Abstract: Exosomes are nano-scale vesicles secreted by living cells into the extracellular matrix, and they play an important role in material exchange and signal transduction between cells. It can transfer the lipids, proteins, and nucleic acids to the recipient cells through ligand binding, phagocytosisand plasma membrane fusion, and regulate the physiological and pathological processes of the recipient cells. As an important "cargo" in exosomes, microRNAs are transported to recipient cells and participate in gene transcription and regulatory signaling pathways, thereby regulating the development of diseases. In recent years, research on exosomal miRNAs in periodontal diseases, mucosal-related diseases, oral cancer and other diseases has been increasing. This article reviewed the regulatory mechanisms of exosomal miRNAs in oral diseases, and discussed the potential prospects of exosomal miRNAs as biomarkers in the diagnosis of oral diseases.

Key words: Exosome, MicroRNA, Oral diseases