Progress in the regulation and mechanisms of osteoinduction by the surface microstructure of calcium phosphate ceramics

doi:10.19438/j.cjoms.2026.01.013

Abstract

Abstract: Critical bone defects caused by trauma, tumors, congenital malformations, infections, and other factors present significant challenges in clinical treatment. Calcium phosphate ceramics(CaPs) not only promote bone formation at the defect site but also induce ectopic bone formation in sites such as muscle and subcutaneous tissue, addressing challenges in repairing critical bone defects. The surface microstructure of CaPs is a key factor influencing their osteoinductive properties. This paper reviewed the impact of microstructural features on the osteoinductive potential of CaPs, explored the mechanisms by which surface microstructure induces ectopic bone formation, and provided theoretical insights for future design and clinical application of CaPs materials.

Key words: Calcium phosphate ceramics, Surface microstructure, Osteoinduction, Mechanical transduction, Immunomodulation

CLC Number:

R782.2
R318

Wang Yue, Bao Chongyun. Progress in the regulation and mechanisms of osteoinduction by the surface microstructure of calcium phosphate ceramics[J]. China Journal of Oral and Maxillofacial Surgery, 2026, 24(1): 83-88.

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