Research progress in the pathogenesis of tenosynovial giant cell tumor

doi:10.19438/j.cjoms.2026.02.015

Abstract

Abstract: Tenosynovial giant cell tumor(TGCT) is a benign mesenchymal tumor originated from the synovium of joints and tendon sheaths, which might occur in any joint of the body. It is classified into localized and diffused types based on its different growth patterns. The exact pathogenesis of TGCT remains unclear presently. While it was initially thought to be an inflammatory condition, the majority now perceives TGCT to be a neoplastic lesion due to its genetically clonal abnormalities, the autonomous growth of tumors and the highly specific expression of certain genes. This review summarized the latest advancements in genetic alterations, molecular changes in various cytokines and cellular interactions of TGCT, and explored the mechanisms that lead to the formation and progression of tumor, aiming to provide references for basic research, clinical diagnosis and treatment.

Key words: Tenosynovial giant cell tumor, Pathogenesis, Gene mutation, Cytokines, Intercellular Interactions

CLC Number:

R739.8

Shen Jiachen, Yan Siqi, Li Ye, Yang Chi, Zheng Jisi. Research progress in the pathogenesis of tenosynovial giant cell tumor[J]. China Journal of Oral and Maxillofacial Surgery, 2026, 24(2): 190-195.

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