biol, 2005, 123(3): 275-281.
【4】Roy H, Bhardwaj S, Yl?-Herttuala S. Biology of vascular endothelial growth factors. FEBS Lett,2006,580(12):2879-2887.
【5】Wagner M, Siddiqui MA. Signal transduction in early heart development(Ⅱ):ventricular chamber specification, traheculation, and heart valve formation. Exp Bio Med (Maywood),2007,232(7): 866-880.
【6】Sun Y, Jin K, Childs JT, et al. Vascular endothelial growth factor-B (VEGFB) stimulates neurogenesis: evidence from knockout mice and growth factor administration. Dev Biol, 2006, 289(2): 329-335.
【7】Hagberg CE, Falkevall A, Wang X, et al. Vascular endothelial growth factor B controls endothelial fatty acid uptake . Nature, 2010, 464(7290): 917-921.
【8】Ding M, Fu X, Tan H, et al. The effect of vascular endothelial growth factor C expression in tumor-associated macrophages on lymphangiogenesis and lymphatic metastasis in breast cancer . Mol Med Rep, 2012, 6(5): 1023-1029.
【9】Lingaraj K, Poh CK, Wang W. Vascular endothelial growth factor (VEGF) is expressed during articular cartilage growth and re-expressed in osteoarthritis. Ann Acad Med Singapore,2010,39(5): 399-403.
【10】Ludin A, Sela JJ, Schroeder A, et al. Injection of vascular endothelial growth factor into knee joints induces osteoarthritis in mice . Osteoarthritis Cartilage, 2013, 21(3): 491-497.
【11】Young MF. Mouse models of osteoarthritis provide new research tools . Trends Pharmacol Sci, 2005, 26(7): 333-335.
【12】Pritzker KP, Gay S, Jimenez SA, et al. Osteoarthritis cartilage histopathology: grading and staging. Osteoarthritis Cartilage, 2006, 14(1): 13-29.
【13】满城, 张碧, 马永清, 等. 关节腔注射TGF-1治疗兔颞下颌关节骨关节炎的实验研究. 临床口腔医学杂志, 2009, 25(12): 714-717.
【14】Rosethal AK, Gohr CM, Ninomiya J, et al. Proteomic analysis of articular cartilage vesicles from normal and osteoarthritic cartilage . Arthritis Rheum, 2011, 63(2): 401-411.
【15】Tibesku CO, Daniilidis K, Skwara A, et a1. Expression of vascular endothelial growth factor on chondrocytes increases with osteoarthritis-an animal experimental investigation. Open Orthop J, 2011, 5: 177-180.
【16】Walsh DA, MeWilliams DF, Turley MJ, et a1. Angiogenesis and nerve growth factor at the ostcochondral junction in rheumatoid arthritis and osteoarthritis. Rheumatology(Oxford),2010, 49(10): 1852-1861.
【17】Jansen H, Meffert RH, Birkenfeld F, et al. Detection of vascular endothelial growth factor (VEGF) in moderate osteoarthritis in a rabbit model . Ann Anat, 2012, 194(5): 452-456.
【18】Wang YL, Li XJ, Qin RF, et al. Matrix metalloproteinase and its inhibitor in temporomandibular joint osteoarthrosis after indirect trauma in young goats . Br J Oral Maxillofac Surg, 2008, 46(3): 192-197.
【19】Wang GW, Wang MQ, Wang XJ, et al. Changes in the expression of MMP-3, MMP-9, TIMP-1 and aggrecan in the condylar cartilage of rats induced by experimentally created disordered occlusion . Arch Oral Biol, 2010, 55(11): 887-895.
【20】李俊, 刘日光, 邱波, 等. 血管内皮生长因子对关节软骨细胞MMP-1及MMP-3表达的影响 . 中国医药导刊, 2013, 15(3): 519-521.
【21】Yamairi F, Utsumi H, Ono Y, et al. Expression of vascular endothelial growth factor (VEGF) associated with histopathological changes in rodent models of osteoarthritis. J Toxicol Pathol, 2011, 24(2): 137-142.
【22】Murata M, Yudoh K, Masuko K. The potential role of vascular endothelial growth factor (VEGF) in cartilage: how the angiogenic factor could be involved in the pathogenesis of osteoarthritis? . Osteoarthritis Cartilage, 2008, 16(3): 279-286.
【23】Fuerst M, Bertrand J, Lammers L, et al. Calcification of articular cartilage in human osteoarthritis. Arthritis Rheum, 2009, 60(9): 2694-2703.
【24】郝亚荣, 陈宣银, 邱波, 等. 血管内皮生长因子对关节软骨细胞Ⅱ型胶原表达的影响.中华风湿病学杂志, 2011, 15(10): 710-712.
【25】Mapp PI, Walsh DA. Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis . Nat Rev Rheumatol, 2012, 8(7): 390-398.
【26】Zhang S, Cao W, Wei K, et al. Expression of VEGF-receptors in TMJ synovium of rabbits with experimentally induced internal derangement . Br J Oral Maxillofac Surg, 2013, 51(1): 69-73.
【27】Fransès RE, McWilliams DF, Mapp PI, et al. Osteochondral angiogenesis and increased protease inhibitor expression in OA. Osteoarthritis Cartilage, 2010, 18(4): 563-571.
【28】Emami MJ, Jaberi FM, Azarpira N, et al. Prevention of arthrofibrosis by monoclonal antibody against vascular endothelial growth factor: a novel use of bevacizumab in rabbits. Orthop　Traumatol Surg Res, 2012, 98(7): 759-764.
【29】Nagai T, Sato M, Kutsuna T, et al. Intravenous administration of anti-vascular endothelial growth factor humanized monoclonal antibody bevacizumab improves articular cartilage repair. Arthritis Res Ther, 2010, 12(5): R178.
【30】段鑫, 李奇, 林荔军, 等. 骨关节炎滑膜组织中缺氧诱导因子-1α、血管内皮生长因子的表达. 南方医科大学学报,2011,31(1): 117-120.
【31】Shen P, Zhang S, Yang C, et al. Synovial tissue in internal derangement of temporomandibular joint. J Craniofac Surg, 2013, 24(3): 748-752.
【32】Sato J, Segami N, Kaneyama K, et al. Vascular endothelial growth factor concentrations in synovial fluids of patients with symptomatic internal derangement of the temporomandibular joint . J Oral Pathol Med, 2005, 34(3): 170-177.
【33】Kumagai K, Hamada Y, Holmlund AB, et al. The levels of vascular endothelial growth factor in the synovial fluid correlated with the severity of arthroscopically observed synovitis and clinical outcome after temporomandibular joint irrigation in patients with chronic closed lock. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2010, 109(2): 185-190.

[1]	WANG Chu-yao, ZOU Lu-xiang, LU Chuan, HE Dong-mei. Study on the mechanism of miR-330-3p in cartilage degeneration in temporomandibular joint osteoarthritis in rats [J]. China Journal of Oral and Maxillofacial Surgery, 2022, 20(4): 320-327.
[2]	YOU Yuan-he, DU Zhong, LIU Jia-liang, ZHENG Jia-wei, WANG Yan-an. Research progress of regulating endothelial cell related arteriovenous differentiation [J]. China Journal of Oral and Maxillofacial Surgery, 2021, 19(1): 82-87.
[3]	SUN Hua-liang, XU Da-peng, XUE Lei, SUN Ning-ning, ZHONG Ming, WANG Xu-kai. Expression and correlation of MIC-1, VEGF and p53 in infantile hemangioma [J]. China Journal of Oral and Maxillofacial Surgery, 2014, 12(4): 328-332.